EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140836 (Gene tree)
Gene ID: 463
Gene Symbol: ZFHX3
Alias: ZNF927|ATBF1
Full Name: zinc finger homeobox 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 1,108,987 bases
Position: chr16:72,782,885-73,891,871
Accession: 777
RBP type: canonical RBP
Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000268489	zf-C2H2	PF00096.26	4.6e-13	1	2
ENSP00000268489	zf-C2H2	PF00096.26	4.6e-13	2	2
ENSP00000493252	zf-C2H2	PF00096.26	4.6e-13	1	2
ENSP00000493252	zf-C2H2	PF00096.26	4.6e-13	2	2
ENSP00000438926	zf-C2H2	PF00096.26	2.9e-10	1	1
ENSP00000268489	zf-met	PF12874.7	2.4e-06	1	1
ENSP00000493252	zf-met	PF12874.7	2.4e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000563625	ZFHX3-205	455	-	-	- (aa)	-	-
ENST00000397992	ZFHX3-203	13841	XM_017023251	ENSP00000438926	2789 (aa)	XP_016878740	Q15911
ENST00000641018	ZFHX3-206	837	-	-	- (aa)	-	-
ENST00000641077	ZFHX3-207	942	-	-	- (aa)	-	-
ENST00000641206	ZFHX3-208	17219	-	ENSP00000493252	3703 (aa)	-	Q15911
ENST00000358463	ZFHX3-202	1308	-	-	- (aa)	-	-
ENST00000268489	ZFHX3-201	16064	XM_005255957	ENSP00000268489	3703 (aa)	XP_005256014	Q15911
ENST00000642085	ZFHX3-209	1603	-	-	- (aa)	-	-
ENST00000558842	ZFHX3-204	240	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000140836's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04550	Signaling pathways regulating pluripotency of stem cells	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140836	Cardiovascular Diseases	3.08229721345304E-11	17903304
ENSG00000140836	Cardiovascular Diseases	1.7707092227539E-9	17903304
ENSG00000140836	Cardiovascular Diseases	3.1686443324061E-9	17903304
ENSG00000140836	Cardiovascular Diseases	2.61163771674666E-8	17903304
ENSG00000140836	Cardiovascular Diseases	2.39538039477632E-8	17903304
ENSG00000140836	Cardiovascular Diseases	2.3717326436264E-7	17903304
ENSG00000140836	Body Mass Index	3.0320000E-005	-
ENSG00000140836	Obesity	2.8880000E-005	-
ENSG00000140836	Waist Circumference	7.8720000E-006	-
ENSG00000140836	Waist Circumference	6.2680000E-005	-
ENSG00000140836	Platelet Function Tests	8.0100000E-006	-
ENSG00000140836	Platelet Function Tests	1.7762800E-005	-
ENSG00000140836	Platelet Function Tests	2.0018300E-005	-
ENSG00000140836	Vitamin B 6	7.6570000E-005	-
ENSG00000140836	Plaque, Atherosclerotic	1.8810000E-005	21909108
ENSG00000140836	Atrial Fibrillation	1E-10	19597491
ENSG00000140836	Atrial Fibrillation	5E-10	27790247
ENSG00000140836	Coronary Disease	5E-10	27790247
ENSG00000140836	Diabetes Mellitus	5E-10	27790247
ENSG00000140836	Heart Failure	5E-10	27790247
ENSG00000140836	Mortality	5E-10	27790247
ENSG00000140836	Neoplasms	5E-10	27790247
ENSG00000140836	Stroke	5E-10	27790247
ENSG00000140836	Glucocorticoids	1E-6	26265699
ENSG00000140836	Osteonecrosis	1E-6	26265699
ENSG00000140836	Atrial Fibrillation	2E-15	19597492
ENSG00000140836	Cholesterol, LDL	5E-6	21347282
ENSG00000140836	Stroke	2E-8	23041239
ENSG00000140836	Hypospadias	1E-18	25108383
ENSG00000140836	Atrial Fibrillation	3E-11	27790247
ENSG00000140836	Blood Pressure	3E-11	27790247
ENSG00000140836	Cholesterol	3E-11	27790247
ENSG00000140836	Coronary Disease	3E-11	27790247
ENSG00000140836	Diabetes Mellitus	3E-11	27790247
ENSG00000140836	Electrocardiography	3E-11	27790247
ENSG00000140836	Glucose	3E-11	27790247
ENSG00000140836	Heart Failure	3E-11	27790247
ENSG00000140836	Hematocrit	3E-11	27790247
ENSG00000140836	Cholesterol, HDL	3E-11	27790247
ENSG00000140836	Mortality	3E-11	27790247
ENSG00000140836	Neoplasms	3E-11	27790247
ENSG00000140836	Triglycerides	3E-11	27790247
ENSG00000140836	Body Mass Index	3E-11	27790247
ENSG00000140836	Stroke	3E-11	27790247
ENSG00000140836	Mucocutaneous Lymph Node Syndrome	2E-6	19132087
ENSG00000140836	Embolism	2E-10	26708676
ENSG00000140836	Stroke	2E-10	26708676
ENSG00000140836	Schizophrenia	6E-6	26198764
ENSG00000140836	Atrial Fibrillation	3E-16	22544366

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140836	rs1480570	16	73642843	A	Subjective well-being	27089181	[0.0082-0.019] unit increase	0.0136	EFO_0007869
ENSG00000140836	rs1858800	16	72990377	T	Hypospadias	25108383	[NR]	1.36	EFO_0004209
ENSG00000140836	rs143661751	16	73688392	G	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.464	GO_0097366\|EFO_0004713
ENSG00000140836	rs427576	16	73795371	C	Thiazide-induced adverse metabolic effects in hypertensive patients	23400010	[1.5-3.74] mg/dL decrease	2.62	EFO_0005202\|EFO_0004465
ENSG00000140836	rs7193343	16	72995261	T	Ischemic stroke (cardioembolic)	26708676	[1.11-1.23]	1.17	HP_0002140\|EFO_1001493
ENSG00000140836	rs16971384	16	72897186	A	LDL cholesterol	21347282	[0.041-0.102] unit decrease	0.0715	EFO_0004611
ENSG00000140836	rs2229288	16	72794405	C	Glucocorticoid-induced osteonecrosis	26265699			GO_0051384\|EFO_0004259
ENSG00000140836	rs16971465	16	72983162	C	Schizophrenia	26198764	[NR]	1.08	EFO_0000692
ENSG00000140836	rs879324	16	73034779	A	Stroke (ischemic)	23041239	[1.15-1.35]	1.25	EFO_0000712
ENSG00000140836	rs764255	16	73679784	T	Word reading	23738518	[0.048-0.106] unit decrease	0.077	EFO_0005300
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	22544366	[1.17-1.30]	1.24	EFO_0000275
ENSG00000140836	rs7191888	16	73547159	?	Multiple sclerosis (severity)	19010793	[NR]		EFO_0003885
ENSG00000140836	rs7199343	16	72975125	T	Kawasaki disease	19132087	[1.33-1.92]	1.56	EFO_0004246
ENSG00000140836	rs7193343	16	72995261	T	Atrial fibrillation	19597491	[1.14-1.29]	1.21	EFO_0000275
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	19597492		1.25	EFO_0000275
ENSG00000140836	rs147089336	16	73318730	A	QT interval	29213071	[5.48-13.68] ms increase	9.58	EFO_0004682
ENSG00000140836	rs4788694	16	73036184	G	Body mass index	28892062	[0.013-0.029] kg/m2 decrease	0.021	EFO_0004340
ENSG00000140836	rs756717	16	72962263	A	Body mass index	28892062	[0.0091-0.0209] kg/m2 decrease	0.015	EFO_0004340
ENSG00000140836	rs4404097	16	72998133	A	Atrial fibrillation	29290336	[1.12-1.24]	1.18	EFO_0000275
ENSG00000140836	rs1364064	16	73428587	?	Colonoscopy-negative controls vs population controls	29228715	[NR]	1.393	EFO_0008460
ENSG00000140836	rs2359171	16	73019123	A	Atrial fibrillation	30061737	[1.17-1.21]	1.19	EFO_0000275
ENSG00000140836	rs417278	16	73796577	T	Self-reported math ability	30038396	[0.007-0.0148] unit decrease	0.0109	EFO_0004875
ENSG00000140836	rs12932445	16	73035989	?	Stroke	29531354			EFO_0000712
ENSG00000140836	rs12932445	16	73035989	?	Ischemic stroke	29531354			HP_0002140
ENSG00000140836	rs12932445	16	73035989	?	Ischemic stroke (cardioembolic)	29531354			EFO_1001976
ENSG00000140836	rs2063506	16	73759653	G	Height	29782485			EFO_0004339
ENSG00000140836	rs8054028	16	73126071	?	Midgestational circulating levels of PBDEs (fetal genetic effect)	28235828	[0.25-0.53] unit decrease	0.39	EFO_0007961\|EFO_0007964\|EFO_0007959\|EFO_0007962
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	28416818	[1.15-1.23]	1.19	EFO_0000275
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	28416818	[1.17-1.37]	1.2	EFO_0000275
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	28416818	[1.20-1.35]	1.27	EFO_0000275
ENSG00000140836	rs2106261	16	73017721	T	Early onset atrial fibrillation	28460022	[1.83-2.36]	2.08	EFO_0000275
ENSG00000140836	rs4499262	16	73025260	A	Incident atrial fibrillation	28416818	1.09-1.19	1.14	EFO_0000275
ENSG00000140836	rs2106261	16	73017721	T	Prevalent atrial fibrillation	28416818	1.19-1.31	1.25	EFO_0000275
ENSG00000140836	rs75232769	16	72812192	A	Facial morphology (factor 19)	28441456	[0.53-1.27] unit decrease	0.8967	EFO_0007841
ENSG00000140836	rs7190256	16	72963084	?	Age-related diseases and mortality	27790247			EFO_0000311\|EFO_0003144\|EFO_0000400\|EFO_0000712\|EFO_0001645\|EFO_0000275\|EFO_0004352
ENSG00000140836	rs2359171	16	73019123	A	Atrial fibrillation	29892015	[1.19-1.23]	1.21	EFO_0000275
ENSG00000140836	rs2359171	16	73019123	A	Atrial fibrillation	29892015	[1.17-1.22]	1.2	EFO_0000275
ENSG00000140836	rs12446956	16	73467637	C	Major depressive disorder	21042317	[NR]	1.22	EFO_0003761
ENSG00000140836	rs9934948	16	73405456	C	Breast cancer (survival)	22232737	[1.16-1.44]	1.29	EFO_0000714\|EFO_0000305
ENSG00000140836	rs7189864	16	73600037	?	Photic sneeze reflex	27182965	[1.046-1.094]	1.069	EFO_0007887
ENSG00000140836	rs2106261	16	73017721	T	Atrial fibrillation	28416822	[1.267-1.387]	1.326	EFO_0000275
ENSG00000140836	rs4888280	16	73431477	A	Behavioural changes in frontotemporal lobe dementia	29724592	[1.71-2.29]	2	Orphanet_282\|GO_0007610
ENSG00000140836	rs4888921	16	73866095	?	Reaction time	29844566	[0.0047-0.0116] unit increase	0.0081513	EFO_0008393
ENSG00000140836	rs756717	16	72962263	G	Body mass index	30108127	[NR] unit increase	0.015	EFO_0004340
ENSG00000140836	rs876727	16	73033862	T	Atrial fibrillation	30061737	[1.03-1.07]	1.05	EFO_0000275
ENSG00000140836	rs7197197	16	72877507	?	Heel bone mineral density	30048462	[0.0097-0.0181] unit decrease	0.0139025	EFO_0009270
ENSG00000140836	rs374035142	16	73883400	?	Heel bone mineral density	30048462	[0.0097-0.018] unit increase	0.0138308	EFO_0009270
ENSG00000140836	rs7198843	16	72877840	T	Heel bone mineral density	30598549	[0.011-0.018] unit decrease	0.0144254	EFO_0009270
ENSG00000140836	rs756717	16	72962263	?	Body mass index	30595370			EFO_0004340
ENSG00000140836	rs117934006	16	73392991	?	Body mass index	30595370			EFO_0004340
ENSG00000140836	rs825680	16	73572664	?	Body mass index	30595370			EFO_0004340
ENSG00000140836	rs12932445	16	73035989	?	Stroke	29531354			EFO_0000712
ENSG00000140836	rs12932445	16	73035989	?	Ischemic stroke (cardioembolic)	29531354			EFO_1001976
ENSG00000140836	rs12930834	16	72917728	A	Smoking status (ever vs never smokers)	30643258	[0.0091-0.0183] unit increase	0.013715122	EFO_0004318
ENSG00000140836	rs16972552	16	73776555	C	Smoking status (ever vs never smokers)	30643258	[0.011-0.024] unit decrease	0.017533675	EFO_0004318
ENSG00000140836	rs6499595	16	72900544	C	Number of sexual partners	30643258	[0.0085-0.0179] unit decrease	0.013198892	EFO_0007877
ENSG00000140836	rs62055084	16	73063946	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000140836	rs825702	16	73566673	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000140836	rs12922127	16	72925068	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000140836	rs4788676	16	72916569	?	Smoking status	30595370			EFO_0006527
ENSG00000140836	rs1104608	16	73878689	C	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0068-0.0122] unit decrease	0.00948981	EFO_0007878
ENSG00000140836	rs739414	16	73064057	T	Pulse pressure	30578418	[0.084-0.171] mmHg increase	0.1276	EFO_0005763
ENSG00000140836	rs6499595	16	72900544	C	Risk-taking tendency (4-domain principal component model)	30643258	[0.0093-0.0196] unit decrease	0.014426594	EFO_0008579
ENSG00000140836	rs4788488	16	72926384	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000140836	rs62041356	16	73676251	C	Well-being spectrum (multivariate analysis)	30643256	[0.005-0.0104] unit increase	0.007699552	EFO_0007869
ENSG00000140836	rs7198843	16	72877840	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000140836	rs4788676	16	72916569	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0048-0.0098] unit decrease	0.00731008	EFO_0006527
