EuRBPDB

Description

Ensembl ID: ENSG00000140374 (Gene tree)
Gene ID: 2108
Gene Symbol: ETFA
Alias: GA2|EMA|MADD
Full Name: electron transfer flavoprotein subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 96,118 bases
Position: chr15:76,215,355-76,311,472
Accession: 3481
RBP type: non-canonical RBP
Summary: ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561092	ETFA-219	461	-	-	- (aa)	-	-
ENST00000559758	ETFA-209	893	-	-	- (aa)	-	-
ENST00000560044	ETFA-211	1054	-	ENSP00000452942	45 (aa)	-	H0YMU8
ENST00000560899	ETFA-218	910	-	ENSP00000453422	39 (aa)	-	H0YM12
ENST00000559075	ETFA-206	1735	-	-	- (aa)	-	-
ENST00000560309	ETFA-213	633	-	ENSP00000453753	45 (aa)	-	H0YMU8
ENST00000560595	ETFA-215	917	-	ENSP00000453345	303 (aa)	-	H0YLU7
ENST00000558803	ETFA-205	447	-	-	- (aa)	-	-
ENST00000559386	ETFA-207	893	-	ENSP00000452777	289 (aa)	-	H0YKF0
ENST00000560726	ETFA-216	942	-	ENSP00000453098	73 (aa)	-	H0YL83
ENST00000557943	ETFA-203	2287	-	ENSP00000452762	333 (aa)	-	P13804
ENST00000560345	ETFA-214	717	-	ENSP00000453017	239 (aa)	-	H0YL12
ENST00000559973	ETFA-210	804	-	ENSP00000454194	254 (aa)	-	H0YNX6
ENST00000559602	ETFA-208	792	-	ENSP00000452659	229 (aa)	-	H0YK49
ENST00000565910	ETFA-220	609	-	ENSP00000458001	46 (aa)	-	H3BV91
ENST00000557975	ETFA-204	1086	-	-	- (aa)	-	-
ENST00000267950	ETFA-201	1289	-	ENSP00000267950	64 (aa)	-	J3KN60
ENST00000433983	ETFA-202	1346	-	ENSP00000399273	284 (aa)	-	P13804
ENST00000560816	ETFA-217	412	-	-	- (aa)	-	-
ENST00000560179	ETFA-212	650	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140374	Cholesterol	7.5800000E-005	-
ENSG00000140374	Glioma	6E-9	26424050
ENSG00000140374	Arthritis, Rheumatoid	7E-7	22491018
ENSG00000140374	Drug Resistance	7E-7	22491018

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140374	rs77633900	15	76246118	C	Non-glioblastoma glioma	28346443	1.25-1.46	1.35	EFO_0000326\|EFO_0005543
ENSG00000140374	rs1914816	15	76254592	?	Response to tocilizumab in rheumatoid arthritis	22491018	[NR] unit increase	0.87	EFO_0000685\|GO_0042493
ENSG00000140374	rs77633900	15	76246118	C	Glioma	28346443	1.11-1.25	1.18	EFO_0000326\|EFO_0005543
ENSG00000140374	rs10519134	15	76286749	A	Diverticular disease	30177863	[NR] unit increase	0.0038848	EFO_1001460
ENSG00000140374	rs2938697	15	76262650	T	Heel bone mineral density	30598549	[0.0079-0.016] unit increase	0.0119617	EFO_0009270

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140374	ETFA	100	100.000	ENSMUSG00000032314	Etfa	100	95.796	Mus_musculus
ENSG00000140374	ETFA	99	73.611	YPR004C		99	46.064	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	24606901.27499296.28380382.	IPI	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0009055	electron transfer activity	21873635.	IBA	Function
GO:0009055	electron transfer activity	10423253.25416781.	IDA	Function
GO:0016491	oxidoreductase activity	21873635.	IBA	Function
GO:0016491	oxidoreductase activity	9334218.10423253.	IDA	Function
GO:0022904	respiratory electron transport chain	-	TAS	Process
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	21873635.	IBA	Process
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	25416781.	IDA	Process
GO:0050660	flavin adenine dinucleotide binding	21873635.	IBA	Function
GO:0050660	flavin adenine dinucleotide binding	9334218.10423253.	IDA	Function