EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140694 (Gene tree)
Gene ID: 5073
Gene Symbol: PARN
Alias: DAN
Full Name: poly(A)-specific ribonuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 197,029 bases
Position: chr16:14,435,700-14,632,728
Accession: 8609
RBP type: canonical RBP
Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000345456	R3H	PF01424.22	0.00014	1	1
ENSP00000410525	R3H	PF01424.22	0.00014	1	1
ENSP00000387911	R3H	PF01424.22	0.00016	1	1
ENSP00000444381	RNA_bind	PF08675.11	2.6e-33	1	1
ENSP00000345456	RNA_bind	PF08675.11	3.4e-33	1	1
ENSP00000410525	RNA_bind	PF08675.11	3.6e-33	1	1
ENSP00000387911	RNA_bind	PF08675.11	3.9e-33	1	1
ENSP00000387911	CAF1	PF04857.20	7.9e-89	1	1
ENSP00000345456	CAF1	PF04857.20	9.8e-70	1	1
ENSP00000410525	CAF1	PF04857.20	1.4e-67	1	2
ENSP00000410525	CAF1	PF04857.20	1.4e-67	2	2
ENSP00000444381	CAF1	PF04857.20	4.9e-52	1	2
ENSP00000444381	CAF1	PF04857.20	4.9e-52	2	2
ENSP00000456279	CAF1	PF04857.20	3.3e-37	1	1
ENSP00000456982	CAF1	PF04857.20	2.4e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17785461	A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties.	J Biol Chem	2007 Nov 9	Nilsson P	-
21741754	Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering.	Biophys Chem	2011 Oct	Niedzwiecka A	doi: 10.1016/j.bpc.2011.06.010
28053121	ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.	Nucleic Acids Res	2017 Apr 20	Anantharaman A	doi: 10.1093/nar/gkw1304.
17938241	RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB.	Genes Dev	2007 Oct 15	Kim JH	-
17624302	The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain.	Biochem Biophys Res Commun	2007 Sep 7	Liu WF	-
16281054	Structural insight into poly(A) binding and catalytic mechanism of human PARN.	EMBO J	2005 Dec 7	Wu M	-
15175153	A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.	Mol Cell	2004 Jun 4	Gherzi R	-
17391638	Role of the RRM domain in the activity, structure and stability of poly(A)-specific ribonuclease.	Arch Biochem Biophys	2007 May 15	Zhang A	-
22834816	Modulation of poly(A)-specific ribonuclease (PARN): current knowledge and perspectives.	Curr Med Chem	2012	Balatsos NA	-
23388391	Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis.	Biochim Biophys Acta	2013 Jun	He GJ	doi: 10.1016/j.bbapap.2013.01.038
25239613	Self-association of poly(A)-specific ribonuclease (PARN) triggered by the R3H domain.	Biochim Biophys Acta	2014 Dec	He GJ	doi: 10.1016/j.bbapap.2014.09.010
29168431	Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response.	RNA Biol	2018 Feb 1	Zhang X	doi: 10.1080/15476286.2017.1408764
23769768	Binding of the plant alkaloid aristololactam-β-d-glucoside and antitumor antibiotic daunomycin to single stranded polyribonucleotides.	Biochim Biophys Acta	2013 Oct	Das A	doi: 10.1016/j.bbagen.2013.06.001

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000341484	PARN-201	2100	XM_011522513	ENSP00000345456	578 (aa)	XP_011520815	O95453
ENST00000563155	PARN-208	335	-	-	- (aa)	-	-
ENST00000564882	PARN-212	452	-	-	- (aa)	-	-
ENST00000566021	PARN-214	598	-	-	- (aa)	-	-
ENST00000569444	PARN-215	783	-	ENSP00000456279	261 (aa)	-	H3BRK1