ENSG00000140836	rs4129177	16	73243690	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0039-0.0083] unit increase	0.00609175	EFO_0006527
ENSG00000140836	rs4788676	16	72916569	C	Smoking initiation (ever regular vs never regular)	30643251	[0.012-0.024] unit decrease	0.017745035	EFO_0006527
ENSG00000140836	rs1104608	16	73878689	C	Alcohol consumption (drinks per week)	30643251	[0.0081-0.0139] unit decrease	0.010974988	EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140836's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140836	ZFHX3	100	93.738	ENSAMEG00000002197	ZFHX3	100	94.249	Ailuropoda_melanoleuca
ENSG00000140836	ZFHX3	100	66.289	ENSATEG00000004640	zfhx3	100	62.487	Anabas_testudineus
ENSG00000140836	ZFHX3	84	88.186	ENSAPLG00000002327	ZFHX3	99	86.268	Anas_platyrhynchos
ENSG00000140836	ZFHX3	100	97.929	ENSANAG00000033325	ZFHX3	100	97.849	Aotus_nancymaae
ENSG00000140836	ZFHX3	69	64.677	ENSACLG00000001914	zfhx3	100	62.676	Astatotilapia_calliptera
ENSG00000140836	ZFHX3	100	66.233	ENSAMXG00000004340	zfhx3	100	63.033	Astyanax_mexicanus
ENSG00000140836	ZFHX3	100	93.455	ENSBTAG00000014636	ZFHX3	100	93.965	Bos_taurus
ENSG00000140836	ZFHX3	100	98.038	ENSCJAG00000043080	ZFHX3	100	98.010	Callithrix_jacchus
ENSG00000140836	ZFHX3	100	96.592	ENSCAFG00000020243	ZFHX3	100	96.592	Canis_familiaris
ENSG00000140836	ZFHX3	100	96.906	ENSCAFG00020020336	ZFHX3	100	96.906	Canis_lupus_dingo
ENSG00000140836	ZFHX3	100	93.672	ENSCHIG00000018446	ZFHX3	100	94.050	Capra_hircus
ENSG00000140836	ZFHX3	100	97.031	ENSTSYG00000029930	ZFHX3	100	96.765	Carlito_syrichta
ENSG00000140836	ZFHX3	95	100.000	ENSCAPG00000010889	ZFHX3	99	94.915	Cavia_aperea
ENSG00000140836	ZFHX3	100	95.881	ENSCPOG00000009111	ZFHX3	100	94.042	Cavia_porcellus
ENSG00000140836	ZFHX3	100	97.735	ENSCCAG00000026346	ZFHX3	100	97.735	Cebus_capucinus
ENSG00000140836	ZFHX3	100	98.435	ENSCATG00000022545	ZFHX3	100	98.435	Cercocebus_atys
ENSG00000140836	ZFHX3	100	94.552	ENSCLAG00000007000	ZFHX3	100	95.535	Chinchilla_lanigera
ENSG00000140836	ZFHX3	100	98.545	ENSCSAG00000004171	ZFHX3	100	98.545	Chlorocebus_sabaeus
ENSG00000140836	ZFHX3	100	98.920	ENSCANG00000034216	ZFHX3	100	98.920	Colobus_angolensis_palliatus
ENSG00000140836	ZFHX3	100	93.957	ENSCGRG00001012831	Zfhx3	100	94.335	Cricetulus_griseus_chok1gshd
ENSG00000140836	ZFHX3	100	93.797	ENSCGRG00000001001	Zfhx3	100	93.470	Cricetulus_griseus_crigri
ENSG00000140836	ZFHX3	100	65.074	ENSCSEG00000001762	zfhx3	100	61.357	Cynoglossus_semilaevis
ENSG00000140836	ZFHX3	100	64.949	ENSDARG00000103057	zfhx3	100	61.878	Danio_rerio
ENSG00000140836	ZFHX3	100	94.712	ENSDNOG00000046047	ZFHX3	100	94.217	Dasypus_novemcinctus
ENSG00000140836	ZFHX3	100	95.038	ENSEASG00005021387	ZFHX3	100	96.407	Equus_asinus_asinus
ENSG00000140836	ZFHX3	100	95.036	ENSECAG00000022984	ZFHX3	100	96.432	Equus_caballus
ENSG00000140836	ZFHX3	94	95.134	ENSEEUG00000008705	ZFHX3	92	94.680	Erinaceus_europaeus
ENSG00000140836	ZFHX3	100	66.815	ENSELUG00000014311	zfhx3	100	63.171	Esox_lucius
ENSG00000140836	ZFHX3	100	96.314	ENSFCAG00000023839	ZFHX3	100	96.314	Felis_catus
ENSG00000140836	ZFHX3	97	87.340	ENSFALG00000002706	ZFHX3	98	84.342	Ficedula_albicollis
ENSG00000140836	ZFHX3	100	93.720	ENSFDAG00000015753	ZFHX3	100	94.847	Fukomys_damarensis
ENSG00000140836	ZFHX3	100	65.324	ENSFHEG00000013474	zfhx3	97	76.560	Fundulus_heteroclitus
ENSG00000140836	ZFHX3	81	70.468	ENSGMOG00000002909	zfhx3	100	63.338	Gadus_morhua
ENSG00000140836	ZFHX3	100	85.300	ENSGALG00000000713	ZFHX3	100	85.917	Gallus_gallus
ENSG00000140836	ZFHX3	100	65.954	ENSGAFG00000017278	zfhx3	100	61.874	Gambusia_affinis
ENSG00000140836	ZFHX3	100	65.269	ENSGACG00000015779	zfhx3	100	62.477	Gasterosteus_aculeatus
ENSG00000140836	ZFHX3	100	86.314	ENSGAGG00000002102	ZFHX3	100	86.156	Gopherus_agassizii
ENSG00000140836	ZFHX3	99	99.268	ENSGGOG00000012083	ZFHX3	100	99.260	Gorilla_gorilla
ENSG00000140836	ZFHX3	69	64.639	ENSHBUG00000013200	zfhx3	100	62.676	Haplochromis_burtoni
ENSG00000140836	ZFHX3	100	95.391	ENSHGLG00000012541	ZFHX3	100	95.391	Heterocephalus_glaber_female
ENSG00000140836	ZFHX3	100	94.987	ENSHGLG00100000797	ZFHX3	100	94.960	Heterocephalus_glaber_male
ENSG00000140836	ZFHX3	81	68.960	ENSHCOG00000003135	zfhx3	100	61.060	Hippocampus_comes
ENSG00000140836	ZFHX3	81	69.949	ENSIPUG00000006119	zfhx3	100	62.809	Ictalurus_punctatus
ENSG00000140836	ZFHX3	100	96.130	ENSSTOG00000027206	ZFHX3	100	96.130	Ictidomys_tridecemlineatus
ENSG00000140836	ZFHX3	100	66.483	ENSKMAG00000006781	zfhx3	100	62.383	Kryptolebias_marmoratus
ENSG00000140836	ZFHX3	100	68.637	ENSLOCG00000004206	zfhx3	100	64.948	Lepisosteus_oculatus
ENSG00000140836	ZFHX3	100	96.009	ENSLAFG00000017476	ZFHX3	100	94.699	Loxodonta_africana
ENSG00000140836	ZFHX3	100	98.734	ENSMFAG00000034225	ZFHX3	100	98.734	Macaca_fascicularis
ENSG00000140836	ZFHX3	100	98.653	ENSMMUG00000021041	ZFHX3	100	98.330	Macaca_mulatta
ENSG00000140836	ZFHX3	100	98.653	ENSMNEG00000030137	ZFHX3	100	98.653	Macaca_nemestrina
ENSG00000140836	ZFHX3	100	98.812	ENSMLEG00000042563	ZFHX3	100	98.812	Mandrillus_leucophaeus
ENSG00000140836	ZFHX3	100	65.576	ENSMAMG00000021509	zfhx3	100	62.687	Mastacembelus_armatus
ENSG00000140836	ZFHX3	69	64.578	ENSMZEG00005014216	zfhx3	100	62.626	Maylandia_zebra
ENSG00000140836	ZFHX3	78	89.478	ENSMGAG00000008764	ZFHX3	97	89.226	Meleagris_gallopavo
ENSG00000140836	ZFHX3	100	93.152	ENSMAUG00000000602	Zfhx3	100	93.502	Mesocricetus_auratus
ENSG00000140836	ZFHX3	100	95.967	ENSMICG00000003537	ZFHX3	100	95.939	Microcebus_murinus
ENSG00000140836	ZFHX3	100	93.387	ENSMOCG00000017998	Zfhx3	100	93.925	Microtus_ochrogaster
ENSG00000140836	ZFHX3	100	66.518	ENSMMOG00000016551	zfhx3	100	62.503	Mola_mola
ENSG00000140836	ZFHX3	100	66.540	ENSMALG00000021055	zfhx3	100	62.974	Monopterus_albus
ENSG00000140836	ZFHX3	100	92.460	ENSMUSG00000038872	Zfhx3	100	93.289	Mus_musculus
ENSG00000140836	ZFHX3	100	92.584	MGP_PahariEiJ_G0023139	Zfhx3	100	92.905	Mus_pahari
ENSG00000140836	ZFHX3	100	92.406	MGP_SPRETEiJ_G0032657	Zfhx3	100	93.342	Mus_spretus
ENSG00000140836	ZFHX3	100	92.374	ENSMPUG00000007747	ZFHX3	100	92.374	Mustela_putorius_furo
ENSG00000140836	ZFHX3	100	95.202	ENSMLUG00000016100	ZFHX3	100	95.171	Myotis_lucifugus
ENSG00000140836	ZFHX3	100	91.876	ENSNGAG00000001724	Zfhx3	100	92.362	Nannospalax_galili
ENSG00000140836	ZFHX3	69	64.593	ENSNBRG00000010822	zfhx3	100	62.824	Neolamprologus_brichardi
ENSG00000140836	ZFHX3	88	97.436	ENSNLEG00000032567	ZFHX3	99	97.436	Nomascus_leucogenys
ENSG00000140836	ZFHX3	100	92.530	ENSODEG00000014257	ZFHX3	100	92.238	Octodon_degus
ENSG00000140836	ZFHX3	57	79.137	ENSONIG00000005914	zfhx3	95	77.199	Oreochromis_niloticus
ENSG00000140836	ZFHX3	86	91.147	ENSOANG00000005084	ZFHX3	100	90.780	Ornithorhynchus_anatinus
ENSG00000140836	ZFHX3	100	94.957	ENSOCUG00000017910	-	99	94.198	Oryctolagus_cuniculus
ENSG00000140836	ZFHX3	81	68.988	ENSORLG00000007874	zfhx3	100	61.723	Oryzias_latipes
ENSG00000140836	ZFHX3	100	65.331	ENSORLG00020009729	zfhx3	100	61.803	Oryzias_latipes_hni
ENSG00000140836	ZFHX3	81	68.918	ENSORLG00015007912	zfhx3	100	61.546	Oryzias_latipes_hsok
ENSG00000140836	ZFHX3	81	69.667	ENSOMEG00000001800	zfhx3	100	61.861	Oryzias_melastigma
ENSG00000140836	ZFHX3	100	95.899	ENSPPRG00000005184	ZFHX3	100	95.899	Panthera_pardus
ENSG00000140836	ZFHX3	100	99.217	ENSPTRG00000008340	ZFHX3	100	99.217	Pan_troglodytes
ENSG00000140836	ZFHX3	100	98.626	ENSPANG00000010456	ZFHX3	100	98.626	Papio_anubis
ENSG00000140836	ZFHX3	99	64.690	ENSPKIG00000001525	-	83	65.114	Paramormyrops_kingsleyae
ENSG00000140836	ZFHX3	96	67.964	ENSPKIG00000009598	zfhx3	98	63.415	Paramormyrops_kingsleyae
ENSG00000140836	ZFHX3	81	70.667	ENSPMGG00000006062	zfhx3	98	70.866	Periophthalmus_magnuspinnatus
ENSG00000140836	ZFHX3	100	94.232	ENSPEMG00000010630	Zfhx3	100	94.771	Peromyscus_maniculatus_bairdii
ENSG00000140836	ZFHX3	100	65.311	ENSPFOG00000001702	zfhx3	100	61.858	Poecilia_formosa
ENSG00000140836	ZFHX3	100	65.931	ENSPLAG00000018955	zfhx3	100	62.069	Poecilia_latipinna
ENSG00000140836	ZFHX3	100	65.299	ENSPMEG00000022333	zfhx3	100	61.905	Poecilia_mexicana
ENSG00000140836	ZFHX3	100	98.570	ENSPPYG00000007513	ZFHX3	100	98.709	Pongo_abelii
ENSG00000140836	ZFHX3	100	93.209	ENSPCAG00000010600	ZFHX3	99	93.736	Procavia_capensis
ENSG00000140836	ZFHX3	100	96.505	ENSPCOG00000025382	ZFHX3	100	96.477	Propithecus_coquereli
ENSG00000140836	ZFHX3	96	95.925	ENSPVAG00000006664	ZFHX3	96	96.145	Pteropus_vampyrus
ENSG00000140836	ZFHX3	69	64.110	ENSPNYG00000013409	zfhx3	100	62.431	Pundamilia_nyererei
ENSG00000140836	ZFHX3	100	93.647	ENSRNOG00000014452	Zfhx3	100	94.051	Rattus_norvegicus
ENSG00000140836	ZFHX3	100	97.813	ENSRBIG00000031579	ZFHX3	100	97.813	Rhinopithecus_bieti
ENSG00000140836	ZFHX3	100	98.761	ENSRROG00000039904	ZFHX3	100	98.761	Rhinopithecus_roxellana
ENSG00000140836	ZFHX3	92	97.857	ENSSBOG00000034332	ZFHX3	96	97.857	Saimiri_boliviensis_boliviensis
ENSG00000140836	ZFHX3	100	65.410	ENSSFOG00015019511	zfhx3	99	63.100	Scleropages_formosus
ENSG00000140836	ZFHX3	100	66.337	ENSSFOG00015014986	zfhx3	99	71.795	Scleropages_formosus
ENSG00000140836	ZFHX3	100	66.974	ENSSMAG00000000110	zfhx3	100	62.829	Scophthalmus_maximus
ENSG00000140836	ZFHX3	100	66.380	ENSSPAG00000002113	zfhx3	100	63.190	Stegastes_partitus
ENSG00000140836	ZFHX3	100	96.161	ENSSSCG00000002752	ZFHX3	100	95.824	Sus_scrofa
ENSG00000140836	ZFHX3	85	85.348	ENSTGUG00000008190	ZFHX3	86	85.448	Taeniopygia_guttata
ENSG00000140836	ZFHX3	100	96.594	ENSVVUG00000017344	ZFHX3	100	96.594	Vulpes_vulpes
ENSG00000140836	ZFHX3	100	65.636	ENSXMAG00000027288	zfhx3	100	62.085	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	11314020.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	10318867.	IGI	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	7507206.	IDA	Function
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	1719379.	TAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	-	IC	Function
GO:0003700	DNA-binding transcription factor activity	1719379.	NAS	Function
GO:0005515	protein binding	20599712.22452784.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	20599712.24651376.	IDA	Component
GO:0005634	nucleus	1719379.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	10318867.	IDA	Component
GO:0005737	cytoplasm	20599712.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	1719379.	TAS	Process
GO:0006366	transcription by RNA polymerase II	1719379.	TAS	Process
GO:0007050	cell cycle arrest	-	IEA	Process
GO:0007420	brain development	21873635.	IBA	Process
GO:0007517	muscle organ development	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016604	nuclear body	24651376.	IDA	Component
GO:0019899	enzyme binding	14715251.	IPI	Function
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0045664	regulation of neuron differentiation	21873635.	IBA	Process
GO:0045785	positive regulation of cell adhesion	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045893	positive regulation of transcription, DNA-templated	20599712.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0071559	response to transforming growth factor beta	20599712.	IDA	Process
GO:1904059	regulation of locomotor rhythm	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19035517	Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.	Prostate	2009 Mar 1	Lange EM	doi: 10.1002/pros.20891.
