EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140948 (Gene tree)
Gene ID: 23174
Gene Symbol: ZCCHC14
Alias: BDG29|MGC14139
Full Name: zinc finger CCHC-type containing 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 86,024 bases
Position: chr16:87,406,246-87,492,269
Accession: 24134
RBP type: canonical RBP
Summary: (Zinc Finger CCHC-Type Containing 14) is a Protein Coding gene. Diseases associated with ZCCHC14 include Vesicoureteral Reflux 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and phosphatidylinositol binding. An important paralog of this gene is ZCCHC2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000456499	zf-CCHC	PF00098.23	1.6e-05	1	1
ENSP00000268616	zf-CCHC	PF00098.23	1.8e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000568020	ZCCHC14-204	6242	-	ENSP00000455431	949 (aa)	-	Q8WYQ9
ENST00000565193	ZCCHC14-203	523	-	-	- (aa)	-	-
ENST00000268616	ZCCHC14-201	7102	XM_005255858	ENSP00000268616	949 (aa)	XP_005255915	Q8WYQ9
ENST00000561928	ZCCHC14-202	2548	-	ENSP00000456499	846 (aa)	-	H3BS18

Gene Model

Click here to download ENSG00000140948's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140948	Platelet Function Tests	1.3061400E-005	-
ENSG00000140948	Platelet Function Tests	1.9400908E-006	-
ENSG00000140948	Platelet Function Tests	1.0173600E-005	-
ENSG00000140948	Depressive Disorder	5E-6	22472876
ENSG00000140948	Schizophrenia	2E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140948	rs7194676	16	87456285	C	Schizophrenia	26198764	[NR]	1.0638298	EFO_0000692
ENSG00000140948	rs1050846	16	87411757	A	Neuroticism	29255261	z score decrease	4.87	EFO_0007660
ENSG00000140948	rs1050847	16	87410128	T	Educational attainment (MTAG)	30038396	[0.0069-0.0119] unit increase	0.0094	EFO_0004784
ENSG00000140948	rs3748400	16	87412233	T	Highest math class taken (MTAG)	30038396	[0.0084-0.0158] unit increase	0.0121	EFO_0004875
ENSG00000140948	rs1050847	16	87410128	T	Cognitive performance (MTAG)	30038396	[0.01-0.019] unit increase	0.0149	EFO_0008354
ENSG00000140948	rs8050237	16	87458843	T	Feeling nervous	29500382	z score increase	5.52	EFO_0009597
ENSG00000140948	rs9646303	16	87428363	?	Major depressive disorder	22472876			EFO_0003761
ENSG00000140948	rs1050847	16	87410128	?	General cognitive ability	29844566	z-score increase	4.489	EFO_0004337
ENSG00000140948	rs2042395	16	87412447	A	Neuroticism	29942085	z score decrease	5.803	EFO_0007660
ENSG00000140948	rs9936170	16	87477955	G	Worry	29942085	[0.012-0.024] unit increase	0.01787	EFO_0005230
ENSG00000140948	rs1050847	16	87410128	T	Educational attainment (years of education)	30038396	[0.0065-0.0119] unit increase	0.0092	EFO_0004784
ENSG00000140948	rs4843613	16	87456092	T	Broad depression or schizophrenia	30626913			EFO_0003761\|EFO_0000692
ENSG00000140948	rs1050847	16	87410128	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000140948	rs1050847	16	87410128	?	Smoking status	30595370			EFO_0006527
ENSG00000140948	rs3748400	16	87412233	?	Neuroticism	30595370			EFO_0007660
ENSG00000140948	rs2042395	16	87412447	A	Well-being spectrum (multivariate analysis)	30643256	[0.0038-0.008] unit decrease	0.005913557	EFO_0007869