ENST00000538472	PARN-204	808	-	ENSP00000445659	207 (aa)	-	F5H1Z4
ENST00000437198	PARN-203	3078	XM_011522510	ENSP00000387911	639 (aa)	XP_011520812	O95453
ENST00000539279	PARN-205	1557	-	ENSP00000444381	464 (aa)	-	O95453
ENST00000564904	PARN-213	468	-	-	- (aa)	-	-
ENST00000563697	PARN-210	508	-	-	- (aa)	-	-
ENST00000563641	PARN-209	1029	-	ENSP00000458103	65 (aa)	-	H3BVG1
ENST00000562715	PARN-206	505	-	-	- (aa)	-	-
ENST00000562896	PARN-207	577	-	ENSP00000456982	109 (aa)	-	H3BT23
ENST00000564113	PARN-211	565	-	-	- (aa)	-	-
ENST00000420015	PARN-202	2360	-	ENSP00000410525	593 (aa)	-	O95453

Gene Model

Click here to download ENSG00000140694's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140694	Cholesterol, HDL	1.0390000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140694	rs112210983	16	14580347	A	Educational attainment (MTAG)	30038396	[0.008-0.0142] unit increase	0.0111	EFO_0004784
ENSG00000140694	rs112210983	16	14580347	A	Highest math class taken (MTAG)	30038396	[0.0096-0.017] unit increase	0.0133	EFO_0004875
ENSG00000140694	rs112210983	16	14580347	A	Educational attainment (years of education)	30038396	[0.0072-0.0138] unit increase	0.0105	EFO_0004784
ENSG00000140694	rs182059586	16	14558363	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140694's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140694	PARN	98	75.000	ENSAPOG00000019730	-	100	75.000	Acanthochromis_polyacanthus
ENSG00000140694	PARN	100	96.610	ENSAMEG00000011208	PARN	100	92.812	Ailuropoda_melanoleuca
ENSG00000140694	PARN	92	78.333	ENSACIG00000000619	parn	83	76.493	Amphilophus_citrinellus
ENSG00000140694	PARN	99	70.383	ENSAOCG00000003465	parn	84	73.773	Amphiprion_ocellaris
ENSG00000140694	PARN	99	70.035	ENSAPEG00000010661	parn	91	77.778	Amphiprion_percula
ENSG00000140694	PARN	99	71.777	ENSATEG00000004661	parn	88	72.213	Anabas_testudineus
ENSG00000140694	PARN	99	87.037	ENSAPLG00000013914	PARN	99	84.858	Anas_platyrhynchos
ENSG00000140694	PARN	100	89.831	ENSACAG00000004973	PARN	100	78.769	Anolis_carolinensis
ENSG00000140694	PARN	100	100.000	ENSANAG00000031516	PARN	100	100.000	Aotus_nancymaae
ENSG00000140694	PARN	99	70.383	ENSACLG00000004742	parn	84	74.872	Astatotilapia_calliptera
ENSG00000140694	PARN	91	79.661	ENSAMXG00000012390	parn	100	66.966	Astyanax_mexicanus
ENSG00000140694	PARN	100	98.305	ENSBTAG00000018097	PARN	100	93.945	Bos_taurus
ENSG00000140694	PARN	100	100.000	ENSCJAG00000015866	PARN	100	100.000	Callithrix_jacchus
ENSG00000140694	PARN	100	94.915	ENSCAFG00000018795	PARN	100	92.958	Canis_familiaris
ENSG00000140694	PARN	100	96.610	ENSCAFG00020024126	PARN	100	92.958	Canis_lupus_dingo
ENSG00000140694	PARN	100	98.305	ENSCHIG00000018143	PARN	100	94.366	Capra_hircus
ENSG00000140694	PARN	94	61.215	ENSCAPG00000007984	PARN	78	63.825	Cavia_aperea
ENSG00000140694	PARN	100	98.305	ENSCPOG00000002263	PARN	100	91.080	Cavia_porcellus
ENSG00000140694	PARN	100	100.000	ENSCCAG00000030367	PARN	100	100.000	Cebus_capucinus
ENSG00000140694	PARN	91	100.000	ENSCATG00000041368	PARN	100	100.000	Cercocebus_atys
ENSG00000140694	PARN	62	32.353	ENSCATG00000033196	PNLDC1	70	35.862	Cercocebus_atys
