EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141642 (Gene tree)
Gene ID: 55520
Gene Symbol: ELAC1
Alias: D29
Full Name: elaC ribonuclease Z 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 20,131 bases
Position: chr18:50,967,991-50,988,121
Accession: 14197
RBP type: canonical RBP
Summary: (ElaC Ribonuclease Z 1) is a Protein Coding gene. Among its related pathways are RNA transport. Gene Ontology (GO) annotations related to this gene include endoribonuclease activity, producing 5'-phosphomonoesters and 3'-tRNA processing endoribonuclease activity. An important paralog of this gene is ELAC2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000464770	Lactamase_B_4	PF13691.6	1.9e-07	1	1
ENSP00000269466	Lactamase_B_4	PF13691.6	5.1e-07	1	1
ENSP00000269466	Lactamase_B	PF00753.27	7.6e-11	1	1
ENSP00000464770	Lactamase_B	PF00753.27	2.7e-10	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000586966	ELAC1-202	1505	-	-	- (aa)	-	-
ENST00000269466	ELAC1-201	2235	-	ENSP00000269466	363 (aa)	-	Q9H777
ENST00000591429	ELAC1-204	975	-	ENSP00000464770	223 (aa)	-	K7EIJ1
ENST00000588577	ELAC1-203	694	-	ENSP00000467389	88 (aa)	-	K7EPH7

Gene Model

Click here to download ENSG00000141642's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141642	Hemoglobin A, Glycosylated	6.2800000E-005	19875614
ENSG00000141642	Cytokines	2E-7	22610502
ENSG00000141642	Vaccine Potency	2E-7	22610502
ENSG00000141642	Multiple Sclerosis	8E-7	25616667
ENSG00000141642	Oligoclonal Bands	8E-7	25616667

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141642	rs8088712	18	50988025	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141642's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141642	ELAC1	100	58.152	ENSAPOG00000003911	elac1	99	58.152	Acanthochromis_polyacanthus
ENSG00000141642	ELAC1	100	93.188	ENSAMEG00000002931	ELAC1	99	93.188	Ailuropoda_melanoleuca
ENSG00000141642	ELAC1	100	58.424	ENSAOCG00000013054	elac1	99	58.424	Amphiprion_ocellaris
ENSG00000141642	ELAC1	100	58.424	ENSAPEG00000004222	elac1	99	58.424	Amphiprion_percula
ENSG00000141642	ELAC1	100	56.757	ENSATEG00000015907	elac1	99	56.757	Anabas_testudineus
ENSG00000141642	ELAC1	70	73.885	ENSAPLG00000007218	ELAC1	100	75.217	Anas_platyrhynchos
ENSG00000141642	ELAC1	100	71.901	ENSACAG00000010178	ELAC1	93	71.901	Anolis_carolinensis
ENSG00000141642	ELAC1	100	98.347	ENSANAG00000035626	ELAC1	100	98.347	Aotus_nancymaae
ENSG00000141642	ELAC1	100	57.880	ENSACLG00000016736	elac1	99	58.266	Astatotilapia_calliptera
ENSG00000141642	ELAC1	93	54.976	ENSAMXG00000043092	elac1	85	54.321	Astyanax_mexicanus
ENSG00000141642	ELAC1	100	94.215	ENSBTAG00000005683	ELAC1	100	94.215	Bos_taurus
ENSG00000141642	ELAC1	100	96.694	ENSCJAG00000001925	ELAC1	100	96.694	Callithrix_jacchus
