EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140718 (Gene tree)
Gene ID: 79068
Gene Symbol: FTO
Alias: KIAA1752|MGC5149|ALKBH9
Full Name: FTO alpha-ketoglutarate dependent dioxygenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 456,821 bases
Position: chr16:53,701,692-54,158,512
Accession: 24678
RBP type: canonical RBP
Summary: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000490300	FTO_CTD	PF12934.7	8.8e-61	1	1
ENSP00000418823	FTO_CTD	PF12934.7	9e-60	1	1
ENSP00000490516	FTO_CTD	PF12934.7	1.7e-59	1	1
ENSP00000489936	FTO_CTD	PF12934.7	1.8e-44	1	1
ENSP00000489714	FTO_CTD	PF12934.7	2e-43	1	1
ENSP00000489641	FTO_CTD	PF12934.7	3.2e-43	1	1
ENSP00000490047	FTO_CTD	PF12934.7	1.4e-42	1	1
ENSP00000415636	FTO_CTD	PF12934.7	2e-27	1	1
ENSP00000417422	FTO_CTD	PF12934.7	2e-27	1	1
ENSP00000417843	FTO_CTD	PF12934.7	2.6e-22	1	1
ENSP00000489904	FTO_CTD	PF12934.7	2e-14	1	1
ENSP00000489936	FTO_NTD	PF12933.7	1.2e-121	1	1
ENSP00000490047	FTO_NTD	PF12933.7	1.2e-121	1	1
ENSP00000489641	FTO_NTD	PF12933.7	1.2e-121	1	1
ENSP00000418823	FTO_NTD	PF12933.7	1.6e-121	1	1
ENSP00000490516	FTO_NTD	PF12933.7	2.1e-121	1	1
ENSP00000489714	FTO_NTD	PF12933.7	1.9e-61	1	1

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25412662	FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.	Cell Res	2014 Dec	Zhao X	doi: 10.1038/cr.2014.151
28977517	N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.	Nucleic Acids Res	2017 Nov 2	Bartosovic M	doi: 10.1093/nar/gkx778.
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965
27072590	Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia.	Sci Rep	2016 Apr 13	Yang Y	doi: 10.1038/srep24345.
27179969	N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.	Mol Biotechnol	2016 Jul	Wu R	doi: 10.1007/s12033-016-9947-9.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570395	FTO-209	555	-	-	- (aa)	-	-
ENST00000636091	FTO-213	5323	-	-	- (aa)	-	-
ENST00000563011	FTO-208	2015	-	ENSP00000489714	275 (aa)	-	A0A1B0GTI3
ENST00000635892	FTO-211	1085	-	-	- (aa)	-	-
ENST00000636992	FTO-216	1514	-	ENSP00000489886	421 (aa)	-	A0A1B0GTY1
ENST00000636491	FTO-215	1676	-	ENSP00000490047	450 (aa)	-	A0A1B0GUC3
ENST00000463855	FTO-204	3056	-	ENSP00000417843	127 (aa)	-	Q9C0B1
ENST00000636030	FTO-212	1636	-	-	- (aa)	-	-
ENST00000640179	FTO-223	210	-	ENSP00000490980	70 (aa)	-	F8WCB8
ENST00000637562	FTO-220	1524	-	ENSP00000490426	455 (aa)	-	A0A1B0GV98
ENST00000460382	FTO-203	1517	-	ENSP00000417422	106 (aa)	-	Q9C0B1
ENST00000637845	FTO-221	2472	-	ENSP00000489638	533 (aa)	-	A0A1B0GTC3
ENST00000637969	FTO-222	2889	-	ENSP00000490516	559 (aa)	-	A0A1B0GVH5
ENST00000612285	FTO-210	1852	-	ENSP00000490300	173 (aa)	-	A0A1B0GUY7
ENST00000431610	FTO-202	707	-	ENSP00000415636	106 (aa)	-	Q9C0B1
ENST00000637049	FTO-218	2105	-	ENSP00000489891	61 (aa)	-	A0A1B0GTY5
ENST00000472835	FTO-207	847	-	-	- (aa)	-	-
ENST00000637062	FTO-219	459	-	ENSP00000489904	66 (aa)	-	A0A1B0GTZ8
ENST00000268349	FTO-201	2799	-	ENSP00000268349	129 (aa)	-	X6R3I0
ENST00000637001	FTO-217	1609	XM_011523314	ENSP00000489936	481 (aa)	XP_011521616	A0A1B0GU26
ENST00000636218	FTO-214	2227	XM_011523315	ENSP00000489641	457 (aa)	XP_011521617	A0A1B0GTC5
ENST00000471389	FTO-206	11766	XM_011523313	ENSP00000418823	505 (aa)	-	Q9C0B1
ENST00000464071	FTO-205	1065	-	ENSP00000418424	70 (aa)	-	F8WCB8

Gene Model

Click here to download ENSG00000140718's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140718	Body Mass Index	2.237e-005	17658951
ENSG00000140718	Body Mass Index	3.378e-005	17658951
ENSG00000140718	Body Mass Index	1.802e-005	17658951
ENSG00000140718	Body Mass Index	1.802e-005	17658951
ENSG00000140718	Body Mass Index	3.954e-005	17658951
ENSG00000140718	Body Mass Index	1.013e-005	17658951
ENSG00000140718	Body Mass Index	1.802e-005	17658951
ENSG00000140718	Body Mass Index	2.767e-005	17658951
ENSG00000140718	Body Mass Index	2.604e-005	17658951
ENSG00000140718	Body Mass Index	7.241e-005	17658951
ENSG00000140718	Body Weights and Measures	9.547e-006	17658951
ENSG00000140718	Body Weights and Measures	6.989e-005	17658951
ENSG00000140718	Body Weights and Measures	2.954e-005	17658951
ENSG00000140718	Body Weights and Measures	3.42e-005	17658951
ENSG00000140718	Body Weights and Measures	3.42e-005	17658951
ENSG00000140718	Body Weights and Measures	8.726e-005	17658951
ENSG00000140718	Body Weights and Measures	1.466e-005	17658951
ENSG00000140718	Body Weights and Measures	3.42e-005	17658951
ENSG00000140718	Body Weights and Measures	1.052e-005	17658951
ENSG00000140718	Body Weights and Measures	1.007e-005	17658951
ENSG00000140718	Waist Circumference	3.141e-005	-
ENSG00000140718	Waist Circumference	1.128e-005	-
ENSG00000140718	Body Weight	1.503e-005	17658951
ENSG00000140718	Body Weight	4.917e-006	17658951
ENSG00000140718	Acceleration	7.888e-005	-
ENSG00000140718	Blood Pressure	9.284e-005	-
ENSG00000140718	Blood Pressure	7.618e-005	-
ENSG00000140718	Coronary Disease	8.6460000E-005	-
ENSG00000140718	Potassium	2.7840000E-005	-
ENSG00000140718	Body Mass Index	3.3947667E-005	-
ENSG00000140718	Body Mass Index	9.5155245E-005	-
ENSG00000140718	Body Mass Index	9.9574260E-005	-
ENSG00000140718	Platelet Function Tests	2.5876800E-005	-
ENSG00000140718	Platelet Function Tests	1.5066100E-005	-
ENSG00000140718	Platelet Function Tests	2.2874400E-005	-
ENSG00000140718	Platelet Function Tests	8.3500973E-006	-
ENSG00000140718	Intelligence Tests	1.6674600E-005	-
ENSG00000140718	Intelligence Tests	2.1792800E-005	-
ENSG00000140718	Child Development Disorders, Pervasive	2.1737300E-005	-
ENSG00000140718	Child Development Disorders, Pervasive	2.8861500E-005	-
ENSG00000140718	Child Development Disorders, Pervasive	3.3854000E-005	-
ENSG00000140718	Child Development Disorders, Pervasive	1.3875000E-006	-
ENSG00000140718	Child Development Disorders, Pervasive	4.0257000E-006	-
ENSG00000140718	Adiponectin	7.0640000E-006	-
ENSG00000140718	Adiponectin	7.4040000E-005	-
ENSG00000140718	25-Hydroxyvitamin D 2	3.6780000E-005	-
ENSG00000140718	Obesity	1E-28	19151714
ENSG00000140718	Obesity	7E-18	19151714
ENSG00000140718	Obesity	5E-13	19151714
ENSG00000140718	Breast Neoplasms	6E-7	23535733
ENSG00000140718	Body Fat Distribution	1E-13	26833246
ENSG00000140718	Obesity	1E-7	21544081
ENSG00000140718	Body Mass Index	3E-35	17434869
ENSG00000140718	Body Mass Index	5E-120	20935630
ENSG00000140718	Diabetes Mellitus, Type 2	3E-8	20581827
ENSG00000140718	Obesity	6E-12	19553259
ENSG00000140718	Obesity	5E-110	23563607
ENSG00000140718	Obesity	6E-39	23563607
ENSG00000140718	Hair	3E-6	26926045
ENSG00000140718	Body Mass Index	8E-153	25673413
ENSG00000140718	Hip	3E-52	25673412
ENSG00000140718	Waist-Hip Ratio	1E-17	25673412
ENSG00000140718	Body Mass Index	2E-7	19396169
ENSG00000140718	Rhinitis, Allergic	6E-7	25085501
ENSG00000140718	Breast	4E-7	27182965
ENSG00000140718	Subcutaneous Fat	6E-8	22589738
ENSG00000140718	Body Mass Index	4E-84	25673413
ENSG00000140718	Diabetes Mellitus, Type 2	7E-14	17463249
ENSG00000140718	Diabetes Mellitus, Type 2	1E-12	17463248
ENSG00000140718	Body Mass Index	2E-10	22982992
ENSG00000140718	Breast Neoplasms	3E-7	27117709
ENSG00000140718	Osteoarthritis	4E-6	22763110
ENSG00000140718	Body Mass Index	1E-7	24348519
ENSG00000140718	Waist Circumference	4E-101	25673412
ENSG00000140718	Body Weight	6E-14	19079260
ENSG00000140718	Body Mass Index	1E-47	19079260
ENSG00000140718	Diabetes Mellitus, Type 2	2E-17	19056611
ENSG00000140718	Menarche	2E-17	25231870
ENSG00000140718	Body Mass Index	2E-16	25953783
ENSG00000140718	Obesity	3E-26	21706003
ENSG00000140718	Body Mass Index	1E-93	25673413
ENSG00000140718	Body Mass Index	1E-10	23583978