23144151	Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients.	Cancer Biomark	2012	Minamiya Y	doi: 10.3233/CBM-2012-00272.
20599712	Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.	Biochem Biophys Res Commun	2010 Jul 23	Mabuchi M	doi: 10.1016/j.bbrc.2010.06.090
23317484	Nuclear translocation of ATBF1 is a potential prognostic marker for skin cancer.	Acta Dermatovenerol Croat	2012	Nishio E	-
17671116	Genetic alterations of the ATBF1 gene in gastric cancer.	Clin Cancer Res	2007 Aug 1	Cho YG	-
26330387	Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.	J Natl Cancer Inst	2015 Sep 1	Walker CJ	doi: 10.1093/jnci/djv249
17330845	Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.	Int J Cancer	2007 Jul 15	Mori Y	-
15750593	Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.	Nat Genet	2005 Apr	Sun X	-
18416817	ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.	BMC Cancer	2008 Apr 16	Cleton-Jansen AM	doi: 10.1186/1471-2407-8-105.
16932943	Infrequent mutation of ATBF1 in human breast cancer.	J Cancer Res Clin Oncol	2007 Feb	Sun X	-
21367855	Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells.	J Biol Chem	2011 Apr 22	Dong XY	doi: 10.1074/jbc.M110.187849
16637072	Germline ATBF1 mutations and prostate cancer risk.	Prostate	2006 Jul 1	Xu J	-
14654895	Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?	Oncol Rep	2004 Jan	Iida M	-
28624455	Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells.	Biochem Biophys Res Commun	2017 Aug 19	Li M	doi: 10.1016/j.bbrc.2017.06.068

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr16	72788687	Frame_Shift_Del	NA	*Q3197Sfs44**	0.42
ACC	chr16	72959618	Silent	rs760303298	G176G	0.35
BLCA	chr16	72958822	Missense_Mutation	NA	E442K	0.12
BLCA	chr16	72950706	Silent	NA	T993T	0.43
BLCA	chr16	72811922	Missense_Mutation	novel	E1216K	0.12
BLCA	chr16	72957547	Missense_Mutation	rs772007732	A867S	0.05
BLCA	chr16	72959857	Missense_Mutation	novel	H97Y	0.21
BLCA	chr16	72797164	Missense_Mutation	NA	Q1840E	0.45
BLCA	chr16	72797712	Missense_Mutation	novel	T1657S	0.06
BLCA	chr16	72798708	Nonsense_Mutation	novel	S1325*	0.63
BLCA	chr16	72796115	Missense_Mutation	novel	I2189M	0.09
BLCA	chr16	72797568	Missense_Mutation	novel	S1705L	0.14
BLCA	chr16	72795155	Silent	novel	L2509L	0.46
BLCA	chr16	72787958	Missense_Mutation	novel	E3440Q	0.15
BLCA	chr16	72958146	Missense_Mutation	rs544260229	S667L	0.35
BLCA	chr16	72958966	Missense_Mutation	novel	L394V	0.32
BLCA	chr16	72957433	Missense_Mutation	novel	A905T	0.48
BLCA	chr16	72959570	Silent	rs753637843	P192P	0.53
BLCA	chr16	72787515	Silent	rs776903532	S3587S	0.45
BLCA	chr16	72889876	Silent	NA	L1101L	0.1
BLCA	chr16	72793676	Missense_Mutation	novel	K3002N	0.05
BLCA	chr16	72958854	Missense_Mutation	novel	S431L	0.28
BLCA	chr16	72957834	Missense_Mutation	rs777386793	G771V	0.34
BLCA	chr16	72958349	Missense_Mutation	novel	N599K	0.3
BLCA	chr16	72959075	Silent	novel	L357L	0.42
BLCA	chr16	72797119	Missense_Mutation	novel	Q1855E	0.12
BLCA	chr16	72794503	Nonsense_Mutation	NA	E2727*	0.22
BLCA	chr16	72957968	Silent	novel	F726F	0.2
BLCA	chr16	72787064	3'UTR	novel		0.63
BLCA	chr16	72959075	Silent	novel	L357L	0.14
BLCA	chr16	72797294	Silent	novel	L1796L	0.09
BLCA	chr16	72793295	Silent	novel	L3129L	0.65
BLCA	chr16	72795115	Silent	novel	L2523L	0.13
BLCA	chr16	72787599	Silent	novel	T3559T	0.37
BLCA	chr16	72958925	Silent	rs754058260	T407T	0.28
BLCA	chr16	72795308	Silent	novel	E2458E	0.32
BLCA	chr16	72795106	Nonsense_Mutation	novel	Q2526*	0.14
BLCA	chr16	72787213	Missense_Mutation	NA	P3688H	0.25
BLCA	chr16	72796812	Missense_Mutation	novel	V1957G	0.47
BLCA	chr16	72794913	Missense_Mutation	novel	S2590F	0.34
BLCA	chr16	72829845	Missense_Mutation	novel	D1155N	0.1
BRCA	chr16	72787252	Missense_Mutation	NA	P3675Q	0.16
BRCA	chr16	72788542	Frame_Shift_Del	NA	*K3245Rfs39**	0.39
BRCA	chr16	72796511	Frame_Shift_Ins	novel	*P2058Afs98**	0.56
BRCA	chr16	72787516	Missense_Mutation	NA	S3587L	0.31
BRCA	chr16	72960190	5'UTR	rs12922464		0.39
BRCA	chr16	72796358	Silent	NA	Q2108Q	0.4
BRCA	chr16	72798490	Frame_Shift_Del	novel	*D1395Vfs6**	0.47
BRCA	chr16	72796867	Missense_Mutation	NA	D1939H	0.28
BRCA	chr16	72798405	Missense_Mutation	novel	R1426T	0.09
BRCA	chr16	72795726	Missense_Mutation	novel	R2319K	0.13
BRCA	chr16	72796210	Nonsense_Mutation	NA	R2158*	0.64
BRCA	chr16	72793929	Nonsense_Mutation	NA	S2918*	0.34
BRCA	chr16	72798153	Missense_Mutation	NA	S1510F	0.17
BRCA	chr16	72796579	Nonsense_Mutation	NA	Q2035*	0.25
BRCA	chr16	72798150	Missense_Mutation	NA	G1511V	0.81
BRCA	chr16	72889766	Missense_Mutation	rs768186851	I1138N	0.22
BRCA	chr16	72787644	Silent	rs200990996	L3544L	0.14
BRCA	chr16	72795138	Nonsense_Mutation	NA	S2515*	0.41
BRCA	chr16	72796733	Silent	rs754722414	L1983L	0.46
BRCA	chr16	72797243	Silent	NA	V1813V	0.4
BRCA	chr16	72797546	Silent	rs561355331	R1712R	0.5
BRCA	chr16	72950583	Silent	rs150708280	I1034I	0.42
BRCA	chr16	72796287	Missense_Mutation	rs759633185	Y2132C	0.37
BRCA	chr16	72958124	Silent	NA	P674P	0.3
BRCA	chr16	72889940	Missense_Mutation	NA	G1080A	0.36
BRCA	chr16	72796551	Missense_Mutation	novel	P2044H	0.16
BRCA	chr16	72798514	Nonsense_Mutation	NA	Q1390*	0.55
CESC	chr16	72785011	3'UTR	novel		0.29
CESC	chr16	72795130	Nonsense_Mutation	NA	Q2518*	0.18
CESC	chr16	72786407	3'UTR	novel		0.18
CESC	chr16	72788841	Silent	novel	T3145T	0.24
CESC	chr16	72788300	Missense_Mutation	rs781682309	A3326T	0.11
CESC	chr16	72786421	3'UTR	novel		0.3
CESC	chr16	72793833	Missense_Mutation	NA	R2950H	0.47
CESC	chr16	72811944	Silent	rs140481719	S1208S	0.5
CESC	chr16	72788407	Missense_Mutation	novel	A3290V	0.49
CESC	chr16	72794645	Silent	novel	G2679G	0.31
CESC	chr16	72796907	Frame_Shift_Ins	novel	*G1926Wfs3**	0.38
CESC	chr16	72793682	Frame_Shift_Del	novel	*E3001Kfs6**	0.47
CESC	chr16	72783191	3'UTR	novel		0.36
CESC	chr16	72786709	3'UTR	novel		0.16
CESC	chr16	72787314	Silent	novel	S3654S	0.13
CESC	chr16	72794927	Silent	novel	A2585A	0.24
CESC	chr16	72797153	Missense_Mutation	NA	Q1843H	0.27
CESC	chr16	72787634	Missense_Mutation	rs754638782	L3548F	0.57
CESC	chr16	72784737	3'UTR	novel		0.46
CESC	chr16	72811592	Silent	NA	E1283E	0.15
CESC	chr16	72797767	Missense_Mutation	NA	T1639A	0.15
CESC	chr16	72794579	Silent	NA	F2701F	0.38
CESC	chr16	72889838	Missense_Mutation	rs187631913	R1114Q	0.11
CESC	chr16	72787272	Silent	NA	L3668L	0.35
CESC	chr16	72958896	Missense_Mutation	NA	S417L	0.45
CESC	chr16	72784497	3'UTR	novel		0.12
CESC	chr16	72788788	Missense_Mutation	rs745902190	G3163D	0.3
CESC	chr16	72793639	Missense_Mutation	novel	N3015H	0.33
CESC	chr16	72795221	Silent	rs150337976	A2487A	0.28
CESC	chr16	72795898	Missense_Mutation	NA	D2262N	0.58
CESC	chr16	72796791	Missense_Mutation	novel	K1964T	0.44
CESC	chr16	72889729	Splice_Site	novel	X1150_splice	0.39
CESC	chr16	72794899	Missense_Mutation	novel	Q2595E	0.24
CESC	chr16	72950928	Silent	rs141768802	G919G	0.18
CESC	chr16	72793711	Nonsense_Mutation	NA	Q2991*	0.29
CESC	chr16	72794899	Nonsense_Mutation	NA	Q2595*	0.32
CESC	chr16	72798430	Missense_Mutation	NA	L1418F	0.19
CESC	chr16	72959780	Silent	NA	E122E	0.16
CHOL	chr16	72797674	Missense_Mutation	novel	S1670G	0.45
CHOL	chr16	72782896	3'UTR	novel		0.45
COAD	chr16	72959962	Missense_Mutation	rs756319969	A62T	0.42
COAD	chr16	72959676	Missense_Mutation	NA	C157F	0.22
COAD	chr16	72950810	Missense_Mutation	NA	D959Y	0.35
COAD	chr16	72787445	Frame_Shift_Del	NA	*H3611Tfs83**	0.4
COAD	chr16	72795481	Missense_Mutation	novel	T2401P	0.34
COAD	chr16	72788301	Silent	rs746288766	G3325G	0.33
COAD	chr16	72798400	Missense_Mutation	novel	A1428T	0.12
COAD	chr16	72793347	Missense_Mutation	novel	P3112H	0.05
COAD	chr16	72793631	Silent	novel	T3017T	0.18
COAD	chr16	72797059	Missense_Mutation	novel	E1875K	0.18
COAD	chr16	72798087	Missense_Mutation	rs374743360	N1532S	0.27
COAD	chr16	72811931	Frame_Shift_Del	novel	*T1213Qfs31**	0.24
COAD	chr16	72959716	Missense_Mutation	novel	V144M	0.37
COAD	chr16	72797281	Missense_Mutation	novel	Y1801N	0.22
COAD	chr16	72950518	Missense_Mutation	rs745871900	R1056Q	0.39
COAD	chr16	72787172	Nonsense_Mutation	NA	R3702*	0.17
COAD	chr16	72960041	Silent	novel	K35K	0.17
COAD	chr16	72958229	Silent	rs527561596	G639G	0.37
COAD	chr16	72798546	Missense_Mutation	rs753592536	T1379M	0.09
COAD	chr16	72795240	Missense_Mutation	NA	P2481L	0.11
COAD	chr16	72959437	Nonsense_Mutation	NA	R237*	0.07
COAD	chr16	72795431	Silent	NA	A2417A	0.18
COAD	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.33
COAD	chr16	72794098	Missense_Mutation	NA	A2862S	0.24
COAD	chr16	72794654	Silent	rs771903702	H2676H	0.26
COAD	chr16	72797002	Frame_Shift_Del	novel	*D1894Qfs34**	0.05
COAD	chr16	72959942	Silent	novel	A68A	0.33
COAD	chr16	72795449	Silent	rs769762758	A2411A	0.43
COAD	chr16	72796364	Silent	rs368070331	P2106P	0.49
COAD	chr16	72798476	Silent	NA	R1402R	0.45
COAD	chr16	72957742	Frame_Shift_Ins	NA	*P802Tfs9**	0.26
COAD	chr16	72959591	Silent	rs747235758	S185S	0.46
COAD	chr16	72959533	Missense_Mutation	NA	G205R	0.17
COAD	chr16	72795599	Silent	rs767177678	D2361D	0.36
COAD	chr16	72788481	Frame_Shift_Del	novel	*T3266Rfs18**	0.31
COAD	chr16	72795996	Missense_Mutation	NA	P2229H	0.19
COAD	chr16	72787466	Missense_Mutation	rs745550429	A3604T	0.29
COAD	chr16	72957437	Silent	rs150583300	T903T	0.4
COAD	chr16	72794125	Missense_Mutation	rs200701402	A2853T	0.38
COAD	chr16	72889840	Silent	novel	Q1113Q	0.32
COAD	chr16	72796782	Missense_Mutation	novel	V1967A	0.08
COAD	chr16	72950550	Silent	novel	C1045C	0.34
COAD	chr16	72788644	Missense_Mutation	novel	P3211H	0.07
COAD	chr16	72788142	Missense_Mutation	NA	Q3378H	0.35
COAD	chr16	72796712	Silent	NA	K1990K	0.35
COAD	chr16	72959290	Missense_Mutation	NA	L286M	0.2