ENSG00000140694	PARN	100	96.610	ENSCLAG00000015406	PARN	99	90.923	Chinchilla_lanigera
ENSG00000140694	PARN	100	100.000	ENSCSAG00000008142	PARN	100	98.905	Chlorocebus_sabaeus
ENSG00000140694	PARN	98	98.077	ENSCHOG00000007014	PARN	100	76.899	Choloepus_hoffmanni
ENSG00000140694	PARN	97	85.918	ENSCPBG00000006609	PARN	97	86.220	Chrysemys_picta_bellii
ENSG00000140694	PARN	99	43.003	ENSCING00000010142	-	99	44.465	Ciona_intestinalis
ENSG00000140694	PARN	98	94.089	ENSCANG00000023734	-	100	94.089	Colobus_angolensis_palliatus
ENSG00000140694	PARN	100	100.000	ENSCANG00000028849	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000140694	PARN	100	96.610	ENSCGRG00001012096	Parn	100	85.826	Cricetulus_griseus_chok1gshd
ENSG00000140694	PARN	100	96.610	ENSCGRG00000004939	Parn	100	85.826	Cricetulus_griseus_crigri
ENSG00000140694	PARN	94	79.661	ENSCSEG00000002064	parn	100	69.608	Cynoglossus_semilaevis
ENSG00000140694	PARN	99	70.035	ENSCVAG00000014848	parn	83	73.630	Cyprinodon_variegatus
ENSG00000140694	PARN	100	71.186	ENSDARG00000102634	parn	100	64.438	Danio_rerio
ENSG00000140694	PARN	100	98.305	ENSDNOG00000000833	PARN	100	93.271	Dasypus_novemcinctus
ENSG00000140694	PARN	98	95.074	ENSDORG00000027812	-	100	95.074	Dipodomys_ordii
ENSG00000140694	PARN	92	95.000	ENSETEG00000014828	-	78	94.677	Echinops_telfairi
ENSG00000140694	PARN	76	33.023	ENSEBUG00000008118	PNLDC1	61	30.086	Eptatretus_burgeri
ENSG00000140694	PARN	76	52.394	ENSEBUG00000007052	PARN	70	70.982	Eptatretus_burgeri
ENSG00000140694	PARN	100	98.305	ENSEASG00005011400	PARN	100	92.801	Equus_asinus_asinus
ENSG00000140694	PARN	100	96.610	ENSECAG00000017792	PARN	100	92.645	Equus_caballus
ENSG00000140694	PARN	92	96.667	ENSEEUG00000010370	PARN	86	84.615	Erinaceus_europaeus
ENSG00000140694	PARN	91	79.661	ENSELUG00000013139	parn	77	72.344	Esox_lucius
ENSG00000140694	PARN	100	96.610	ENSFCAG00000044961	PARN	100	96.610	Felis_catus
ENSG00000140694	PARN	98	88.462	ENSFALG00000003911	PARN	98	83.703	Ficedula_albicollis
ENSG00000140694	PARN	100	98.305	ENSFDAG00000009234	PARN	100	90.610	Fukomys_damarensis
ENSG00000140694	PARN	98	71.875	ENSFHEG00000013738	parn	100	71.875	Fundulus_heteroclitus
ENSG00000140694	PARN	91	77.966	ENSGMOG00000003231	parn	97	77.239	Gadus_morhua
ENSG00000140694	PARN	100	91.525	ENSGALG00000003091	PARN	100	82.582	Gallus_gallus
ENSG00000140694	PARN	91	79.661	ENSGAFG00000011061	parn	84	72.987	Gambusia_affinis
ENSG00000140694	PARN	99	69.338	ENSGACG00000019501	parn	100	68.567	Gasterosteus_aculeatus
ENSG00000140694	PARN	70	80.061	ENSGAGG00000023281	PARN	83	80.061	Gopherus_agassizii
ENSG00000140694	PARN	100	100.000	ENSGGOG00000025224	PARN	100	100.000	Gorilla_gorilla
ENSG00000140694	PARN	99	70.383	ENSHBUG00000017906	parn	90	77.654	Haplochromis_burtoni
ENSG00000140694	PARN	100	98.305	ENSHGLG00000010886	PARN	100	90.923	Heterocephalus_glaber_female
ENSG00000140694	PARN	100	98.305	ENSHGLG00100014659	PARN	100	90.923	Heterocephalus_glaber_male
ENSG00000140694	PARN	99	70.357	ENSHCOG00000008683	parn	91	73.913	Hippocampus_comes
ENSG00000140694	PARN	91	69.492	ENSIPUG00000012401	parn	84	62.995	Ictalurus_punctatus
ENSG00000140694	PARN	100	96.610	ENSSTOG00000007519	PARN	100	91.549	Ictidomys_tridecemlineatus
