EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140386 (Gene tree)
Gene ID: 49855
Gene Symbol: SCAPER
Alias: Zfp291|ZNF291
Full Name: S-phase cyclin A associated protein in the ER
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 557,552 bases
Position: chr15:76,347,904-76,905,455
Accession: 13081
RBP type: canonical RBP
Summary: (S-Phase Cyclin A Associated Protein In The ER) is a Protein Coding gene. Diseases associated with SCAPER include Intellectual Developmental Disorder And Retinitis Pigmentosa and Brachydactyly. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000442190	zf-met	PF12874.7	5.5e-05	1	1
ENSP00000326924	zf-met	PF12874.7	7.6e-05	1	1
ENSP00000454973	zf-met	PF12874.7	7.6e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000563919	SCAPER-209	641	-	ENSP00000455231	111 (aa)	-	H3BPB0
ENST00000567618	SCAPER-218	565	-	-	- (aa)	-	-
ENST00000564177	SCAPER-211	576	-	ENSP00000457382	60 (aa)	-	H3BTY2
ENST00000563246	SCAPER-206	552	-	-	- (aa)	-	-
ENST00000564757	SCAPER-213	626	-	ENSP00000457234	99 (aa)	-	H3BTL8
ENST00000565372	SCAPER-214	572	-	ENSP00000455751	154 (aa)	-	H3BQF3
ENST00000569395	SCAPER-222	558	-	-	- (aa)	-	-
ENST00000538941	SCAPER-203	4853	XM_011521656	ENSP00000442190	1154 (aa)	XP_011519958	Q9BY12
ENST00000564022	SCAPER-210	574	-	ENSP00000456987	191 (aa)	-	H3BT27
ENST00000568428	SCAPER-220	590	-	-	- (aa)	-	-
ENST00000568549	SCAPER-221	625	-	ENSP00000457434	62 (aa)	-	H3BU24
ENST00000563290	SCAPER-207	5028	-	ENSP00000454973	1400 (aa)	-	Q9BY12
ENST00000567601	SCAPER-217	131	-	-	- (aa)	-	-
ENST00000562890	SCAPER-204	671	-	-	- (aa)	-	-
ENST00000563688	SCAPER-208	549	-	-	- (aa)	-	-
ENST00000568382	SCAPER-219	544	-	ENSP00000456065	115 (aa)	-	H3BR40
ENST00000324767	SCAPER-202	4707	XM_005254417	ENSP00000326924	1400 (aa)	XP_005254474	Q9BY12
ENST00000565507	SCAPER-215	2627	-	ENSP00000455623	75 (aa)	-	H3BQ61
ENST00000303521	SCAPER-201	5438	-	-	- (aa)	-	-
ENST00000564590	SCAPER-212	2507	XM_017022283	ENSP00000456508	767 (aa)	XP_016877772	H3BS25
ENST00000565970	SCAPER-216	2388	-	ENSP00000455378	747 (aa)	-	H3BPM0
ENST00000562948	SCAPER-205	3795	-	-	- (aa)	-	-
ENST00000569784	SCAPER-223	580	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000140386's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140386	Body Weight	2.11059124980797E-7	17903300
ENSG00000140386	Varicose Veins	1.11868783199433E-19	-
ENSG00000140386	Fructose-Bisphosphate Aldolase	5.6090000E-005	-
ENSG00000140386	Metabolism	4E-13	24816252
ENSG00000140386	Dermatitis, Atopic	3E-7	25935106
ENSG00000140386	Schizophrenia	5E-6	26198764
ENSG00000140386	Alzheimer Disease	2E-6	27770636
ENSG00000140386	Alzheimer Disease	3E-6	27770636

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140386	rs183291664	15	76713822	T	Late-onset Alzheimer's disease	27770636	[0.34-0.82] unit decrease	0.58	EFO_1001870
ENSG00000140386	rs144077517	15	76352686	A	Late-onset Alzheimer's disease	27770636	[0.32-0.76] unit increase	0.54	EFO_1001870