COAD	chr16	72958077	Missense_Mutation	NA	M690T	0.42
COAD	chr16	72959065	Missense_Mutation	rs561634666	G361R	0.18
COAD	chr16	72796855	Missense_Mutation	novel	N1943D	0.11
COAD	chr16	72794534	Silent	novel	C2716C	0.18
COAD	chr16	72794535	Missense_Mutation	novel	C2716F	0.19
COAD	chr16	72957577	Missense_Mutation	rs146607776	A857T	0.33
COAD	chr16	72787339	Missense_Mutation	NA	C3646Y	0.1
COAD	chr16	72958993	Missense_Mutation	rs764687875	A385T	0.33
COAD	chr16	72959838	Missense_Mutation	rs776936617	R103H	0.22
COAD	chr16	72798185	Silent	NA	L1499L	0.12
COAD	chr16	72794759	Silent	rs148910628	D2641D	0.11
COAD	chr16	72788801	Missense_Mutation	novel	V3159I	0.14
COAD	chr16	72795015	Missense_Mutation	rs147043604	A2556V	0.37
COAD	chr16	72795302	Silent	rs748787751	P2460P	0.22
COAD	chr16	72787639	Missense_Mutation	novel	Q3546R	0.17
COAD	chr16	72793376	Silent	novel	D3102D	0.18
COAD	chr16	72950679	Silent	novel	H1002H	0.33
COAD	chr16	72788814	Silent	rs201412119	L3154L	0.1
COAD	chr16	72797458	In_Frame_Ins	rs552138038	Q1741dup	0.47
COAD	chr16	72788296	Missense_Mutation	novel	L3327P	0.19
COAD	chr16	72960154	5'UTR	rs750363589		0.6
COAD	chr16	72959262	Missense_Mutation	rs754613484	R295H	0.24
COAD	chr16	72960196	Splice_Site	novel		0.25
COAD	chr16	72795629	Silent	novel	C2351C	0.3
COAD	chr16	72959338	Missense_Mutation	novel	D270N	0.4
COAD	chr16	72950574	Silent	rs746294646	P1037P	0.18
COAD	chr16	72788622	Silent	NA	P3218P	0.49
COAD	chr16	72797489	Missense_Mutation	rs144110473	Q1731H	0.3
COAD	chr16	72787820	Missense_Mutation	novel	S3486P	0.26
COAD	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.27
COAD	chr16	72957967	Missense_Mutation	rs201721439	R727C	0.26	zf-C2H2
COAD	chr16	72795570	Missense_Mutation	NA	A2371V	0.29
COAD	chr16	72797458	In_Frame_Ins	rs552138038	Q1741dup	0.36
COAD	chr16	72811945	Missense_Mutation	rs760400785	S1208L	0.17
COAD	chr16	72795215	Frame_Shift_Ins	novel	*P2490Sfs44**	0.33
COAD	chr16	72957766	Frame_Shift_Ins	novel	*S794Lfs17**	0.18
COAD	chr16	72795860	Missense_Mutation	NA	Q2274H	0.17
COAD	chr16	72797040	Missense_Mutation	NA	V1881D	0.48
COAD	chr16	72811683	Missense_Mutation	rs370933867	R1253H	0.26
COAD	chr16	72794254	Missense_Mutation	novel	I2810L	0.17
COAD	chr16	72787851	Silent	rs759330286	S3475S	0.16
COAD	chr16	72795744	Missense_Mutation	rs763494543	R2313H	0.25
COAD	chr16	72958128	Missense_Mutation	novel	C673F	0.24
COAD	chr16	72958805	Silent	rs148524035	G447G	0.11
COAD	chr16	72794436	Missense_Mutation	rs774192226	A2749V	0.24
DLBC	chr16	72796867	Missense_Mutation	novel	D1939N	0.4
ESCA	chr16	72811912	Missense_Mutation	rs776155336	P1219L	0.42
ESCA	chr16	72950518	Missense_Mutation	rs745871900	R1056Q	0.25
ESCA	chr16	72784920	3'UTR	novel		0.27
ESCA	chr16	72794398	Nonsense_Mutation	novel	G2762*	0.81
ESCA	chr16	72784788	3'UTR	novel		0.35
ESCA	chr16	72788839	Missense_Mutation	novel	S3146F	0.14
ESCA	chr16	72797953	Missense_Mutation	novel	L1577F	0.35
ESCA	chr16	72783573	3'UTR	novel		0.31
ESCA	chr16	72785586	3'UTR	novel		0.14
ESCA	chr16	72950928	Silent	rs141768802	G919G	0.44
GBM	chr16	72795353	Silent	novel	T2443T	0.1
GBM	chr16	72798132	Missense_Mutation	rs144091993	S1517L	0.6
GBM	chr16	72958781	Missense_Mutation	novel	K455N	0.16
GBM	chr16	72796604	Silent	rs780736697	Y2026Y	0.48
GBM	chr16	72958184	Silent	rs761002113	S654S	0.28
GBM	chr16	72796600	Missense_Mutation	novel	K2028E	0.05
GBM	chr16	72788620	Missense_Mutation	novel	P3219Q	0.08
GBM	chr16	72795477	Missense_Mutation	novel	A2402G	0.12
GBM	chr16	72959196	Missense_Mutation	novel	L317P	0.33
GBM	chr16	72788378	Missense_Mutation	novel	T3300S	0.14
GBM	chr16	72793468	Missense_Mutation	rs368568803	V3072I	0.09
GBM	chr16	72788169	Missense_Mutation	novel	Q3369H	0.25
GBM	chr16	72788333	Missense_Mutation	novel	F3315V	0.48
GBM	chr16	72794800	Missense_Mutation	rs762362472	E2628K	0.23
GBM	chr16	72795449	Silent	rs769762758	A2411A	0.18
GBM	chr16	72950779	Missense_Mutation	novel	R969H	0.23
GBM	chr16	72959462	Silent	novel	L228L	0.18
GBM	chr16	72889885	Missense_Mutation	novel	K1098N	0.1
GBM	chr16	72795955	Frame_Shift_Del	novel	*R2243Gfs12**	0.27
GBM	chr16	72797789	Silent	novel	A1631A	0.2
GBM	chr16	72811638	Missense_Mutation	novel	Q1268L	0.44
GBM	chr16	72795043	Missense_Mutation	novel	E2547K	0.08
GBM	chr16	72958137	Missense_Mutation	novel	T670R	0.07
GBM	chr16	72795918	Missense_Mutation	novel	R2255M	0.06
GBM	chr16	72795919	Missense_Mutation	novel	R2255G	0.06
GBM	chr16	72793855	Missense_Mutation	rs773228518	R2943W	0.51
GBM	chr16	72794563	Missense_Mutation	rs759463798	A2707T	0.27
GBM	chr16	72811945	Missense_Mutation	rs760400785	S1208L	0.3
GBM	chr16	72958350	Missense_Mutation	novel	N599S	0.35
GBM	chr16	72787763	Missense_Mutation	novel	P3505S	0.21
GBM	chr16	72957631	Missense_Mutation	novel	M839V	0.13
GBM	chr16	72787813	Missense_Mutation	novel	C3488Y	0.09
GBM	chr16	72795474	Missense_Mutation	novel	S2403Y	0.2
GBM	chr16	72787955	Nonsense_Mutation	NA	E3441*	0.12
GBM	chr16	72811586	Silent	rs201438617	L1285L	0.3
GBM	chr16	72795946	Missense_Mutation	novel	R2246G	0.13
HNSC	chr16	72959680	Missense_Mutation	rs769010742	A156T	0.11
HNSC	chr16	72787693	Missense_Mutation	rs781184186	S3528L	0.28
HNSC	chr16	72959075	Silent	novel	L357L	0.24
HNSC	chr16	72958660	Missense_Mutation	NA	P496S	0.37
HNSC	chr16	72959291	Missense_Mutation	novel	F285L	0.3
HNSC	chr16	72957688	Missense_Mutation	novel	R820C	0.4
HNSC	chr16	72787830	Silent	novel	S3482S	0.21
HNSC	chr16	72795191	Silent	rs750881472	S2497S	0.29
HNSC	chr16	72950904	Silent	novel	L927L	0.13
HNSC	chr16	72797615	Silent	novel	G1689G	0.15
HNSC	chr16	72796237	Missense_Mutation	NA	R2149C	0.18
HNSC	chr16	72950565	Silent	novel	L1040L	0.43
HNSC	chr16	72788517	Silent	novel	P3253P	0.34
HNSC	chr16	72788518	Missense_Mutation	novel	P3253L	0.34
HNSC	chr16	72787173	Silent	novel	F3701F	0.21
HNSC	chr16	72788829	Silent	NA	P3149P	0.05
HNSC	chr16	72958375	Missense_Mutation	NA	A591S	0.41
HNSC	chr16	72950583	Silent	rs150708280	I1034I	0.29
HNSC	chr16	72957445	Missense_Mutation	novel	A901P	0.59
HNSC	chr16	72959616	Missense_Mutation	rs202071159	A177V	0.21
HNSC	chr16	72960057	Missense_Mutation	novel	T30I	0.22
HNSC	chr16	72794534	Silent	novel	C2716C	0.2
HNSC	chr16	72797950	Missense_Mutation	novel	Q1578E	0.13
HNSC	chr16	72788464	Missense_Mutation	rs759418149	T3271M	0.31
KICH	chr16	72788745	Silent	rs138129897	S3177S	0.09
KIRC	chr16	72811585	Missense_Mutation	NA	I1286V	0.42
KIRC	chr16	72959681	Silent	rs774845273	G155G	0.3
KIRC	chr16	72794330	Frame_Shift_Del	novel	*V2783Afs6**	0.37
KIRC	chr16	72959115	Missense_Mutation	NA	N344I	0.18
KIRC	chr16	72957578	Silent	NA	P856P	0.27
KIRC	chr16	72797226	Missense_Mutation	NA	S1819I	0.35
KIRP	chr16	72794835	Missense_Mutation	NA	R2616K	0.42
KIRP	chr16	72957551	Silent	novel	Y865Y	0.34
KIRP	chr16	72787194	Silent	NA	T3694T	0.27
KIRP	chr16	72950799	Silent	novel	G962G	0.25
KIRP	chr16	72950506	Missense_Mutation	NA	V1060G	0.51
KIRP	chr16	72889891	Frame_Shift_Del	novel	*T1097Pfs14**	0.35
LAML	chr16	72796908	Frame_Shift_Del	NA	*G1925Vfs72**	0.05
LAML	chr16	72798090	Missense_Mutation	novel	P1531L	0.04
LAML	chr16	72795121	Frame_Shift_Ins	novel	*A2521Cfs13**	0.03
LAML	chr16	72795959	Silent	novel	S2241S	0.29
LGG	chr16	72959785	Missense_Mutation	NA	D121Y	0.16
LGG	chr16	72958040	Silent	NA	V702V	0.07
LGG	chr16	72960131	Frame_Shift_Ins	novel	*D5Efs52**	0.4
LGG	chr16	72794528	Silent	rs150499144	A2718A	0.33
LGG	chr16	72798495	Missense_Mutation	rs774988278	R1396H	0.37
LGG	chr16	72958326	Missense_Mutation	novel	E607G	0.08
LGG	chr16	72958875	Missense_Mutation	novel	A424D	0.37
LIHC	chr16	72959229	Missense_Mutation	rs142256050	R306Q	0.23
LIHC	chr16	72794137	Missense_Mutation	NA	D2849H	0.5
LIHC	chr16	72796084	Missense_Mutation	NA	E2200K	0.38
LIHC	chr16	72796407	Missense_Mutation	novel	M2092T	0.31
LIHC	chr16	72950488	Missense_Mutation	NA	A1066G	0.39
LIHC	chr16	72950669	Missense_Mutation	novel	D1006H	0.41
LIHC	chr16	72889838	Missense_Mutation	rs187631913	R1114Q	0.11
LIHC	chr16	72787088	3'UTR	novel		0.24
LUAD	chr16	72795962	Frame_Shift_Ins	novel	*S2241Kfs30**	0.48
LUAD	chr16	72796882	Missense_Mutation	NA	P1934S	0.16
LUAD	chr16	72796912	Missense_Mutation	NA	G1924R	0.17
LUAD	chr16	72787395	Silent	NA	A3627A	0.17
LUAD	chr16	72794271	Missense_Mutation	novel	S2804C	0.21
LUAD	chr16	72797486	Silent	NA	Q1732Q	0.12
LUAD	chr16	72958807	Missense_Mutation	novel	G447C	0.08
LUAD	chr16	72958808	Silent	novel	V446V	0.08
LUAD	chr16	72957984	Missense_Mutation	novel	C721F	0.18
LUAD	chr16	72959238	Missense_Mutation	rs750145538	H303R	0.21
LUAD	chr16	72957701	Silent	NA	V815V	0.21
LUAD	chr16	72950620	Missense_Mutation	novel	G1022A	0.08
LUAD	chr16	72793674	Missense_Mutation	novel	K3003M	0.35
LUAD	chr16	72798362	Silent	novel	T1440T	0.1
LUAD	chr16	72797568	Missense_Mutation	novel	S1705L	0.08
LUAD	chr16	72959478	Missense_Mutation	novel	G223V	0.36
LUAD	chr16	72959609	Frame_Shift_Ins	novel	*K180Qfs30**	0.14
LUAD	chr16	72950895	Silent	NA	L930L	0.3
LUAD	chr16	72958282	Missense_Mutation	NA	H622Y	0.69
LUAD	chr16	72959584	Missense_Mutation	NA	A188S	0.29
LUAD	chr16	72794041	Missense_Mutation	novel	M2881V	0.37
LUAD	chr16	72797717	Silent	novel	V1655V	0.12
LUAD	chr16	72794180	Missense_Mutation	NA	D2834E	0.21
LUAD	chr16	72958526	Silent	novel	L540L	0.2
LUAD	chr16	72811683	Missense_Mutation	rs370933867	R1253H	0.5
LUAD	chr16	72958760	Frame_Shift_Del	novel	*E461Gfs39**	0.27
LUAD	chr16	72787084	3'UTR	novel		0.5
LUAD	chr16	72795125	Missense_Mutation	NA	Q2519H	0.19
LUAD	chr16	72811652	Missense_Mutation	novel	N1263K	0.31
LUAD	chr16	72800119	Missense_Mutation	rs770124724	P1292R	0.28
LUAD	chr16	72796431	Missense_Mutation	NA	P2084Q	0.07