ENSG00000140694	PARN	100	98.305	ENSJJAG00000023049	Parn	100	88.106	Jaculus_jaculus
ENSG00000140694	PARN	99	70.732	ENSKMAG00000009462	parn	84	74.061	Kryptolebias_marmoratus
ENSG00000140694	PARN	91	77.966	ENSLBEG00000009167	parn	90	73.005	Labrus_bergylta
ENSG00000140694	PARN	99	73.171	ENSLACG00000004207	PARN	100	77.594	Latimeria_chalumnae
ENSG00000140694	PARN	91	81.356	ENSLOCG00000000715	parn	87	73.684	Lepisosteus_oculatus
ENSG00000140694	PARN	100	98.305	ENSLAFG00000015036	PARN	100	93.114	Loxodonta_africana
ENSG00000140694	PARN	100	100.000	ENSMFAG00000044852	PARN	100	100.000	Macaca_fascicularis
ENSG00000140694	PARN	100	100.000	ENSMMUG00000018849	PARN	100	100.000	Macaca_mulatta
ENSG00000140694	PARN	100	100.000	ENSMNEG00000045108	PARN	100	100.000	Macaca_nemestrina
ENSG00000140694	PARN	100	100.000	ENSMLEG00000031743	PARN	100	100.000	Mandrillus_leucophaeus
ENSG00000140694	PARN	99	70.035	ENSMAMG00000006939	parn	84	72.987	Mastacembelus_armatus
ENSG00000140694	PARN	99	70.383	ENSMZEG00005013590	parn	90	77.425	Maylandia_zebra
ENSG00000140694	PARN	94	100.000	ENSMGAG00000001004	PARN	95	82.708	Meleagris_gallopavo
ENSG00000140694	PARN	95	94.286	ENSMAUG00000008025	Parn	100	80.556	Mesocricetus_auratus
ENSG00000140694	PARN	100	98.462	ENSMICG00000016053	PARN	100	98.462	Microcebus_murinus
ENSG00000140694	PARN	91	94.915	ENSMOCG00000022211	Parn	100	91.296	Microtus_ochrogaster
ENSG00000140694	PARN	91	79.661	ENSMMOG00000011333	parn	87	76.262	Mola_mola
ENSG00000140694	PARN	99	86.411	ENSMODG00000004915	PARN	99	94.556	Monodelphis_domestica
ENSG00000140694	PARN	99	71.429	ENSMALG00000019426	parn	91	79.330	Monopterus_albus
ENSG00000140694	PARN	100	94.915	MGP_CAROLIEiJ_G0020466	Parn	100	86.541	Mus_caroli
ENSG00000140694	PARN	100	93.220	ENSMUSG00000022685	Parn	100	92.683	Mus_musculus
ENSG00000140694	PARN	58	30.147	ENSMUSG00000073460	Pnldc1	66	36.496	Mus_musculus
ENSG00000140694	PARN	100	96.610	MGP_PahariEiJ_G0016172	Parn	100	86.385	Mus_pahari
ENSG00000140694	PARN	100	94.915	MGP_SPRETEiJ_G0021361	Parn	100	86.541	Mus_spretus
ENSG00000140694	PARN	100	98.305	ENSMPUG00000014464	PARN	100	92.958	Mustela_putorius_furo
ENSG00000140694	PARN	91	94.915	ENSMLUG00000005414	PARN	100	94.737	Myotis_lucifugus
ENSG00000140694	PARN	98	95.567	ENSNGAG00000024082	-	100	95.567	Nannospalax_galili
ENSG00000140694	PARN	91	77.966	ENSNBRG00000006805	parn	90	77.154	Neolamprologus_brichardi
ENSG00000140694	PARN	100	100.000	ENSNLEG00000010241	PARN	100	100.000	Nomascus_leucogenys
ENSG00000140694	PARN	93	92.308	ENSMEUG00000008178	-	100	61.076	Notamacropus_eugenii
ENSG00000140694	PARN	98	98.077	ENSOPRG00000012187	PARN	100	86.392	Ochotona_princeps
ENSG00000140694	PARN	100	98.305	ENSODEG00000001617	PARN	100	82.087	Octodon_degus
ENSG00000140694	PARN	100	77.966	ENSONIG00000000151	parn	100	70.046	Oreochromis_niloticus
ENSG00000140694	PARN	82	82.677	ENSOANG00000020155	-	97	83.202	Ornithorhynchus_anatinus
ENSG00000140694	PARN	69	79.245	ENSOANG00000029996	-	93	87.500	Ornithorhynchus_anatinus
ENSG00000140694	PARN	100	91.696	ENSOCUG00000000322	PARN	100	91.667	Oryctolagus_cuniculus
ENSG00000140694	PARN	100	76.923	ENSORLG00000024893	-	100	73.529	Oryzias_latipes