ENSG00000141642	ELAC1	100	94.766	ENSCAFG00000000166	ELAC1	100	94.766	Canis_familiaris
ENSG00000141642	ELAC1	100	94.766	ENSCAFG00020021678	ELAC1	100	94.766	Canis_lupus_dingo
ENSG00000141642	ELAC1	100	94.215	ENSCHIG00000014278	ELAC1	100	94.215	Capra_hircus
ENSG00000141642	ELAC1	100	93.956	ENSTSYG00000005985	-	100	93.956	Carlito_syrichta
ENSG00000141642	ELAC1	100	94.490	ENSCAPG00000012671	ELAC1	100	94.490	Cavia_aperea
ENSG00000141642	ELAC1	100	94.490	ENSCPOG00000012588	ELAC1	100	94.490	Cavia_porcellus
ENSG00000141642	ELAC1	100	97.796	ENSCCAG00000035586	ELAC1	100	97.796	Cebus_capucinus
ENSG00000141642	ELAC1	100	99.174	ENSCATG00000036385	ELAC1	100	99.174	Cercocebus_atys
ENSG00000141642	ELAC1	100	95.041	ENSCLAG00000008334	ELAC1	100	95.041	Chinchilla_lanigera
ENSG00000141642	ELAC1	100	92.837	ENSCHOG00000002863	ELAC1	100	92.837	Choloepus_hoffmanni
ENSG00000141642	ELAC1	100	77.961	ENSCPBG00000025613	ELAC1	99	77.961	Chrysemys_picta_bellii
ENSG00000141642	ELAC1	93	49.038	ENSCING00000004292	-	99	43.889	Ciona_intestinalis
ENSG00000141642	ELAC1	100	99.174	ENSCANG00000025643	ELAC1	100	99.174	Colobus_angolensis_palliatus
ENSG00000141642	ELAC1	100	92.837	ENSCGRG00001008766	Elac1	100	92.837	Cricetulus_griseus_chok1gshd
ENSG00000141642	ELAC1	100	92.837	ENSCGRG00000002780	Elac1	100	92.837	Cricetulus_griseus_crigri
ENSG00000141642	ELAC1	100	58.808	ENSCSEG00000017064	elac1	100	58.808	Cynoglossus_semilaevis
ENSG00000141642	ELAC1	100	63.043	ENSCVAG00000011103	elac1	98	63.043	Cyprinodon_variegatus
ENSG00000141642	ELAC1	100	57.337	ENSDARG00000045095	elac1	99	57.337	Danio_rerio
ENSG00000141642	ELAC1	100	94.490	ENSDORG00000025215	Elac1	100	94.490	Dipodomys_ordii
ENSG00000141642	ELAC1	100	85.675	ENSETEG00000003871	ELAC1	100	85.675	Echinops_telfairi
ENSG00000141642	ELAC1	93	49.333	ENSEBUG00000003774	elac1	95	51.020	Eptatretus_burgeri
ENSG00000141642	ELAC1	100	95.868	ENSEASG00005003810	ELAC1	69	95.868	Equus_asinus_asinus
ENSG00000141642	ELAC1	100	95.592	ENSECAG00000016230	ELAC1	69	95.592	Equus_caballus
ENSG00000141642	ELAC1	100	92.837	ENSEEUG00000010128	ELAC1	100	92.837	Erinaceus_europaeus
ENSG00000141642	ELAC1	100	57.065	ENSELUG00000020106	elac1	99	57.065	Esox_lucius
ENSG00000141642	ELAC1	100	95.592	ENSFCAG00000039876	ELAC1	100	95.592	Felis_catus
ENSG00000141642	ELAC1	94	66.667	ENSFALG00000013601	ELAC1	99	66.986	Ficedula_albicollis
ENSG00000141642	ELAC1	100	93.939	ENSFDAG00000009939	ELAC1	100	93.939	Fukomys_damarensis
ENSG00000141642	ELAC1	99	59.128	ENSGMOG00000007878	elac1	100	59.128	Gadus_morhua
ENSG00000141642	ELAC1	100	60.326	ENSGAFG00000013386	elac1	99	60.326	Gambusia_affinis
ENSG00000141642	ELAC1	100	59.511	ENSGACG00000007275	elac1	100	59.511	Gasterosteus_aculeatus