LUAD	chr16	72958511	Missense_Mutation	NA	R545S	0.08
LUAD	chr16	72796720	Missense_Mutation	NA	C1988S	0.23
LUAD	chr16	72794049	Frame_Shift_Del	novel	*S2868Gfs7**	0.09
LUAD	chr16	72787408	Missense_Mutation	novel	R3623L	0.2
LUAD	chr16	72798655	Missense_Mutation	novel	D1343H	0.14
LUSC	chr16	72795428	Silent	novel	T2418T	0.28
LUSC	chr16	72811952	Missense_Mutation	NA	L1206V	0.26
LUSC	chr16	72798457	Missense_Mutation	NA	A1409S	0.23
LUSC	chr16	72889745	Missense_Mutation	novel	P1145L	0.73
LUSC	chr16	72793621	Missense_Mutation	novel	G3021R	0.13
LUSC	chr16	72957733	Frame_Shift_Del	novel	*W804Vfs5**	0.6
LUSC	chr16	72950853	Silent	novel	L944L	0.35
LUSC	chr16	72795454	Missense_Mutation	NA	T2410A	0.28
LUSC	chr16	72889832	Missense_Mutation	novel	E1116V	0.36
LUSC	chr16	72889833	Nonsense_Mutation	novel	E1116*	0.33
LUSC	chr16	72950963	Missense_Mutation	novel	G908C	0.18
LUSC	chr16	72788431	Missense_Mutation	rs756436707	A3282V	0.11
LUSC	chr16	72957609	Missense_Mutation	rs755878058	R846H	0.23
LUSC	chr16	72959831	Silent	rs763854220	P105P	0.14
LUSC	chr16	72958425	Missense_Mutation	NA	S574T	0.13
LUSC	chr16	72812011	Missense_Mutation	NA	L1186R	0.3
LUSC	chr16	72794529	Missense_Mutation	NA	A2718E	0.23
LUSC	chr16	72795494	Silent	novel	P2396P	0.24
LUSC	chr16	72787234	Nonsense_Mutation	novel	*G3681Dfs11**	0.05
LUSC	chr16	72796295	Silent	novel	A2129A	0.13
LUSC	chr16	72787629	Missense_Mutation	NA	E3549D	0.35
LUSC	chr16	72787474	Missense_Mutation	NA	S3601W	0.19
LUSC	chr16	72796125	Missense_Mutation	novel	Q2186L	0.26
LUSC	chr16	72959617	Missense_Mutation	rs772845316	A177T	0.26
LUSC	chr16	72811660	Missense_Mutation	novel	L1261F	0.1
LUSC	chr16	72958382	Silent	NA	L588L	0.18
LUSC	chr16	72889898	Missense_Mutation	novel	N1094I	0.13
LUSC	chr16	72796637	Silent	novel	L2015L	0.14
LUSC	chr16	72795454	Missense_Mutation	NA	T2410A	0.2
LUSC	chr16	72797988	Missense_Mutation	rs572518232	N1565S	0.32
LUSC	chr16	72958223	Silent	rs150601682	E641E	0.3
LUSC	chr16	72797733	Missense_Mutation	novel	S1650C	0.29
LUSC	chr16	72796431	Missense_Mutation	NA	P2084Q	0.57
LUSC	chr16	72889742	Missense_Mutation	novel	S1146C	0.44
LUSC	chr16	72788492	Missense_Mutation	NA	G3262R	0.47
LUSC	chr16	72795730	Missense_Mutation	NA	D2318N	0.37
LUSC	chr16	72957463	Missense_Mutation	NA	P895S	0.45
LUSC	chr16	72794231	Silent	NA	S2817S	0.04
LUSC	chr16	72788803	Missense_Mutation	novel	T3158I	0.11
LUSC	chr16	72794526	Missense_Mutation	novel	L2719P	0.11
LUSC	chr16	72958994	Silent	rs144650397	A384A	0.21
LUSC	chr16	72787916	Missense_Mutation	NA	D3454Y	0.24
LUSC	chr16	72957550	Missense_Mutation	novel	L866V	0.24
LUSC	chr16	72796259	Silent	novel	L2141L	0.21
LUSC	chr16	72795735	Missense_Mutation	novel	T2316I	0.04
LUSC	chr16	72950657	Nonsense_Mutation	novel	Q1010*	0.46
LUSC	chr16	72950664	Silent	NA	K1007K	0.21
LUSC	chr16	72788004	Silent	rs749869759	Q3424Q	0.2
LUSC	chr16	72787891	Missense_Mutation	NA	Q3462R	0.21
LUSC	chr16	72957803	Silent	novel	A781A	0.29
LUSC	chr16	72798640	Missense_Mutation	novel	P1348S	0.23
LUSC	chr16	72795983	Silent	novel	P2233P	0.3
LUSC	chr16	72794868	Missense_Mutation	novel	S2605L	0.29
LUSC	chr16	72958517	Silent	novel	L543L	0.5
LUSC	chr16	72959617	Missense_Mutation	rs772845316	A177T	0.09
LUSC	chr16	72958507	Missense_Mutation	novel	T547S	0.1
LUSC	chr16	72797260	Nonsense_Mutation	novel	Q1808*	0.08
MESO	chr16	72795984	Missense_Mutation	novel	P2233R	0.25
OV	chr16	72795337	Nonsense_Mutation	novel	Q2449*	0.08
OV	chr16	72788321	Missense_Mutation	novel	Y3319D	0.22
OV	chr16	72788582	Missense_Mutation	novel	R3232C	0.04
OV	chr16	72794735	Silent	novel	T2649T	0.07
OV	chr16	72829825	Silent	novel	E1161E	0.06
OV	chr16	72788821	Missense_Mutation	novel	M3152R	0.08
OV	chr16	72788573	In_Frame_Ins	novel	D3234_K3235insCR	0.05
OV	chr16	72788575	In_Frame_Ins	novel	D3234delinsACSPTALH	0.03
OV	chr16	72959189	Frame_Shift_Ins	novel	*N319Kfs11**	0.1
OV	chr16	72957632	Missense_Mutation	novel	N838K	0.1
OV	chr16	72787982	Missense_Mutation	NA	S3432T	0.81
OV	chr16	72950848	Frame_Shift_Del	novel	*N938Sfs20**	0.08
OV	chr16	72957990	Missense_Mutation	novel	Y719C	0.67
OV	chr16	72957722	Silent	novel	V808V	0.05
OV	chr16	72957936	Missense_Mutation	novel	T737I	0.08	zf-C2H2
OV	chr16	72797927	Silent	novel	P1585P	0.12
OV	chr16	72794664	Missense_Mutation	novel	H2673P	0.06
OV	chr16	72788673	In_Frame_Ins	novel	Q3201_Q3202insKV	0.05
OV	chr16	72788638	Missense_Mutation	NA	P3213Q	0.29
OV	chr16	72957560	Silent	novel	Y862Y	0.09
OV	chr16	72788529	Silent	NA	G3249G	0.51
OV	chr16	72795523	Missense_Mutation	novel	P2387S	0.09
OV	chr16	72794313	Missense_Mutation	NA	K2790I	0.35
OV	chr16	72798592	Nonsense_Mutation	novel	K1364*	0.08
OV	chr16	72798593	Missense_Mutation	novel	W1363C	0.08
OV	chr16	72958481	Silent	novel	A555A	1
OV	chr16	72958856	Silent	novel	S430S	0.11
OV	chr16	72957460	Missense_Mutation	rs766792088	A896T	0.38
OV	chr16	72794126	Silent	rs749610266	N2852N	0.1
OV	chr16	72794880	Missense_Mutation	novel	A2601G	0.07
OV	chr16	72795515	Silent	novel	Q2389Q	0.08
OV	chr16	72798496	Missense_Mutation	rs762462194	R1396C	0.25
OV	chr16	72787199	Missense_Mutation	novel	L3693M	0.12
OV	chr16	72788731	Missense_Mutation	novel	T3182I	0.31
OV	chr16	72957705	Missense_Mutation	novel	N814T	0.13
OV	chr16	72787876	Missense_Mutation	novel	C3467Y	0.06
OV	chr16	72798014	Frame_Shift_Del	novel	*E1552Rfs5**	0.21
PAAD	chr16	72796518	Missense_Mutation	rs144401383	P2055L	0.13
PAAD	chr16	72958418	Silent	rs756457277	G576G	0.26
PAAD	chr16	72889866	Nonsense_Mutation	novel	Q1105*	0.13
PAAD	chr16	72787493	Missense_Mutation	novel	D3595N	0.28
PAAD	chr16	72788181	Silent	rs770673807	Q3365Q	0.16
PAAD	chr16	72788667	Silent	novel	Q3203Q	0.28
PAAD	chr16	72794221	Missense_Mutation	novel	V2821F	0.06
PAAD	chr16	72795809	Missense_Mutation	novel	Q2291H	0.16
PAAD	chr16	72796348	Missense_Mutation	novel	A2112S	0.2
PAAD	chr16	72797309	Missense_Mutation	novel	Q1791H	0.14
PAAD	chr16	72959065	Missense_Mutation	rs561634666	G361R	0.26
PAAD	chr16	72796561	Missense_Mutation	novel	P2041T	0.07
PCPG	chr16	72794328	Missense_Mutation	novel	L2785R	0.27
PRAD	chr16	72795912	Missense_Mutation	NA	L2257S	0.13
PRAD	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.36
PRAD	chr16	72798535	Nonsense_Mutation	novel	E1383*	0.35
PRAD	chr16	72957819	Missense_Mutation	rs544025035	A776V	0.33
PRAD	chr16	72793689	Missense_Mutation	NA	R2998Q	0.18
PRAD	chr16	72787951	Frame_Shift_Del	novel	*P3442Qfs43**	0.18
PRAD	chr16	72796981	Frame_Shift_Ins	novel	*G1901Rfs14**	0.42
PRAD	chr16	72795932	Silent	rs139895950	T2250T	0.3
PRAD	chr16	72788213	Frame_Shift_Ins	novel	*L3355Afs76**	0.33
PRAD	chr16	72957493	Nonsense_Mutation	NA	Q885*	0.28
PRAD	chr16	72797274	Frame_Shift_Del	novel	*F1798Qfs3**	0.38
PRAD	chr16	72811937	Missense_Mutation	rs774793921	P1211T	0.05
PRAD	chr16	72811639	Nonsense_Mutation	novel	Q1268*	0.39
PRAD	chr16	72797320	Frame_Shift_Del	novel	*L1787Afs18**	0.07
PRAD	chr16	72950700	Silent	rs367709501	L995L	0.53
PRAD	chr16	72794125	Missense_Mutation	rs200701402	A2853T	0.47
PRAD	chr16	72889784	Missense_Mutation	novel	D1132G	0.36
PRAD	chr16	72959152	Missense_Mutation	novel	D332Y	0.23
READ	chr16	72788829	Silent	NA	P3149P	0.37
READ	chr16	72796181	Silent	rs367687288	N2167N	0.18
READ	chr16	72797361	Missense_Mutation	novel	P1774H	0.19
READ	chr16	72788687	Frame_Shift_Del	NA	*Q3197Sfs44**	0.35
READ	chr16	72959517	Missense_Mutation	novel	G210D	0.29
READ	chr16	72959637	Missense_Mutation	novel	F170S	0.46
READ	chr16	72959904	Missense_Mutation	novel	C81F	0.69
READ	chr16	72959782	Frame_Shift_Ins	novel	E122*	0.29
READ	chr16	72959246	Silent	rs150869238	H300H	0.15
READ	chr16	72787968	Silent	rs368345791	P3436P	0.29
READ	chr16	72797070	Missense_Mutation	NA	S1871N	0.39
READ	chr16	72787138	3'UTR	novel		0.15
READ	chr16	72795135	Missense_Mutation	NA	T2516I	0.34
SARC	chr16	72798506	Silent	rs200609704	P1392P	0.51
SARC	chr16	72795865	Missense_Mutation	novel	E2273Q	0.2
SARC	chr16	72958984	Missense_Mutation	novel	E388Q	0.17
SARC	chr16	72950823	Silent	rs755083262	T954T	0.84
SARC	chr16	72796176	Missense_Mutation	NA	S2169F	0.64
SARC	chr16	72782896	3'UTR	novel		0.25
SARC	chr16	72784294	3'UTR	novel		0.16
SARC	chr16	72793859	Silent	novel	G2941G	0.65
SKCM	chr16	72793844	Silent	NA	Q2946Q	0.26
SKCM	chr16	72798366	Missense_Mutation	rs267604632	R1439Q	0.52
SKCM	chr16	72794591	Silent	NA	R2697R	0.45
SKCM	chr16	72959259	Missense_Mutation	NA	S296L	0.37
SKCM	chr16	72811945	Missense_Mutation	rs760400785	S1208L	0.39
SKCM	chr16	72795898	Missense_Mutation	NA	D2262N	0.42
SKCM	chr16	72958241	Silent	novel	P635P	0.73
SKCM	chr16	72958242	Missense_Mutation	novel	P635L	0.74
SKCM	chr16	72958441	Missense_Mutation	rs148894513	R569C	0.41
SKCM	chr16	72959032	Nonsense_Mutation	NA	R372*	0.3
SKCM	chr16	72787727	Missense_Mutation	novel	G3517S	0.18
SKCM	chr16	72958711	Missense_Mutation	NA	E479K	0.18
SKCM	chr16	72958920	Missense_Mutation	rs370750954	S409L	0.13
SKCM	chr16	72959068	Missense_Mutation	rs752689508	P360S	0.41
SKCM	chr16	72793266	Missense_Mutation	NA	P3139L	0.91
SKCM	chr16	72959264	Silent	rs747634887	V294V	0.94
SKCM	chr16	72787225	Missense_Mutation	NA	D3684V	0.22
SKCM	chr16	72795422	Silent	NA	N2420N	0.94
SKCM	chr16	72797748	Missense_Mutation	NA	I1645S	0.38
SKCM	chr16	72797261	Silent	novel	F1807F	0.53
SKCM	chr16	72889872	Missense_Mutation	rs372026184	L1103F	0.3
SKCM	chr16	72958219	Missense_Mutation	novel	P643S	0.23
SKCM	chr16	72959487	Missense_Mutation	novel	A220V	0.6
SKCM	chr16	72959345	Silent	novel	S267S	0.37
SKCM	chr16	72960092	Silent	rs552696439	I18I	0.21
SKCM	chr16	72798366	Missense_Mutation	rs267604632	R1439Q	0.32
SKCM	chr16	72811764	Missense_Mutation	NA	P1226L	0.71
SKCM	chr16	72959159	Silent	rs369733305	I329I	0.4