ENSG00000140718	Melanoma	4E-12	28212542
ENSG00000140718	Melanoma	4E-12	23455637
ENSG00000140718	Body Mass Index	4E-14	26604143
ENSG00000140718	Waist Circumference	8E-59	25673412
ENSG00000140718	Menarche	3E-8	21102462
ENSG00000140718	Subcutaneous Fat	3E-6	22589738
ENSG00000140718	Obesity	1E-7	18159244
ENSG00000140718	Obesity	2E-12	21552555
ENSG00000140718	Breast Neoplasms	2E-6	27117709
ENSG00000140718	Body Mass Index	2E-51	23563607
ENSG00000140718	Menarche	1E-12	27182965
ENSG00000140718	Body Mass Index	4E-13	19079260
ENSG00000140718	Body Weight	5E-36	19079260
ENSG00000140718	Waist Circumference	5E-19	19557197
ENSG00000140718	Body Fat Distribution	1E-25	26833246
ENSG00000140718	Obesity	1E-79	23563607
ENSG00000140718	Metabolic Syndrome X	2E-9	22399527
ENSG00000140718	Leptin	1E-9	26833098
ENSG00000140718	Cholesterol, HDL	7E-9	24097068
ENSG00000140718	Hip	4E-43	25673412
ENSG00000140718	Atrial Fibrillation	1E-14	27790247
ENSG00000140718	Blood Pressure	1E-14	27790247
ENSG00000140718	Cholesterol	1E-14	27790247
ENSG00000140718	Coronary Disease	1E-14	27790247
ENSG00000140718	Diabetes Mellitus	1E-14	27790247
ENSG00000140718	Electrocardiography	1E-14	27790247
ENSG00000140718	Glucose	1E-14	27790247
ENSG00000140718	Heart Failure	1E-14	27790247
ENSG00000140718	Hematocrit	1E-14	27790247
ENSG00000140718	Cholesterol, HDL	1E-14	27790247
ENSG00000140718	Mortality	1E-14	27790247
ENSG00000140718	Neoplasms	1E-14	27790247
ENSG00000140718	Triglycerides	1E-14	27790247
ENSG00000140718	Body Mass Index	1E-14	27790247
ENSG00000140718	Stroke	1E-14	27790247
ENSG00000140718	Body Mass Index	7E-27	24861553
ENSG00000140718	Breast Neoplasms	3E-8	27117709
ENSG00000140718	Body Fat Distribution	4E-27	26833246
ENSG00000140718	Body Mass Index	4E-51	19079261
ENSG00000140718	Diabetes Mellitus, Type 2	2E-7	17554300
ENSG00000140718	Diabetes Mellitus, Type 2	1E-20	22693455
ENSG00000140718	Waist-Hip Ratio	1E-38	25673412
ENSG00000140718	Breast Neoplasms	4E-8	23535733
ENSG00000140718	Diabetes Mellitus, Type 2	7E-6	18372903
ENSG00000140718	Body Fat Distribution	7E-14	26833246
ENSG00000140718	Body Mass Index	5E-22	22344221
ENSG00000140718	Body Fat Distribution	2E-13	26833246
ENSG00000140718	Body Mass Index	1E-26	25953783
ENSG00000140718	Diabetes Mellitus, Type 2	1E-12	24509480
ENSG00000140718	Sex Hormone-Binding Globulin	9E-6	22675492
ENSG00000140718	Body Mass Index	5E-16	26604143
ENSG00000140718	Obesity	3E-28	23563609
ENSG00000140718	Diabetes Mellitus, Type 2	6E-6	23209189
ENSG00000140718	Body Mass Index	1E-26	25953783
ENSG00000140718	Body Mass Index	9E-10	25044758
ENSG00000140718	Diabetes Mellitus, Type 2	4E-15	26818947
ENSG00000140718	Body Mass Index	2E-14	24064335
ENSG00000140718	Leukopenia	1E-8	27558924
ENSG00000140718	Purines	1E-8	27558924
ENSG00000140718	Inflammatory Bowel Diseases	1E-8	27558924
ENSG00000140718	Obesity	5E-19	20421936
ENSG00000140718	Obesity	2E-81	23563607
ENSG00000140718	Waist-Hip Ratio	1E-23	25673412
ENSG00000140718	C-Reactive Protein	5E-9	27286809
ENSG00000140718	Cholesterol, HDL	5E-9	27286809
ENSG00000140718	Body Mass Index	4E-23	23669352
ENSG00000140718	Body Mass Index	1E-156	25673413
ENSG00000140718	Energy Intake	1E-9	23636237
ENSG00000140718	Body Mass Index	4E-8	21037115
ENSG00000140718	Pulmonary Disease, Chronic Obstructive	4E-8	21037115
ENSG00000140718	Body Fat Distribution	4E-15	26833246
ENSG00000140718	Breast Neoplasms	5E-8	27117709
ENSG00000140718	Waist Circumference	1E-57	25673412
ENSG00000140718	Leptin	9E-8	26833098
ENSG00000140718	Breast Neoplasms	6E-14	23535729
ENSG00000140718	Body Mass Index	4E-8	18454148
ENSG00000140718	sam so eum	1E-7	25888059
ENSG00000140718	Medicine, Korean Traditional	1E-7	25888059
ENSG00000140718	Hip	2E-86	25673412
ENSG00000140718	Body Weight	9E-7	17658951
ENSG00000140718	Waist-Hip Ratio	3E-8	17658951
ENSG00000140718	Body Mass Index	9E-7	17658951
ENSG00000140718	Blood Pressure	2E-17	27790247
ENSG00000140718	Cholesterol	2E-17	27790247
ENSG00000140718	Electrocardiography	2E-17	27790247
ENSG00000140718	Glucose	2E-17	27790247
ENSG00000140718	Hematocrit	2E-17	27790247
ENSG00000140718	Cholesterol, HDL	2E-17	27790247
ENSG00000140718	Triglycerides	2E-17	27790247
ENSG00000140718	Body Mass Index	2E-17	27790247
ENSG00000140718	Subcutaneous Fat	1E-9	27918534
ENSG00000140718	Triglycerides	3E-8	24097068

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140718	rs9936385	16	53785257	C	Body mass index (age <50)	26426971	unit increase	0.093	EFO_0004340
ENSG00000140718	rs9936385	16	53785257	C	Body mass index (age>50)	26426971	unit increase	0.073	EFO_0004340
ENSG00000140718	rs9936385	16	53785257	C	Body mass index x sex x age interaction (4df test)	26426971			EFO_0008343\|EFO_0004340\|EFO_0008007
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer (estrogen-receptor negative)	29058716	[1.04-1.11] (Oncoarray)	1.0752687	EFO_1000650
ENSG00000140718	rs11075995	16	53821379	A	Breast cancer (estrogen-receptor negative)	29058716	[1.06-1.12]	1.09	EFO_1000650
ENSG00000140718	rs9936385	16	53785257	C	Type 2 diabetes	22885922	[1.10-1.16]	1.13	EFO_0001360
ENSG00000140718	rs9936385	16	53785257	C	Type 2 diabetes	22885922	[1.11-1.17]	1.14	EFO_0001360
ENSG00000140718	rs9936385	16	53785257	C	Type 2 diabetes	22885922	[1.08-1.15]	1.12	EFO_0001360
ENSG00000140718	rs1558902	16	53769662	A	C-reactive protein levels or HDL-cholesterol levels (pleiotropy)	27286809			EFO_0004458\|EFO_0004612
ENSG00000140718	rs1558902	16	53769662	A	Height adjusted BMI	25044758	[0.13-0.27] unit increase	0.21	EFO_0005851
ENSG00000140718	rs7187423	16	54056583	?	Allergic rhinitis	25085501	[1.75-2.30]	2.02	EFO_0005854
ENSG00000140718	rs9939973	16	53766656	A	Hip circumference	25673412	[0.063-0.077] unit increase	0.07	EFO_0005093
ENSG00000140718	rs9939973	16	53766656	A	Hip circumference	25673412	[0.062-0.081] unit increase	0.0716	EFO_0005093
ENSG00000140718	rs9939973	16	53766656	A	Hip circumference	25673412	[0.058-0.077] unit increase	0.0677	EFO_0005093
ENSG00000140718	rs9939609	16	53786615	?	Age-related disease endophenotypes	27790247			EFO_0004574\|EFO_0006336\|EFO_0004530\|EFO_0006335\|EFO_0004348\|EFO_0007928\|EFO_0004468\|EFO_0004340\|EFO_0004612
ENSG00000140718	rs62033406	16	53790314	?	Breast size	27182965	[0.038-0.087] unit increase	0.062	EFO_0004884
ENSG00000140718	rs1558902	16	53769662	?	Menarche (age at onset)	27182965	[0.023-0.040] unit increase	0.031	EFO_0004703
ENSG00000140718	rs17817449	16	53779455	?	Breast cancer	27117709	[1.01-1.09] (BRCA1 carriers)	1.0526316	EFO_0000305
ENSG00000140718	rs11075995	16	53821379	?	Breast cancer	27117709	[0.97-1.06] (BRCA1 carriers)	1.01	EFO_0000305
ENSG00000140718	rs17817449	16	53779455	?	Breast cancer (estrogen-receptor negative)	27117709	[1.05-1.12]	1.098901	EFO_1000650
ENSG00000140718	rs11075995	16	53821379	?	Breast cancer (estrogen-receptor negative)	27117709	[1.07-1.15]	1.11	EFO_1000650
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.041-0.061] body fat % increase	0.051	EFO_0007800
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.037-0.063] body fat % increase	0.05	EFO_0007800
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.041-0.061] body fat % increase	0.051	EFO_0007800
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.037-0.065] body fat % increase	0.051	EFO_0007800
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.037-0.065] body fat % increase	0.051	EFO_0007800
ENSG00000140718	rs1558902	16	53769662	A	Body fat percentage	26833246	[0.038-0.064] body fat % increase	0.051	EFO_0007800
ENSG00000140718	rs8043757	16	53779538	T	circulating leptin levels	26833098	[0.026-0.056] unit increase	0.041	EFO_0005000
