EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140395 (Gene tree)
Gene ID: 80349
Gene Symbol: WDR61
Alias: REC14
Full Name: WD repeat domain 61
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 21,960 bases
Position: chr15:78,277,835-78,299,794
Accession: 30300
RBP type: canonical RBP
Summary: WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000453902	eIF2A	PF08662.11	9.6e-11	1	1
ENSP00000267973	eIF2A	PF08662.11	1.1e-10	1	1
ENSP00000453801	eIF2A	PF08662.11	1.1e-10	1	1
ENSP00000453024	eIF2A	PF08662.11	2.9e-07	1	1
ENSP00000455689	eIF2A	PF08662.11	3.1e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22114319	The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome.	RNA	2012 Jan	Halbach F	doi: 10.1261/rna.029553.111
23953113	The yeast ski complex: crystal structure and RNA channeling to the exosome complex.	Cell	2013 Aug 15	Halbach F	doi: 10.1016/j.cell.2013.07.017.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558412	WDR61-203	927	-	-	- (aa)	-	-
ENST00000560946	WDR61-215	603	-	-	- (aa)	-	-
ENST00000559332	WDR61-207	844	-	-	- (aa)	-	-
ENST00000561347	WDR61-216	1131	-	-	- (aa)	-	-
ENST00000558459	WDR61-205	884	-	ENSP00000453024	212 (aa)	-	H0YL19
ENST00000560063	WDR61-211	1355	-	-	- (aa)	-	-
ENST00000560569	WDR61-212	1036	-	ENSP00000453902	294 (aa)	-	H0YN81
ENST00000558311	WDR61-202	1266	XM_011522094	ENSP00000453801	305 (aa)	XP_011520396	Q9GZS3
ENST00000558453	WDR61-204	463	-	ENSP00000453118	72 (aa)	-	H0YLA1
ENST00000267973	WDR61-201	1387	XM_017022637	ENSP00000267973	305 (aa)	XP_016878126	Q9GZS3
ENST00000560807	WDR61-214	789	-	ENSP00000455689	163 (aa)	-	H3BQA8
ENST00000559700	WDR61-208	948	-	-	- (aa)	-	-
ENST00000559848	WDR61-209	756	-	ENSP00000453589	189 (aa)	-	H0YMF9
ENST00000559940	WDR61-210	3629	-	-	- (aa)	-	-
ENST00000558840	WDR61-206	554	-	-	- (aa)	-	-
ENST00000560610	WDR61-213	832	-	ENSP00000453493	48 (aa)	-	H0YM76

Gene Model

Click here to download ENSG00000140395's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140395	Body Height	2.0220000E-005	-
ENSG00000140395	Body Height	8.5520000E-005	-
ENSG00000140395	Body Height	1.6300000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140395	rs56299741	15	78296630	T	Cognitive performance (MTAG)	30038396	[0.01-0.021] unit decrease	0.0158	EFO_0008354
ENSG00000140395	rs2867933	15	78282445	T	Red cell distribution width	28957414	[0.038-0.066] unit increase	0.0520158	EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140395's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000140395	WDR61	98	40.397	ENSG00000196363	WDR5	89	39.506

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140395	WDR61	100	89.950	ENSAPOG00000016749	wdr61	100	89.950	Acanthochromis_polyacanthus
ENSG00000140395	WDR61	100	99.320	ENSAMEG00000012599	WDR61	100	98.995	Ailuropoda_melanoleuca
