EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140350 (Gene tree)
Gene ID: 8125
Gene Symbol: ANP32A
Alias: LANP|PP32|I1PP2A|PHAPI|MAPM|mapmodulin|C15orf1
Full Name: acidic nuclear phosphoprotein 32 family member A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 42,388 bases
Position: chr15:68,778,535-68,820,922
Accession: 13233
RBP type: non-canonical RBP
Summary: (Acidic Nuclear Phosphoprotein 32 Family Member A) is a Protein Coding gene. Diseases associated with ANP32A include Spinocerebellar Ataxia 1 and Primary Cerebellar Degeneration. Among its related pathways are DNA Damage and Gene Expression. An important paralog of this gene is ANP32B.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21325029	pp32, an INHAT component, is a transcription machinery recruiter for maximal induction of IFN-stimulated genes.	J Cell Sci	2011 Mar 15	Kadota S	doi: 10.1242/jcs.078253

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560303	ANP32A-210	724	-	ENSP00000453838	177 (aa)	-	H0YN26
ENST00000561430	ANP32A-211	508	-	-	- (aa)	-	-
ENST00000409628	ANP32A-202	2001	-	ENSP00000386496	79 (aa)	-	H7BZ09
ENST00000267918	ANP32A-201	1084	-	-	- (aa)	-	-
ENST00000483221	ANP32A-205	420	-	-	- (aa)	-	-
ENST00000495764	ANP32A-209	504	-	-	- (aa)	-	-
ENST00000483551	ANP32A-206	3711	-	-	- (aa)	-	-
ENST00000495420	ANP32A-208	707	-	-	- (aa)	-	-
ENST00000480858	ANP32A-204	352	-	-	- (aa)	-	-
ENST00000486054	ANP32A-207	2015	-	-	- (aa)	-	-
ENST00000465139	ANP32A-203	2440	-	ENSP00000417864	249 (aa)	-	P39687