ENSG00000140718	rs1421085	16	53767042	C	Type 2 diabetes	26818947	[1.1191628661761-1.20613294479771]	1.1618342	EFO_0001360
ENSG00000140718	rs12597422	16	53853826	?	Eyebrow thickness	26926045			EFO_0007823
ENSG00000140718	rs16953002	16	54080912	A	Melanoma	23455637	[1.11-1.20]	1.16	EFO_0000756
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer	23535729	[1.05-1.1]	1.08	EFO_0000305
ENSG00000140718	rs11075995	16	53821379	?	Breast cancer	23535733	[1.07-1.15]	1.11	EFO_0000305
ENSG00000140718	rs1421085	16	53767042	C	Obesity (early onset extreme)	23563609	[1.35-1.54]	1.44	EFO_0001073
ENSG00000140718	rs17817964	16	53794154	T	Body mass index	23583978	[0.051-0.095] unit increase	0.073	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index	24348519	[NR] z score increase	5.26	EFO_0004340
ENSG00000140718	rs1121980	16	53775335	A	HDL cholesterol	24097068	[NR] unit decrease	0.02	EFO_0004612
ENSG00000140718	rs1121980	16	53775335	A	Triglycerides	24097068	[NR] mg/dL increase	0.021	EFO_0004530
ENSG00000140718	rs1421085	16	53767042	C	Childhood body mass index	26604143	[0.045-0.073] unit increase	0.059	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Childhood body mass index	26604143			EFO_0004340
ENSG00000140718	rs79206939	16	53826140	A	Thiopurine-induced leukopenia in inflammatory bowel disease	27558924	[2.50-7.40]	4.3	EFO_0004233\|EFO_0006317\|EFO_0003767
ENSG00000140718	rs8050136	16	53782363	C	Menarche (age at onset)	25231870	[0.03-0.05] unit increase	0.04	EFO_0004703
ENSG00000140718	rs7193144	16	53776774	T	Sasang constitutional medicine type (So-Eum)	25888059	[1.22-1.54]	1.37	EFO_0007123\|EFO_0007119
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	25953783	[0.0081-0.0159] unit increase	0.012	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	25953783			EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Weight	19079260	[5.95-8.15] percentage SD increase	7.05	EFO_0004338
ENSG00000140718	rs6499640	16	53735765	A	Weight	19079260	[4.07-6.93] percentage SD increase	5.5	EFO_0004338
ENSG00000140718	rs8043757	16	53779538	T	circulating leptin levels	26833098	[0.02-0.04] unit increase	0.03	EFO_0005000
ENSG00000140718	rs1421085	16	53767042	C	Obesity	19151714			EFO_0001073
ENSG00000140718	rs1421085	16	53767042	C	Obesity	19151714	[1.27-1.51]	1.39	EFO_0001073
ENSG00000140718	rs1421085	16	53767042	C	Obesity	19151714	[1.10-1.40]	1.25	EFO_0001073
ENSG00000140718	rs6499640	16	53735765	A	Body mass index	19079260	[3.82-6.68] % SD increase	5.25	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index	19079260	[6.96-9.12] % SD increase	8.04	EFO_0004340
ENSG00000140718	rs9940128	16	53766842	A	Body mass index	23669352	[0.067-0.099] unit increase	0.083	EFO_0004340
ENSG00000140718	rs8043757	16	53779538	T	Obesity	23563607	[NR]	1.23	EFO_0001073
ENSG00000140718	rs7185735	16	53788739	G	Obesity	23563607	[NR]	1.33	EFO_0001073
ENSG00000140718	rs1421085	16	53767042	C	Obesity	23563607	[NR]	1.45	EFO_0001073
ENSG00000140718	rs11075990	16	53785981	G	Body mass index	23563607	[NR]	1.35	EFO_0004340
ENSG00000140718	rs7202116	16	53787703	G	Body mass index	22982992	[0.025-0.047] unit increase	0.036	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	23209189	[1.09-1.24]	1.16	EFO_0001360
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer	23535733	[1.05-1.12]	1.09	EFO_0000305
ENSG00000140718	rs1558902	16	53769662	A	Obesity	23563607	[NR]	1.14	EFO_0001073
ENSG00000140718	rs1421085	16	53767042	C	Dietary macronutrient intake	23636237	[0.061-0.139] % increase	0.1	EFO_0003939
ENSG00000140718	rs8044769	16	53805223	C	Osteoarthritis	22763110	[1.04-1.10]	1.07	EFO_0002506
ENSG00000140718	rs9939609	16	53786615	A	Type 2 diabetes	22693455	[1.19-1.30]	1.25	EFO_0001360
ENSG00000140718	rs9922619	16	53797859	T	Subcutaneous adipose tissue	22589738			EFO_0004766
ENSG00000140718	rs1421084	16	53723828	A	Subcutaneous adipose tissue	22589738			EFO_0004766
ENSG00000140718	rs1558902	16	53769662	A	Obesity (early onset extreme)	20421936	[1.26-1.50]	1.37	EFO_0001073
ENSG00000140718	rs11642841	16	53811575	A	Type 2 diabetes	20581827	[1.08-1.18]	1.13	EFO_0001360
ENSG00000140718	rs9936385	16	53785257	C	Type 2 diabetes	24509480	[1.09-1.18]	1.13	EFO_0001360
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	24861553	[0.062-0.089] unit increase	0.0756	EFO_0004340
ENSG00000140718	rs62033400	16	53777876	G	Body mass index	24064335	[0.060-0.100] kg/m2 increase	0.08	EFO_0004340
ENSG00000140718	rs9939609	16	53786615	A	Biomedical quantitative traits	19396169	[0.14-0.32] kg/m2 increase	0.24	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	17463249	[1.18-1.32]	1.23	EFO_0001360
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	17463248	[1.12-1.22]	1.17	EFO_0001360
ENSG00000140718	rs9941349	16	53791576	T	Obesity (extreme)	19553259	[1.33-1.66]	1.48	EFO_0001073
ENSG00000140718	rs1558902	16	53769662	?	Waist circumference	19557197			EFO_0004342
ENSG00000140718	rs11642015	16	53768582	T	Body mass index	28892062	[0.073-0.089] kg/m2 increase	0.081	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	28892062	[0.075-0.087] kg/m2 increase	0.081	EFO_0004340
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer	25751625	[1.05-1.1]	1.0752687	EFO_0000305
ENSG00000140718	rs11075995	16	53821379	A	Breast cancer	25751625	[1.02-1.06]	1.04	EFO_0000305
ENSG00000140718	rs1558902	16	53769662	A	Glycated hemoglobin levels	28898252	[0.0066-0.014] unit increase	0.0103	EFO_0004541
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	28869590	[0.09-0.122] unit increase	0.106	EFO_0001360
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	28869590	[0.087-0.127] unit increase	0.107	EFO_0001360
ENSG00000140718	rs9972653	16	53780451	G	Heel bone mineral density	28869591	[0.014-0.027] unit decrease	0.020378	EFO_0009270
ENSG00000140718	rs9972653	16	53780451	G	Heel bone mineral density	28869591	[0.014-0.032] unit decrease	0.0227727	EFO_0009270
ENSG00000140718	rs9936385	16	53785257	?	Lean body mass	28724990	[0.11-0.19] unit decrease	0.15	EFO_0004995
ENSG00000140718	rs1421085	16	53767042	C	Dietary macronutrient intake	29988085	[0.059-0.099] % increase	0.079	EFO_0003939
ENSG00000140718	rs11642015	16	53768582	?	Blood urea nitrogen levels	29403010	[0.026-0.043] unit increase novel	0.03452	EFO_0004741
ENSG00000140718	rs17817964	16	53794154	T	Body mass index (adult)	28430825	[0.049-0.089] unit increase	0.069	EFO_0004340
ENSG00000140718	rs17817964	16	53794154	T	Body mass index (adult)	28430825	[0.049-0.089] unit increase	0.069	EFO_0004340
ENSG00000140718	rs17817964	16	53794154	T	Body mass index (adult)	28430825	[0.046-0.096] unit increase	0.071	EFO_0004340
ENSG00000140718	rs16953002	16	54080912	A	Melanoma	28212542	[NR]	1.16	EFO_0000756
ENSG00000140718	rs55872725	16	53775211	?	Strenuous sports or other exercises	29899525		1.0416667	EFO_0008002
ENSG00000140718	rs55872725	16	53775211	T	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000140718	rs9928094	16	53765993	A	Pulse pressure x alcohol consumption interaction (2df test)	29912962			EFO_0005763\|EFO_0004329
ENSG00000140718	rs9928094	16	53765993	A	Pulse pressure x alcohol consumption interaction (2df test)	29912962			EFO_0005763\|EFO_0004329
ENSG00000140718	rs7185735	16	53788739	A	Pulse pressure x alcohol consumption interaction (2df test)	29912962			EFO_0005763\|EFO_0004329
ENSG00000140718	rs62033406	16	53790314	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000140718	rs62033406	16	53790314	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	20935630	[0.35-0.43] kg/m2 increase	0.39	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass in chronic obstructive pulmonary disease	21037115			EFO_0000341\|EFO_0004340