ENSG00000140395	WDR61	90	95.238	ENSACIG00000012517	wdr61	100	89.855	Amphilophus_citrinellus
ENSG00000140395	WDR61	100	89.950	ENSAOCG00000007418	wdr61	100	89.950	Amphiprion_ocellaris
ENSG00000140395	WDR61	100	89.950	ENSAPEG00000009046	wdr61	100	89.950	Amphiprion_percula
ENSG00000140395	WDR61	100	88.945	ENSATEG00000021123	wdr61	100	88.945	Anabas_testudineus
ENSG00000140395	WDR61	98	92.683	ENSATEG00000021194	wdr61	99	88.945	Anabas_testudineus
ENSG00000140395	WDR61	100	93.467	ENSACAG00000005963	WDR61	100	93.467	Anolis_carolinensis
ENSG00000140395	WDR61	100	100.000	ENSANAG00000021280	WDR61	100	100.000	Aotus_nancymaae
ENSG00000140395	WDR61	100	85.714	ENSACLG00000024779	wdr61	100	88.945	Astatotilapia_calliptera
ENSG00000140395	WDR61	98	92.683	ENSAMXG00000008741	wdr61	100	88.945	Astyanax_mexicanus
ENSG00000140395	WDR61	100	100.000	ENSBTAG00000015944	WDR61	100	100.000	Bos_taurus
ENSG00000140395	WDR61	100	100.000	ENSCJAG00000010208	WDR61	100	100.000	Callithrix_jacchus
ENSG00000140395	WDR61	100	98.995	ENSCAFG00000014230	WDR61	100	98.995	Canis_familiaris
ENSG00000140395	WDR61	96	99.288	ENSCAFG00020015137	-	98	98.630	Canis_lupus_dingo
ENSG00000140395	WDR61	99	96.465	ENSCHIG00000014587	-	94	96.465	Capra_hircus
ENSG00000140395	WDR61	100	100.000	ENSCHIG00000026894	-	100	100.000	Capra_hircus
ENSG00000140395	WDR61	100	100.000	ENSTSYG00000008605	WDR61	100	100.000	Carlito_syrichta
ENSG00000140395	WDR61	100	99.016	ENSCPOG00000026884	WDR61	100	100.000	Cavia_porcellus
ENSG00000140395	WDR61	100	100.000	ENSCCAG00000030775	WDR61	100	100.000	Cebus_capucinus
ENSG00000140395	WDR61	100	100.000	ENSCATG00000043772	WDR61	100	100.000	Cercocebus_atys
ENSG00000140395	WDR61	100	100.000	ENSCLAG00000005339	WDR61	100	100.000	Chinchilla_lanigera
ENSG00000140395	WDR61	100	100.000	ENSCSAG00000014890	WDR61	100	99.672	Chlorocebus_sabaeus
ENSG00000140395	WDR61	100	100.000	ENSCANG00000030967	WDR61	100	100.000	Colobus_angolensis_palliatus
ENSG00000140395	WDR61	100	97.959	ENSCGRG00001015563	Wdr61	100	99.497	Cricetulus_griseus_chok1gshd
ENSG00000140395	WDR61	100	97.959	ENSCGRG00000016902	Wdr61	100	99.497	Cricetulus_griseus_crigri
ENSG00000140395	WDR61	90	94.558	ENSCSEG00000003113	wdr61	99	88.945	Cynoglossus_semilaevis
ENSG00000140395	WDR61	98	92.683	ENSCVAG00000010673	wdr61	98	90.957	Cyprinodon_variegatus
ENSG00000140395	WDR61	100	99.023	ENSDNOG00000032975	WDR61	100	100.000	Dasypus_novemcinctus
ENSG00000140395	WDR61	100	98.299	ENSDORG00000005973	Wdr61	99	100.000	Dipodomys_ordii
ENSG00000140395	WDR61	100	97.917	ENSETEG00000004321	WDR61	100	98.492	Echinops_telfairi
ENSG00000140395	WDR61	99	89.510	ENSEBUG00000010267	wdr61	99	89.362	Eptatretus_burgeri
ENSG00000140395	WDR61	100	99.344	ENSEASG00005015618	WDR61	100	100.000	Equus_asinus_asinus
ENSG00000140395	WDR61	100	99.344	ENSECAG00000005595	WDR61	100	100.000	Equus_caballus