ENSG00000141642	ELAC1	100	99.449	ENSGGOG00000002624	ELAC1	100	99.449	Gorilla_gorilla
ENSG00000141642	ELAC1	100	58.424	ENSHBUG00000011212	elac1	99	58.808	Haplochromis_burtoni
ENSG00000141642	ELAC1	100	95.041	ENSHGLG00000004360	ELAC1	100	95.041	Heterocephalus_glaber_female
ENSG00000141642	ELAC1	100	95.041	ENSHGLG00100009228	ELAC1	100	95.041	Heterocephalus_glaber_male
ENSG00000141642	ELAC1	100	59.459	ENSHCOG00000007752	elac1	99	59.459	Hippocampus_comes
ENSG00000141642	ELAC1	100	94.262	ENSSTOG00000010591	ELAC1	100	94.262	Ictidomys_tridecemlineatus
ENSG00000141642	ELAC1	100	93.113	ENSJJAG00000010672	Elac1	100	93.113	Jaculus_jaculus
ENSG00000141642	ELAC1	100	59.511	ENSKMAG00000015019	elac1	98	59.511	Kryptolebias_marmoratus
ENSG00000141642	ELAC1	100	59.239	ENSLBEG00000016660	elac1	100	59.239	Labrus_bergylta
ENSG00000141642	ELAC1	100	69.126	ENSLACG00000016367	ELAC1	99	68.852	Latimeria_chalumnae
ENSG00000141642	ELAC1	100	62.735	ENSLOCG00000012870	elac1	99	63.003	Lepisosteus_oculatus
ENSG00000141642	ELAC1	100	94.505	ENSLAFG00000001538	ELAC1	100	94.505	Loxodonta_africana
ENSG00000141642	ELAC1	85	99.032	ENSMFAG00000004789	ELAC1	100	99.032	Macaca_fascicularis
ENSG00000141642	ELAC1	100	99.449	ENSMMUG00000003127	ELAC1	100	99.449	Macaca_mulatta
ENSG00000141642	ELAC1	100	98.898	ENSMNEG00000034310	ELAC1	100	98.898	Macaca_nemestrina
ENSG00000141642	ELAC1	100	98.898	ENSMLEG00000042560	ELAC1	100	98.898	Mandrillus_leucophaeus
ENSG00000141642	ELAC1	100	57.995	ENSMAMG00000000619	elac1	99	57.995	Mastacembelus_armatus
ENSG00000141642	ELAC1	100	57.880	ENSMZEG00005005839	elac1	99	58.266	Maylandia_zebra
ENSG00000141642	ELAC1	76	84.211	ENSMAUG00000000413	-	86	88.608	Mesocricetus_auratus
ENSG00000141642	ELAC1	100	95.592	ENSMICG00000017524	ELAC1	100	95.592	Microcebus_murinus
ENSG00000141642	ELAC1	100	93.113	ENSMOCG00000013625	Elac1	100	93.113	Microtus_ochrogaster
ENSG00000141642	ELAC1	100	58.967	ENSMMOG00000000351	elac1	100	58.967	Mola_mola
ENSG00000141642	ELAC1	100	82.369	ENSMODG00000010972	ELAC1	99	82.369	Monodelphis_domestica
ENSG00000141642	ELAC1	100	60.705	ENSMALG00000016039	elac1	92	60.705	Monopterus_albus
ENSG00000141642	ELAC1	100	92.011	MGP_CAROLIEiJ_G0022393	Elac1	100	92.011	Mus_caroli
ENSG00000141642	ELAC1	100	91.736	ENSMUSG00000036941	Elac1	100	91.736	Mus_musculus
ENSG00000141642	ELAC1	100	91.736	MGP_PahariEiJ_G0019121	Elac1	100	91.736	Mus_pahari
ENSG00000141642	ELAC1	100	92.011	MGP_SPRETEiJ_G0023306	Elac1	100	92.011	Mus_spretus
ENSG00000141642	ELAC1	100	95.868	ENSMPUG00000008787	ELAC1	100	95.868	Mustela_putorius_furo
ENSG00000141642	ELAC1	100	94.231	ENSMLUG00000013941	ELAC1	100	94.231	Myotis_lucifugus
ENSG00000141642	ELAC1	100	93.388	ENSNGAG00000011863	Elac1	100	93.388	Nannospalax_galili