Gene Model

Click here to download ENSG00000140350's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140350	Platelet Function Tests	2.5385200E-005	-
ENSG00000140350	Platelet Function Tests	1.7414600E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140350's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140350	ANP32A	90	81.250	ENSG00000136938	ANP32B	64	81.366	Homo_sapiens
ENSG00000140350	ANP32A	86	71.053	ENSG00000143401	ANP32E	97	50.932	Homo_sapiens
ENSG00000140350	ANP32A	89	70.253	ENSMUSG00000015749	Anp32e	98	76.190	Mus_musculus
ENSG00000140350	ANP32A	91	72.671	ENSMUSG00000028333	Anp32b	59	72.671	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	16169070.17557114.21806989.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11555662.11729309.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	11729309.12524539.	IDA	Component
GO:0005783	endoplasmic reticulum	11555662.12524539.	IDA	Component
GO:0006913	nucleocytoplasmic transport	21873635.	IBA	Process
GO:0006913	nucleocytoplasmic transport	11729309.	IDA	Process
GO:0006913	nucleocytoplasmic transport	11555662.	NAS	Process
GO:0035556	intracellular signal transduction	8192856.	TAS	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0048471	perinuclear region of cytoplasm	21873635.	IBA	Component
GO:0048471	perinuclear region of cytoplasm	11555662.12524539.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21152064	pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.	PLoS One	2010 Nov 29	Williams TK	doi: 10.1371/journal.pone.0015455.
21317927	MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.	Oncogene	2011 Jun 30	Schramedei K	doi: 10.1038/onc.2011.15
12522243	Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway.	Science	2003 Jan 10	Jiang X	-
17962813	pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer.	Cell Death Differ	2008 Jan	Hoffarth S	-
26918356	Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients.	Oncotarget	2016 Mar 8	Velmurugan BK	doi: 10.18632/oncotarget.7681.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	68787812	Silent	novel	L54L	0.26
BLCA	chr15	68787807	Missense_Mutation	NA	S56L	0.18
BLCA	chr15	68787476	Silent	rs770857235	P88P	0.5
BLCA	chr15	68787456	Missense_Mutation	novel	L95S	0.4
BLCA	chr15	68787845	Silent	novel	E43E	0.19
BLCA	chr15	68787824	Missense_Mutation	novel	I50M	0.3
BLCA	chr15	68787510	Missense_Mutation	novel	S77L	0.3
BLCA	chr15	68787887	Silent	rs768549533	S29S	0.27
BLCA	chr15	68787523	Missense_Mutation	novel	D73N	0.2
BRCA	chr15	68787534	Missense_Mutation	NA	L69R	0.28
BRCA	chr15	68779918	3'UTR	novel		0.68
BRCA	chr15	68780076	3'UTR	novel		0.34
BRCA	chr15	68784526	Nonsense_Mutation	NA	E133*	0.1
CESC	chr15	68780092	Missense_Mutation	novel	D247N	0.14
CESC	chr15	68820883	5'UTR	novel		0.32
CESC	chr15	68779816	3'UTR	novel		0.07
CESC	chr15	68820845	5'UTR	novel		0.32
CHOL	chr15	68779807	3'UTR	novel		0.26
COAD	chr15	68787533	Splice_Region	novel	L69L	0.28
COAD	chr15	68787429	Missense_Mutation	novel	S104N	0.37
ESCA	chr15	68779909	3'UTR	novel		0.56
ESCA	chr15	68787809	Silent	rs755371580	T55T	0.17
GBM	chr15	68784474	Missense_Mutation	novel	R150L	0.47
GBM	chr15	68787503	Silent	novel	G79G	0.06
GBM	chr15	68784561	Missense_Mutation	novel	F121C	0.27
HNSC	chr15	68820710	Silent	rs373044896	R14R	0.22
HNSC	chr15	68787803	Missense_Mutation	novel	I57M	0.22
KICH	chr15	68787477	Missense_Mutation	NA	P88L	0.1
LUAD	chr15	68787525	Frame_Shift_Ins	novel	*S72Mfs31**	0.11
LUAD	chr15	68780416	Missense_Mutation	NA	L228F	0.14
LUAD	chr15	68780095	Missense_Mutation	NA	E246Q	0.11
LUAD	chr15	68787453	In_Frame_Del	novel	L80_G97del	0.04
LUSC	chr15	68820780	5'UTR	novel		0.28
LUSC	chr15	68820713	Missense_Mutation	NA	N13K	0.16
OV	chr15	68784483	Missense_Mutation	novel	G147V	0.1
OV	chr15	68787770	Splice_Region	novel	K68K	0.17
PRAD	chr15	68787833	Silent	novel	L47L	0.37
READ	chr15	68780452	Missense_Mutation	NA	D216N	0.31
READ	chr15	68820790	5'UTR	novel		0.38
READ	chr15	68779965	3'UTR	novel		1
READ	chr15	68780113	Nonsense_Mutation	novel	E240*	0.12
SARC	chr15	68784470	Silent	rs116525439	D151D	0.19
SKCM	chr15	68787506	Silent	rs774050405	G78G	0.48
SKCM	chr15	68787850	Nonsense_Mutation	NA	E42*	0.6
SKCM	chr15	68820717	Missense_Mutation	NA	R12Q	0.17
SKCM	chr15	68784490	Missense_Mutation	NA	L145F	0.39
SKCM	chr15	68780450	Missense_Mutation	novel	D216E	0.4
SKCM	chr15	68820754	5'UTR	novel		0.31
STAD	chr15	68787504	Frame_Shift_Del	novel	*G79Afs15**	0.12
STAD	chr15	68780104	Missense_Mutation	NA	D243Y	0.26
STAD	chr15	68787898	Missense_Mutation	NA	N26H	0.17
STAD	chr15	68780116	Nonsense_Mutation	novel	R239*	0.14
STAD	chr15	68820761	5'UTR	rs773787712		0.47
STAD	chr15	68787815	Silent	NA	G53G	0.24
THCA	chr15	68780425	Missense_Mutation	NA	E225K	0.12
UCEC	chr15	68784419	Silent	novel	D168D	0.12
UCEC	chr15	68787830	Silent	rs774366260	S48S	0.08
UCEC	chr15	68820725	Silent	NA	L9L	0.46
UCEC	chr15	68787440	Silent	novel	I100I	0.09
UCEC	chr15	68780116	Nonsense_Mutation	novel	R239*	0.19
UCEC	chr15	68801876	Intron	novel		0.3
UCEC	chr15	68820845	5'UTR	novel		0.28
UCEC	chr15	68779879	3'UTR	novel		0.24
UCEC	chr15	68779858	3'UTR	novel		0.37
UCEC	chr15	68782990	Missense_Mutation	novel	E197G	0.44
UCEC	chr15	68787861	Missense_Mutation	novel	T38I	0.47
UCEC	chr15	68779867	3'UTR	novel		0.33
UCEC	chr15	68780054	3'UTR	novel		0.35
UCEC	chr15	68780100	Missense_Mutation	novel	E244G	0.33
UCEC	chr15	68787780	Missense_Mutation	NA	K65T	0.32
UCEC	chr15	68780460	Missense_Mutation	novel	G213D	0.17
UCEC	chr15	68784575	Missense_Mutation	novel	K116N	0.23
UCEC	chr15	68787913	Nonsense_Mutation	novel	E21*	0.19
UCEC	chr15	68820759	5'UTR	novel		0.39
UCEC	chr15	68780435	Silent	rs771627129	D221D	0.34
UCEC	chr15	68784475	Missense_Mutation	novel	R150W	0.36
UCS	chr15	68784535	Missense_Mutation	rs771143708	D130N	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LGG	AMP	0.0156	0.19963
PAAD	AMP	0.0652	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0034	Kaplan-Meier Survival Analysis
MESO	0.0078	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.016	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
READ	0.043	Kaplan-Meier Survival Analysis
LIHC	0.0087	Kaplan-Meier Survival Analysis
LUAD	0.0039	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742