EuRBPDB

Description

Ensembl ID: ENSG00000141279 (Gene tree)
Gene ID: 9520
Gene Symbol: NPEPPS
Alias: PSA|MP100
Full Name: aminopeptidase puromycin sensitive
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 100,335 bases
Position: chr17:47,522,942-47,623,276
Accession: 7900
RBP type: non-canonical RBP
Summary: This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527964	NPEPPS-211	554	-	ENSP00000435639	158 (aa)	-	E9PJ74
ENST00000525048	NPEPPS-205	534	-	ENSP00000432127	65 (aa)	-	H0YCQ5
ENST00000525021	NPEPPS-203	735	-	-	- (aa)	-	-
ENST00000530173	NPEPPS-215	2864	XM_017025373	ENSP00000433287	915 (aa)	XP_016880862	E9PLK3
ENST00000322157	NPEPPS-201	4353	XM_017025372	ENSP00000320324	919 (aa)	XP_016880861	P55786
ENST00000528751	NPEPPS-213	558	-	-	- (aa)	-	-
ENST00000533538	NPEPPS-219	1281	-	-	- (aa)	-	-
ENST00000528565	NPEPPS-212	558	-	ENSP00000433549	169 (aa)	-	H0YDG0
ENST00000529602	NPEPPS-214	512	-	-	- (aa)	-	-
ENST00000530514	NPEPPS-216	2092	-	ENSP00000436733	127 (aa)	-	E9PI82
ENST00000531486	NPEPPS-217	2290	-	-	- (aa)	-	-
ENST00000534727	NPEPPS-222	518	-	-	- (aa)	-	-
ENST00000533573	NPEPPS-220	559	-	-	- (aa)	-	-
ENST00000525401	NPEPPS-206	394	-	-	- (aa)	-	-
ENST00000534691	NPEPPS-221	548	-	ENSP00000433649	141 (aa)	-	E9PJY4
ENST00000534807	NPEPPS-223	838	-	-	- (aa)	-	-
ENST00000527298	NPEPPS-208	1569	-	ENSP00000434585	163 (aa)	-	E9PPD4
ENST00000525037	NPEPPS-204	1406	-	-	- (aa)	-	-
ENST00000602788	NPEPPS-225	4698	-	-	- (aa)	-	-
ENST00000532729	NPEPPS-218	711	-	ENSP00000434554	178 (aa)	-	E9PPZ2
ENST00000527360	NPEPPS-209	534	-	ENSP00000435966	172 (aa)	-	E9PRQ5
ENST00000526247	NPEPPS-207	678	-	ENSP00000433735	134 (aa)	-	E9PJF9
ENST00000527824	NPEPPS-210	684	-	-	- (aa)	-	-
ENST00000525007	NPEPPS-202	649	-	ENSP00000437019	201 (aa)	-	E9PP11
ENST00000534814	NPEPPS-224	512	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141279	Fatty Acids	4E-7	25378659
ENSG00000141279	Amyotrophic Lateral Sclerosis	5E-7	24234648
ENSG00000141279	Multiple Sclerosis	5E-7	24234648

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141279	rs62073968	17	47531904	G	Mean platelet volume	27863252	[0.022-0.04] unit decrease	0.03100656	EFO_0004584
ENSG00000141279	rs2935183	17	47530206	?	Multiple sclerosis or amyotrophic lateral sclerosis	24234648			EFO_0003885\|EFO_0000253
ENSG00000141279	rs8072100	17	47597321	A	Very long-chain saturated fatty acid levels (fatty acid 20:0)	25378659	[NR] Z score increase	5.059	EFO_0006796
ENSG00000141279	rs4793836	17	47592946	G	Self-reported math ability	30038396	[0.015-0.023] unit increase	0.019	EFO_0004875
ENSG00000141279	rs4793836	17	47592946	A	Self-reported math ability (MTAG)	30038396	[0.014-0.021] unit decrease	0.0171	EFO_0004875
ENSG00000141279	rs62074014	17	47591143	?	Total cholesterol levels	29403010	[0.018-0.035] unit decrease novel	0.02651	EFO_0004574

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141279	NPEPPS	100	54.430	YHR047C	AAP1	99	35.771	Saccharomyces_cerevisiae
ENSG00000141279	NPEPPS	100	55.063	YKL157W	APE2	89	35.525	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0004177	aminopeptidase activity	10329370.	TAS	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	21873635.	IBA	Process
GO:0008270	zinc ion binding	21873635.	IBA	Function
GO:0042277	peptide binding	21873635.	IBA	Function
GO:0043171	peptide catabolic process	21873635.	IBA	Process
GO:0070006	metalloaminopeptidase activity	21873635.	IBA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071456	cellular response to hypoxia	21056661.	IDA	Process
GO:1903955	positive regulation of protein targeting to mitochondrion	24270810.	HMP	Process