ENSG00000141642	ELAC1	100	58.808	ENSNBRG00000013006	elac1	99	58.808	Neolamprologus_brichardi
ENSG00000141642	ELAC1	100	99.174	ENSNLEG00000011855	ELAC1	100	99.174	Nomascus_leucogenys
ENSG00000141642	ELAC1	100	83.471	ENSMEUG00000016758	ELAC1	99	83.471	Notamacropus_eugenii
ENSG00000141642	ELAC1	100	89.256	ENSOPRG00000013590	ELAC1	100	89.256	Ochotona_princeps
ENSG00000141642	ELAC1	100	94.215	ENSODEG00000018368	ELAC1	100	94.215	Octodon_degus
ENSG00000141642	ELAC1	100	58.065	ENSONIG00000015083	elac1	99	58.065	Oreochromis_niloticus
ENSG00000141642	ELAC1	94	77.143	ENSOANG00000008118	ELAC1	97	76.991	Ornithorhynchus_anatinus
ENSG00000141642	ELAC1	100	89.560	ENSOCUG00000009509	ELAC1	93	89.560	Oryctolagus_cuniculus
ENSG00000141642	ELAC1	100	59.239	ENSORLG00000004777	elac1	89	59.239	Oryzias_latipes
ENSG00000141642	ELAC1	100	59.239	ENSORLG00020020737	elac1	100	59.239	Oryzias_latipes_hni
ENSG00000141642	ELAC1	100	59.239	ENSORLG00015009175	elac1	100	59.239	Oryzias_latipes_hsok
ENSG00000141642	ELAC1	100	59.239	ENSOMEG00000022868	elac1	100	59.239	Oryzias_melastigma
ENSG00000141642	ELAC1	100	94.490	ENSOGAG00000012076	ELAC1	100	94.490	Otolemur_garnettii
ENSG00000141642	ELAC1	100	92.055	ENSOARG00000004626	ELAC1	100	92.055	Ovis_aries
ENSG00000141642	ELAC1	100	100.000	ENSPPAG00000036817	ELAC1	100	100.000	Pan_paniscus
ENSG00000141642	ELAC1	100	95.317	ENSPPRG00000009439	ELAC1	100	95.317	Panthera_pardus
ENSG00000141642	ELAC1	100	95.592	ENSPTIG00000006619	ELAC1	100	95.592	Panthera_tigris_altaica
ENSG00000141642	ELAC1	100	100.000	ENSPTRG00000010027	ELAC1	100	100.000	Pan_troglodytes
ENSG00000141642	ELAC1	100	99.174	ENSPANG00000026392	ELAC1	100	99.174	Papio_anubis
ENSG00000141642	ELAC1	100	59.788	ENSPKIG00000016890	elac1	99	59.788	Paramormyrops_kingsleyae
ENSG00000141642	ELAC1	100	75.758	ENSPSIG00000015619	ELAC1	99	75.758	Pelodiscus_sinensis
ENSG00000141642	ELAC1	99	60.090	ENSPMGG00000015036	elac1	99	58.424	Periophthalmus_magnuspinnatus
ENSG00000141642	ELAC1	100	93.388	ENSPEMG00000002394	Elac1	99	93.388	Peromyscus_maniculatus_bairdii
ENSG00000141642	ELAC1	58	73.077	ENSPMAG00000007852	elac1	100	45.130	Petromyzon_marinus
ENSG00000141642	ELAC1	100	82.920	ENSPCIG00000014958	ELAC1	99	82.920	Phascolarctos_cinereus
ENSG00000141642	ELAC1	100	60.054	ENSPFOG00000019172	elac1	99	60.054	Poecilia_formosa
ENSG00000141642	ELAC1	100	59.783	ENSPFOG00000019162	ELAC1	99	59.783	Poecilia_formosa
ENSG00000141642	ELAC1	100	59.783	ENSPLAG00000001605	elac1	99	59.783	Poecilia_latipinna
ENSG00000141642	ELAC1	100	59.783	ENSPMEG00000008966	elac1	99	59.783	Poecilia_mexicana
ENSG00000141642	ELAC1	100	60.054	ENSPREG00000018030	elac1	99	60.054	Poecilia_reticulata