SKCM	chr16	72959886	Missense_Mutation	novel	S87F	0.2
SKCM	chr16	72795899	Silent	rs565137406	F2261F	0.1
SKCM	chr16	72796394	Silent	NA	I2096I	0.1
SKCM	chr16	72958002	Missense_Mutation	rs147160019	R715Q	0.27
SKCM	chr16	72958272	Missense_Mutation	NA	S625F	0.69
SKCM	chr16	72796986	Missense_Mutation	NA	G1899V	0.37
SKCM	chr16	72950659	Missense_Mutation	NA	V1009G	0.49
SKCM	chr16	72957944	Silent	rs780113574	S734S	0.33
SKCM	chr16	72787302	Silent	rs769344872	D3658D	0.48
SKCM	chr16	72959538	Missense_Mutation	NA	S203F	0.22
SKCM	chr16	72829853	Missense_Mutation	NA	A1152V	0.18
SKCM	chr16	72795998	Silent	NA	P2228P	0.38
SKCM	chr16	72796586	Silent	NA	L2032L	0.39
SKCM	chr16	72959931	Missense_Mutation	NA	S72F	0.79
SKCM	chr16	72798505	Missense_Mutation	NA	V1393L	0.39
SKCM	chr16	72950951	Missense_Mutation	rs765294332	P912S	0.45
SKCM	chr16	72793489	Missense_Mutation	NA	E3065K	0.24
SKCM	chr16	72811957	Missense_Mutation	NA	S1204Y	0.27
SKCM	chr16	72959747	Silent	rs368497120	I133I	0.38
SKCM	chr16	72795966	Nonsense_Mutation	NA	W2239*	0.09
SKCM	chr16	72794235	Missense_Mutation	NA	P2816L	0.5
SKCM	chr16	72787764	Silent	NA	V3504V	0.24
SKCM	chr16	72959747	Silent	rs368497120	I133I	0.36
SKCM	chr16	72787995	Silent	novel	T3427T	0.9
SKCM	chr16	72787996	Missense_Mutation	rs751991168	T3427I	0.9
SKCM	chr16	72796931	Silent	rs772844151	E1917E	0.44
SKCM	chr16	72950482	Missense_Mutation	novel	L1068Q	0.17
SKCM	chr16	72795578	Silent	NA	S2368S	0.08
SKCM	chr16	72958476	Missense_Mutation	NA	S557F	0.08
SKCM	chr16	72794484	Missense_Mutation	NA	R2733H	0.14
SKCM	chr16	72798355	Missense_Mutation	NA	A1443T	0.42
SKCM	chr16	72794742	Missense_Mutation	NA	T2647I	0.42
SKCM	chr16	72959753	Silent	novel	G131G	0.11
SKCM	chr16	72795403	Missense_Mutation	novel	D2427N	0.5
SKCM	chr16	72957459	Missense_Mutation	rs760913906	A896V	0.36
SKCM	chr16	72950774	Silent	rs772902362	L971L	0.3
SKCM	chr16	72797337	Missense_Mutation	NA	M1782K	0.74
SKCM	chr16	72793884	Missense_Mutation	rs764820113	S2933F	0.43
SKCM	chr16	72793533	Missense_Mutation	NA	S3050F	0.29
SKCM	chr16	72958013	Silent	novel	P711P	0.26
SKCM	chr16	72958014	Missense_Mutation	novel	P711L	0.27
SKCM	chr16	72794015	Silent	novel	R2889R	0.28
SKCM	chr16	72794591	Silent	NA	R2697R	0.14
SKCM	chr16	72796176	Missense_Mutation	NA	S2169F	0.56
SKCM	chr16	72958948	Silent	rs535536647	L400L	0.3
SKCM	chr16	72959736	Missense_Mutation	rs140908169	P137L	0.25
SKCM	chr16	72959737	Missense_Mutation	novel	P137S	0.25
SKCM	chr16	72958939	Missense_Mutation	rs758176150	L403F	0.24
SKCM	chr16	72787459	Missense_Mutation	novel	S3606F	0.58
SKCM	chr16	72795787	Missense_Mutation	novel	K2299E	0.56
SKCM	chr16	72958890	Missense_Mutation	NA	P419L	0.4
SKCM	chr16	72798535	Missense_Mutation	novel	E1383K	0.21
SKCM	chr16	72959259	Missense_Mutation	NA	S296L	0.23
SKCM	chr16	72958891	Missense_Mutation	novel	P419S	0.36
SKCM	chr16	72793304	Silent	NA	L3126L	0.27
SKCM	chr16	72794103	Missense_Mutation	NA	G2860E	0.27
SKCM	chr16	72795203	Silent	NA	P2493P	0.66
SKCM	chr16	72959925	Missense_Mutation	NA	P74L	0.37
SKCM	chr16	72794965	Missense_Mutation	NA	P2573S	0.26
SKCM	chr16	72794375	Silent	novel	S2769S	0.29
SKCM	chr16	72889759	Silent	NA	T1140T	0.42
SKCM	chr16	72793887	Missense_Mutation	NA	G2932E	0.46
SKCM	chr16	72797489	Silent	rs144110473	Q1731Q	0.48
SKCM	chr16	72811945	Missense_Mutation	rs760400785	S1208L	0.54
SKCM	chr16	72959799	Missense_Mutation	rs779515687	T116I	0.56
STAD	chr16	72960121	Missense_Mutation	rs200637584	V9I	0.28
STAD	chr16	72794653	Missense_Mutation	NA	E2677K	0.16
STAD	chr16	72793580	Silent	novel	S3034S	0.07
STAD	chr16	72959875	Frame_Shift_Del	novel	*L91Rfs17**	0.24
STAD	chr16	72788464	Missense_Mutation	rs759418149	T3271M	0.06
STAD	chr16	72959680	Missense_Mutation	rs769010742	A156T	0.2
STAD	chr16	72795451	Missense_Mutation	novel	A2411P	0.09
STAD	chr16	72787046	3'UTR	novel		0.43
STAD	chr16	72959381	Silent	rs752424561	C255C	0.36
STAD	chr16	72787677	Silent	NA	A3533A	0.13
STAD	chr16	72957609	Missense_Mutation	rs755878058	R846H	0.08
STAD	chr16	72788258	Missense_Mutation	rs764053422	G3340C	0.3
STAD	chr16	72794602	Missense_Mutation	NA	A2694T	0.04
STAD	chr16	72811709	Silent	rs373469033	T1244T	0.5
STAD	chr16	72795998	Silent	novel	P2228P	0.19
STAD	chr16	72800107	Missense_Mutation	NA	M1296T	0.09
STAD	chr16	72960055	Missense_Mutation	NA	H31N	0.17
STAD	chr16	72793465	Missense_Mutation	rs149453115	R3073C	0.23
STAD	chr16	72796236	Missense_Mutation	NA	R2149H	0.31
STAD	chr16	72950610	Silent	rs137984545	N1025N	0.35
STAD	chr16	72959452	Missense_Mutation	rs752231847	R232C	0.34
STAD	chr16	72795730	Missense_Mutation	NA	D2318N	0.42
STAD	chr16	72958757	Silent	rs376777497	A463A	0.16
STAD	chr16	72787515	Silent	rs776903532	S3587S	0.4
STAD	chr16	72795862	Nonsense_Mutation	NA	Q2274*	0.29
STAD	chr16	72796669	Missense_Mutation	rs368676441	V2005I	0.43
STAD	chr16	72797059	Missense_Mutation	novel	E1875K	0.33
STAD	chr16	72959401	Missense_Mutation	rs745631900	G249S	0.3
STAD	chr16	72959471	Silent	NA	S225S	0.32
STAD	chr16	72787879	Missense_Mutation	NA	V3466A	0.1
STAD	chr16	72794754	Missense_Mutation	rs777599986	R2643H	0.16
STAD	chr16	72797888	Silent	NA	C1598C	0.07
STAD	chr16	72798496	Missense_Mutation	rs762462194	R1396C	0.12
STAD	chr16	72959267	Nonsense_Mutation	NA	Y293*	0.07
STAD	chr16	72788830	Missense_Mutation	rs753461356	P3149L	0.3
STAD	chr16	72797003	Frame_Shift_Ins	novel	*D1894Gfs21**	0.29
STAD	chr16	72787445	Frame_Shift_Del	NA	*H3611Tfs83**	0.21
STAD	chr16	72788370	Silent	NA	L3302L	0.19
STAD	chr16	72958606	Missense_Mutation	rs150708008	A514T	0.13
STAD	chr16	72950865	Silent	rs745377225	P940P	0.24
STAD	chr16	72958802	Silent	rs781434863	D448D	0.11
STAD	chr16	72798375	Missense_Mutation	novel	R1436H	0.21
STAD	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.38
STAD	chr16	72797536	Missense_Mutation	NA	A1716T	0.24
STAD	chr16	72959945	Silent	rs761080933	S67S	0.36
STAD	chr16	72957858	Frame_Shift_Ins	novel	*E763Gfs62**	0.22
STAD	chr16	72795913	Missense_Mutation	novel	L2257I	0.08
STAD	chr16	72796719	Missense_Mutation	novel	C1988Y	0.29
STAD	chr16	72957858	Frame_Shift_Ins	rs760959844	*E763Gfs26**	0.34
STAD	chr16	72957660	Missense_Mutation	NA	M829T	0.23
STAD	chr16	72959437	Nonsense_Mutation	NA	R237*	0.07
STAD	chr16	72788686	Frame_Shift_Ins	rs764626362	*Q3197Pfs42**	0.38
STAD	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.24
STAD	chr16	72959004	Missense_Mutation	rs142313117	A381V	0.18
STAD	chr16	72794536	Frame_Shift_Del	novel	*C2716Afs30**	0.14
STAD	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.28
STAD	chr16	72958989	Missense_Mutation	NA	G386D	0.26
STAD	chr16	72950817	Silent	novel	D956D	0.26
STAD	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.43
STAD	chr16	72797045	Missense_Mutation	NA	K1879N	0.27
STAD	chr16	72957654	Missense_Mutation	NA	N831S	0.42
STAD	chr16	72787195	Missense_Mutation	NA	T3694I	0.24
STAD	chr16	72795011	Missense_Mutation	NA	Q2557H	0.26
STAD	chr16	72797733	Missense_Mutation	NA	S1650Y	0.27
STAD	chr16	72957610	Missense_Mutation	rs141276031	R846C	0.29
STAD	chr16	72958730	Silent	rs756105315	A472A	0.3
STAD	chr16	72795339	Missense_Mutation	NA	G2448A	0.19
STAD	chr16	72957772	Frame_Shift_Del	novel	*A792Pfs32**	0.39
STAD	chr16	72958050	Frame_Shift_Del	rs757302188	*G699Afs125**	0.19
STAD	chr16	72795605	Silent	NA	G2359G	0.24
STAD	chr16	72797806	Missense_Mutation	NA	A1626T	0.22
STAD	chr16	72811708	Nonsense_Mutation	NA	Q1245*	0.21
STAD	chr16	72959216	Silent	rs35466869	S310S	0.13
STAD	chr16	72797066	Silent	novel	Q1872Q	0.3
STAD	chr16	72959389	Frame_Shift_Del	novel	*S253Afs30**	0.29
STAD	chr16	72812018	Nonsense_Mutation	novel	K1184*	0.38
STAD	chr16	72958516	Missense_Mutation	novel	S544P	0.38
STAD	chr16	72795009	Missense_Mutation	NA	N2558S	0.14
STAD	chr16	72795686	Frame_Shift_Del	NA	*K2332Nfs44**	0.22
STAD	chr16	72796905	Missense_Mutation	NA	G1926D	0.25
STAD	chr16	72889902	Missense_Mutation	NA	C1093R	0.24
STAD	chr16	72788464	Missense_Mutation	rs759418149	T3271M	0.42
STAD	chr16	72959968	Missense_Mutation	rs200390317	R60C	0.27
STAD	chr16	72811992	Silent	NA	T1192T	0.18
STAD	chr16	72793714	Missense_Mutation	rs757947521	V2990I	0.21
STAD	chr16	72787930	Missense_Mutation	rs140437495	A3449V	0.31
STAD	chr16	72788581	Missense_Mutation	NA	R3232H	0.25
STAD	chr16	72957609	Missense_Mutation	rs755878058	R846H	0.31
TGCT	chr16	72958666	Missense_Mutation	novel	L494V	0.39
THCA	chr16	72787329	Silent	NA	S3649S	0.42
THCA	chr16	72795261	Missense_Mutation	NA	L2474R	0.05
THCA	chr16	72793721	Frame_Shift_Ins	novel	*R2988Efs33**	0.35
THCA	chr16	72797899	Missense_Mutation	NA	P1595A	0.31
THCA	chr16	72811927	Missense_Mutation	NA	A1214G	0.35
THCA	chr16	72797948	Frame_Shift_Del	novel	*K1572Rfs19**	0.22
THCA	chr16	72797039	Silent	novel	V1881V	0.17
THCA	chr16	72787521	Silent	NA	S3585S	0.38
THCA	chr16	72797970	Missense_Mutation	NA	H1571R	0.48
THYM	chr16	72784545	3'UTR	novel		0.03
THYM	chr16	72794754	Missense_Mutation	rs777599986	R2643H	0.26
UCEC	chr16	72796385	Silent	rs536413540	P2099P	0.34
UCEC	chr16	72786366	3'UTR	novel		0.4
UCEC	chr16	72798573	Frame_Shift_Del	novel	*K1365Ifs55**	0.28
UCEC	chr16	72793905	Frame_Shift_Del	novel	*P2926Rfs28**	0.47
UCEC	chr16	72889935	Missense_Mutation	NA	E1082K	0.19
UCEC	chr16	72958369	Nonsense_Mutation	NA	E593*	0.31
UCEC	chr16	72793676	Missense_Mutation	NA	K3002N	0.33
UCEC	chr16	72794395	Missense_Mutation	NA	D2763Y	0.31
UCEC	chr16	72794800	Missense_Mutation	rs762362472	E2628K	0.33
UCEC	chr16	72958654	Missense_Mutation	rs376702079	E498K	0.3
UCEC	chr16	72959031	Missense_Mutation	NA	R372Q	0.33
UCEC	chr16	72959402	Missense_Mutation	novel	D248E	0.07
UCEC	chr16	72959235	Missense_Mutation	novel	D304G	0.17
