EuRBPDB

Description

Ensembl ID: ENSG00000142186 (Gene tree)
Gene ID: 57410
Gene Symbol: SCYL1
Alias: HT019|P105|GKLP|NKTL|TAPK|TRAP|TEIF|MGC78454|NTKL
Full Name: SCY1 like pseudokinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,647 bases
Position: chr11:65,525,065-65,538,711
Accession: 14372
RBP type: non-canonical RBP
Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14729709	Regulation of the tryptophan biosynthetic genes in Bacillus halodurans: common elements but different strategies than those used by Bacillus subtilis.	J Bacteriol	2004 Feb	Szigeti R	-
18801747	The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition.	J Biol Chem	2008 Nov 21	Sudhamsu J	doi: 10.1074/jbc.M804837200
28004350	Identification of an RNA aptamer binding hTERT-derived peptide and inhibiting telomerase activity in MCF7 cells.	Mol Cell Biochem	2017 Mar	Varshney A	doi: 10.1007/s11010-016-2907-7
14976255	Recycling of a regulatory protein by degradation of the RNA to which it binds.	Proc Natl Acad Sci U S A	2004 Mar 2	Deikus G	-
18556652	Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.	J Biol Chem	2008 Aug 15	Burman JL	doi: 10.1074/jbc.M801869200

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000270176	SCYL1-201	2642	XM_005274118	ENSP00000270176	808 (aa)	XP_005274175	Q96KG9
ENST00000529981	SCYL1-211	497	-	-	- (aa)	-	-
ENST00000524897	SCYL1-204	820	-	-	- (aa)	-	-
ENST00000420247	SCYL1-203	2583	XM_017018030	ENSP00000408192	791 (aa)	XP_016873519	Q96KG9
ENST00000534462	SCYL1-215	579	-	-	- (aa)	-	-
ENST00000279270	SCYL1-202	1659	-	ENSP00000279270	270 (aa)	-	A0A0A0MQX4
ENST00000524944	SCYL1-205	2715	-	ENSP00000432175	775 (aa)	-	E9PS17
ENST00000528545	SCYL1-209	981	-	ENSP00000433604	280 (aa)	-	H0YDH0
ENST00000532290	SCYL1-213	856	-	-	- (aa)	-	-
ENST00000533862	SCYL1-214	2570	-	ENSP00000437254	787 (aa)	-	Q96KG9
ENST00000531601	SCYL1-212	896	-	ENSP00000431664	175 (aa)	-	H0YCI6
ENST00000529178	SCYL1-210	696	-	-	- (aa)	-	-
ENST00000525364	SCYL1-206	2584	XM_005274120	ENSP00000431635	780 (aa)	XP_005274177	E9PK59
ENST00000527009	SCYL1-208	2586	XM_017018033	ENSP00000436993	665 (aa)	XP_016873522	E9PPN3
ENST00000526454	SCYL1-207	954	-	-	- (aa)	-	-

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142186	SCYL1	100	90.741	ENSMUSG00000024941	Scyl1	100	90.741	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0004713	protein tyrosine kinase activity	10843802.	NAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	12783284.	ISS	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	18556652.	IDA	Component
GO:0005794	Golgi apparatus	18556652.	IDA	Component
GO:0005801	cis-Golgi network	18556652.	IDA	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	18556652.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0030126	COPI vesicle coat	18556652.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function