EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000141556 (Gene tree)
Gene ID: 6904
Gene Symbol: TBCD
Alias: N
Full Name: tubulin folding cofactor D
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 193,863 bases
Position: chr17:82,752,060-82,945,922
Accession: 11581
RBP type: non-canonical RBP
Summary: Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11854408	Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae.	Mol Biol Cell	2002 Feb	Du LL	-
19962308	Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control.	Curr Biol	2009 Dec 29	Jansen JM	doi: 10.1016/j.cub.2009.10.071
19570907	Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells.	Mol Biol Cell	2009 Sep	Li L	doi: 10.1091/mbc.E09-04-0347
24465507	Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.	PLoS One	2014 Jan 21	Wanless AG	doi: 10.1371/journal.pone.0085212
28877986	Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1.	Mol Biol Cell	2017 Nov 1	Kurischko C	doi: 10.1091/mbc.E17-02-0100
31141453	Ssd1 and the Cell Wall Integrity Pathway promote entry, maintenance and recovery from the quiescent state in budding yeast.	Mol Biol Cell	2019 May 29:mbcE19040190	Miles S	doi: 10.1091/mbc.E19-04-0190

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000574818	TBCD-215	771	-	-	- (aa)	-	-
ENST00000574975	TBCD-217	867	-	ENSP00000461680	251 (aa)	-	I3L500
ENST00000572794	TBCD-209	1380	-	ENSP00000458916	68 (aa)	-	I3L1L0
ENST00000576160	TBCD-219	942	-	ENSP00000458535	141 (aa)	-	I3L131
ENST00000576760	TBCD-224	1059	-	ENSP00000460949	256 (aa)	-	I3L439
ENST00000355528	TBCD-201	7168	XM_005256396	ENSP00000347719	1192 (aa)	XP_005256453	Q9BTW9
ENST00000576677	TBCD-222	1926	-	-	- (aa)	-	-
ENST00000576432	TBCD-220	684	-	-	- (aa)	-	-
ENST00000576996	TBCD-225	827	-	ENSP00000460450	134 (aa)	-	I3L3H4
ENST00000571316	TBCD-204	1509	-	ENSP00000458365	237 (aa)	-	I3L0V3
ENST00000574422	TBCD-213	879	-	ENSP00000458599	244 (aa)	-	I3L163
ENST00000571796	TBCD-207	1940	-	-	- (aa)	-	-
ENST00000574886	TBCD-216	883	-	-	- (aa)	-	-
ENST00000577051	TBCD-226	979	-	ENSP00000458512	260 (aa)	-	I3L120
ENST00000571618	TBCD-205	775	-	-	- (aa)	-	-
ENST00000539345	TBCD-202	3975	-	ENSP00000440671	1230 (aa)	-	J3KR97
ENST00000572984	TBCD-211	682	-	ENSP00000461167	109 (aa)	-	I3L4D2
ENST00000576691	TBCD-223	929	-	-	- (aa)	-	-
ENST00000571712	TBCD-206	850	-	ENSP00000459063	117 (aa)	-	I3L1S3
ENST00000573364	TBCD-212	626	-	-	- (aa)	-	-
ENST00000574801	TBCD-214	586	-	-	- (aa)	-	-
ENST00000572953	TBCD-210	702	-	ENSP00000458556	211 (aa)	-	I3L143
ENST00000575132	TBCD-218	707	-	-	- (aa)	-	-
ENST00000576603	TBCD-221	765	-	-	- (aa)	-	-
ENST00000572389	TBCD-208	776	-	-	- (aa)	-	-
ENST00000570679	TBCD-203	689	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141556's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141556	Body Height	9.0110000E-005	-
ENSG00000141556	Platelet Function Tests	1.9358800E-005	-
ENSG00000141556	Resistin	1.8630000E-005	-
ENSG00000141556	Adrenal Cortex Hormones	3E-8	26025128
ENSG00000141556	Asthma	3E-8	26025128
ENSG00000141556	Bone Density	3E-8	26025128

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141556	rs9896933	17	82940212	?	Bone mineral accretion in asthma (oral corticosteroid dose interaction)	26025128			EFO_0007591\|GO_0031960\|EFO_0000270
ENSG00000141556	rs79316200	17	82935712	T	Blond vs. brown/black hair color	30531825	NR	1.082	EFO_0003924
ENSG00000141556	rs35653278	17	82831592	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141556's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	27666370.	IMP	Process
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005096	GTPase activator activity	20740604.	IDA	Function
GO:0005096	GTPase activator activity	10831612.	IMP	Function
GO:0005515	protein binding	10831612.21044950.27666374.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005813	centrosome	27666370.	IDA	Component
GO:0005874	microtubule	8706133.	TAS	Component
GO:0005912	adherens junction	21873635.	IBA	Component
GO:0005912	adherens junction	-	ISS	Component
GO:0005923	bicellular tight junction	21873635.	IBA	Component
GO:0005923	bicellular tight junction	-	ISS	Component
GO:0006457	protein folding	21873635.	IBA	Process
GO:0006457	protein folding	20740604.	IDA	Process
GO:0006457	protein folding	8706133.	TAS	Process
GO:0007021	tubulin complex assembly	28158450.	IDA	Process
GO:0007023	post-chaperonin tubulin folding pathway	11847227.	IDA	Process
GO:0010812	negative regulation of cell-substrate adhesion	-	ISS	Process
GO:0016328	lateral plasma membrane	21873635.	IBA	Component
GO:0016328	lateral plasma membrane	-	ISS	Component
GO:0031115	negative regulation of microtubule polymerization	10831612.20740604.	IDA	Process
GO:0034333	adherens junction assembly	21873635.	IBA	Process
GO:0034333	adherens junction assembly	-	ISS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0048487	beta-tubulin binding	21873635.	IBA	Function
GO:0048487	beta-tubulin binding	10831612.	IDA	Function
GO:0048667	cell morphogenesis involved in neuron differentiation	27666374.	IMP	Process
GO:0051087	chaperone binding	8706133.	TAS	Function
GO:0070830	bicellular tight junction assembly	21873635.	IBA	Process
GO:0070830	bicellular tight junction assembly	-	ISS	Process