ENSG00000140718	rs9939609	16	53786615	A	Menarche (age at onset)	21102462	[1.32-2.88] week decrease	2.1	EFO_0004703
ENSG00000140718	rs12149832	16	53808996	A	Body mass index (SNP x SNP interaction)	22344221	[0.057-0.089] unit increase	0.073	EFO_0004340
ENSG00000140718	rs9940128	16	53766842	A	Metabolic syndrome	22399527	[NR] cm increase	0.09	EFO_0000195
ENSG00000140718	rs12596210	16	53994059	C	Sex hormone-binding globulin levels	22675492	[NR] unit decrease	0.12	EFO_0004696
ENSG00000140718	rs9930506	16	53796553	A	Obesity-related traits	17658951	[NR] SD decrease	0.13	EFO_0004340
ENSG00000140718	rs9930506	16	53796553	A	Obesity-related traits	17658951	[NR] SD decrease	0.16	EFO_0004343
ENSG00000140718	rs9930506	16	53796553	A	Obesity-related traits	17658951	[NR] SD decrease	0.12	EFO_0004338
ENSG00000140718	rs9939609	16	53786615	A	Type 2 diabetes	17554300	[1.17-1.52]	1.34	EFO_0001360
ENSG00000140718	rs9939609	16	53786615	A	Body mass index	17434869	[0.34 - 0.46] kg/m2 increase (adults)	0.36	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Type 2 diabetes	18372903	[1.09-1.22]	1.15	EFO_0001360
ENSG00000140718	rs1121980	16	53775335	?	Body mass index	18454148	[0.04-0.08] unit increase	0.06	EFO_0004340
ENSG00000140718	rs1121980	16	53775335	T	Obesity (early onset extreme)	18159244	[1.37-2.01]	1.66	EFO_0001073
ENSG00000140718	rs9939609	16	53786615	A	Body mass index	19079261	[0.27-0.39] kg/m2 increase	0.33	EFO_0004340
ENSG00000140718	rs8050136	16	53782363	?	Type 2 diabetes	19056611	[1.23-1.39]	1.3	EFO_0001360
ENSG00000140718	rs1558902	16	53769662	T	Obesity	21544081	[0.06-0.12] unit decrease	0.09	EFO_0001073
ENSG00000140718	rs17817449	16	53779455	?	Obesity	21552555			EFO_0001073
ENSG00000140718	rs8050136	16	53782363	C	Adiposity	21706003	[NR] % decrease	0.06	EFO_0001073
ENSG00000140718	rs9930333	16	53766065	G	Body mass index in physically active individuals	28448500	[0.064-0.084] kg/m2 increase	0.074	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index in physically active individuals	28448500	[0.066-0.083] kg/m2 increase	0.0747	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index in physically inactive individuals	28448500	[0.074-0.123] unit increase	0.0986	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9941349	16	53791576	T	Body mass index in physically inactive individuals	28448500	[0.097-0.137] unit increase	0.1169	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index in physically inactive individuals	28448500	[0.093-0.124] unit increase	0.1086	EFO_0008002\|EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index in physically inactive individuals	28448500	[0.072-0.114] unit increase	0.0931	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index in physically inactive individuals	28448500	[0.089-0.128] unit increase	0.1088	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index in physically inactive individuals	28448500	[0.089-0.119] unit increase	0.1039	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs7185735	16	53788739	A	Subcutaneous adipose tissue	27918534	z-score decrease	6.05	EFO_0004766
ENSG00000140718	rs1121980	16	53775335	A	Waist-hip ratio	25673412	[0.03-0.047] unit increase	0.0384	EFO_0004343
ENSG00000140718	rs1121980	16	53775335	A	Waist-hip ratio	25673412	[0.037-0.05] unit increase	0.0432	EFO_0004343
ENSG00000140718	rs1121980	16	53775335	A	Waist-hip ratio	25673412	[0.039-0.058] unit increase	0.0484	EFO_0004343
ENSG00000140718	rs1558902	16	53769662	A	Waist circumference	25673412	[0.063-0.08] unit increase	0.0714	EFO_0004342
ENSG00000140718	rs1558902	16	53769662	A	Waist circumference	25673412	[0.067-0.081] unit increase	0.0739	EFO_0004342
ENSG00000140718	rs1558902	16	53769662	A	Waist circumference	25673412	[0.067-0.086] unit increase	0.0767	EFO_0004342
ENSG00000140718	rs1558902	16	53769662	A	Body mass index (age interaction)	25953783			EFO_0005937
ENSG00000140718	rs1558902	16	53769662	A	BMI (adjusted for smoking behaviour)	28443625	[0.062-0.079] kg/m2 increase	0.0707	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI (adjusted for smoking behaviour)	28443625	[0.068-0.082] kg/m2 increase	0.075	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI (adjusted for smoking behaviour)	28443625	[0.071-0.09] kg/m2 increase	0.0806	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in smokers	28443625	[0.079-0.108] kg/m2 increase	0.0936	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in smokers	28443625	[0.075-0.113] kg/m2 increase	0.0938	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in smokers	28443625	[0.075-0.115] kg/m2 increase	0.0948	EFO_0004318\|EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in non-smokers	28443625	[0.059-0.078] kg/m2 increase	0.0685	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in non-smokers	28443625	[0.065-0.079] kg/m2 increase	0.072	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	BMI in non-smokers	28443625	[0.066-0.088] kg/m2 increase	0.0771	EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index	28448500	[0.073-0.087] kg/m2 increase	0.0803	EFO_0008002\|EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index	28448500	[0.075-0.097] kg/m2 increase	0.0857	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index	28448500	[0.076-0.091] kg/m2 increase	0.0835	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index	28448500	[0.075-0.095] kg/m2 increase	0.0847	EFO_0008002\|EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index	28448500	[0.074-0.095] kg/m2 increase	0.0844	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index	28448500	[0.072-0.091] kg/m2 increase	0.0819	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	T	Body mass index in physically active individuals	28448500	[0.061-0.095] kg/m2 increase	0.0783	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index in physically active individuals	28448500	[0.066-0.087] kg/m2 increase	0.0763	EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	G	Body mass index in physically active individuals	28448500	[0.068-0.085] kg/m2 increase	0.0762	EFO_0008002\|EFO_0004340
ENSG00000140718	rs8050136	16	53782363	A	Body mass index in physically active individuals	28448500	[0.067-0.091] kg/m2 increase	0.0792	EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs8050136	16	53782363	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs9930333	16	53766065	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs3751812	16	53784548	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000140718	rs55872725	16	53775211	T	Body mass index	28270201	[0.083-0.126] kg/m2 increase	0.10437275	EFO_0004340
ENSG00000140718	rs55872725	16	53775211	T	Body fat percentage	28270201	[0.49-0.80] % increase	0.6429834	EFO_0007800
ENSG00000140718	rs1121980	16	53775335	A	HDL cholesterol levels	28334899	[0.013-0.026] unit decrease (EA Beta values)	0.0196	EFO_0004612
ENSG00000140718	rs9930333	16	53766065	T	Triglyceride levels	28334899	[0.014-0.028] unit decrease (EA Beta values)	0.0208	EFO_0004530
ENSG00000140718	rs9936385	16	53785257	C	Body mass index	26426971			EFO_0004340
ENSG00000140718	rs1558902	16	53769662	A	Body mass index	26426971	unit increase	0.08215689	EFO_0004340
ENSG00000140718	rs1421085	16	53767042	C	Hand grip strength	29691431	[0.0034-0.0046] unit decrease	0.004	EFO_0006941
ENSG00000140718	rs11642015	16	53768582	T	Hand grip strength	29691431	[0.0034-0.0046] unit decrease	0.004	EFO_0006941
ENSG00000140718	rs7185735	16	53788739	G	Type 2 diabetes	30054458	[0.091-0.12] unit increase	0.1056	EFO_0001360