ENSG00000140948	rs1050847	16	87410128	T	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0053-0.0096] unit decrease	0.00745744	EFO_0006527
ENSG00000140948	rs1050847	16	87410128	T	Smoking initiation (ever regular vs never regular)	30643251	[0.0098-0.0199] unit decrease	0.014830017	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140948's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000140948	ZCCHC14	55	37.500	ENSG00000141664	ZCCHC2	100	43.925

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140948	ZCCHC14	100	82.211	ENSAMEG00000018253	ZCCHC14	77	84.945	Ailuropoda_melanoleuca
ENSG00000140948	ZCCHC14	100	75.862	ENSAPLG00000005595	ZCCHC14	77	78.249	Anas_platyrhynchos
ENSG00000140948	ZCCHC14	68	38.150	ENSAPLG00000003573	ZCCHC2	63	39.869	Anas_platyrhynchos
ENSG00000140948	ZCCHC14	96	65.947	ENSACAG00000014623	ZCCHC14	74	68.274	Anolis_carolinensis
ENSG00000140948	ZCCHC14	100	97.893	ENSANAG00000035488	ZCCHC14	100	97.893	Aotus_nancymaae
ENSG00000140948	ZCCHC14	100	85.430	ENSBTAG00000014267	ZCCHC14	87	85.430	Bos_taurus
ENSG00000140948	ZCCHC14	100	97.260	ENSCJAG00000004460	ZCCHC14	100	95.785	Callithrix_jacchus
ENSG00000140948	ZCCHC14	100	83.979	ENSCAFG00000019907	ZCCHC14	100	84.398	Canis_familiaris
ENSG00000140948	ZCCHC14	100	83.874	ENSCAFG00020004411	ZCCHC14	100	84.293	Canis_lupus_dingo
ENSG00000140948	ZCCHC14	100	83.474	ENSCHIG00000016741	ZCCHC14	98	84.771	Capra_hircus
ENSG00000140948	ZCCHC14	100	89.927	ENSTSYG00000034736	ZCCHC14	100	90.136	Carlito_syrichta
ENSG00000140948	ZCCHC14	88	95.604	ENSCAPG00000016164	ZCCHC14	95	95.604	Cavia_aperea
ENSG00000140948	ZCCHC14	96	82.577	ENSCPOG00000007705	ZCCHC14	100	83.654	Cavia_porcellus
ENSG00000140948	ZCCHC14	100	97.576	ENSCCAG00000024606	ZCCHC14	100	97.576	Cebus_capucinus
ENSG00000140948	ZCCHC14	100	99.368	ENSCATG00000035317	ZCCHC14	100	99.368	Cercocebus_atys
ENSG00000140948	ZCCHC14	100	82.124	ENSCLAG00000001784	ZCCHC14	100	82.229	Chinchilla_lanigera
ENSG00000140948	ZCCHC14	100	99.157	ENSCSAG00000003131	ZCCHC14	100	99.157	Chlorocebus_sabaeus
ENSG00000140948	ZCCHC14	81	82.883	ENSCHOG00000012076	ZCCHC14	87	85.156	Choloepus_hoffmanni
ENSG00000140948	ZCCHC14	100	76.471	ENSCPBG00000023517	ZCCHC14	87	76.236	Chrysemys_picta_bellii
ENSG00000140948	ZCCHC14	100	99.052	ENSCANG00000033306	ZCCHC14	100	99.052	Colobus_angolensis_palliatus
ENSG00000140948	ZCCHC14	100	86.934	ENSCGRG00001019291	Zcchc14	100	86.723	Cricetulus_griseus_chok1gshd
ENSG00000140948	ZCCHC14	96	86.626	ENSCGRG00000015489	Zcchc14	100	87.165	Cricetulus_griseus_crigri
ENSG00000140948	ZCCHC14	58	41.216	ENSCSEG00000013994	zcchc14	71	40.365	Cynoglossus_semilaevis
ENSG00000140948	ZCCHC14	100	79.789	ENSDNOG00000005247	ZCCHC14	100	79.368	Dasypus_novemcinctus
ENSG00000140948	ZCCHC14	100	78.848	ENSDORG00000013867	Zcchc14	100	78.953	Dipodomys_ordii
ENSG00000140948	ZCCHC14	100	88.340	ENSEASG00005013865	ZCCHC14	87	88.025	Equus_asinus_asinus
ENSG00000140948	ZCCHC14	100	88.000	ENSECAG00000013066	ZCCHC14	87	88.000	Equus_caballus
ENSG00000140948	ZCCHC14	87	80.562	ENSEEUG00000011890	ZCCHC14	92	81.250	Erinaceus_europaeus
ENSG00000140948	ZCCHC14	85	51.190	ENSELUG00000010668	zcchc14	76	48.684	Esox_lucius
ENSG00000140948	ZCCHC14	100	83.525	ENSFCAG00000031468	ZCCHC14	100	83.733	Felis_catus
