EuRBPDB

Description

Ensembl ID: ENSG00000141030 (Gene tree)
Gene ID: 8533
Gene Symbol: COPS3
Alias: SGN3|CSN3
Full Name: COP9 signalosome subunit 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 34,680 bases
Position: chr17:17,246,624-17,281,303
Accession: 2239
RBP type: non-canonical RBP
Summary: The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471414	COPS3-206	455	-	-	- (aa)	-	-
ENST00000584216	COPS3-218	876	-	ENSP00000463098	107 (aa)	-	J3KTQ1
ENST00000417352	COPS3-202	1009	-	ENSP00000409028	318 (aa)	-	C9JLV5
ENST00000583160	COPS3-217	365	-	ENSP00000468536	122 (aa)	-	K7ES36
ENST00000439936	COPS3-203	1394	-	ENSP00000413298	345 (aa)	-	H7C3P9
ENST00000539941	COPS3-212	1699	XM_005256837	ENSP00000437606	403 (aa)	XP_005256894	Q9UNS2
ENST00000477299	COPS3-207	656	-	ENSP00000463195	116 (aa)	-	J3QKR0
ENST00000577210	COPS3-213	752	-	ENSP00000463340	20 (aa)	-	J3QL22
ENST00000492672	COPS3-210	809	-	ENSP00000463477	31 (aa)	-	J3QS85
ENST00000268717	COPS3-201	1641	-	ENSP00000268717	423 (aa)	-	Q9UNS2
ENST00000579716	COPS3-216	419	-	ENSP00000466153	51 (aa)	-	K7ELN6
ENST00000462236	COPS3-204	551	-	-	- (aa)	-	-
ENST00000463097	COPS3-205	288	-	-	- (aa)	-	-
ENST00000486032	COPS3-208	725	-	-	- (aa)	-	-
ENST00000495640	COPS3-211	333	-	ENSP00000465156	17 (aa)	-	K7EJF9
ENST00000578317	COPS3-215	1625	-	ENSP00000464572	31 (aa)	-	J3QS85
ENST00000486810	COPS3-209	938	-	-	- (aa)	-	-
ENST00000577246	COPS3-214	639	-	ENSP00000464369	20 (aa)	-	J3QL22

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141030	rs1029830	17	17280783	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000338	protein deneddylation	19141280.	IDA	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0005515	protein binding	11418127.12620389.15861129.18850735.19615732.20399188.24421388.25043011.26456823.26496610.27173435.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	9535219.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0007165	signal transduction	9535219.	TAS	Process
GO:0008180	COP9 signalosome	21873635.	IBA	Component
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0009416	response to light stimulus	9535219.	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process