ENSG00000140694	PARN	93	79.661	ENSORLG00020010313	parn	88	70.984	Oryzias_latipes_hni
ENSG00000140694	PARN	93	79.661	ENSORLG00015000300	parn	88	70.984	Oryzias_latipes_hsok
ENSG00000140694	PARN	100	72.596	ENSOMEG00000019555	parn	99	72.596	Oryzias_melastigma
ENSG00000140694	PARN	92	98.333	ENSOGAG00000014626	PARN	100	94.747	Otolemur_garnettii
ENSG00000140694	PARN	91	98.305	ENSOARG00000007574	PARN	100	98.178	Ovis_aries
ENSG00000140694	PARN	100	100.000	ENSPPAG00000031438	PARN	100	100.000	Pan_paniscus
ENSG00000140694	PARN	100	96.610	ENSPPRG00000018583	PARN	100	96.610	Panthera_pardus
ENSG00000140694	PARN	100	96.610	ENSPTIG00000012135	PARN	100	96.610	Panthera_tigris_altaica
ENSG00000140694	PARN	100	100.000	ENSPTRG00000007792	PARN	100	100.000	Pan_troglodytes
ENSG00000140694	PARN	100	100.000	ENSPANG00000020099	PARN	100	100.000	Papio_anubis
ENSG00000140694	PARN	96	79.661	ENSPKIG00000022807	parn	95	67.532	Paramormyrops_kingsleyae
ENSG00000140694	PARN	98	89.831	ENSPSIG00000014804	PARN	100	83.737	Pelodiscus_sinensis
ENSG00000140694	PARN	91	76.271	ENSPMGG00000014431	parn	75	74.954	Periophthalmus_magnuspinnatus
ENSG00000140694	PARN	100	94.915	ENSPEMG00000018439	Parn	100	83.881	Peromyscus_maniculatus_bairdii
ENSG00000140694	PARN	99	60.627	ENSPMAG00000003956	parn	99	67.500	Petromyzon_marinus
ENSG00000140694	PARN	100	92.308	ENSPCIG00000001259	PARN	100	92.308	Phascolarctos_cinereus
ENSG00000140694	PARN	91	79.661	ENSPFOG00000012823	parn	84	72.896	Poecilia_formosa
ENSG00000140694	PARN	91	79.661	ENSPLAG00000006395	parn	84	73.064	Poecilia_latipinna
ENSG00000140694	PARN	91	79.661	ENSPMEG00000007711	parn	84	73.232	Poecilia_mexicana
ENSG00000140694	PARN	91	79.661	ENSPREG00000000147	parn	84	72.896	Poecilia_reticulata
ENSG00000140694	PARN	100	99.481	ENSPPYG00000007123	PARN	100	99.064	Pongo_abelii
ENSG00000140694	PARN	93	96.154	ENSPCAG00000001741	PARN	100	83.003	Procavia_capensis
ENSG00000140694	PARN	100	98.462	ENSPCOG00000019292	PARN	100	98.462	Propithecus_coquereli
ENSG00000140694	PARN	98	98.077	ENSPVAG00000002547	PARN	100	89.715	Pteropus_vampyrus
ENSG00000140694	PARN	99	70.383	ENSPNYG00000006835	parn	90	74.674	Pundamilia_nyererei
ENSG00000140694	PARN	99	69.231	ENSPNAG00000018905	parn	86	73.371	Pygocentrus_nattereri
ENSG00000140694	PARN	100	93.220	ENSRNOG00000002912	Parn	98	88.889	Rattus_norvegicus
ENSG00000140694	PARN	72	98.498	ENSRBIG00000018726	PARN	100	98.498	Rhinopithecus_bieti
ENSG00000140694	PARN	72	98.498	ENSRROG00000011162	-	100	98.498	Rhinopithecus_roxellana
ENSG00000140694	PARN	92	98.333	ENSRROG00000020116	-	86	98.361	Rhinopithecus_roxellana
ENSG00000140694	PARN	100	100.000	ENSSBOG00000034726	PARN	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000140694	PARN	96	84.651	ENSSHAG00000008493	PARN	94	93.541	Sarcophilus_harrisii
ENSG00000140694	PARN	94	79.661	ENSSFOG00015014165	parn	94	73.038	Scleropages_formosus
ENSG00000140694	PARN	99	69.338	ENSSMAG00000000685	parn	100	63.287	Scophthalmus_maximus
ENSG00000140694	PARN	99	70.732	ENSSDUG00000014555	parn	83	73.549	Seriola_dumerili
ENSG00000140694	PARN	98	69.608	ENSSLDG00000007603	-	100	69.608	Seriola_lalandi_dorsalis