ENSG00000140386	rs3099143	15	76812515	C	Recalcitrant atopic dermatitis	25935106	[1.594-2.841]	2.126	EFO_1000651
ENSG00000140386	rs2957613	15	76408248	T	Schizophrenia	26198764	[NR]	1.09	EFO_0000692
ENSG00000140386	rs2404602	15	76738451	A	Blood metabolite levels	24816252	[0.018-0.034] unit increase	0.026	EFO_0005664
ENSG00000140386	rs2056544	15	76533662	A	Diverticular disease	30177863	[NR] unit increase	0.0029364	EFO_1001460
ENSG00000140386	rs140802894	15	76607515	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140386's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140386	SCAPER	74	80.769	ENSAPOG00000009444	scaper	91	80.769	Acanthochromis_polyacanthus
ENSG00000140386	SCAPER	100	96.667	ENSAMEG00000008276	SCAPER	100	91.710	Ailuropoda_melanoleuca
ENSG00000140386	SCAPER	95	91.228	ENSACIG00000000798	scaper	99	67.048	Amphilophus_citrinellus
ENSG00000140386	SCAPER	95	89.474	ENSAOCG00000003198	scaper	100	67.308	Amphiprion_ocellaris
ENSG00000140386	SCAPER	95	89.474	ENSAPEG00000018493	scaper	100	67.595	Amphiprion_percula
ENSG00000140386	SCAPER	95	92.982	ENSATEG00000006785	scaper	97	76.041	Anabas_testudineus
ENSG00000140386	SCAPER	100	93.651	ENSAPLG00000014716	-	99	81.329	Anas_platyrhynchos
ENSG00000140386	SCAPER	100	96.667	ENSACAG00000011770	SCAPER	99	78.672	Anolis_carolinensis
ENSG00000140386	SCAPER	100	98.333	ENSANAG00000028694	SCAPER	99	97.368	Aotus_nancymaae
ENSG00000140386	SCAPER	95	89.474	ENSACLG00000019392	scaper	93	76.393	Astatotilapia_calliptera
ENSG00000140386	SCAPER	95	94.737	ENSAMXG00000000557	scaper	100	67.211	Astyanax_mexicanus
ENSG00000140386	SCAPER	100	75.879	ENSBTAG00000007382	SCAPER	93	87.874	Bos_taurus
ENSG00000140386	SCAPER	100	100.000	ENSCJAG00000010868	SCAPER	99	97.368	Callithrix_jacchus
ENSG00000140386	SCAPER	100	98.333	ENSCAFG00000018100	SCAPER	100	90.656	Canis_familiaris
ENSG00000140386	SCAPER	100	98.333	ENSCAFG00020003622	SCAPER	100	90.514	Canis_lupus_dingo
ENSG00000140386	SCAPER	100	100.000	ENSCHIG00000022995	SCAPER	100	92.439	Capra_hircus
ENSG00000140386	SCAPER	80	97.500	ENSTSYG00000012246	-	99	100.000	Carlito_syrichta
ENSG00000140386	SCAPER	100	100.000	ENSCPOG00000010059	SCAPER	99	89.207	Cavia_porcellus
ENSG00000140386	SCAPER	100	82.234	ENSCCAG00000030339	-	99	97.297	Cebus_capucinus
ENSG00000140386	SCAPER	100	100.000	ENSCATG00000039987	SCAPER	99	100.000	Cercocebus_atys
ENSG00000140386	SCAPER	100	100.000	ENSCLAG00000009206	SCAPER	99	90.178	Chinchilla_lanigera
ENSG00000140386	SCAPER	88	98.723	ENSCSAG00000014700	SCAPER	100	98.723	Chlorocebus_sabaeus
ENSG00000140386	SCAPER	100	98.333	ENSCHOG00000001406	SCAPER	74	98.630	Choloepus_hoffmanni
ENSG00000140386	SCAPER	100	100.000	ENSCANG00000035150	SCAPER	99	100.000	Colobus_angolensis_palliatus
ENSG00000140386	SCAPER	100	96.667	ENSCGRG00001022568	Scaper	100	89.143	Cricetulus_griseus_chok1gshd
ENSG00000140386	SCAPER	100	96.667	ENSCGRG00000005674	Scaper	100	89.143	Cricetulus_griseus_crigri
ENSG00000140386	SCAPER	95	85.965	ENSCSEG00000008433	scaper	96	71.719	Cynoglossus_semilaevis