ENSG00000140718	rs11642015	16	53768582	?	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000140718	rs11642015	16	53768582	?	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000140718	rs11642015	16	53768582	?	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000140718	rs11642015	16	53768582	?	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000140718	rs11642015	16	53768582	?	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000140718	rs11642015	16	53768582	?	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000140718	rs11642015	16	53768582	?	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000140718	rs11642015	16	53768582	?	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000140718	rs17817712	16	53787213	?	Body mass index	30045251	[0.21-0.49] unit increase	0.348	EFO_0004340
ENSG00000140718	rs1558902	16	53769662	T	Body mass index	30108127	[NR] unit decrease	0.079	EFO_0004340
ENSG00000140718	rs9936385	16	53785257	C	Type 2 diabetes	26961502	[1.11-1.2]	1.152	EFO_0001360
ENSG00000140718	rs1421085	16	53767042	C	Body mass index	26961502	[0.068-0.084] unit increase	0.076	EFO_0004340
ENSG00000140718	rs57292959	16	53765367	T	Body mass index	26961502	[0.018-0.042] unit decrease	0.03	EFO_0004340
ENSG00000140718	rs28429148	16	53764407	A	Red cell distribution width	28957414	[0.013-0.029] unit increase	0.0211418	EFO_0005192
ENSG00000140718	rs57292959	16	53765367	?	Heel bone mineral density	30048462	[0.011-0.019] unit decrease	0.0147039	EFO_0009270
ENSG00000140718	rs12600060	16	54067549	?	Heel bone mineral density	30048462	[0.015-0.025] unit increase	0.0198229	EFO_0009270
ENSG00000140718	rs9972653	16	53780451	?	Heel bone mineral density	30048462	[0.01-0.018] unit decrease	0.014208	EFO_0009270
ENSG00000140718	rs2540766	16	54072059	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000140718	rs7197239	16	53948837	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000140718	rs56094641	16	53772541	?	Type 2 diabetes nephropathy	30566433	[1.14-1.29]	1.21	EFO_0004997
ENSG00000140718	rs56094641	16	53772541	G	Type 2 diabetes nephropathy including microalbuminuria	30566433	[1.12-1.24]	1.18	HP_0012594\|EFO_0004997
ENSG00000140718	rs1421085	16	53767042	?	Body fat percentage	30593698	[0.28-0.36] unit increase	0.3207	EFO_0007800
ENSG00000140718	rs1421085	16	53767042	?	Body fat percentage	30593698	[0.26-0.4] unit increase	0.32912	EFO_0007800
ENSG00000140718	rs1421085	16	53767042	?	Body fat percentage	30593698	[0.26-0.37] unit increase	0.31384	EFO_0007800
ENSG00000140718	rs8063057	16	53778521	T	Heel bone mineral density	30598549	[0.016-0.024] unit decrease	0.019986	EFO_0009270
ENSG00000140718	rs9924983	16	53986530	C	Heel bone mineral density	30598549	[0.0073-0.0147] unit increase	0.0110109	EFO_0009270
ENSG00000140718	rs1121980	16	53775335	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.016	EFO_0004612
ENSG00000140718	rs1421085	16	53767042	?	Type 2 diabetes	30595370			EFO_0001360
ENSG00000140718	rs11642015	16	53768582	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000140718	rs10521305	16	53874572	?	Age at menopause	30595370			EFO_0004704
ENSG00000140718	rs1421085	16	53767042	?	Body mass index	30595370			EFO_0004340
ENSG00000140718	rs12920255	16	53898001	?	Body mass index	30595370			EFO_0004340
ENSG00000140718	rs62034143	16	54114716	?	Body mass index	30595370			EFO_0004340
ENSG00000140718	rs12596638	16	54081917	?	Nevus count or cutaneous melanoma	30429480			EFO_0004632\|EFO_0000389
ENSG00000140718	rs7195994	16	54026293	?	Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count)	30166627	[0.32-0.64] unit decrease	0.48	EFO_0000685\|EFO_0004653\|EFO_0005413
ENSG00000140718	rs72805613	16	53803430	A	Number of sexual partners	30643258	[0.0095-0.019] unit increase	0.01425656	EFO_0007877
ENSG00000140718	rs1421085	16	53767042	?	Morning person	30595370			EFO_0008328
ENSG00000140718	rs56094641	16	53772541	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000140718	rs1558902	16	53769662	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000140718	rs9972653	16	53780451	?	White blood cell count	30595370			EFO_0004308
ENSG00000140718	rs16953002	16	54080912	?	Hair color	30595370			EFO_0007822
ENSG00000140718	rs7187250	16	53776634	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000140718	rs62033406	16	53790314	A	Pulse pressure	30578418	[0.083-0.161] mmHg decrease	0.1219	EFO_0005763
ENSG00000140718	rs35420030	16	53901495	T	Lung function (FEV1/FVC)	30804560	[0.035-0.055] unit decrease	0.045	EFO_0004713
ENSG00000140718	rs1421085	16	53767042	?	Fat-free mass	30593698	[0.21-0.31] unit increase	0.26138	EFO_0004995
ENSG00000140718	rs1421085	16	53767042	?	Fat-free mass	30593698	[0.39-0.53] unit increase	0.46248	EFO_0004995
ENSG00000140718	rs9930333	16	53766065	G	Osteoarthritis of the hip or knee	30664745	[1.03-1.06]	1.05	EFO_1000786\|EFO_0004616
ENSG00000140718	rs9930333	16	53766065	G	Obese vs. thin	30677029	[1.42-1.54]	1.48	EFO_0007041
ENSG00000140718	rs9928094	16	53765993	G	Obesity (extreme)	30677029	[1.29-1.36]	1.32	EFO_0007041
ENSG00000140718	rs1421085	16	53767042	?	Fat-free mass	30593698	[0.33-0.42] unit increase	0.37353	EFO_0004995
ENSG00000140718	rs35420030	16	53901495	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000140718	rs7187250	16	53776634	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000140718	rs12600060	16	54067549	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer	25751625	[1.05-1.1]	1.0752687	EFO_0000305
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (arm fat ratio)	30664634	NR unit increase (replication)	0.06203	EFO_0004341
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (arm fat ratio)	30664634	NR unit increase (replication)	0.03568	EFO_0004341
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (arm fat ratio)	30664634	NR unit increase (replication)	0.05017	EFO_0004341
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.02094	EFO_0004341
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.01312	EFO_0004341
ENSG00000140718	rs55872725	16	53775211	T	Body fat distribution (leg fat ratio)	30664634	NR unit decrease (replication)	0.02017	EFO_0004341
ENSG00000140718	rs62048402	16	53769311	A	Breast cancer	29059683	[0.05-0.075] unit decrease	0.0624	EFO_0000305
ENSG00000140718	rs17817449	16	53779455	T	Breast cancer	29059683	[1.04-1.08] (Oncoarray)	1.0526316	EFO_0000305
ENSG00000140718	rs11075995	16	53821379	A	Breast cancer	29059683	[1.01-1.06] (Oncoarray)	1.03	EFO_0000305
ENSG00000140718	rs56077980	16	54107655	CT	Breast cancer	29059683	[0.021-0.048] unit increase	0.0346	EFO_0000305
ENSG00000140718	rs1421085	16	53767042	C	Chronotype	30696823		1.0427902	EFO_0008328
ENSG00000140718	rs1421085	16	53767042	C	Morning person	30696823		1.0432968	EFO_0008328
ENSG00000140718	rs17817288	16	53773852	A	Sleep duration (long sleep)	30846698		1.04	EFO_0005271
ENSG00000140718	rs1558902	16	53769662	A	C-reactive protein levels	30388399	[0.026-0.042] unit increase	0.034	EFO_0004458

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140718's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140718	FTO	99	49.708	ENSAPOG00000023136	fto	69	55.705	Acanthochromis_polyacanthus
ENSG00000140718	FTO	100	90.751	ENSAMEG00000016388	FTO	100	89.307	Ailuropoda_melanoleuca
ENSG00000140718	FTO	99	50.292	ENSACIG00000004055	fto	97	45.889	Amphilophus_citrinellus
ENSG00000140718	FTO	99	49.708	ENSAOCG00000005573	fto	72	55.705	Amphiprion_ocellaris
ENSG00000140718	FTO	90	58.296	ENSAPEG00000009752	fto	72	55.369	Amphiprion_percula
ENSG00000140718	FTO	99	51.462	ENSATEG00000002699	fto	72	56.711	Anabas_testudineus
