EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141367 (Gene tree)
Gene ID: 1213
Gene Symbol: CLTC
Alias: Hc|CLTCL2
Full Name: clathrin heavy chain
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 77,268 bases
Position: chr17:59,619,689-59,696,956
Accession: 2092
RBP type: non-canonical RBP
Summary: Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29328377	Feature genes in metastatic breast cancer identified by MetaDE and SVM classifier methods.	Mol Med Rep	2018 Mar	Tuo Y	doi: 10.3892/mmr.2018.8398
16428770	Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting.	Infect Immun	2006 Feb	Zhou Q	-
16716190	Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes.	Genes Cells	2006 Jun	Nakamura M	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498711	CLTC-209	2941	-	-	- (aa)	-	-
ENST00000466513	CLTC-203	793	-	-	- (aa)	-	-
ENST00000579815	CLTC-211	609	-	-	- (aa)	-	-
ENST00000483176	CLTC-207	760	-	ENSP00000463068	24 (aa)	-	J3KTN1
ENST00000496076	CLTC-208	678	-	-	- (aa)	-	-
ENST00000393043	CLTC-202	5292	-	ENSP00000376763	1639 (aa)	-	Q00610
ENST00000475458	CLTC-206	479	-	ENSP00000461977	131 (aa)	-	J3KRF5
ENST00000584313	CLTC-213	715	-	ENSP00000463336	97 (aa)	-	J3QL20
ENST00000579456	CLTC-210	2301	-	ENSP00000462252	612 (aa)	-	J3KS13
ENST00000472651	CLTC-205	665	-	ENSP00000465200	222 (aa)	-	K7EJJ5
ENST00000621829	CLTC-215	8587	-	ENSP00000479606	1679 (aa)	-	A0A087WVQ6
ENST00000472129	CLTC-204	654	-	-	- (aa)	-	-
ENST00000580081	CLTC-212	575	-	ENSP00000462592	122 (aa)	-	J3KSQ2
ENST00000585198	CLTC-214	477	-	-	- (aa)	-	-
ENST00000269122	CLTC-201	7760	XM_005257012	ENSP00000269122	1675 (aa)	XP_005257069	Q00610

Gene Model

Click here to download ENSG00000141367's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04142	Lysosome	KEGG
hsa04144	Endocytosis	KEGG
hsa04721	Synaptic vesicle cycle	KEGG
hsa04961	Endocrine and other factor-regulated calcium reabsorption	KEGG
hsa05016	Huntington disease	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141367	Platelet Function Tests	1.1218600E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141367's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141367	CLTC	99	72.352	WBGene00011867	chc-1	99	71.318	Caenorhabditis_elegans
ENSG00000141367	CLTC	100	100.000	ENSMUSG00000047126	Cltc	100	99.881	Mus_musculus
ENSG00000141367	CLTC	99	49.909	YGL206C	CHC1	99	49.909	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	15858577.	IMP	Process
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0005198	structural molecule activity	1765375.	NAS	Function
GO:0005515	protein binding	12429846.16902405.18548008.19478182.19536138.19798056.21297582.25107275.25241761.26005850.26496610.30021884.	IPI	Function
GO:0005764	lysosome	-	IDA	Component
GO:0005768	endosome	-	IDA	Component
GO:0005819	spindle	21873635.	IBA	Component
GO:0005819	spindle	15858577.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006886	intracellular protein transport	1765375.	NAS	Process
GO:0006898	receptor-mediated endocytosis	21873635.	IBA	Process
GO:0006898	receptor-mediated endocytosis	15858577.	IMP	Process
GO:0006914	autophagy	-	IEA	Process
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	-	ISS	Function
GO:0030118	clathrin coat	11756460.	IMP	Component
GO:0030118	clathrin coat	1765375.	NAS	Component
GO:0030130	clathrin coat of trans-Golgi network vesicle	-	IEA	Component
GO:0030132	clathrin coat of coated pit	-	IEA	Component
GO:0030136	clathrin-coated vesicle	19478182.	IDA	Component
GO:0030669	clathrin-coated endocytic vesicle membrane	-	TAS	Component
GO:0031623	receptor internalization	14985334.	IMP	Process
GO:0032051	clathrin light chain binding	21873635.	IBA	Function
GO:0032051	clathrin light chain binding	4066749.	IPI	Function
GO:0032588	trans-Golgi network membrane	-	TAS	Component
GO:0032802	low-density lipoprotein particle receptor catabolic process	-	TAS	Process
GO:0032991	protein-containing complex	21266579.	IDA	Component
GO:0033572	transferrin transport	14985334.	IMP	Process
GO:0034383	low-density lipoprotein particle clearance	-	TAS	Process
GO:0036020	endolysosome membrane	-	TAS	Component
GO:0042147	retrograde transport, endosome to Golgi	20065094.	IMP	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045334	clathrin-coated endocytic vesicle	21873635.	IBA	Component
GO:0045334	clathrin-coated endocytic vesicle	25898166.	NAS	Component
GO:0048268	clathrin coat assembly	21873635.	IBA	Process
GO:0048268	clathrin coat assembly	11756460.	IMP	Process
GO:0050750	low-density lipoprotein particle receptor binding	26005850.	IPI	Function
GO:0051301	cell division	-	IEA	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0060236	regulation of mitotic spindle organization	21297582.	IMP	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	12519789.19056867.19199708.20458337.21362503.23533145.	HDA	Component
GO:0071439	clathrin complex	21873635.	IBA	Component
GO:0071439	clathrin complex	4066749.	IDA	Component
GO:0072583	clathrin-dependent endocytosis	26005850.	IMP	Process
GO:0072686	mitotic spindle	-	IDA	Component
GO:0097718	disordered domain specific binding	11756460.	IPI	Function
GO:0150093	amyloid-beta clearance by transcytosis	26005850.	IMP	Process
GO:1900126	negative regulation of hyaluronan biosynthetic process	24251095.	IDA	Process
GO:1900126	negative regulation of hyaluronan biosynthetic process	23509262.	IMP	Process
GO:1903077	negative regulation of protein localization to plasma membrane	19581412.	IMP	Process
GO:1903561	extracellular vesicle	24769233.	HDA	Component
GO:1990381	ubiquitin-specific protease binding	26756164.	IPI	Function
GO:1990498	mitotic spindle microtubule	21297582.	IDA	Component