ENSG00000140386	SCAPER	95	91.228	ENSCVAG00000016132	scaper	99	67.234	Cyprinodon_variegatus
ENSG00000140386	SCAPER	95	91.228	ENSDARG00000023104	scaper	95	83.242	Danio_rerio
ENSG00000140386	SCAPER	100	98.333	ENSDNOG00000017626	SCAPER	100	91.450	Dasypus_novemcinctus
ENSG00000140386	SCAPER	98	98.305	ENSDORG00000003400	Scaper	100	88.299	Dipodomys_ordii
ENSG00000140386	SCAPER	76	70.293	ENSEBUG00000004562	scaper	99	54.133	Eptatretus_burgeri
ENSG00000140386	SCAPER	100	98.333	ENSEASG00005015656	SCAPER	100	92.902	Equus_asinus_asinus
ENSG00000140386	SCAPER	100	98.333	ENSECAG00000017272	SCAPER	100	95.385	Equus_caballus
ENSG00000140386	SCAPER	100	98.333	ENSEEUG00000012419	SCAPER	87	94.872	Erinaceus_europaeus
ENSG00000140386	SCAPER	95	92.982	ENSELUG00000018590	scaper	96	66.620	Esox_lucius
ENSG00000140386	SCAPER	100	98.333	ENSFCAG00000002872	SCAPER	100	92.154	Felis_catus
ENSG00000140386	SCAPER	100	96.667	ENSFALG00000010716	SCAPER	99	78.985	Ficedula_albicollis
ENSG00000140386	SCAPER	100	98.333	ENSFDAG00000014303	SCAPER	99	90.422	Fukomys_damarensis
ENSG00000140386	SCAPER	95	91.228	ENSFHEG00000002310	scaper	97	73.367	Fundulus_heteroclitus
ENSG00000140386	SCAPER	95	91.228	ENSGMOG00000006763	scaper	99	67.347	Gadus_morhua
ENSG00000140386	SCAPER	100	95.000	ENSGALG00000002883	SCAPER	99	77.889	Gallus_gallus
ENSG00000140386	SCAPER	99	65.585	ENSGAFG00000000748	scaper	99	62.973	Gambusia_affinis
ENSG00000140386	SCAPER	95	89.474	ENSGACG00000010509	scaper	100	66.855	Gasterosteus_aculeatus
ENSG00000140386	SCAPER	100	95.000	ENSGAGG00000025253	SCAPER	99	82.395	Gopherus_agassizii
ENSG00000140386	SCAPER	100	100.000	ENSGGOG00000025692	SCAPER	100	99.429	Gorilla_gorilla
ENSG00000140386	SCAPER	100	96.667	ENSHGLG00000001955	SCAPER	99	90.000	Heterocephalus_glaber_female
ENSG00000140386	SCAPER	95	91.228	ENSIPUG00000020739	scaper	93	74.220	Ictalurus_punctatus
ENSG00000140386	SCAPER	100	100.000	ENSSTOG00000005985	SCAPER	100	93.429	Ictidomys_tridecemlineatus
ENSG00000140386	SCAPER	100	96.667	ENSJJAG00000019627	Scaper	100	89.447	Jaculus_jaculus
ENSG00000140386	SCAPER	95	89.474	ENSKMAG00000016978	scaper	93	74.824	Kryptolebias_marmoratus
ENSG00000140386	SCAPER	100	93.333	ENSLACG00000011359	SCAPER	95	75.231	Latimeria_chalumnae
ENSG00000140386	SCAPER	97	94.828	ENSLOCG00000014697	scaper	99	71.196	Lepisosteus_oculatus
ENSG00000140386	SCAPER	100	98.333	ENSLAFG00000006142	SCAPER	100	93.158	Loxodonta_africana
ENSG00000140386	SCAPER	100	100.000	ENSMFAG00000030020	SCAPER	99	100.000	Macaca_fascicularis
ENSG00000140386	SCAPER	100	100.000	ENSMMUG00000011047	SCAPER	100	95.494	Macaca_mulatta
ENSG00000140386	SCAPER	100	100.000	ENSMNEG00000040140	SCAPER	100	98.429	Macaca_nemestrina
ENSG00000140386	SCAPER	100	100.000	ENSMLEG00000039136	SCAPER	99	100.000	Mandrillus_leucophaeus
ENSG00000140386	SCAPER	95	91.228	ENSMAMG00000008299	scaper	96	75.483	Mastacembelus_armatus
ENSG00000140386	SCAPER	95	89.474	ENSMZEG00005022370	scaper	93	76.393	Maylandia_zebra
ENSG00000140386	SCAPER	100	95.000	ENSMGAG00000003376	SCAPER	100	77.707	Meleagris_gallopavo