ENSG00000140718	FTO	98	60.757	ENSAPLG00000016324	FTO	99	60.757	Anas_platyrhynchos
ENSG00000140718	FTO	96	55.792	ENSACAG00000016467	FTO	99	55.792	Anolis_carolinensis
ENSG00000140718	FTO	100	98.113	ENSANAG00000036534	FTO	100	97.030	Aotus_nancymaae
ENSG00000140718	FTO	99	50.292	ENSACLG00000016803	fto	69	56.711	Astatotilapia_calliptera
ENSG00000140718	FTO	91	53.903	ENSAMXG00000041808	fto	90	44.291	Astyanax_mexicanus
ENSG00000140718	FTO	100	87.723	ENSBTAG00000012501	FTO	100	87.723	Bos_taurus
ENSG00000140718	FTO	100	98.113	ENSCJAG00000001425	FTO	100	96.937	Callithrix_jacchus
ENSG00000140718	FTO	100	91.908	ENSCAFG00000009463	FTO	91	91.000	Canis_familiaris
ENSG00000140718	FTO	100	91.908	ENSCAFG00020003690	FTO	92	91.287	Canis_lupus_dingo
ENSG00000140718	FTO	100	87.525	ENSCHIG00000009126	FTO	100	87.525	Capra_hircus
ENSG00000140718	FTO	100	94.530	ENSTSYG00000008905	FTO	100	94.530	Carlito_syrichta
ENSG00000140718	FTO	98	69.683	ENSCAPG00000017470	FTO	96	69.910	Cavia_aperea
ENSG00000140718	FTO	100	87.527	ENSCPOG00000012935	FTO	100	87.723	Cavia_porcellus
ENSG00000140718	FTO	100	97.170	ENSCCAG00000025984	FTO	100	95.778	Cebus_capucinus
ENSG00000140718	FTO	100	99.057	ENSCATG00000030692	FTO	100	98.468	Cercocebus_atys
ENSG00000140718	FTO	100	89.716	ENSCLAG00000013952	FTO	99	89.960	Chinchilla_lanigera
ENSG00000140718	FTO	99	98.238	ENSCSAG00000005296	FTO	99	98.242	Chlorocebus_sabaeus
ENSG00000140718	FTO	100	89.623	ENSCHOG00000001251	FTO	58	97.561	Choloepus_hoffmanni
ENSG00000140718	FTO	100	62.446	ENSCPBG00000012192	FTO	99	62.741	Chrysemys_picta_bellii
ENSG00000140718	FTO	100	99.057	ENSCANG00000027251	-	100	98.031	Colobus_angolensis_palliatus
ENSG00000140718	FTO	100	95.283	ENSCANG00000037225	-	100	91.683	Colobus_angolensis_palliatus
ENSG00000140718	FTO	100	88.840	ENSCGRG00001013545	Fto	100	88.515	Cricetulus_griseus_chok1gshd
ENSG00000140718	FTO	100	88.840	ENSCGRG00000011994	Fto	100	88.515	Cricetulus_griseus_crigri
ENSG00000140718	FTO	99	49.123	ENSCSEG00000009135	fto	73	52.885	Cynoglossus_semilaevis
ENSG00000140718	FTO	99	49.708	ENSCVAG00000016051	fto	97	44.508	Cyprinodon_variegatus
ENSG00000140718	FTO	99	50.292	ENSDARG00000044216	fto	90	53.333	Danio_rerio
ENSG00000140718	FTO	100	89.623	ENSDNOG00000047481	-	100	90.909	Dasypus_novemcinctus
ENSG00000140718	FTO	100	92.560	ENSDORG00000009325	Fto	99	91.865	Dipodomys_ordii
ENSG00000140718	FTO	100	81.132	ENSETEG00000012512	FTO	100	77.273	Echinops_telfairi
ENSG00000140718	FTO	100	90.591	ENSEASG00005018288	FTO	96	90.989	Equus_asinus_asinus
ENSG00000140718	FTO	100	90.372	ENSECAG00000022922	FTO	100	82.971	Equus_caballus
ENSG00000140718	FTO	99	51.462	ENSELUG00000005837	fto	94	46.490	Esox_lucius
ENSG00000140718	FTO	100	91.509	ENSFCAG00000005267	FTO	100	91.287	Felis_catus
ENSG00000140718	FTO	96	61.165	ENSFALG00000007914	FTO	98	61.165	Ficedula_albicollis
ENSG00000140718	FTO	98	88.688	ENSFDAG00000020796	FTO	89	89.116	Fukomys_damarensis
ENSG00000140718	FTO	93	58.744	ENSFHEG00000006142	fto	70	55.298	Fundulus_heteroclitus
ENSG00000140718	FTO	76	61.033	ENSGMOG00000006006	fto	79	61.033	Gadus_morhua
ENSG00000140718	FTO	92	68.379	ENSGALG00000041036	FTO	99	56.537	Gallus_gallus
ENSG00000140718	FTO	99	50.292	ENSGAFG00000010096	fto	71	56.040	Gambusia_affinis
ENSG00000140718	FTO	98	46.988	ENSGACG00000016684	fto	99	47.711	Gasterosteus_aculeatus
ENSG00000140718	FTO	99	62.850	ENSGAGG00000001078	FTO	100	62.151	Gopherus_agassizii
ENSG00000140718	FTO	100	100.000	ENSGGOG00000011151	FTO	100	100.000	Gorilla_gorilla
ENSG00000140718	FTO	99	50.292	ENSHBUG00000023512	fto	69	56.711	Haplochromis_burtoni
ENSG00000140718	FTO	100	90.153	ENSHGLG00000005386	FTO	99	90.361	Heterocephalus_glaber_female
ENSG00000140718	FTO	100	90.153	ENSHGLG00100006980	FTO	99	90.361	Heterocephalus_glaber_male
ENSG00000140718	FTO	90	58.108	ENSHCOG00000000892	fto	99	45.577	Hippocampus_comes
ENSG00000140718	FTO	99	49.123	ENSIPUG00000016830	fto	99	44.286	Ictalurus_punctatus
ENSG00000140718	FTO	100	91.287	ENSSTOG00000023410	FTO	100	91.287	Ictidomys_tridecemlineatus
ENSG00000140718	FTO	100	87.283	ENSJJAG00000013186	Fto	100	86.139	Jaculus_jaculus
ENSG00000140718	FTO	99	50.292	ENSKMAG00000016992	fto	69	55.369	Kryptolebias_marmoratus
ENSG00000140718	FTO	90	55.645	ENSLBEG00000011970	fto	67	56.929	Labrus_bergylta
ENSG00000140718	FTO	94	59.705	ENSLACG00000007809	FTO	96	59.705	Latimeria_chalumnae
ENSG00000140718	FTO	99	53.801	ENSLOCG00000007139	-	98	58.500	Lepisosteus_oculatus
ENSG00000140718	FTO	100	88.119	ENSLAFG00000015645	FTO	100	88.119	Loxodonta_africana
ENSG00000140718	FTO	100	98.468	ENSMFAG00000033026	FTO	100	98.468	Macaca_fascicularis
ENSG00000140718	FTO	100	99.057	ENSMMUG00000020583	FTO	100	98.416	Macaca_mulatta
ENSG00000140718	FTO	100	98.249	ENSMNEG00000045021	FTO	100	98.249	Macaca_nemestrina
ENSG00000140718	FTO	100	99.057	ENSMLEG00000017912	FTO	100	97.822	Mandrillus_leucophaeus
ENSG00000140718	FTO	99	49.123	ENSMAMG00000003830	fto	71	55.298	Mastacembelus_armatus
ENSG00000140718	FTO	99	50.292	ENSMZEG00005006743	fto	69	56.711	Maylandia_zebra
ENSG00000140718	FTO	92	67.857	ENSMGAG00000004464	FTO	99	59.252	Meleagris_gallopavo
ENSG00000140718	FTO	100	89.497	ENSMAUG00000000439	Fto	100	88.911	Mesocricetus_auratus
ENSG00000140718	FTO	100	95.405	ENSMICG00000016837	FTO	100	95.405	Microcebus_murinus
ENSG00000140718	FTO	100	87.527	ENSMOCG00000012365	Fto	99	87.000	Microtus_ochrogaster
ENSG00000140718	FTO	99	46.199	ENSMMOG00000016417	fto	98	44.841	Mola_mola
ENSG00000140718	FTO	100	67.031	ENSMODG00000009684	FTO	100	67.505	Monodelphis_domestica
ENSG00000140718	FTO	99	49.123	ENSMALG00000013226	fto	80	46.736	Monopterus_albus
ENSG00000140718	FTO	100	86.433	MGP_CAROLIEiJ_G0031369	Fto	99	86.706	Mus_caroli
ENSG00000140718	FTO	100	86.871	ENSMUSG00000055932	Fto	100	87.260	Mus_musculus
ENSG00000140718	FTO	100	87.527	MGP_PahariEiJ_G0022968	Fto	99	87.500	Mus_pahari
ENSG00000140718	FTO	100	86.871	MGP_SPRETEiJ_G0032488	Fto	99	87.103	Mus_spretus
ENSG00000140718	FTO	100	90.173	ENSMPUG00000003354	FTO	92	86.346	Mustela_putorius_furo
ENSG00000140718	FTO	96	81.728	ENSMLUG00000003855	FTO	98	81.728	Myotis_lucifugus
ENSG00000140718	FTO	100	89.901	ENSNGAG00000000461	Fto	100	89.901	Nannospalax_galili
ENSG00000140718	FTO	99	50.292	ENSNBRG00000009670	fto	96	48.566	Neolamprologus_brichardi
ENSG00000140718	FTO	100	99.125	ENSNLEG00000033330	FTO	100	99.125	Nomascus_leucogenys
ENSG00000140718	FTO	100	63.208	ENSMEUG00000011296	FTO	100	62.846	Notamacropus_eugenii
ENSG00000140718	FTO	100	87.965	ENSOPRG00000017285	FTO	99	88.294	Ochotona_princeps
ENSG00000140718	FTO	100	87.965	ENSODEG00000004439	FTO	99	87.525	Octodon_degus
ENSG00000140718	FTO	99	47.653	ENSONIG00000002809	fto	100	47.664	Oreochromis_niloticus
ENSG00000140718	FTO	99	60.000	ENSOANG00000013407	FTO	100	60.000	Ornithorhynchus_anatinus
ENSG00000140718	FTO	100	92.123	ENSOCUG00000001741	FTO	100	91.881	Oryctolagus_cuniculus
ENSG00000140718	FTO	99	49.708	ENSORLG00000013729	fto	71	54.605	Oryzias_latipes
ENSG00000140718	FTO	99	50.292	ENSORLG00020020752	fto	71	54.934	Oryzias_latipes_hni
ENSG00000140718	FTO	99	49.708	ENSORLG00015019222	fto	71	54.605	Oryzias_latipes_hsok
ENSG00000140718	FTO	95	55.061	ENSOMEG00000015831	fto	75	52.905	Oryzias_melastigma
ENSG00000140718	FTO	95	91.980	ENSOGAG00000005135	FTO	100	91.542	Otolemur_garnettii
ENSG00000140718	FTO	100	87.327	ENSOARG00000017939	FTO	100	87.327	Ovis_aries
ENSG00000140718	FTO	100	99.821	ENSPPAG00000028022	FTO	100	99.821	Pan_paniscus
ENSG00000140718	FTO	100	91.509	ENSPPRG00000008968	FTO	100	91.089	Panthera_pardus
ENSG00000140718	FTO	100	90.693	ENSPTIG00000014386	FTO	100	90.693	Panthera_tigris_altaica
