EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000142230 (Gene tree)
Gene ID: 10055
Gene Symbol: SAE1
Alias: AOS1|FLJ3091|Sua1
Full Name: SUMO1 activating enzyme subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 97,363 bases
Position: chr19:47,113,274-47,210,636
Accession: 30660
RBP type: non-canonical RBP
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000594144	SAE1-205	723	-	ENSP00000471010	157 (aa)	-	M0R054
ENST00000600706	SAE1-210	744	-	ENSP00000468931	205 (aa)	-	M0QX65
ENST00000596995	SAE1-207	2106	-	ENSP00000473037	50 (aa)	-	M0R375
ENST00000270225	SAE1-201	2049	XM_006722963	ENSP00000270225	346 (aa)	XP_006723026	Q9UBE0
ENST00000597808	SAE1-208	570	-	ENSP00000469938	133 (aa)	-	M0QYM8
ENST00000392776	SAE1-202	1851	-	ENSP00000440818	266 (aa)	-	Q9UBE0
ENST00000594526	SAE1-206	709	-	ENSP00000472389	98 (aa)	-	M0R286
ENST00000598840	SAE1-209	1831	-	ENSP00000470741	265 (aa)	-	M0QZS6
ENST00000413379	SAE1-203	2313	XM_006722965	ENSP00000416557	299 (aa)	XP_006723028	Q9UBE0
ENST00000600753	SAE1-211	483	-	ENSP00000469978	71 (aa)	-	M0QYP2
ENST00000414294	SAE1-204	2211	-	ENSP00000398818	299 (aa)	-	B3KNJ4

Gene Model

Click here to download ENSG00000142230's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000142230	Multiple Sclerosis	5E-7	21833088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000142230	rs307896	19	47158236	G	Multiple sclerosis	21833088	[1.08-1.11]	1.09	EFO_0003885
ENSG00000142230	rs307896	19	47158236	?	Multiple sclerosis and triglyceride levels (pleiotropy)	26920376	[1.0574-1.1396]		EFO_0003885\|EFO_0004530
ENSG00000142230	rs3745621	19	47186664	G	Lymphocyte counts	27863252	[0.026-0.042] unit increase	0.03376649	EFO_0004587
ENSG00000142230	rs309190	19	47126007	C	White blood cell count	27863252	[0.023-0.046] unit decrease	0.03460707	EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142230's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004839	ubiquitin activating enzyme activity	10187858.	TAS	Function
GO:0005515	protein binding	15660128.16189514.20164921.26496610.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	10187858.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008022	protein C-terminus binding	10187858.	IDA	Function
GO:0008047	enzyme activator activity	9920803.	TAS	Function
GO:0016567	protein ubiquitination	10187858.	TAS	Process
GO:0016925	protein sumoylation	21873635.	IBA	Process
GO:0016925	protein sumoylation	15660128.20164921.	IDA	Process
GO:0016925	protein sumoylation	-	IEA	Process
GO:0016925	protein sumoylation	21968017.	IMP	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0019948	SUMO activating enzyme activity	21873635.	IBA	Function
GO:0019948	SUMO activating enzyme activity	20164921.	IDA	Function
GO:0031510	SUMO activating enzyme complex	21873635.	IBA	Component
GO:0031510	SUMO activating enzyme complex	15660128.20164921.	IDA	Component
GO:0032446	protein modification by small protein conjugation	21873635.	IBA	Process
GO:0043008	ATP-dependent protein binding	10187858.	IDA	Function
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0044388	small protein activating enzyme binding	15660128.	IPI	Function
GO:0046982	protein heterodimerization activity	15660128.	IDA	Function
GO:0046982	protein heterodimerization activity	20164921.	IPI	Function
GO:0046982	protein heterodimerization activity	10187858.	TAS	Function
GO:1903955	positive regulation of protein targeting to mitochondrion	24270810.	HMP	Process