UCEC	chr16	72787526	Missense_Mutation	NA	A3584T	0.28
UCEC	chr16	72794249	Missense_Mutation	NA	E2811D	0.35
UCEC	chr16	72798366	Missense_Mutation	rs267604632	R1439Q	0.35
UCEC	chr16	72798676	Missense_Mutation	rs751584946	A1336T	0.29
UCEC	chr16	72889823	Missense_Mutation	NA	R1119Q	0.36
UCEC	chr16	72783320	3'UTR	novel		0.1
UCEC	chr16	72794282	Silent	novel	L2800L	0.13
UCEC	chr16	72794794	Missense_Mutation	rs145288413	D2630N	0.41
UCEC	chr16	72795717	Missense_Mutation	rs745878919	R2322Q	0.31
UCEC	chr16	72811710	Missense_Mutation	rs190630040	T1244M	0.13
UCEC	chr16	72957447	Missense_Mutation	novel	A900V	0.28
UCEC	chr16	72958968	Missense_Mutation	rs773725055	G393D	0.38
UCEC	chr16	72787976	Frame_Shift_Del	novel	*L3434Sfs51**	0.37
UCEC	chr16	72796487	Frame_Shift_Del	novel	*A2066Hfs35**	0.47
UCEC	chr16	72958642	Nonsense_Mutation	novel	E502*	0.42
UCEC	chr16	72787916	Missense_Mutation	rs770453754	D3454N	0.48
UCEC	chr16	72794490	Missense_Mutation	rs750838080	R2731Q	0.35
UCEC	chr16	72794794	Missense_Mutation	rs145288413	D2630N	0.23
UCEC	chr16	72796993	Missense_Mutation	rs150923130	E1897K	0.36
UCEC	chr16	72797729	Silent	rs758724659	T1651T	0.49
UCEC	chr16	72959899	Missense_Mutation	novel	E83K	0.28
UCEC	chr16	72784561	3'UTR	novel		0.56
UCEC	chr16	72785133	3'UTR	novel		0.37
UCEC	chr16	72788007	Silent	novel	E3423E	0.36
UCEC	chr16	72793468	Missense_Mutation	rs368568803	V3072I	0.35
UCEC	chr16	72793985	Silent	rs751040735	P2899P	0.45
UCEC	chr16	72794159	Silent	novel	A2841A	0.41
UCEC	chr16	72794528	Silent	rs150499144	A2718A	0.2
UCEC	chr16	72795032	Missense_Mutation	novel	Q2550H	0.34
UCEC	chr16	72795863	Silent	novel	E2273E	0.37
UCEC	chr16	72797557	Nonsense_Mutation	novel	E1709*	0.44
UCEC	chr16	72798495	Missense_Mutation	rs774988278	R1396H	0.24
UCEC	chr16	72783190	3'UTR	novel		0.68
UCEC	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.41
UCEC	chr16	72798126	Nonsense_Mutation	NA	S1519*	0.51
UCEC	chr16	72958708	Missense_Mutation	novel	E480Q	0.49
UCEC	chr16	72794074	Missense_Mutation	novel	A2870P	0.06
UCEC	chr16	72783015	3'UTR	novel		0.18
UCEC	chr16	72784787	3'UTR	novel		0.42
UCEC	chr16	72795014	Frame_Shift_Ins	novel	*Q2557Afs22**	0.46
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.38
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.28
UCEC	chr16	72788829	Silent	NA	P3149P	0.11
UCEC	chr16	72797671	Missense_Mutation	NA	A1671S	0.41
UCEC	chr16	72800038	Missense_Mutation	rs199774638	G1319E	0.09
UCEC	chr16	72829857	Nonsense_Mutation	NA	E1151*	0.46
UCEC	chr16	72958309	Missense_Mutation	rs761739295	D613N	0.39
UCEC	chr16	72788829	Silent	NA	P3149P	0.32
UCEC	chr16	72786366	3'UTR	novel		0.4
UCEC	chr16	72794794	Missense_Mutation	rs145288413	D2630N	0.45
UCEC	chr16	72798100	Missense_Mutation	novel	R1528G	0.38
UCEC	chr16	72811940	Nonsense_Mutation	novel	R1210*	0.32
UCEC	chr16	72796315	Missense_Mutation	novel	P2123S	0.34
UCEC	chr16	72811984	Missense_Mutation	rs756387925	R1195H	0.4
UCEC	chr16	72793302	Missense_Mutation	rs138835662	P3127L	0.17
UCEC	chr16	72794185	Missense_Mutation	novel	D2833N	0.32
UCEC	chr16	72950470	Missense_Mutation	rs747057237	K1072T	0.79
UCEC	chr16	72950865	Silent	rs745377225	P940P	0.79
UCEC	chr16	72959765	Missense_Mutation	novel	E127D	0.22
UCEC	chr16	72794754	Missense_Mutation	rs777599986	R2643H	0.03
UCEC	chr16	72794107	Missense_Mutation	NA	T2859P	0.23
UCEC	chr16	72795641	Missense_Mutation	NA	Q2347H	0.15
UCEC	chr16	72957881	Missense_Mutation	novel	Q755H	0.24
UCEC	chr16	72798367	Nonsense_Mutation	NA	R1439*	0.4
UCEC	chr16	72958584	Frame_Shift_Del	NA	*K521Rfs15**	0.44
UCEC	chr16	72793489	Nonsense_Mutation	NA	E3065*	0.24
UCEC	chr16	72794530	Missense_Mutation	NA	A2718T	0.29
UCEC	chr16	72794653	Missense_Mutation	NA	E2677K	0.27
UCEC	chr16	72795469	Missense_Mutation	rs201280219	A2405T	0.08
UCEC	chr16	72796614	Missense_Mutation	novel	R2023I	0.09
UCEC	chr16	72796852	Missense_Mutation	rs761415382	A1944T	0.28
UCEC	chr16	72798704	Missense_Mutation	novel	E1326D	0.15
UCEC	chr16	72958309	Missense_Mutation	rs761739295	D613N	0.28
UCEC	chr16	72960128	Silent	novel	S6S	0.13
UCEC	chr16	72795192	Missense_Mutation	rs756694889	S2497L	0.2
UCEC	chr16	72957881	Missense_Mutation	novel	Q755H	0.26
UCEC	chr16	72957825	Missense_Mutation	rs377474264	A774V	0.13
UCEC	chr16	72788035	Frame_Shift_Del	novel	*P3414Lfs71**	0.33
UCEC	chr16	72959517	Missense_Mutation	novel	G210D	0.2
UCEC	chr16	72784308	3'UTR	novel		0.5
UCEC	chr16	72788829	Silent	NA	P3149P	0.42
UCEC	chr16	72795245	Silent	rs182754861	S2479S	0.38
UCEC	chr16	72795898	Missense_Mutation	NA	D2262N	0.56
UCEC	chr16	72782896	3'UTR	novel		0.6
UCEC	chr16	72950507	Missense_Mutation	novel	V1060I	0.42
UCEC	chr16	72795385	Missense_Mutation	NA	A2433T	0.11
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.51
UCEC	chr16	72794720	Missense_Mutation	novel	E2654D	0.13
UCEC	chr16	72798253	Missense_Mutation	novel	G1477R	0.43
UCEC	chr16	72959785	Missense_Mutation	novel	D121N	0.42
UCEC	chr16	72784663	3'UTR	novel		0.36
UCEC	chr16	72785421	3'UTR	novel		0.07
UCEC	chr16	72794065	Missense_Mutation	rs768307205	E2873K	0.26
UCEC	chr16	72794639	Missense_Mutation	novel	K2681N	0.29
UCEC	chr16	72798366	Missense_Mutation	rs267604632	R1439Q	0.35
UCEC	chr16	72798650	Silent	novel	L1344L	0.26
UCEC	chr16	72797820	Frame_Shift_Ins	NA	*Q1621Pfs41**	0.21
UCEC	chr16	72797730	Frame_Shift_Del	novel	*T1651Afs10**	0.43
UCEC	chr16	72794099	Missense_Mutation	novel	I2861M	0.26
UCEC	chr16	72797516	Silent	novel	R1722R	0.13
UCEC	chr16	72957772	Missense_Mutation	NA	A792T	0.29
UCEC	chr16	72958266	Missense_Mutation	novel	C627Y	0.08
UCEC	chr16	72959570	Silent	rs753637843	P192P	0.29
UCEC	chr16	72782896	3'UTR	novel		0.43
UCEC	chr16	72797156	Frame_Shift_Del	NA	*L1835Sfs18**	0.63
UCEC	chr16	72784338	3'UTR	novel		0.22
UCEC	chr16	72795480	Frame_Shift_Ins	novel	*T2401Nfs14**	0.48
UCEC	chr16	72958310	Silent	rs767241081	D612D	0.24
UCEC	chr16	72793711	Frame_Shift_Ins	NA	*Q2991Sfs30**	0.43
UCEC	chr16	72784788	3'UTR	novel		0.47
UCEC	chr16	72787916	Missense_Mutation	rs770453754	D3454N	0.24
UCEC	chr16	72788704	Missense_Mutation	novel	G3191D	0.33
UCEC	chr16	72797935	Missense_Mutation	rs139530177	G1583S	0.27
UCEC	chr16	72798310	Missense_Mutation	novel	A1458T	0.34
UCEC	chr16	72798495	Missense_Mutation	rs774988278	R1396H	0.31
UCEC	chr16	72950862	Silent	rs141321462	S941S	0.39
UCEC	chr16	72957858	Frame_Shift_Ins	rs760959844	*E763Gfs26**	0.33
UCEC	chr16	72957860	Silent	rs141353191	G762G	0.38
UCEC	chr16	72958730	Silent	rs756105315	A472A	0.37
UCEC	chr16	72782896	3'UTR	novel		0.53
UCEC	chr16	72788622	Silent	NA	P3218P	0.05
UCEC	chr16	72783172	3'UTR	novel		0.47
UCEC	chr16	72796297	Missense_Mutation	NA	A2129T	0.36
UCEC	chr16	72786814	3'UTR	novel		0.11
UCEC	chr16	72786366	3'UTR	novel		0.45
UCEC	chr16	72787692	Silent	rs377246983	S3528S	0.52
UCEC	chr16	72784771	3'UTR	novel		0.25
UCEC	chr16	72787626	Silent	rs768842602	S3550S	0.08
UCEC	chr16	72794395	Missense_Mutation	novel	D2763N	0.53
UCEC	chr16	72794653	Missense_Mutation	NA	E2677K	0.31
UCEC	chr16	72795011	Silent	novel	Q2557Q	0.12
UCEC	chr16	72957536	Missense_Mutation	novel	M870I	0.38
UCEC	chr16	72959262	Missense_Mutation	rs754613484	R295H	0.3
UCEC	chr16	72950609	Nonsense_Mutation	novel	E1026*	0.58
UCEC	chr16	72783093	3'UTR	novel		0.53
UCEC	chr16	72784559	3'UTR	novel		0.53
UCEC	chr16	72784788	3'UTR	novel		0.41
UCEC	chr16	72787667	Missense_Mutation	NA	A3537T	0.33
UCEC	chr16	72795570	Missense_Mutation	NA	A2371V	0.16
UCEC	chr16	72796041	Missense_Mutation	novel	P2214L	0.46
UCEC	chr16	72797757	Missense_Mutation	novel	S1642I	0.55
UCEC	chr16	72889956	Missense_Mutation	novel	Q1075E	0.36
UCEC	chr16	72889824	Nonsense_Mutation	NA	R1119*	0.4
UCEC	chr16	72784950	3'UTR	novel		0.47
UCEC	chr16	72785644	3'UTR	novel		0.39
UCEC	chr16	72794395	Missense_Mutation	novel	D2763N	0.44
UCEC	chr16	72788027	Nonsense_Mutation	NA	E3417*	0.44
UCEC	chr16	72798676	Missense_Mutation	rs751584946	A1336T	0.06
UCEC	chr16	72959770	Missense_Mutation	NA	V126L	0.52
UCEC	chr16	72793704	Nonsense_Mutation	novel	W2993*	0.07
UCEC	chr16	72795383	Silent	rs767810299	A2433A	0.36
UCEC	chr16	72798608	Silent	novel	S1358S	0.4
UCEC	chr16	72957595	Missense_Mutation	novel	G851S	0.1
UCEC	chr16	72785577	3'UTR	novel		0.43
UCEC	chr16	72786910	3'UTR	novel		0.48
UCEC	chr16	72796908	Frame_Shift_Del	NA	*G1925Vfs72**	0.35
UCEC	chr16	72796986	Frame_Shift_Del	novel	*G1899Efs15**	0.09
UCEC	chr16	72797170	Nonsense_Mutation	NA	Q1838*	0.51
UCEC	chr16	72783414	3'UTR	novel		0.38
UCEC	chr16	72959283	Missense_Mutation	novel	K288T	0.09
UCEC	chr16	72959803	Missense_Mutation	NA	D115N	0.35
UCEC	chr16	72950893	Missense_Mutation	NA	G931D	0.41
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.5
UCEC	chr16	72785233	3'UTR	novel		0.08
UCEC	chr16	72786368	3'UTR	novel		0.39
UCEC	chr16	72794653	Missense_Mutation	NA	E2677K	0.39
UCEC	chr16	72795403	Missense_Mutation	novel	D2427N	0.41
UCEC	chr16	72795785	Missense_Mutation	novel	K2299N	0.35
UCEC	chr16	72797557	Nonsense_Mutation	novel	E1709*	0.45
UCEC	chr16	72798545	Silent	NA	T1379T	0.4
UCEC	chr16	72783278	3'UTR	novel		0.19
UCEC	chr16	72788814	Silent	rs201412119	L3154L	0.34
UCEC	chr16	72793898	Silent	novel	P2928P	0.41
UCEC	chr16	72797128	Nonsense_Mutation	novel	Q1852*	0.31
UCEC	chr16	72798487	Missense_Mutation	novel	Y1399H	0.18
UCEC	chr16	72811582	Missense_Mutation	novel	M1287V	0.31
UCEC	chr16	72950561	Missense_Mutation	novel	C1042R	0.3
UCEC	chr16	72959053	Frame_Shift_Del	NA	*Y365Mfs31**	0.36
UCEC	chr16	72782896	3'UTR	novel		0.47
UCEC	chr16	72788163	Silent	novel	L3371L	0.47
UCEC	chr16	72959727	Missense_Mutation	novel	S140F	0.25
UCEC	chr16	72788687	Frame_Shift_Del	NA	*Q3197Sfs44**	0.33