ENSG00000140694	PARN	99	86.411	ENSSARG00000014339	PARN	100	80.517	Sorex_araneus
ENSG00000140694	PARN	100	89.831	ENSSPUG00000007719	PARN	100	85.133	Sphenodon_punctatus
ENSG00000140694	PARN	99	72.125	ENSSPAG00000007095	parn	86	74.906	Stegastes_partitus
ENSG00000140694	PARN	100	98.305	ENSSSCG00000007878	PARN	89	92.801	Sus_scrofa
ENSG00000140694	PARN	58	30.029	ENSTGUG00000011418	PNLDC1	68	30.556	Taeniopygia_guttata
ENSG00000140694	PARN	99	87.037	ENSTGUG00000004971	PARN	99	83.438	Taeniopygia_guttata
ENSG00000140694	PARN	100	71.212	ENSTRUG00000015208	-	94	71.212	Takifugu_rubripes
ENSG00000140694	PARN	100	79.661	ENSTNIG00000008252	parn	100	69.397	Tetraodon_nigroviridis
ENSG00000140694	PARN	100	79.931	ENSTBEG00000010407	PARN	100	79.828	Tupaia_belangeri
ENSG00000140694	PARN	98	98.077	ENSTTRG00000002843	PARN	100	89.082	Tursiops_truncatus
ENSG00000140694	PARN	99	70.318	ENSUAMG00000008283	PARN	90	84.404	Ursus_americanus
ENSG00000140694	PARN	100	98.305	ENSUMAG00000004527	PARN	100	93.271	Ursus_maritimus
ENSG00000140694	PARN	95	98.077	ENSVPAG00000008968	PARN	100	89.902	Vicugna_pacos
ENSG00000140694	PARN	100	96.610	ENSVVUG00000019509	PARN	100	93.427	Vulpes_vulpes
ENSG00000140694	PARN	100	81.967	ENSXETG00000010994	parn	100	82.890	Xenopus_tropicalis
ENSG00000140694	PARN	91	79.661	ENSXCOG00000015990	parn	96	69.205	Xiphophorus_couchianus
ENSG00000140694	PARN	91	79.661	ENSXMAG00000014783	parn	84	73.232	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	IEA	Process
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	21873635.	IBA	Process
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	-	TAS	Process
GO:0000495	box H/ACA snoRNA 3'-end processing	22442037.	IDA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	9736620.	TAS	Function
GO:0004518	nuclease activity	9736620.	TAS	Function
GO:0004535	poly(A)-specific ribonuclease activity	21873635.	IBA	Function
GO:0004535	poly(A)-specific ribonuclease activity	25049417.	IDA	Function
GO:0004535	poly(A)-specific ribonuclease activity	26482878.26950371.	IMP	Function
GO:0005515	protein binding	14731398.20379136.21876179.	IPI	Function
GO:0005634	nucleus	9736620.	TAS	Component
GO:0005730	nucleolus	22442037.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007292	female gamete generation	9736620.	TAS	Process
GO:0009451	RNA modification	9736620.	TAS	Process
GO:0010587	miRNA catabolic process	25049417.	IDA	Process
GO:0019901	protein kinase binding	20932473.	IPI	Function
GO:0032212	positive regulation of telomere maintenance via telomerase	26482878.26950371.	IMP	Process
GO:0043169	cation binding	15358788.	IMP	Function
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051973	positive regulation of telomerase activity	26482878.	IMP	Process
GO:0070034	telomerase RNA binding	26482878.26950371.	IC	Function
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	22442037.	IDA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	26482878.	IMP	Process
GO:0090669	telomerase RNA stabilization	26482878.26950371.	IMP	Process
GO:0110008	ncRNA deadenylation	26482878.26950371.	IMP	Process
GO:1904872	regulation of telomerase RNA localization to Cajal body	26950371.	IMP	Process