EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000141577 (Gene tree)
Gene ID: 22994
Gene Symbol: CEP131
Alias: AZ1|KIAA1118|AZI1
Full Name: centrosomal protein 131
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,407 bases
Position: chr17:81,189,593-81,222,999
Accession: 29511
RBP type: non-canonical RBP
Summary: (Centrosomal Protein 131) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570482	CEP131-204	613	-	-	- (aa)	-	-
ENST00000269392	CEP131-201	3673	XM_011524547	ENSP00000269392	1083 (aa)	XP_011522849	Q9UPN4
ENST00000374782	CEP131-202	3505	-	ENSP00000363914	1044 (aa)	-	Q9UPN4
ENST00000571292	CEP131-206	619	-	ENSP00000460098	206 (aa)	-	I3L316
ENST00000570817	CEP131-205	1160	-	ENSP00000461374	307 (aa)	-	I3L4M5
ENST00000575907	CEP131-208	3444	XM_011524552	ENSP00000459733	1047 (aa)	XP_011522854	I3L2J8
ENST00000450824	CEP131-203	3543	XM_011524548	ENSP00000393583	1080 (aa)	XP_011522850	Q9UPN4
ENST00000573053	CEP131-207	1747	-	ENSP00000460006	524 (aa)	-	I3L2X7

Gene Model

Click here to download ENSG00000141577's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	8E-7	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	8E-7	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	8E-7	26154020
ENSG00000141577	Frontotemporal Dementia	8E-7	26154020
ENSG00000141577	Frontotemporal Dementia	4E-6	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	8E-7	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	4E-6	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020
ENSG00000141577	Frontotemporal Dementia	4E-6	26154020
ENSG00000141577	Immunoglobulins	4E-7	23382691
ENSG00000141577	Frontotemporal Dementia	4E-6	26154020
ENSG00000141577	Frontotemporal Dementia	1E-7	26154020
ENSG00000141577	Frontotemporal Dementia	4E-6	26154020
ENSG00000141577	Frontotemporal Dementia	7E-6	26154020

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141577	rs906175	17	81199662	T	Frontotemporal dementia	26154020	[1.33-1.87]	1.58	Orphanet_282
ENSG00000141577	rs2279913	17	81194468	C	IgG glycosylation	23382691	[0.097-0.219] unit increase	0.1579	EFO_0005193
ENSG00000141577	rs9319617	17	81218646	C	IgG galactosylation phenotypes (multivariate analysis)	28878392			EFO_0008425
ENSG00000141577	rs9319617	17	81218646	C	IgG N-glycosylation phenotypes (multivariate analysis)	28878392			EFO_0005193
ENSG00000141577	rs8071210	17	81211018	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141577's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0001669	acrosomal vesicle	-	IEA	Component
GO:0005515	protein binding	22797915.24089205.24407287.24550735.24816561.26297806.26638075.	IPI	Function
GO:0005813	centrosome	21399614.22797915.24550735.	IDA	Component
GO:0005813	centrosome	14654843.	IDA	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	22797915.	IMP	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0010824	regulation of centrosome duplication	21873635.	IBA	Process
GO:0010824	regulation of centrosome duplication	22797915.	IMP	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0030154	cell differentiation	-	IEA	Process
GO:0034451	centriolar satellite	21873635.	IBA	Component
GO:0034451	centriolar satellite	22797915.24550735.26297806.	IDA	Component
GO:0035735	intraciliary transport involved in cilium assembly	24550735.	IMP	Process
GO:0035869	ciliary transition zone	24415959.	IDA	Component
GO:0042803	protein homodimerization activity	24550735.	IDA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0044877	protein-containing complex binding	24550735.	IDA	Function