UCEC	chr16	72784787	3'UTR	novel		0.44
UCEC	chr16	72796773	Frame_Shift_Del	novel	*K1970Rfs27**	0.39
UCEC	chr16	72784663	3'UTR	novel		0.22
UCEC	chr16	72793575	Missense_Mutation	rs749152788	R3036Q	0.27
UCEC	chr16	72794722	Nonsense_Mutation	novel	E2654*	0.34
UCEC	chr16	72797248	Missense_Mutation	novel	E1812K	0.2
UCEC	chr16	72797700	Missense_Mutation	novel	N1661S	0.21
UCEC	chr16	72798366	Missense_Mutation	rs267604632	R1439Q	0.09
UCEC	chr16	72812002	Missense_Mutation	novel	S1189Y	0.13
UCEC	chr16	72829825	Missense_Mutation	novel	E1161D	0.19
UCEC	chr16	72889856	Missense_Mutation	rs747650481	R1108H	0.23
UCEC	chr16	72959201	Missense_Mutation	novel	K315N	0.29
UCEC	chr16	72795993	Nonsense_Mutation	novel	S2230*	0.35
UCEC	chr16	72958557	Missense_Mutation	novel	I530T	0.39
UCEC	chr16	72784788	3'UTR	novel		0.37
UCEC	chr16	72787515	Silent	rs776903532	S3587S	0.39
UCEC	chr16	72788124	Silent	novel	Q3384Q	0.15
UCEC	chr16	72796236	Missense_Mutation	NA	R2149H	0.41
UCEC	chr16	72959262	Missense_Mutation	rs754613484	R295H	0.39
UCEC	chr16	72959642	Silent	novel	S168S	0.41
UCEC	chr16	72795685	Frame_Shift_Ins	novel	*C2333Mfs2**	0.36
UCEC	chr16	72950927	Missense_Mutation	rs376414532	G920R	0.44
UCEC	chr16	72960122	Silent	rs775146790	V8V	0.41
UCEC	chr16	72788687	Frame_Shift_Del	NA	*Q3197Sfs44**	0.26
UCEC	chr16	72960048	Missense_Mutation	NA	P33H	0.11
UCEC	chr16	72782896	3'UTR	novel		0.54
UCEC	chr16	72796335	Frame_Shift_Del	novel	*P2116Rfs60**	0.26
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.18
UCEC	chr16	72959032	Nonsense_Mutation	NA	R372*	0.45
UCEC	chr16	72794493	Missense_Mutation	novel	I2730S	0.33
UCEC	chr16	72786369	3'UTR	novel		0.39
UCEC	chr16	72786574	3'UTR	novel		0.29
UCEC	chr16	72797032	Nonsense_Mutation	novel	E1884*	0.3
UCEC	chr16	72787784	Nonsense_Mutation	NA	Q3498*	0.76
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.61
UCEC	chr16	72784488	3'UTR	novel		0.67
UCEC	chr16	72784907	3'UTR	novel		0.45
UCEC	chr16	72786609	3'UTR	novel		0.44
UCEC	chr16	72787314	Silent	novel	S3654S	0.28
UCEC	chr16	72794395	Missense_Mutation	NA	D2763Y	0.33
UCEC	chr16	72796996	Missense_Mutation	rs770650936	A1896T	0.31
UCEC	chr16	72798692	Missense_Mutation	novel	K1330N	0.3
UCEC	chr16	72812019	Missense_Mutation	novel	E1183D	0.38
UCEC	chr16	72959380	Missense_Mutation	rs764820053	V256I	0.38
UCEC	chr16	72784788	3'UTR	novel		0.37
UCEC	chr16	72889824	Nonsense_Mutation	NA	R1119*	0.37
UCEC	chr16	72788375	Missense_Mutation	rs373052102	A3301T	0.55
UCEC	chr16	72794604	Missense_Mutation	novel	R2693Q	0.09
UCEC	chr16	72783191	3'UTR	novel		0.57
UCEC	chr16	72796542	Frame_Shift_Del	novel	*P2047Lfs54**	0.48
UCEC	chr16	72797644	Frame_Shift_Ins	NA	*L1680Tfs7**	0.42
UCEC	chr16	72889750	Frame_Shift_Del	novel	*R1143Sfs44**	0.38
UCEC	chr16	72959831	Frame_Shift_Ins	rs769936196	*P106Afs13**	0.5
UCEC	chr16	72793681	Nonsense_Mutation	NA	E3001*	0.39
UCEC	chr16	72788061	Frame_Shift_Del	NA	*A3407Lfs78**	0.63
UCEC	chr16	72797557	Nonsense_Mutation	novel	E1709*	0.09
UCEC	chr16	72958369	Missense_Mutation	rs746207124	E593K	0.33
UCEC	chr16	72959381	Silent	rs752424561	C255C	0.07
UCEC	chr16	72957767	Frame_Shift_Del	novel	*S794Rfs30**	0.49
UCEC	chr16	72958225	Missense_Mutation	NA	E641K	0.45
UCEC	chr16	72783014	3'UTR	novel		0.12
UCEC	chr16	72786370	3'UTR	novel		0.12
UCEC	chr16	72794177	Silent	novel	C2835C	0.07
UCEC	chr16	72796993	Missense_Mutation	rs150923130	E1897K	0.26
UCEC	chr16	72797223	Missense_Mutation	novel	G1820E	0.19
UCEC	chr16	72798338	Silent	NA	L1448L	0.37
UCEC	chr16	72787228	Missense_Mutation	novel	K3683T	0.24
UCEC	chr16	72793918	Missense_Mutation	novel	D2922Y	0.38
UCEC	chr16	72797547	Missense_Mutation	rs143025874	R1712L	0.32
UCEC	chr16	72797729	Silent	rs758724659	T1651T	0.18
UCEC	chr16	72798233	Missense_Mutation	novel	E1483D	0.1
UCEC	chr16	72950627	Nonsense_Mutation	novel	E1020*	0.24
UCEC	chr16	72958603	Missense_Mutation	novel	A515S	0.34
UCEC	chr16	72958817	Silent	novel	K443K	0.36
UCEC	chr16	72795531	Missense_Mutation	rs749012780	T2384I	0.82
UCEC	chr16	72795181	Frame_Shift_Del	novel	*S2498Ffs32**	0.15
UCEC	chr16	72950871	Silent	rs199635500	N938N	0.26
UCEC	chr16	72793759	Nonsense_Mutation	NA	E2975*	0.33
UCEC	chr16	72957609	Frame_Shift_Ins	novel	*R846Pfs65**	0.48
UCEC	chr16	72797003	Frame_Shift_Ins	novel	*D1894Gfs21**	0.38
UCEC	chr16	72787290	Missense_Mutation	novel	E3662D	0.09
UCEC	chr16	72793564	Missense_Mutation	rs750717662	R3040C	0.35
UCEC	chr16	72794125	Missense_Mutation	rs200701402	A2853T	0.13
UCEC	chr16	72798037	Missense_Mutation	rs181722888	V1549I	0.16
UCEC	chr16	72958211	Silent	rs369430915	C645C	0.33
UCEC	chr16	72788071	Missense_Mutation	novel	P3402Q	0.56
UCEC	chr16	72793793	Silent	novel	S2963S	0.11
UCEC	chr16	72794603	Silent	novel	R2693R	0.43
UCEC	chr16	72950912	Missense_Mutation	novel	E925K	0.43
UCEC	chr16	72958496	Silent	rs755375220	T550T	0.31
UCEC	chr16	72959635	Missense_Mutation	novel	L171M	0.11
UCEC	chr16	72960191	5'UTR	rs770387236		0.3
UCEC	chr16	72786366	3'UTR	novel		0.25
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.23
UCEC	chr16	72795802	Nonsense_Mutation	NA	R2294*	0.39
UCEC	chr16	72958050	Frame_Shift_Del	rs757302188	*G699Afs125**	0.27
UCEC	chr16	72794329	Frame_Shift_Del	novel	*L2785Sfs4**	0.39
UCEC	chr16	72798538	Frame_Shift_Ins	novel	N1382*	0.39
UCEC	chr16	72782896	3'UTR	novel		0.41
UCEC	chr16	72784788	3'UTR	novel		0.59
UCEC	chr16	72795231	Missense_Mutation	novel	P2484H	0.43
UCEC	chr16	72957610	Missense_Mutation	rs141276031	R846C	0.2
UCEC	chr16	72796972	Missense_Mutation	rs145361431	G1904S	0.39
UCEC	chr16	72959430	Missense_Mutation	NA	K239R	0.2
UCEC	chr16	72793681	Nonsense_Mutation	NA	E3001*	0.35
UCEC	chr16	72795717	Missense_Mutation	rs745878919	R2322Q	0.42
UCEC	chr16	72959200	Missense_Mutation	NA	I316L	0.35
UCEC	chr16	72782896	3'UTR	novel		0.65
UCEC	chr16	72788109	In_Frame_Ins	rs745803083	Q3389dup	0.65
UCEC	chr16	72797671	Missense_Mutation	novel	A1671T	0.34
UCEC	chr16	72812016	In_Frame_Del	novel	K1184del	0.38
UCEC	chr16	72957610	Missense_Mutation	rs141276031	R846C	0.29
UCEC	chr16	72794323	Missense_Mutation	rs200665174	P2787S	0.27
UCEC	chr16	72798367	Nonsense_Mutation	NA	R1439*	0.05
UCEC	chr16	72787293	Silent	rs374846350	S3661S	0.33
UCEC	chr16	72793676	Missense_Mutation	NA	K3002N	0.32
UCEC	chr16	72793902	Missense_Mutation	novel	S2927I	0.06
UCEC	chr16	72795383	Silent	rs767810299	A2433A	0.39
UCEC	chr16	72889823	Missense_Mutation	NA	R1119Q	0.41
UCEC	chr16	72811591	Frame_Shift_Del	novel	*D1280Efs10**	0.32
UCEC	chr16	72788334	Silent	rs536827364	G3314G	0.29
UCEC	chr16	72811939	Missense_Mutation	rs762268017	R1210Q	0.3
UCEC	chr16	72796997	Silent	rs775959112	S1895S	0.42
UCEC	chr16	72798054	Missense_Mutation	novel	R1543H	0.25
UCEC	chr16	72800069	Nonsense_Mutation	rs529603227	R1309*	0.37
UCEC	chr16	72811710	Missense_Mutation	rs190630040	T1244M	0.25
UCEC	chr16	72785504	3'UTR	novel		0.35
UCEC	chr16	72795768	Missense_Mutation	novel	G2305E	0.34
UCEC	chr16	72784764	3'UTR	novel		0.44
UCEC	chr16	72797802	Missense_Mutation	novel	A1627V	0.27
UCEC	chr16	72957484	Missense_Mutation	novel	M888L	0.45
UCEC	chr16	72797644	Frame_Shift_Ins	NA	*L1680Tfs7**	0.39
UCEC	chr16	72958050	Frame_Shift_Del	rs757302188	*G699Afs125**	0.32
UCEC	chr16	72958490	Silent	novel	S552S	0.37
UCEC	chr16	72795387	Missense_Mutation	novel	L2432P	0.11
UCEC	chr16	72796448	Silent	rs764333385	P2078P	0.35
UCEC	chr16	72796673	Missense_Mutation	NA	E2003D	0.3
UCEC	chr16	72797126	Silent	NA	Q1852Q	0.28
UCEC	chr16	72797971	Missense_Mutation	NA	H1571Y	0.29
UCEC	chr16	72950716	Missense_Mutation	rs753727111	R990H	0.17
UCEC	chr16	72957687	Missense_Mutation	rs768340392	R820H	0.31
UCEC	chr16	72959271	Missense_Mutation	NA	G292E	0.28
UCEC	chr16	72798072	Frame_Shift_Del	novel	*K1537Vfs35**	0.33
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.38
UCEC	chr16	72782896	3'UTR	novel		0.83
UCEC	chr16	72811940	Nonsense_Mutation	novel	R1210*	0.55
UCEC	chr16	72957859	Frame_Shift_Del	NA	*E763Sfs61**	0.44
UCEC	chr16	72786366	3'UTR	novel		0.42
UCEC	chr16	72959831	Frame_Shift_Ins	rs769936196	*P106Afs13**	0.51
UCEC	chr16	72787646	Missense_Mutation	rs757184727	L3544V	0.33
UCEC	chr16	72793833	Missense_Mutation	NA	R2950H	0.45
UCEC	chr16	72796388	Silent	rs765381340	S2098S	0.39
UCEC	chr16	72959591	Silent	rs747235758	S185S	0.46
UCEC	chr16	72784723	3'UTR	novel		0.31
UCEC	chr16	72795762	Missense_Mutation	novel	G2307D	0.33
UCEC	chr16	72798114	Missense_Mutation	novel	R1523I	0.41
UCEC	chr16	72950621	Missense_Mutation	rs778703804	G1022S	0.32
UCEC	chr16	72957437	Silent	rs150583300	T903T	0.42
UCEC	chr16	72957661	Missense_Mutation	novel	M829V	0.25
UCEC	chr16	72959154	Missense_Mutation	novel	K331R	0.39
UCEC	chr16	72959770	Missense_Mutation	rs762692938	V126M	0.36
UCEC	chr16	72960074	Missense_Mutation	novel	W24C	0.33
UCEC	chr16	72788606	Missense_Mutation	rs759757430	L3224F	0.51
UCS	chr16	72787911	Frame_Shift_Del	novel	*F3456Sfs29**	0.83
UCS	chr16	72788673	Silent	novel	Q3201Q	0.43
UCS	chr16	72958333	Missense_Mutation	novel	P605T	0.27
UCS	chr16	72795598	Missense_Mutation	rs761486040	D2362N	0.42
UVM	chr16	72959267	Silent	rs183134469	Y293Y	0.52
UVM	chr16	72959756	Silent	rs144573608	A130A	0.52

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1838	0.063591
CHOL	DEL	0.1667	0.23475
GBM	DEL	0.1179	0.023089
LAML	DEL	0.0262	0.0010312
PRAD	DEL	0.3618	8.9841e-33
UCEC	DEL	0.2894	8.9376e-11

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.047	Kaplan-Meier Survival Analysis
MESO	0.0028	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
BRCA	0.0015	Kaplan-Meier Survival Analysis
LAML	0.00026	Kaplan-Meier Survival Analysis
UCEC	0.0047	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742