ENSG00000140395	WDR61	95	98.571	ENSEEUG00000007076	WDR61	100	97.938	Erinaceus_europaeus
ENSG00000140395	WDR61	99	92.982	ENSELUG00000023597	wdr61	98	92.982	Esox_lucius
ENSG00000140395	WDR61	100	100.000	ENSFCAG00000010517	WDR61	100	99.497	Felis_catus
ENSG00000140395	WDR61	100	100.000	ENSFDAG00000005093	WDR61	100	100.000	Fukomys_damarensis
ENSG00000140395	WDR61	100	90.452	ENSFHEG00000000901	wdr61	100	90.452	Fundulus_heteroclitus
ENSG00000140395	WDR61	100	87.940	ENSGMOG00000009216	wdr61	100	87.940	Gadus_morhua
ENSG00000140395	WDR61	100	89.950	ENSGAFG00000005123	wdr61	100	89.950	Gambusia_affinis
ENSG00000140395	WDR61	100	88.442	ENSGACG00000007380	wdr61	100	88.442	Gasterosteus_aculeatus
ENSG00000140395	WDR61	100	100.000	ENSGGOG00000011473	WDR61	100	100.000	Gorilla_gorilla
ENSG00000140395	WDR61	100	85.714	ENSHBUG00000007122	wdr61	100	88.945	Haplochromis_burtoni
ENSG00000140395	WDR61	100	100.000	ENSHGLG00000001505	WDR61	100	100.000	Heterocephalus_glaber_female
ENSG00000140395	WDR61	100	100.000	ENSHGLG00100009790	WDR61	100	100.000	Heterocephalus_glaber_male
ENSG00000140395	WDR61	98	92.683	ENSIPUG00000014671	wdr61	100	88.945	Ictalurus_punctatus
ENSG00000140395	WDR61	100	99.672	ENSSTOG00000007784	WDR61	100	100.000	Ictidomys_tridecemlineatus
ENSG00000140395	WDR61	100	99.497	ENSJJAG00000019990	Wdr61	100	99.497	Jaculus_jaculus
ENSG00000140395	WDR61	87	92.958	ENSJJAG00000008979	-	100	85.465	Jaculus_jaculus
ENSG00000140395	WDR61	99	90.426	ENSKMAG00000016116	wdr61	99	89.899	Kryptolebias_marmoratus
ENSG00000140395	WDR61	100	87.940	ENSLBEG00000020456	wdr61	100	87.940	Labrus_bergylta
ENSG00000140395	WDR61	100	90.452	ENSLOCG00000015047	wdr61	100	90.452	Lepisosteus_oculatus
ENSG00000140395	WDR61	100	99.672	ENSLAFG00000003176	WDR61	100	100.000	Loxodonta_africana
ENSG00000140395	WDR61	100	100.000	ENSMFAG00000036343	WDR61	100	100.000	Macaca_fascicularis
ENSG00000140395	WDR61	100	100.000	ENSMMUG00000014207	WDR61	100	100.000	Macaca_mulatta
ENSG00000140395	WDR61	100	100.000	ENSMNEG00000021857	WDR61	100	100.000	Macaca_nemestrina
ENSG00000140395	WDR61	100	100.000	ENSMLEG00000035694	WDR61	100	100.000	Mandrillus_leucophaeus
ENSG00000140395	WDR61	98	93.902	ENSMAMG00000023099	wdr61	100	89.447	Mastacembelus_armatus
ENSG00000140395	WDR61	100	85.714	ENSMZEG00005010903	wdr61	100	88.945	Maylandia_zebra
ENSG00000140395	WDR61	100	98.980	ENSMAUG00000019417	Wdr61	100	99.497	Mesocricetus_auratus
ENSG00000140395	WDR61	100	100.000	ENSMICG00000008797	WDR61	100	100.000	Microcebus_murinus
ENSG00000140395	WDR61	99	100.000	ENSMOCG00000003274	Wdr61	100	98.995	Microtus_ochrogaster
ENSG00000140395	WDR61	90	95.238	ENSMMOG00000001369	wdr61	99	87.591	Mola_mola
ENSG00000140395	WDR61	100	89.447	ENSMALG00000015256	wdr61	100	89.447	Monopterus_albus
ENSG00000140395	WDR61	100	98.492	MGP_CAROLIEiJ_G0032233	Wdr61	100	98.492	Mus_caroli