ENSG00000140948	ZCCHC14	100	76.261	ENSFALG00000006573	ZCCHC14	77	77.686	Ficedula_albicollis
ENSG00000140948	ZCCHC14	76	41.420	ENSFHEG00000004620	zcchc14	63	41.892	Fundulus_heteroclitus
ENSG00000140948	ZCCHC14	100	75.521	ENSGALG00000034166	ZCCHC14	66	77.517	Gallus_gallus
ENSG00000140948	ZCCHC14	72	38.596	ENSGACG00000003190	zcchc14	75	40.000	Gasterosteus_aculeatus
ENSG00000140948	ZCCHC14	100	75.735	ENSGAGG00000001754	ZCCHC14	87	75.605	Gopherus_agassizii
ENSG00000140948	ZCCHC14	96	99.632	ENSGGOG00000026113	ZCCHC14	99	99.554	Gorilla_gorilla
ENSG00000140948	ZCCHC14	100	81.368	ENSHGLG00000012701	ZCCHC14	76	79.945	Heterocephalus_glaber_female
ENSG00000140948	ZCCHC14	100	71.682	ENSHGLG00100013732	ZCCHC14	100	69.005	Heterocephalus_glaber_male
ENSG00000140948	ZCCHC14	55	37.500	ENSSTOG00000015357	ZCCHC2	52	37.415	Ictidomys_tridecemlineatus
ENSG00000140948	ZCCHC14	97	87.391	ENSSTOG00000006167	ZCCHC14	98	86.961	Ictidomys_tridecemlineatus
ENSG00000140948	ZCCHC14	100	86.947	ENSJJAG00000021656	Zcchc14	100	86.947	Jaculus_jaculus
ENSG00000140948	ZCCHC14	96	55.957	ENSLACG00000010970	ZCCHC14	73	55.502	Latimeria_chalumnae
ENSG00000140948	ZCCHC14	100	46.843	ENSLOCG00000003530	zcchc14	77	44.609	Lepisosteus_oculatus
ENSG00000140948	ZCCHC14	96	81.350	ENSLAFG00000013845	ZCCHC14	100	81.940	Loxodonta_africana
ENSG00000140948	ZCCHC14	100	99.262	ENSMFAG00000044504	ZCCHC14	100	96.632	Macaca_fascicularis
ENSG00000140948	ZCCHC14	100	99.262	ENSMMUG00000017615	ZCCHC14	100	99.262	Macaca_mulatta
ENSG00000140948	ZCCHC14	100	99.262	ENSMNEG00000045229	ZCCHC14	100	96.632	Macaca_nemestrina
ENSG00000140948	ZCCHC14	100	96.737	ENSMLEG00000043156	ZCCHC14	100	96.737	Mandrillus_leucophaeus
ENSG00000140948	ZCCHC14	100	72.374	ENSMGAG00000007316	ZCCHC14	81	77.548	Meleagris_gallopavo
ENSG00000140948	ZCCHC14	100	86.632	ENSMAUG00000005513	Zcchc14	100	86.526	Mesocricetus_auratus
ENSG00000140948	ZCCHC14	100	88.620	ENSMICG00000034441	ZCCHC14	94	89.744	Microcebus_murinus
ENSG00000140948	ZCCHC14	100	86.925	ENSMOCG00000021269	Zcchc14	100	86.925	Microtus_ochrogaster
ENSG00000140948	ZCCHC14	96	82.073	ENSMODG00000004488	ZCCHC14	73	84.488	Monodelphis_domestica
ENSG00000140948	ZCCHC14	51	50.000	ENSMALG00000006282	zcchc14	65	44.828	Monopterus_albus
ENSG00000140948	ZCCHC14	100	85.654	MGP_CAROLIEiJ_G0031650	Zcchc14	97	89.744	Mus_caroli
ENSG00000140948	ZCCHC14	100	85.565	ENSMUSG00000061410	Zcchc14	97	89.316	Mus_musculus
ENSG00000140948	ZCCHC14	100	85.340	MGP_PahariEiJ_G0023248	-	97	89.744	Mus_pahari
ENSG00000140948	ZCCHC14	100	85.251	MGP_SPRETEiJ_G0032768	Zcchc14	97	89.316	Mus_spretus
ENSG00000140948	ZCCHC14	100	85.519	ENSMLUG00000015605	ZCCHC14	100	85.624	Myotis_lucifugus
ENSG00000140948	ZCCHC14	100	85.579	ENSNGAG00000021549	Zcchc14	100	85.789	Nannospalax_galili
ENSG00000140948	ZCCHC14	100	95.364	ENSNLEG00000011527	ZCCHC14	100	95.364	Nomascus_leucogenys
ENSG00000140948	ZCCHC14	76	86.121	ENSOPRG00000008429	ZCCHC14	76	85.765	Ochotona_princeps
ENSG00000140948	ZCCHC14	100	80.608	ENSODEG00000003749	ZCCHC14	100	80.503	Octodon_degus
ENSG00000140948	ZCCHC14	96	80.098	ENSOANG00000003350	ZCCHC14	100	80.024	Ornithorhynchus_anatinus