ENSG00000140718	FTO	100	99.642	ENSPTRG00000008118	FTO	100	99.642	Pan_troglodytes
ENSG00000140718	FTO	100	98.468	ENSPANG00000016386	FTO	100	98.222	Papio_anubis
ENSG00000140718	FTO	99	49.123	ENSPKIG00000025376	fto	99	46.821	Paramormyrops_kingsleyae
ENSG00000140718	FTO	100	61.670	ENSPSIG00000007424	FTO	99	60.947	Pelodiscus_sinensis
ENSG00000140718	FTO	99	48.538	ENSPMGG00000021823	fto	95	43.798	Periophthalmus_magnuspinnatus
ENSG00000140718	FTO	100	87.965	ENSPEMG00000021137	Fto	100	87.327	Peromyscus_maniculatus_bairdii
ENSG00000140718	FTO	100	69.651	ENSPCIG00000024376	FTO	98	69.499	Phascolarctos_cinereus
ENSG00000140718	FTO	99	50.292	ENSPFOG00000015987	fto	98	48.544	Poecilia_formosa
ENSG00000140718	FTO	94	55.785	ENSPLAG00000010924	fto	74	53.943	Poecilia_latipinna
ENSG00000140718	FTO	94	55.785	ENSPMEG00000014981	fto	74	53.943	Poecilia_mexicana
ENSG00000140718	FTO	99	50.292	ENSPREG00000006358	fto	71	56.040	Poecilia_reticulata
ENSG00000140718	FTO	100	98.614	ENSPPYG00000007353	FTO	100	98.614	Pongo_abelii
ENSG00000140718	FTO	92	85.246	ENSPCAG00000009838	FTO	100	75.810	Procavia_capensis
ENSG00000140718	FTO	100	94.748	ENSPCOG00000021567	FTO	100	94.748	Propithecus_coquereli
ENSG00000140718	FTO	99	83.810	ENSPVAG00000011099	FTO	66	100.000	Pteropus_vampyrus
ENSG00000140718	FTO	99	50.292	ENSPNYG00000011161	fto	72	56.711	Pundamilia_nyererei
ENSG00000140718	FTO	99	50.292	ENSPNAG00000024295	fto	97	43.007	Pygocentrus_nattereri
ENSG00000140718	FTO	100	87.746	ENSRNOG00000011728	Fto	99	87.302	Rattus_norvegicus
ENSG00000140718	FTO	100	98.113	ENSRBIG00000037512	-	100	98.113	Rhinopithecus_bieti
ENSG00000140718	FTO	100	95.111	ENSRBIG00000038496	-	96	96.154	Rhinopithecus_bieti
ENSG00000140718	FTO	100	99.057	ENSRROG00000039169	FTO	100	98.687	Rhinopithecus_roxellana
ENSG00000140718	FTO	100	96.499	ENSSBOG00000031008	FTO	100	96.499	Saimiri_boliviensis_boliviensis
ENSG00000140718	FTO	100	69.432	ENSSHAG00000009174	FTO	100	69.170	Sarcophilus_harrisii
ENSG00000140718	FTO	99	52.047	ENSSFOG00015001159	fto	97	49.383	Scleropages_formosus
ENSG00000140718	FTO	99	49.123	ENSSMAG00000008928	fto	73	55.776	Scophthalmus_maximus
ENSG00000140718	FTO	99	50.292	ENSSDUG00000006070	fto	71	56.291	Seriola_dumerili
ENSG00000140718	FTO	99	50.292	ENSSLDG00000018141	fto	96	49.068	Seriola_lalandi_dorsalis
ENSG00000140718	FTO	99	87.791	ENSSARG00000002305	FTO	99	78.958	Sorex_araneus
ENSG00000140718	FTO	93	66.016	ENSSPUG00000018636	FTO	98	63.248	Sphenodon_punctatus
ENSG00000140718	FTO	99	49.708	ENSSPAG00000015208	fto	69	55.705	Stegastes_partitus
ENSG00000140718	FTO	100	89.505	ENSSSCG00000035949	FTO	100	89.505	Sus_scrofa
ENSG00000140718	FTO	98	60.998	ENSTGUG00000007401	FTO	100	61.086	Taeniopygia_guttata
ENSG00000140718	FTO	99	49.123	ENSTRUG00000020259	fto	72	55.263	Takifugu_rubripes
ENSG00000140718	FTO	94	48.030	ENSTNIG00000013612	fto	99	48.030	Tetraodon_nigroviridis
ENSG00000140718	FTO	100	93.064	ENSTBEG00000009722	FTO	100	94.501	Tupaia_belangeri
ENSG00000140718	FTO	100	89.623	ENSTTRG00000012713	FTO	100	82.178	Tursiops_truncatus
ENSG00000140718	FTO	100	90.173	ENSUAMG00000012494	FTO	99	86.830	Ursus_americanus
ENSG00000140718	FTO	100	90.751	ENSUMAG00000002581	FTO	100	88.713	Ursus_maritimus
ENSG00000140718	FTO	100	88.679	ENSVPAG00000003238	FTO	58	100.000	Vicugna_pacos
ENSG00000140718	FTO	100	91.908	ENSVVUG00000019536	FTO	92	91.287	Vulpes_vulpes
ENSG00000140718	FTO	93	60.938	ENSXETG00000005816	fto	99	52.539	Xenopus_tropicalis
ENSG00000140718	FTO	98	50.888	ENSXCOG00000013003	fto	95	49.251	Xiphophorus_couchianus
ENSG00000140718	FTO	99	50.292	ENSXMAG00000022095	fto	71	56.040	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001659	temperature homeostasis	-	IEA	Process
GO:0005634	nucleus	26458103.28002401.30197295.	IDA	Component
GO:0005634	nucleus	17991826.	ISS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	28002401.	IDA	Component
GO:0006307	DNA dealkylation involved in DNA repair	18775698.20376003.	IDA	Process
GO:0006307	DNA dealkylation involved in DNA repair	-	TAS	Process
GO:0008198	ferrous iron binding	20376003.	IDA	Function
GO:0010883	regulation of lipid storage	26287746.	IMP	Process
GO:0016607	nuclear speck	22002720.	IDA	Component
GO:0016740	transferase activity	-	IEA	Function
GO:0035515	oxidative RNA demethylase activity	18775698.22002720.28002401.30197295.	IDA	Function
GO:0035516	oxidative DNA demethylase activity	18775698.20376003.	IDA	Function
GO:0035552	oxidative single-stranded DNA demethylation	18775698.20376003.	IDA	Process
GO:0035553	oxidative single-stranded RNA demethylation	18775698.22002720.25452335.26457839.28002401.30197295.	IDA	Process
GO:0035553	oxidative single-stranded RNA demethylation	26458103.	IMP	Process
GO:0040014	regulation of multicellular organism growth	-	IEA	Process
GO:0042245	RNA repair	18775698.	IDA	Process
GO:0043734	DNA-N1-methyladenine dioxygenase activity	20376003.	IDA	Function
GO:0044065	regulation of respiratory system process	-	IEA	Process
GO:0060612	adipose tissue development	-	IEA	Process
GO:0061157	mRNA destabilization	28002401.30197295.	IDA	Process
GO:0070350	regulation of white fat cell proliferation	-	IEA	Process
GO:0070989	oxidative demethylation	18775698.	IDA	Process
GO:0080111	DNA demethylation	18775698.	IDA	Process
GO:0090335	regulation of brown fat cell differentiation	26287746.	IMP	Process
GO:1990931	RNA N6-methyladenosine dioxygenase activity	25452335.26457839.30197295.	IDA	Function
GO:1990931	RNA N6-methyladenosine dioxygenase activity	26458103.	IMP	Function
GO:1990984	tRNA demethylase activity	30197295.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22396042	Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls.	Tumour Biol	2012 Aug	Li G	doi: 10.1007/s13277-012-0372-9
26146447	Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population.	Dis Markers	2015	Zeng X	doi: 10.1155/2015/101032
27207655	Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.	Carcinogenesis	2016 Jul	Sigurdson AJ	doi: 10.1093/carcin/bgw047
26931363	Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis.	Eur J Cancer Care (Engl)	2017 Sep	Huang X	doi: 10.1111/ecc.12464
24023349	Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer.	Anticancer Res	2013 Sep	Akilzhanova A	-
21489227	The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.	BMC Med Genet	2011 Apr 13	Kaklamani V	doi: 10.1186/1471-2350-12-52.
22857884	The risk of sporadic colorectal cancer development is not influenced by fat mass and obesity related gene polymorphism in Slavs.	Eur J Intern Med	2012 Oct	Hubacek JA	doi: 10.1016/j.ejim.2012.07.002
26427991	Association between the FTOrs8050136 polymorphism and cancer risk: a meta-analysis.	Fam Cancer	2016 Jan	Zhao J	doi: 10.1007/s10689-015-9843-7.
20647405	No association between FTO or HHEX and endometrial cancer risk.	Cancer Epidemiol Biomarkers Prev	2010 Aug	Gaudet MM	doi: 10.1158/1055-9965.EPI-10-0515
23835106	Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan.	BMC Cancer	2013 Jul 8	Lin Y	doi: 10.1186/1471-2407-13-337.
22153534	The obesity gene and colorectal cancer risk: a population study in Northern Italy.	Eur J Intern Med	2012 Jan	Tarabra E	doi: 10.1016/j.ejim.2011.07.011
24091943	Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk.	Mol Biol Rep	2013 Dec	da Cunha PA	doi: 10.1007/s11033-013-2780-3
25387436	Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview.	Mol Biol Rep	2015 Mar	Hern??ndez-Caballero ME	doi: 10.1007/s11033-014-3817-y
21347432	The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.	PLoS One	2011 Feb 8	Lurie G	doi: 10.1371/journal.pone.0016756.