GO:0045171	intercellular bridge	-	IDA	Component
GO:0060271	cilium assembly	21873635.	IBA	Process
GO:0071539	protein localization to centrosome	26297806.	IMP	Process
GO:0090316	positive regulation of intracellular protein transport	24550735.	IMP	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	81197017	Silent	NA	L565L	0.56
BLCA	chr17	81199790	Nonsense_Mutation	novel	Q318*	0.19
BLCA	chr17	81194958	Silent	novel	L680L	0.1
BLCA	chr17	81196746	Silent	novel	E621E	1
BLCA	chr17	81192577	Missense_Mutation	novel	E819K	0.4
BLCA	chr17	81190997	Silent	NA	L954L	0.16
BLCA	chr17	81191038	Missense_Mutation	NA	E941Q	0.2
BLCA	chr17	81190721	Missense_Mutation	novel	E1012K	0.53
BLCA	chr17	81191200	Missense_Mutation	rs577025986	E923K	0.24
BLCA	chr17	81193999	Missense_Mutation	rs763110139	E753K	0.63
BLCA	chr17	81191044	Missense_Mutation	novel	E939K	0.17
BLCA	chr17	81195880	Missense_Mutation	rs760427864	Q660H	0.19
BLCA	chr17	81202312	Nonsense_Mutation	novel	S239*	0.19
BRCA	chr17	81197039	Missense_Mutation	rs573786538	A558V	0.29
BRCA	chr17	81207152	Silent	rs766135433	S120S	0.25
BRCA	chr17	81198874	Splice_Region	novel		0.13
BRCA	chr17	81194950	Missense_Mutation	NA	L683S	0.15
BRCA	chr17	81194970	Missense_Mutation	novel	E676D	0.14
BRCA	chr17	81198951	Missense_Mutation	NA	G405S	0.49
BRCA	chr17	81199441	Nonsense_Mutation	NA	Q378*	0.51
BRCA	chr17	81191244	Missense_Mutation	novel	E908G	0.16
CESC	chr17	81194968	Missense_Mutation	novel	I677N	0.19
CESC	chr17	81191029	Missense_Mutation	NA	E944Q	0.15
CESC	chr17	81198941	Missense_Mutation	novel	D408G	0.37
CESC	chr17	81189647	3'UTR	novel		0.5
COAD	chr17	81195943	Silent	NA	E639E	0.35
COAD	chr17	81199733	Nonsense_Mutation	novel	R337*	0.44
COAD	chr17	81191060	Silent	rs772025386	Y933Y	0.3
COAD	chr17	81189675	3'UTR	novel		0.14
COAD	chr17	81202382	Missense_Mutation	novel	A216T	0.3
COAD	chr17	81199538	Missense_Mutation	novel	Q345H	0.3
COAD	chr17	81189976	Splice_Site	novel	X1039_splice	0.14
COAD	chr17	81197803	Missense_Mutation	novel	T522M	0.25
COAD	chr17	81203580	Silent	rs375867858	C181C	0.38
COAD	chr17	81191077	Missense_Mutation	rs753513530	R928C	0.24
COAD	chr17	81200360	Missense_Mutation	rs575624973	R292H	0.35
COAD	chr17	81189799	Silent	novel	Q1074Q	0.21
COAD	chr17	81189918	Silent	novel	H1058H	0.07
COAD	chr17	81191247	Missense_Mutation	novel	L907P	0.22
COAD	chr17	81207197	Silent	NA	S105S	0.16
COAD	chr17	81194951	Missense_Mutation	novel	L683V	0.12
COAD	chr17	81208938	Missense_Mutation	rs144582854	G88S	0.58
COAD	chr17	81192331	Missense_Mutation	rs771409290	R873H	0.38
COAD	chr17	81191304	Missense_Mutation	novel	L888P	0.05
COAD	chr17	81194873	Nonsense_Mutation	novel	R709*	0.14
COAD	chr17	81208960	Silent	rs140020797	T80T	0.2
COAD	chr17	81198168	Missense_Mutation	rs556177324	V473M	0.27
COAD	chr17	81206796	Missense_Mutation	rs151144885	R155W	0.33
COAD	chr17	81196825	Missense_Mutation	rs376678293	A595V	0.12
ESCA	chr17	81191200	Missense_Mutation	rs577025986	E923K	0.38
ESCA	chr17	81190975	Missense_Mutation	rs755773021	E962K	0.41
GBM	chr17	81190753	Missense_Mutation	rs537921227	R1001H	0.22
GBM	chr17	81202254	Missense_Mutation	novel	E258D	0.6
GBM	chr17	81196826	Missense_Mutation	NA	A595T	0.59
GBM	chr17	81189668	3'UTR	rs578140420		0.49
GBM	chr17	81194926	Missense_Mutation	novel	R691H	0.28
HNSC	chr17	81189883	Intron	novel		0.09
HNSC	chr17	81208979	Missense_Mutation	novel	R74I	0.45
HNSC	chr17	81202270	Missense_Mutation	novel	R253L	0.22
HNSC	chr17	81191212	Missense_Mutation	novel	E919K	0.14
