EuRBPDB

Description

Ensembl ID: ENSG00000141002 (Gene tree)
Gene ID: 22980
Gene Symbol: TCF25
Alias: Nulp1|KIAA1049
Full Name: transcription factor 25
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 40,058 bases
Position: chr16:89,873,570-89,913,627
Accession: 29181
RBP type: non-canonical RBP
Summary: TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000568412	TCF25-222	797	-	ENSP00000457329	265 (aa)	-	H3BTU3
ENST00000562193	TCF25-206	627	-	ENSP00000456344	209 (aa)	-	H3BRP4
ENST00000564957	TCF25-213	459	-	-	- (aa)	-	-
ENST00000563032	TCF25-208	274	-	-	- (aa)	-	-
ENST00000565404	TCF25-215	477	-	ENSP00000456592	146 (aa)	-	H3BS87
ENST00000561958	TCF25-204	763	-	ENSP00000456803	233 (aa)	-	H3BSP8
ENST00000566158	TCF25-217	373	-	-	- (aa)	-	-
ENST00000565196	TCF25-214	655	-	ENSP00000454414	210 (aa)	-	H3BMJ8
ENST00000564652	TCF25-212	860	-	ENSP00000456080	76 (aa)	-	H3BR53
ENST00000640279	TCF25-226	2688	-	ENSP00000491638	676 (aa)	-	Q9BQ70
ENST00000563636	TCF25-211	721	-	-	- (aa)	-	-
ENST00000568409	TCF25-221	857	-	ENSP00000456840	286 (aa)	-	H3BSS3
ENST00000263346	TCF25-201	2233	XM_005256297	ENSP00000263346	676 (aa)	XP_005256354	Q9BQ70
ENST00000561585	TCF25-203	981	-	-	- (aa)	-	-
ENST00000567171	TCF25-220	1535	-	-	- (aa)	-	-
ENST00000565860	TCF25-216	437	-	-	- (aa)	-	-
ENST00000263347	TCF25-202	2377	XM_011522961	ENSP00000263347	473 (aa)	XP_011521263	Q9H384
ENST00000563484	TCF25-210	468	-	-	- (aa)	-	-
ENST00000562256	TCF25-207	1879	-	ENSP00000455611	570 (aa)	-	H3BQ53
ENST00000614813	TCF25-225	2047	-	ENSP00000484773	216 (aa)	-	Q9H7D3
ENST00000566751	TCF25-219	383	-	-	- (aa)	-	-
ENST00000568870	TCF25-223	263	-	-	- (aa)	-	-
ENST00000570116	TCF25-224	1947	-	-	- (aa)	-	-
ENST00000566283	TCF25-218	515	-	ENSP00000455471	117 (aa)	-	H3BPU1
ENST00000563406	TCF25-209	561	-	-	- (aa)	-	-
ENST00000562184	TCF25-205	634	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141002	Eyebrows	7E-14	27182965

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141002	rs78498439	16	89901106	A	Self-reported math ability (MTAG)	30038396	[0.026-0.039] unit increase	0.0326	EFO_0004875
ENSG00000141002	rs78498439	16	89901106	A	Highest math class taken (MTAG)	30038396	[0.025-0.038] unit increase	0.0315	EFO_0004875
ENSG00000141002	rs78498439	16	89901106	?	Monobrow	27182965	[0.059-0.100] unit increase	0.079	EFO_0007906
ENSG00000141002	rs4785736	16	89903185	C	Red vs. brown/black hair color	30531825	NR	1.937	EFO_0003924
ENSG00000141002	rs8045560	16	89913086	C	Red vs. brown/black hair color	30531825	NR	7.44	EFO_0003924
ENSG00000141002	rs13335395	16	89886435	?	Age at menopause	30595370			EFO_0004704
ENSG00000141002	rs117243052	16	89890298	T	Brown vs. black hair color	30531825	NR	1.574	EFO_0003924

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141002	TCF25	100	90.385	ENSMUSG00000001472	Tcf25	99	96.330	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	16574069.	IDA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	16574069.	IDA	Function
GO:0005515	protein binding	16189514.19060904.21516116.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16574069.	IDA	Component
GO:0007507	heart development	16574069.	NAS	Process