26722548	Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications.	Int J Clin Exp Pathol	2015 Oct 1	Tan A	-
23922112	Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.	Br J Cancer	2013 Aug 20	Reddy SM	doi: 10.1038/bjc.2013.441
28591216	Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival.	PLoS One	2017 Jun 7	Zhu RM	doi: 10.1371/journal.pone.0178850
28849183	FTO expression is associated with the occurrence of gastric cancer and prognosis.	Oncol Rep	2017 Oct	Xu D	doi: 10.3892/or.2017.5904
30465076	Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression.	J Cancer Res Clin Oncol	2019 Jan	Chen J	doi: 10.1007/s00432-018-2796-0
29220587	FTO Gene Affects Obesity and Breast Cancer Through Similar Mechanisms: A New Insight into the Molecular Therapeutic Targets.	Nutr Cancer	2018 Jan	Akbari ME	doi: 10.1080/01635581.2018.1397709

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr16	53826330	Missense_Mutation	novel	A197V	0.33
BLCA	chr16	53844182	Missense_Mutation	NA	S260F	0.36
BLCA	chr16	53934015	Missense_Mutation	NA	E424Q	0.34
BLCA	chr16	53879848	Nonsense_Mutation	novel	S327*	0.11
BLCA	chr16	54111953	3'UTR	rs775623288		0.44
BLCA	chr16	54111961	3'UTR	rs768966582		0.54
BLCA	chr16	53826108	Missense_Mutation	novel	S123F	0.41
BRCA	chr16	53826314	Missense_Mutation	NA	D192H	0.47
BRCA	chr16	53826299	Missense_Mutation	rs577569584	G187R	0.29
BRCA	chr16	53888892	Missense_Mutation	NA	D394N	0.29
BRCA	chr16	54112032	3'UTR	novel		0.05
CESC	chr16	53704061	5'UTR	novel		0.21
CESC	chr16	54111980	3'UTR	novel		0.13
CESC	chr16	54111981	3'UTR	novel		0.13
CESC	chr16	53879910	Missense_Mutation	NA	D348N	0.46
CESC	chr16	53888892	Missense_Mutation	NA	D394N	0.07
COAD	chr16	53826299	Missense_Mutation	rs577569584	G187R	0.28
COAD	chr16	53826263	Missense_Mutation	novel	D175Y	0.37
COAD	chr16	53704049	5'UTR	NA		0.27
COAD	chr16	53826018	Missense_Mutation	rs151263395	P93L	0.32	FTO_CTD
COAD	chr16	53844192	Silent	novel	E263E	0.21
COAD	chr16	53873813	Missense_Mutation	novel	C308F	0.06
COAD	chr16	53879878	Missense_Mutation	rs761330347	R337H	0.26
COAD	chr16	53826030	Missense_Mutation	novel	I97S	0.38	FTO_CTD
COAD	chr16	53873854	Nonsense_Mutation	rs200201735	R322*	0.32
COAD	chr16	53704057	5'UTR	novel		0.26
COAD	chr16	53704060	5'UTR	novel		0.21
COAD	chr16	54111788	Missense_Mutation	NA	L464S	0.15
COAD	chr16	53810204	Missense_Mutation	NA	E37A	0.35	FTO_CTD
COAD	chr16	53888932	Missense_Mutation	novel	W407L	0.35
COAD	chr16	53826298	Silent	rs45492996	N186N	0.34
ESCA	chr16	53826181	Missense_Mutation	novel	Q147H	0.41
ESCA	chr16	53934037	Missense_Mutation	novel	R431T	0.51
GBM	chr16	53879853	Nonsense_Mutation	novel	G329*	0.21
GBM	chr16	53879967	Nonsense_Mutation	novel	G367*	0.24
GBM	chr16	54111860	Missense_Mutation	novel	D488G	0.43
GBM	chr16	53879923	Missense_Mutation	novel	D352V	0.06
GBM	chr16	53825925	Missense_Mutation	novel	H62P	0.3	FTO_CTD
GBM	chr16	53873822	Missense_Mutation	NA	A311V	0.06
GBM	chr16	53825884	Silent	novel	K48K	0.15
HNSC	chr16	53810185	Missense_Mutation	novel	L31V	0.31	FTO_CTD
HNSC	chr16	53826024	Missense_Mutation	novel	S95F	0.23	FTO_CTD
HNSC	chr16	53873839	Missense_Mutation	novel	F317I	0.06
HNSC	chr16	54111933	3'UTR	novel		0.05
HNSC	chr16	54111935	3'UTR	novel		0.05
HNSC	chr16	53879848	Nonsense_Mutation	novel	S327*	0.39
HNSC	chr16	53888835	Missense_Mutation	novel	E375Q	0.25
HNSC	chr16	53934003	Missense_Mutation	novel	E420K	0.2
KIRC	chr16	53888927	Silent	NA	A405A	0.32
KIRC	chr16	53844171	Missense_Mutation	NA	S256R	0.3
LIHC	chr16	53704162	5'UTR	novel		0.26
LIHC	chr16	53704071	5'UTR	novel		0.54
LIHC	chr16	53844186	Missense_Mutation	NA	H261Q	0.17
LIHC	chr16	53704058	5'UTR	novel		0.24
LIHC	chr16	53844186	Missense_Mutation	NA	H261Q	0.04
LUAD	chr16	53826051	Missense_Mutation	NA	C104F	0.39	FTO_CTD
LUAD	chr16	53844153	Splice_Site	novel	X251_splice	0.18
LUAD	chr16	53934078	Missense_Mutation	rs758990618	R445C	0.16
LUAD	chr16	53826443	Missense_Mutation	novel	N235Y	0.19
LUAD	chr16	53873809	Missense_Mutation	NA	H307Y	0.28
LUAD	chr16	53879915	Silent	novel	V349V	0.15
LUSC	chr16	53873843	Missense_Mutation	NA	S318I	0.25
LUSC	chr16	53826411	Missense_Mutation	novel	G224E	0.3
LUSC	chr16	54111877	Missense_Mutation	novel	S494P	0.29
LUSC	chr16	54111902	Frame_Shift_Del	novel	*A503Qfs50**	0.17
LUSC	chr16	53873854	Nonsense_Mutation	rs200201735	R322*	0.36
LUSC	chr16	53810208	Missense_Mutation	rs780803760	F38L	0.18	FTO_CTD
LUSC	chr16	53879920	Missense_Mutation	novel	N351S	0.17
LUSC	chr16	53844160	Missense_Mutation	NA	E253Q	0.25
LUSC	chr16	53888905	Missense_Mutation	NA	Q398L	0.1
LUSC	chr16	53879852	Silent	rs772473287	T328T	0.59
LUSC	chr16	53826209	Missense_Mutation	novel	L157V	0.08
LUSC	chr16	53826090	Missense_Mutation	novel	P117L	0.15	FTO_CTD
LUSC	chr16	53810178	Silent	NA	L28L	0.09
OV	chr16	53825895	Missense_Mutation	rs755828209	R52Q	0.04	FTO_CTD
OV	chr16	53704034	5'UTR	novel		0.29
OV	chr16	53826027	Missense_Mutation	NA	R96L	0.44	FTO_CTD
OV	chr16	54111886	Frame_Shift_Del	novel	*R497Efs56**	0.03
OV	chr16	53826477	Missense_Mutation	novel	S246I	0.15
PRAD	chr16	53879879	Silent	NA	R337R	0.38
READ	chr16	53825941	Missense_Mutation	novel	E67D	0.11	FTO_CTD
READ	chr16	54111777	Silent	novel	I460I	0.08
READ	chr16	53826125	Missense_Mutation	rs751544648	E129K	0.46
SKCM	chr16	53879979	Missense_Mutation	novel	H371Y	0.26
SKCM	chr16	54112007	3'UTR	novel		0.6
STAD	chr16	53879879	Silent	NA	R337R	0.97
STAD	chr16	53826299	Missense_Mutation	NA	G187R	0.05
STAD	chr16	54111771	Silent	NA	S458S	0.1
STAD	chr16	53873836	Missense_Mutation	rs777196899	R316W	0.36
STAD	chr16	54111953	3'UTR	rs775623288		0.12
STAD	chr16	53826029	Missense_Mutation	rs368658799	I97V	0.17	FTO_CTD
STAD	chr16	54112064	3'UTR	novel		0.13
THCA	chr16	53934089	Silent	NA	L448L	0.12
UCEC	chr16	53825891	Missense_Mutation	rs371489995	L51I	0.38	FTO_CTD
UCEC	chr16	53879910	Missense_Mutation	NA	D348N	0.34
UCEC	chr16	54111773	Missense_Mutation	novel	R459Q	0.06
UCEC	chr16	54111842	Missense_Mutation	NA	S482L	0.28
UCEC	chr16	54112006	3'UTR	novel		0.44
UCEC	chr16	53844260	Missense_Mutation	rs370075174	A286V	0.44
UCEC	chr16	53825978	Missense_Mutation	rs140101381	R80W	0.51	FTO_CTD
UCEC	chr16	53704117	5'UTR	novel		0.28
UCEC	chr16	53879942	Silent	novel	S358S	0.23
UCEC	chr16	53934055	Missense_Mutation	novel	A437V	0.18
UCEC	chr16	53879878	Missense_Mutation	rs761330347	R337H	0.3
UCEC	chr16	53879878	Missense_Mutation	rs761330347	R337H	0.33
UCEC	chr16	54111842	Missense_Mutation	NA	S482L	0.52
UCEC	chr16	53879973	Nonsense_Mutation	novel	E369*	0.51
UCEC	chr16	53826308	Nonsense_Mutation	novel	E190*	0.5
UCEC	chr16	53844190	Missense_Mutation	rs200452822	E263K	0.2
UCEC	chr16	53934055	Missense_Mutation	novel	A437V	0.36
UCEC	chr16	53844260	Missense_Mutation	rs370075174	A286V	0.25
UCEC	chr16	54111814	Missense_Mutation	NA	R473W	0.39
UCEC	chr16	53879882	Silent	novel	C338C	0.31
UCEC	chr16	54111814	Missense_Mutation	NA	R473W	0.45
UCEC	chr16	54111953	3'UTR	rs775623288		0.48
UCEC	chr16	54111976	3'UTR	novel		0.09
UCEC	chr16	53879846	Splice_Region	novel	C326C	0.28
UCEC	chr16	54111979	3'UTR	novel		0.31
UCEC	chr16	53888883	Missense_Mutation	NA	K391Q	0.15
UCEC	chr16	54112064	3'UTR	novel		0.33
UCEC	chr16	53934079	Missense_Mutation	rs139000284	R445H	0.49
UCEC	chr16	53825891	Missense_Mutation	rs371489995	L51I	0.2	FTO_CTD
UCEC	chr16	54111929	3'UTR	novel		0.36
UCEC	chr16	54111873	Silent	rs376687583	I492I	0.28
UCEC	chr16	53873866	Splice_Site	novel	X325_splice	0.27
UCEC	chr16	53704187	Frame_Shift_Del	NA	*K2Nfs9**	0.26	FTO_CTD
UCEC	chr16	53810217	Missense_Mutation	NA	Q41H	0.27	FTO_CTD
UCEC	chr16	53704040	5'UTR	novel		0.33
UCEC	chr16	53873823	Silent	novel	A311A	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1695	0.017271
CHOL	DEL	0.1667	0.23475
SARC	DEL	0.4825	0.0011106
SKCM	DEL	0.2779	0.036923
TGCT	AMP	0.0933	0.035574
UCEC	DEL	0.2468	4.7164e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00066	Kaplan-Meier Survival Analysis
STAD	0.0014	Kaplan-Meier Survival Analysis
MESO	0.025	Kaplan-Meier Survival Analysis
ACC	0.022	Kaplan-Meier Survival Analysis
LUSC	0.046	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
LAML	0.017	Kaplan-Meier Survival Analysis
LGG	0.00068	Kaplan-Meier Survival Analysis
THCA	0.008	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742