HNSC	chr17	81189826	Silent	rs748731729	A1065A	0.08
HNSC	chr17	81219948	Missense_Mutation	novel	A37T	0.33
KIRC	chr17	81195844	Missense_Mutation	NA	Q672H	0.08
KIRC	chr17	81192753	Silent	NA	L807L	0.17
KIRC	chr17	81194874	Frame_Shift_Del	novel	*V708Efs10**	0.22
KIRP	chr17	81191283	Missense_Mutation	NA	G895V	0.19
KIRP	chr17	81192582	Missense_Mutation	novel	E817G	0.27
KIRP	chr17	81219880	Splice_Region	novel	L59L	0.14
LGG	chr17	81196754	Nonsense_Mutation	novel	Q619*	0.43
LGG	chr17	81199511	Silent	novel	A354A	0.31
LIHC	chr17	81219899	Missense_Mutation	NA	E53V	0.2
LIHC	chr17	81196993	Silent	NA	V573V	0.45
LIHC	chr17	81194068	Nonsense_Mutation	novel	K730*	0.05
LUAD	chr17	81195907	Silent	novel	V651V	0.22
LUAD	chr17	81194881	Missense_Mutation	rs761833623	V706A	0.08
LUAD	chr17	81192736	Missense_Mutation	novel	R813K	0.11
LUAD	chr17	81203494	Missense_Mutation	novel	N210S	0.3
LUAD	chr17	81199501	Nonsense_Mutation	NA	E358*	0.29
LUAD	chr17	81220023	Missense_Mutation	novel	E12K	0.31
LUAD	chr17	81206832	Missense_Mutation	rs146148645	R143W	0.19
LUAD	chr17	81191240	Silent	NA	A909A	0.16
LUAD	chr17	81208988	Missense_Mutation	NA	N71S	0.3
LUSC	chr17	81219968	Missense_Mutation	novel	S30Y	0.68
LUSC	chr17	81206830	Silent	novel	R143R	0.31
LUSC	chr17	81191238	Missense_Mutation	novel	D910V	0.27
LUSC	chr17	81202326	Silent	novel	S234S	0.17
LUSC	chr17	81189711	3'UTR	novel		0.21
LUSC	chr17	81202306	Missense_Mutation	novel	R241L	0.2
LUSC	chr17	81190746	Missense_Mutation	NA	E1003D	0.13
LUSC	chr17	81202314	Missense_Mutation	novel	H238Q	0.17
OV	chr17	81191275	Missense_Mutation	novel	K898E	0.16
OV	chr17	81199763	Missense_Mutation	NA	A327S	0.45
OV	chr17	81189956	Nonsense_Mutation	novel	A1045_R1046insAAFQ	0.69
OV	chr17	81190987	Missense_Mutation	NA	L958V	0.8
OV	chr17	81206860	Silent	NA	P133P	0.09
OV	chr17	81189839	Missense_Mutation	rs774586774	A1061V	0.5
PAAD	chr17	81192337	Missense_Mutation	novel	A871V	0.2
PAAD	chr17	81207233	Silent	novel	T93T	0.18
SARC	chr17	81219962	Missense_Mutation	rs530864094	R32H	0.33
SARC	chr17	81189839	Missense_Mutation	rs774586774	A1061V	0.69
SARC	chr17	81199512	Missense_Mutation	novel	A354E	0.09
SARC	chr17	81191200	Missense_Mutation	rs577025986	E923K	0.27
SKCM	chr17	81207218	Silent	NA	F98F	0.35
SKCM	chr17	81194928	Silent	NA	A690A	0.83
SKCM	chr17	81219982	Silent	NA	L25L	0.26
SKCM	chr17	81203499	Silent	NA	S208S	0.35
SKCM	chr17	81219916	Silent	NA	S47S	0.54
SKCM	chr17	81196708	Missense_Mutation	NA	I634S	0.32
SKCM	chr17	81199760	Missense_Mutation	novel	R328W	0.5
SKCM	chr17	81199761	Silent	novel	A327A	0.5
SKCM	chr17	81207218	Silent	NA	F98F	0.19
SKCM	chr17	81198160	Silent	novel	P475P	0.29
SKCM	chr17	81206780	Missense_Mutation	novel	T160I	0.33
SKCM	chr17	81196956	Missense_Mutation	NA	A586T	0.21
SKCM	chr17	81192362	Missense_Mutation	NA	E863K	0.23
SKCM	chr17	81192527	Silent	NA	A835A	0.38
SKCM	chr17	81190743	Silent	rs139538707	F1004F	0.35
SKCM	chr17	81207136	Missense_Mutation	NA	W126R	0.18
SKCM	chr17	81203518	Missense_Mutation	NA	S202F	0.33
SKCM	chr17	81197840	Nonsense_Mutation	NA	K510*	0.55
SKCM	chr17	81189832	Missense_Mutation	novel	K1063N	0.26
SKCM	chr17	81208933	Silent	novel	S89S	0.14
SKCM	chr17	81199773	Silent	novel	A323A	0.83
SKCM	chr17	81197721	Silent	novel	S549S	0.18
STAD	chr17	81193990	Missense_Mutation	rs769897028	R756W	0.3
STAD	chr17	81202270	Missense_Mutation	rs376964153	R253Q	0.16
STAD	chr17	81199452	Missense_Mutation	rs373880117	R374Q	0.29
STAD	chr17	81191025	Missense_Mutation	rs111464253	R945Q	0.26