ENSG00000140386	SCAPER	100	96.667	ENSMAUG00000016307	Scaper	100	81.187	Mesocricetus_auratus
ENSG00000140386	SCAPER	100	98.462	ENSMICG00000002635	SCAPER	100	92.500	Microcebus_murinus
ENSG00000140386	SCAPER	100	100.000	ENSMOCG00000011135	Scaper	100	87.838	Microtus_ochrogaster
ENSG00000140386	SCAPER	95	91.228	ENSMMOG00000006736	scaper	99	73.669	Mola_mola
ENSG00000140386	SCAPER	100	98.333	ENSMODG00000012042	SCAPER	95	84.226	Monodelphis_domestica
ENSG00000140386	SCAPER	95	92.982	ENSMALG00000009703	scaper	99	66.928	Monopterus_albus
ENSG00000140386	SCAPER	100	100.000	MGP_CAROLIEiJ_G0032248	Scaper	100	88.186	Mus_caroli
ENSG00000140386	SCAPER	100	100.000	ENSMUSG00000034007	Scaper	100	87.946	Mus_musculus
ENSG00000140386	SCAPER	100	98.462	MGP_PahariEiJ_G0015115	Scaper	100	88.397	Mus_pahari
ENSG00000140386	SCAPER	100	100.000	MGP_SPRETEiJ_G0033388	Scaper	100	87.500	Mus_spretus
ENSG00000140386	SCAPER	100	98.333	ENSMPUG00000017346	SCAPER	100	92.582	Mustela_putorius_furo
ENSG00000140386	SCAPER	100	96.667	ENSMLUG00000013275	SCAPER	100	89.758	Myotis_lucifugus
ENSG00000140386	SCAPER	100	95.000	ENSNGAG00000000134	Scaper	100	90.643	Nannospalax_galili
ENSG00000140386	SCAPER	95	89.474	ENSNBRG00000019027	scaper	92	78.312	Neolamprologus_brichardi
ENSG00000140386	SCAPER	98	89.908	ENSMEUG00000004886	SCAPER	94	91.473	Notamacropus_eugenii
ENSG00000140386	SCAPER	84	97.436	ENSOPRG00000000782	SCAPER	84	97.436	Ochotona_princeps
ENSG00000140386	SCAPER	100	100.000	ENSODEG00000013935	SCAPER	99	89.680	Octodon_degus
ENSG00000140386	SCAPER	95	91.228	ENSONIG00000015249	scaper	96	68.897	Oreochromis_niloticus
ENSG00000140386	SCAPER	100	96.667	ENSOANG00000007548	-	100	83.360	Ornithorhynchus_anatinus
ENSG00000140386	SCAPER	100	96.667	ENSOCUG00000015016	-	96	86.801	Oryctolagus_cuniculus
ENSG00000140386	SCAPER	95	87.719	ENSORLG00000007912	scaper	99	65.407	Oryzias_latipes
ENSG00000140386	SCAPER	95	87.719	ENSORLG00020005434	scaper	93	72.992	Oryzias_latipes_hni
ENSG00000140386	SCAPER	95	87.719	ENSORLG00015019417	scaper	99	66.074	Oryzias_latipes_hsok
ENSG00000140386	SCAPER	95	87.719	ENSOMEG00000023175	scaper	99	64.785	Oryzias_melastigma
ENSG00000140386	SCAPER	100	96.667	ENSOGAG00000001993	SCAPER	100	92.505	Otolemur_garnettii
ENSG00000140386	SCAPER	100	100.000	ENSOARG00000001531	SCAPER	100	92.867	Ovis_aries
ENSG00000140386	SCAPER	100	100.000	ENSPPAG00000039046	SCAPER	99	100.000	Pan_paniscus
ENSG00000140386	SCAPER	100	98.333	ENSPPRG00000007109	SCAPER	100	92.154	Panthera_pardus
ENSG00000140386	SCAPER	100	98.333	ENSPTIG00000007100	SCAPER	100	92.154	Panthera_tigris_altaica
ENSG00000140386	SCAPER	100	100.000	ENSPTRG00000007316	SCAPER	100	99.571	Pan_troglodytes
ENSG00000140386	SCAPER	100	100.000	ENSPANG00000015870	SCAPER	99	100.000	Papio_anubis
ENSG00000140386	SCAPER	95	92.982	ENSPKIG00000001843	scaper	96	71.357	Paramormyrops_kingsleyae
ENSG00000140386	SCAPER	100	96.667	ENSPSIG00000008336	SCAPER	100	81.604	Pelodiscus_sinensis