ENSG00000141642	ELAC1	100	99.449	ENSPPYG00000009164	ELAC1	100	99.449	Pongo_abelii
ENSG00000141642	ELAC1	100	96.419	ENSPCOG00000026213	ELAC1	100	96.419	Propithecus_coquereli
ENSG00000141642	ELAC1	100	86.777	ENSPVAG00000002036	ELAC1	100	86.777	Pteropus_vampyrus
ENSG00000141642	ELAC1	100	57.796	ENSPNYG00000009829	elac1	99	57.796	Pundamilia_nyererei
ENSG00000141642	ELAC1	100	92.287	ENSRNOG00000000113	Elac1	100	92.287	Rattus_norvegicus
ENSG00000141642	ELAC1	100	99.449	ENSRBIG00000042639	ELAC1	100	99.449	Rhinopithecus_bieti
ENSG00000141642	ELAC1	100	99.449	ENSRROG00000037616	ELAC1	100	99.449	Rhinopithecus_roxellana
ENSG00000141642	ELAC1	100	98.072	ENSSBOG00000019881	ELAC1	100	98.072	Saimiri_boliviensis_boliviensis
ENSG00000141642	ELAC1	100	83.516	ENSSHAG00000014409	ELAC1	99	83.516	Sarcophilus_harrisii
ENSG00000141642	ELAC1	100	60.870	ENSSFOG00015020776	elac1	99	60.870	Scleropages_formosus
ENSG00000141642	ELAC1	100	57.880	ENSSMAG00000001449	elac1	99	57.880	Scophthalmus_maximus
ENSG00000141642	ELAC1	100	58.152	ENSSDUG00000022411	elac1	98	58.152	Seriola_dumerili
ENSG00000141642	ELAC1	100	58.152	ENSSLDG00000020819	elac1	100	58.152	Seriola_lalandi_dorsalis
ENSG00000141642	ELAC1	100	91.460	ENSSARG00000005180	ELAC1	100	91.460	Sorex_araneus
ENSG00000141642	ELAC1	100	60.054	ENSSPAG00000000888	elac1	99	60.054	Stegastes_partitus
ENSG00000141642	ELAC1	100	95.868	ENSSSCG00000024479	ELAC1	100	95.868	Sus_scrofa
ENSG00000141642	ELAC1	94	66.986	ENSTGUG00000015891	ELAC1	100	66.986	Taeniopygia_guttata
ENSG00000141642	ELAC1	99	62.667	ENSTRUG00000013094	elac1	98	59.946	Takifugu_rubripes
ENSG00000141642	ELAC1	99	59.946	ENSTNIG00000017591	elac1	99	59.946	Tetraodon_nigroviridis
ENSG00000141642	ELAC1	93	94.712	ENSTBEG00000014012	ELAC1	100	94.712	Tupaia_belangeri
ENSG00000141642	ELAC1	83	93.729	ENSTTRG00000012101	ELAC1	100	93.729	Tursiops_truncatus
ENSG00000141642	ELAC1	100	94.766	ENSUAMG00000015748	ELAC1	100	94.766	Ursus_americanus
ENSG00000141642	ELAC1	100	94.766	ENSUMAG00000003132	ELAC1	100	94.766	Ursus_maritimus
ENSG00000141642	ELAC1	100	94.766	ENSVPAG00000006756	ELAC1	100	94.766	Vicugna_pacos
ENSG00000141642	ELAC1	100	94.766	ENSVVUG00000014595	ELAC1	100	94.766	Vulpes_vulpes
ENSG00000141642	ELAC1	100	69.972	ENSXETG00000027126	elac1	99	69.972	Xenopus_tropicalis
ENSG00000141642	ELAC1	99	59.563	ENSXCOG00000005255	elac1	98	59.563	Xiphophorus_couchianus
ENSG00000141642	ELAC1	99	59.290	ENSXMAG00000015453	elac1	98	59.290	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21593607.	IDA	Component
GO:0005829	cytosol	21593607.	IDA	Component
GO:0034414	tRNA 3'-trailer cleavage, endonucleolytic	-	IEA	Process
GO:0042781	3'-tRNA processing endoribonuclease activity	21873635.	IBA	Function
GO:0046872	metal ion binding	-	IEA	Function