STAD	chr17	81197822	Missense_Mutation	rs144147050	E516K	0.38
STAD	chr17	81206862	Missense_Mutation	NA	P133S	0.44
STAD	chr17	81207192	Missense_Mutation	NA	S107T	0.57
STAD	chr17	81194123	Silent	novel	L711L	0.57
STAD	chr17	81189674	3'UTR	novel		0.26
STAD	chr17	81191054	Silent	rs201159775	A935A	0.15
STAD	chr17	81194078	Silent	novel	V726V	0.36
STAD	chr17	81195848	Missense_Mutation	rs368812421	A671V	0.4
STAD	chr17	81203536	Missense_Mutation	rs750232619	A196V	0.19
STAD	chr17	81199815	Silent	NA	G309G	0.2
STAD	chr17	81199452	Missense_Mutation	rs373880117	R374Q	0.38
STAD	chr17	81193999	Missense_Mutation	rs763110139	E753K	0.22
STAD	chr17	81199812	Missense_Mutation	NA	E310D	0.12
STAD	chr17	81191004	Missense_Mutation	rs773523503	S952L	0.39
UCEC	chr17	81194954	Nonsense_Mutation	NA	E682*	0.29
UCEC	chr17	81199829	Missense_Mutation	rs375208941	R305W	0.27
UCEC	chr17	81199498	Missense_Mutation	rs763309058	R359C	0.32
UCEC	chr17	81208939	Silent	rs148304893	S87S	0.48
UCEC	chr17	81197005	Silent	novel	V569V	0.22
UCEC	chr17	81196957	Missense_Mutation	novel	Q585H	0.08
UCEC	chr17	81198973	Splice_Site	novel	X398_splice	0.19
UCEC	chr17	81198119	Missense_Mutation	rs182537101	S489N	0.37
UCEC	chr17	81199530	Missense_Mutation	novel	A348D	0.11
UCEC	chr17	81207160	Missense_Mutation	novel	A118T	0.3
UCEC	chr17	81198965	Missense_Mutation	NA	G400D	0.33
UCEC	chr17	81203545	Missense_Mutation	rs796803247	S193L	0.59
UCEC	chr17	81198883	Missense_Mutation	novel	R427S	0.29
UCEC	chr17	81189702	3'UTR	novel		0.31
UCEC	chr17	81190925	Silent	rs755756902	A978A	0.23
UCEC	chr17	81195847	Silent	rs367990055	A671A	0.58
UCEC	chr17	81190914	Missense_Mutation	rs780940898	A982V	0.14
UCEC	chr17	81192589	Missense_Mutation	rs746435622	R815W	0.43
UCEC	chr17	81189942	Silent	rs775549243	A1050A	0.35
UCEC	chr17	81191006	Silent	novel	C951C	0.46
UCEC	chr17	81196757	Missense_Mutation	novel	R618W	0.1
UCEC	chr17	81203580	Silent	rs375867858	C181C	0.33
UCEC	chr17	81192566	Silent	novel	R822R	0.32
UCEC	chr17	81193948	Missense_Mutation	novel	E770K	0.6
UCEC	chr17	81194927	Missense_Mutation	rs143625194	R691C	0.44
UCEC	chr17	81206747	Missense_Mutation	novel	N171T	0.3
UCEC	chr17	81195916	Silent	rs368017972	C648C	0.31
UCEC	chr17	81196802	Missense_Mutation	rs150527009	R603W	0.34
UCEC	chr17	81199451	Silent	rs756128984	R374R	0.23
UCEC	chr17	81198973	Splice_Site	NA	X398_splice	0.28
UCEC	chr17	81189883	Intron	novel		0.57
UCEC	chr17	81189942	Silent	rs775549243	A1050A	0.14
UCEC	chr17	81189831	Missense_Mutation	rs371210650	R1064W	0.36
UCEC	chr17	81195871	Silent	rs138282299	T663T	0.43
UCEC	chr17	81189920	Missense_Mutation	novel	H1058Y	0.35
UCEC	chr17	81195863	Missense_Mutation	novel	V666A	0.51
UCS	chr17	81206797	Silent	rs781565082	P154P	0.13
UVM	chr17	81192811	Missense_Mutation	rs754140951	A788V	0.37
UVM	chr17	81219965	Missense_Mutation	rs372370793	R31Q	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3897	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0643	1.52e-05
LIHC	AMP	0.3622	1.3152e-14
SARC	AMP	0.2179	0.032181
SKCM	AMP	0.2861	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.027	Kaplan-Meier Survival Analysis
SARC	0.0025	Kaplan-Meier Survival Analysis
MESO	0.0018	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
BRCA	0.038	Kaplan-Meier Survival Analysis
KIRP	0.023	Kaplan-Meier Survival Analysis
PAAD	0.00019	Kaplan-Meier Survival Analysis
BLCA	0.028	Kaplan-Meier Survival Analysis
CESC	0.0056	Kaplan-Meier Survival Analysis
LAML	0.039	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742