ENSG00000140395	WDR61	100	98.492	ENSMUSG00000061559	Wdr61	100	98.492	Mus_musculus
ENSG00000140395	WDR61	100	98.492	MGP_PahariEiJ_G0015101	Wdr61	100	98.492	Mus_pahari
ENSG00000140395	WDR61	100	98.492	MGP_SPRETEiJ_G0033373	Wdr61	100	98.492	Mus_spretus
ENSG00000140395	WDR61	100	98.639	ENSMPUG00000011014	WDR61	100	98.995	Mustela_putorius_furo
ENSG00000140395	WDR61	100	98.980	ENSNGAG00000017454	Wdr61	100	98.492	Nannospalax_galili
ENSG00000140395	WDR61	100	85.714	ENSNBRG00000017776	wdr61	100	88.945	Neolamprologus_brichardi
ENSG00000140395	WDR61	100	100.000	ENSNLEG00000029873	WDR61	100	100.000	Nomascus_leucogenys
ENSG00000140395	WDR61	99	98.276	ENSOPRG00000007604	WDR61	100	97.990	Ochotona_princeps
ENSG00000140395	WDR61	100	99.497	ENSODEG00000013848	-	100	99.497	Octodon_degus
ENSG00000140395	WDR61	100	85.714	ENSONIG00000012845	wdr61	100	88.945	Oreochromis_niloticus
ENSG00000140395	WDR61	92	97.203	ENSOANG00000011913	-	98	99.160	Ornithorhynchus_anatinus
ENSG00000140395	WDR61	98	91.463	ENSORLG00000001904	wdr61	100	87.940	Oryzias_latipes
ENSG00000140395	WDR61	98	91.463	ENSORLG00020020981	wdr61	100	88.442	Oryzias_latipes_hni
ENSG00000140395	WDR61	98	91.463	ENSORLG00015014144	wdr61	100	88.945	Oryzias_latipes_hsok
ENSG00000140395	WDR61	100	88.442	ENSOMEG00000005028	wdr61	100	88.442	Oryzias_melastigma
ENSG00000140395	WDR61	99	100.000	ENSOGAG00000006755	WDR61	99	100.000	Otolemur_garnettii
ENSG00000140395	WDR61	100	100.000	ENSOARG00000000753	-	100	100.000	Ovis_aries
ENSG00000140395	WDR61	100	100.000	ENSPPAG00000036539	WDR61	100	100.000	Pan_paniscus
ENSG00000140395	WDR61	100	100.000	ENSPPRG00000004012	WDR61	100	99.497	Panthera_pardus
ENSG00000140395	WDR61	100	100.000	ENSPTIG00000002989	WDR61	100	99.497	Panthera_tigris_altaica
ENSG00000140395	WDR61	100	100.000	ENSPTRG00000007339	WDR61	100	100.000	Pan_troglodytes
ENSG00000140395	WDR61	100	100.000	ENSPANG00000015828	WDR61	100	100.000	Papio_anubis
ENSG00000140395	WDR61	98	92.683	ENSPKIG00000012667	wdr61	98	91.489	Paramormyrops_kingsleyae
ENSG00000140395	WDR61	100	99.497	ENSPEMG00000010007	Wdr61	100	99.497	Peromyscus_maniculatus_bairdii
ENSG00000140395	WDR61	100	89.950	ENSPFOG00000014439	wdr61	100	89.950	Poecilia_formosa
ENSG00000140395	WDR61	100	89.447	ENSPLAG00000002240	wdr61	100	89.447	Poecilia_latipinna
ENSG00000140395	WDR61	100	89.950	ENSPMEG00000010161	wdr61	100	89.950	Poecilia_mexicana
ENSG00000140395	WDR61	100	90.452	ENSPREG00000012810	wdr61	100	90.452	Poecilia_reticulata
ENSG00000140395	WDR61	100	100.000	ENSPPYG00000006693	WDR61	100	100.000	Pongo_abelii
ENSG00000140395	WDR61	100	100.000	ENSPCOG00000007141	WDR61	100	100.000	Propithecus_coquereli
ENSG00000140395	WDR61	100	99.660	ENSPVAG00000009032	WDR61	100	99.016	Pteropus_vampyrus
ENSG00000140395	WDR61	100	85.374	ENSPNYG00000008912	wdr61	100	88.945	Pundamilia_nyererei
