EuRBPDB

Description

Ensembl ID: ENSG00000141425 (Gene tree)
Gene ID: 55197
Gene Symbol: RPRD1A
Alias: P15RS|FLJ10656|HsT3101
Full Name: regulation of nuclear pre-mRNA domain containing 1A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 83,208 bases
Position: chr18:35,984,387-36,067,594
Accession: 25560
RBP type: non-canonical RBP
Summary: This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000585953	RPRD1A-204	2357	-	ENSP00000467268	123 (aa)	-	K7EP82
ENST00000591994	RPRD1A-210	2484	-	-	- (aa)	-	-
ENST00000399022	RPRD1A-202	4438	-	ENSP00000381984	312 (aa)	-	Q96P16
ENST00000590898	RPRD1A-209	1945	XM_011526049	ENSP00000467991	276 (aa)	XP_011524351	Q96P16
ENST00000592674	RPRD1A-211	566	-	ENSP00000467949	73 (aa)	-	K7EQR8
ENST00000357384	RPRD1A-201	1850	XM_011526048	ENSP00000349955	312 (aa)	XP_011524350	Q96P16
ENST00000585879	RPRD1A-203	425	-	ENSP00000468173	4 (aa)	-	UPI0002668323
ENST00000589050	RPRD1A-208	1022	-	ENSP00000468209	289 (aa)	-	A0A0C4DGQ6
ENST00000588737	RPRD1A-207	1264	XM_017025808	ENSP00000465444	276 (aa)	XP_016881297	Q96P16
ENST00000588459	RPRD1A-206	576	-	-	- (aa)	-	-
ENST00000587563	RPRD1A-205	643	-	ENSP00000468108	49 (aa)	-	K7ER50

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141425	rs17562912	18	36003353	?	Tenofovir clearance in HIV infection	26148204			EFO_0009279\|EFO_0000764
ENSG00000141425	rs28791905	18	36022250	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141425	RPRD1A	100	65.846	ENSMUSG00000027651	Rprd1b	100	65.846	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0005515	protein binding	24997600.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016591	RNA polymerase II, holoenzyme	21873635.	IBA	Component
GO:0016591	RNA polymerase II, holoenzyme	22231121.	IDA	Component
GO:0031124	mRNA 3'-end processing	21873635.	IBA	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain	22231121.	IMP	Process