ENSG00000140948	ZCCHC14	98	84.764	ENSOCUG00000009286	ZCCHC14	99	83.444	Oryctolagus_cuniculus
ENSG00000140948	ZCCHC14	70	79.310	ENSOMEG00000013209	zcchc14	53	37.787	Oryzias_melastigma
ENSG00000140948	ZCCHC14	100	90.411	ENSOGAG00000029811	ZCCHC14	100	90.411	Otolemur_garnettii
ENSG00000140948	ZCCHC14	83	96.825	ENSOARG00000011914	ZCCHC14	95	91.304	Ovis_aries
ENSG00000140948	ZCCHC14	100	99.579	ENSPPAG00000032523	ZCCHC14	100	99.579	Pan_paniscus
ENSG00000140948	ZCCHC14	100	99.684	ENSPTRG00000008446	ZCCHC14	100	99.684	Pan_troglodytes
ENSG00000140948	ZCCHC14	100	99.368	ENSPANG00000022199	ZCCHC14	100	96.737	Papio_anubis
ENSG00000140948	ZCCHC14	67	48.000	ENSPKIG00000014759	zcchc14	77	48.322	Paramormyrops_kingsleyae
ENSG00000140948	ZCCHC14	100	75.971	ENSPSIG00000017111	ZCCHC14	77	76.997	Pelodiscus_sinensis
ENSG00000140948	ZCCHC14	100	86.897	ENSPEMG00000008789	Zcchc14	100	86.897	Peromyscus_maniculatus_bairdii
ENSG00000140948	ZCCHC14	100	81.393	ENSPCIG00000009877	ZCCHC14	66	83.609	Phascolarctos_cinereus
ENSG00000140948	ZCCHC14	88	37.129	ENSPFOG00000007077	-	67	40.278	Poecilia_formosa
ENSG00000140948	ZCCHC14	87	37.306	ENSPLAG00000015486	zcchc14	65	40.278	Poecilia_latipinna
ENSG00000140948	ZCCHC14	85	40.361	ENSPMEG00000005494	zcchc14	65	40.278	Poecilia_mexicana
ENSG00000140948	ZCCHC14	100	91.149	ENSPPYG00000007629	ZCCHC14	86	92.729	Pongo_abelii
ENSG00000140948	ZCCHC14	100	83.841	ENSPCAG00000013438	ZCCHC14	100	83.684	Procavia_capensis
ENSG00000140948	ZCCHC14	96	89.939	ENSPCOG00000003282	ZCCHC14	100	89.397	Propithecus_coquereli
ENSG00000140948	ZCCHC14	85	51.205	ENSPNAG00000005977	zcchc14	74	49.333	Pygocentrus_nattereri
ENSG00000140948	ZCCHC14	100	84.293	ENSRNOG00000018226	Zcchc14	87	83.560	Rattus_norvegicus
ENSG00000140948	ZCCHC14	100	95.996	ENSRBIG00000039663	ZCCHC14	100	99.172	Rhinopithecus_bieti
ENSG00000140948	ZCCHC14	100	99.262	ENSRROG00000040386	ZCCHC14	100	95.996	Rhinopithecus_roxellana
ENSG00000140948	ZCCHC14	100	96.417	ENSSBOG00000024962	ZCCHC14	100	97.639	Saimiri_boliviensis_boliviensis
ENSG00000140948	ZCCHC14	96	81.730	ENSSHAG00000017090	ZCCHC14	72	84.653	Sarcophilus_harrisii
ENSG00000140948	ZCCHC14	81	44.944	ENSSFOG00015023625	-	87	50.000	Scleropages_formosus
ENSG00000140948	ZCCHC14	66	73.171	ENSSARG00000011864	-	70	73.171	Sorex_araneus
ENSG00000140948	ZCCHC14	96	74.265	ENSSPUG00000007612	-	100	74.310	Sphenodon_punctatus
ENSG00000140948	ZCCHC14	100	82.791	ENSSSCG00000002656	ZCCHC14	87	83.526	Sus_scrofa
ENSG00000140948	ZCCHC14	100	75.420	ENSTGUG00000007612	ZCCHC14	100	75.315	Taeniopygia_guttata
ENSG00000140948	ZCCHC14	93	88.340	ENSTBEG00000001210	ZCCHC14	100	86.417	Tupaia_belangeri
ENSG00000140948	ZCCHC14	76	84.232	ENSTTRG00000008840	ZCCHC14	76	84.094	Tursiops_truncatus
ENSG00000140948	ZCCHC14	76	84.232	ENSUAMG00000026990	ZCCHC14	100	83.120	Ursus_americanus
ENSG00000140948	ZCCHC14	78	87.755	ENSVPAG00000010067	ZCCHC14	89	80.160	Vicugna_pacos
ENSG00000140948	ZCCHC14	100	84.155	ENSVVUG00000000929	ZCCHC14	97	84.420	Vulpes_vulpes
ENSG00000140948	ZCCHC14	87	37.306	ENSXMAG00000023980	zcchc14	70	40.278	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0008270	zinc ion binding	-	IEA	Function
GO:0035091	phosphatidylinositol binding	-	IEA	Function