ENSG00000140395	WDR61	100	89.950	ENSPNAG00000004180	wdr61	100	89.950	Pygocentrus_nattereri
ENSG00000140395	WDR61	100	100.000	ENSRBIG00000031619	WDR61	100	100.000	Rhinopithecus_bieti
ENSG00000140395	WDR61	100	100.000	ENSRROG00000043314	WDR61	100	100.000	Rhinopithecus_roxellana
ENSG00000140395	WDR61	94	99.497	ENSSBOG00000029858	WDR61	88	99.497	Saimiri_boliviensis_boliviensis
ENSG00000140395	WDR61	99	93.085	ENSSFOG00015022123	wdr61	100	91.960	Scleropages_formosus
ENSG00000140395	WDR61	99	88.945	ENSSMAG00000005623	wdr61	99	88.945	Scophthalmus_maximus
ENSG00000140395	WDR61	100	89.447	ENSSDUG00000023475	wdr61	100	89.447	Seriola_dumerili
ENSG00000140395	WDR61	100	89.447	ENSSLDG00000001624	wdr61	100	89.447	Seriola_lalandi_dorsalis
ENSG00000140395	WDR61	99	95.745	ENSSARG00000004776	WDR61	100	78.361	Sorex_araneus
ENSG00000140395	WDR61	100	93.970	ENSSPUG00000014807	WDR61	100	93.970	Sphenodon_punctatus
ENSG00000140395	WDR61	100	89.950	ENSSPAG00000000966	wdr61	100	89.950	Stegastes_partitus
ENSG00000140395	WDR61	100	99.344	ENSSSCG00000001757	WDR61	100	100.000	Sus_scrofa
ENSG00000140395	WDR61	98	91.463	ENSTRUG00000021247	wdr61	100	88.945	Takifugu_rubripes
ENSG00000140395	WDR61	90	95.238	ENSTNIG00000008452	wdr61	99	87.342	Tetraodon_nigroviridis
ENSG00000140395	WDR61	100	99.497	ENSTBEG00000009390	-	100	99.497	Tupaia_belangeri
ENSG00000140395	WDR61	100	99.320	ENSUAMG00000017910	WDR61	100	98.995	Ursus_americanus
ENSG00000140395	WDR61	100	99.278	ENSUMAG00000011177	WDR61	85	99.278	Ursus_maritimus
ENSG00000140395	WDR61	100	98.556	ENSVVUG00000001135	-	98	99.415	Vulpes_vulpes
ENSG00000140395	WDR61	98	97.059	ENSVVUG00000014025	-	100	89.362	Vulpes_vulpes
ENSG00000140395	WDR61	100	91.960	ENSXETG00000009511	wdr61	100	91.960	Xenopus_tropicalis
ENSG00000140395	WDR61	90	93.878	ENSXCOG00000020860	wdr61	96	86.007	Xiphophorus_couchianus
ENSG00000140395	WDR61	100	89.950	ENSXMAG00000002207	wdr61	100	89.950	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16024656.20178742.26496610.	IPI	Function
GO:0005634	nucleus	16024656.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	16024656.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016593	Cdc73/Paf1 complex	20178742.	IDA	Component
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742.	IDA	Process
GO:0035327	transcriptionally active chromatin	16024656.	IDA	Component
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045638	negative regulation of myeloid cell differentiation	20541477.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20178742.	IDA	Process
GO:0051571	positive regulation of histone H3-K4 methylation	16024656.	IMP	Process
GO:0055087	Ski complex	16024656.	IDA	Component
GO:0080182	histone H3-K4 trimethylation	16024656.	IMP	Process
GO:2001162	positive regulation of histone H3-K79 methylation	16024656.	IMP	Process