ENSG00000140386	SCAPER	95	87.719	ENSPMGG00000006916	scaper	96	69.301	Periophthalmus_magnuspinnatus
ENSG00000140386	SCAPER	100	100.000	ENSPEMG00000010929	Scaper	100	89.047	Peromyscus_maniculatus_bairdii
ENSG00000140386	SCAPER	100	96.667	ENSPCIG00000028166	SCAPER	99	84.105	Phascolarctos_cinereus
ENSG00000140386	SCAPER	95	92.982	ENSPFOG00000003057	scaper	96	65.560	Poecilia_formosa
ENSG00000140386	SCAPER	95	92.982	ENSPLAG00000017743	scaper	96	65.835	Poecilia_latipinna
ENSG00000140386	SCAPER	95	92.982	ENSPMEG00000001222	scaper	94	72.468	Poecilia_mexicana
ENSG00000140386	SCAPER	95	91.228	ENSPREG00000008179	scaper	97	73.306	Poecilia_reticulata
ENSG00000140386	SCAPER	100	100.000	ENSPPYG00000006677	SCAPER	100	98.857	Pongo_abelii
ENSG00000140386	SCAPER	100	98.198	ENSPCOG00000027910	SCAPER	100	93.143	Propithecus_coquereli
ENSG00000140386	SCAPER	100	98.333	ENSPVAG00000014823	SCAPER	93	88.908	Pteropus_vampyrus
ENSG00000140386	SCAPER	95	89.474	ENSPNYG00000011332	scaper	95	76.292	Pundamilia_nyererei
ENSG00000140386	SCAPER	95	94.737	ENSPNAG00000014454	scaper	100	66.501	Pygocentrus_nattereri
ENSG00000140386	SCAPER	100	100.000	ENSRNOG00000006864	Scaper	100	88.365	Rattus_norvegicus
ENSG00000140386	SCAPER	100	86.294	ENSRBIG00000028430	-	97	100.000	Rhinopithecus_bieti
ENSG00000140386	SCAPER	100	100.000	ENSSBOG00000033819	SCAPER	99	97.222	Saimiri_boliviensis_boliviensis
ENSG00000140386	SCAPER	100	98.333	ENSSHAG00000014849	SCAPER	98	83.974	Sarcophilus_harrisii
ENSG00000140386	SCAPER	95	92.982	ENSSFOG00015020464	scaper	99	67.804	Scleropages_formosus
ENSG00000140386	SCAPER	95	84.211	ENSSMAG00000016667	scaper	95	73.419	Scophthalmus_maximus
ENSG00000140386	SCAPER	95	89.474	ENSSDUG00000010365	scaper	100	67.489	Seriola_dumerili
ENSG00000140386	SCAPER	95	89.474	ENSSLDG00000024996	scaper	100	67.543	Seriola_lalandi_dorsalis
ENSG00000140386	SCAPER	100	98.333	ENSSPUG00000016112	SCAPER	100	81.553	Sphenodon_punctatus
ENSG00000140386	SCAPER	95	89.474	ENSSPAG00000020993	scaper	98	68.495	Stegastes_partitus
ENSG00000140386	SCAPER	100	98.462	ENSSSCG00000001865	SCAPER	99	98.462	Sus_scrofa
ENSG00000140386	SCAPER	100	96.667	ENSTGUG00000003573	SCAPER	99	78.725	Taeniopygia_guttata
ENSG00000140386	SCAPER	95	89.474	ENSTRUG00000008486	scaper	99	65.743	Takifugu_rubripes
ENSG00000140386	SCAPER	95	87.719	ENSTNIG00000008381	scaper	99	64.003	Tetraodon_nigroviridis
ENSG00000140386	SCAPER	83	92.147	ENSTBEG00000012889	SCAPER	82	92.147	Tupaia_belangeri
ENSG00000140386	SCAPER	99	96.396	ENSTTRG00000016065	SCAPER	84	93.498	Tursiops_truncatus
ENSG00000140386	SCAPER	91	92.155	ENSUMAG00000017597	SCAPER	99	92.155	Ursus_maritimus
ENSG00000140386	SCAPER	100	96.667	ENSVPAG00000004528	SCAPER	100	91.447	Vicugna_pacos
ENSG00000140386	SCAPER	100	98.333	ENSVVUG00000019730	SCAPER	100	90.585	Vulpes_vulpes
ENSG00000140386	SCAPER	100	88.333	ENSXETG00000015319	scaper	100	70.769	Xenopus_tropicalis
ENSG00000140386	SCAPER	95	91.228	ENSXMAG00000003057	scaper	94	72.566	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function