EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000142252 (Gene tree)
Gene ID: 79760
Gene Symbol: GEMIN7
Alias: FLJ13956
Full Name: gem nuclear organelle associated protein 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 15,786 bases
Position: chr19:45,075,739-45,091,524
Accession: 20045
RBP type: canonical RBP
Summary: The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear \gems\" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000270257	Gemin7	PF11095.8	9e-33	1	1
ENSP00000375813	Gemin7	PF11095.8	9e-33	1	1
ENSP00000465704	Gemin7	PF11095.8	9e-33	1	1
ENSP00000466342	Gemin7	PF11095.8	9e-33	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000270257	GEMIN7-201	1657	XM_005259262	ENSP00000270257	131 (aa)	XP_005259319	Q9H840
ENST00000591607	GEMIN7-203	848	XM_005259263	ENSP00000466342	131 (aa)	XP_005259320	Q9H840
ENST00000391951	GEMIN7-202	716	XM_017027312	ENSP00000375813	131 (aa)	XP_016882801	Q9H840
ENST00000592351	GEMIN7-205	429	-	-	- (aa)	-	-
ENST00000591747	GEMIN7-204	576	-	ENSP00000465704	131 (aa)	-	Q9H840

Gene Model

Click here to download ENSG00000142252's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000142252	Intelligence Tests	2.1358100E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000142252	rs78620885	19	45087826	?	Alzheimer's disease or family history of Alzheimer's disease	29777097			EFO_0000249\|EFO_0009268
ENSG00000142252	rs8100183	19	45081434	?	Alzheimer's disease or family history of Alzheimer's disease	29777097			EFO_0000249\|EFO_0009268
ENSG00000142252	rs9653111	19	45089217	T	Alzheimer's disease or family history of Alzheimer's disease	30617256	NR z-unit decrease	5.6693845	EFO_0000249\|EFO_0009268

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142252's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142252	GEMIN7	93	53.226	ENSAPOG00000016954	gemin7	83	53.226	Acanthochromis_polyacanthus
ENSG00000142252	GEMIN7	100	86.260	ENSAMEG00000019697	GEMIN7	100	86.260	Ailuropoda_melanoleuca
ENSG00000142252	GEMIN7	93	53.226	ENSACIG00000005522	gemin7	96	53.226	Amphilophus_citrinellus
ENSG00000142252	GEMIN7	93	50.394	ENSAOCG00000024101	gemin7	96	50.394	Amphiprion_ocellaris
ENSG00000142252	GEMIN7	93	50.394	ENSAPEG00000010856	gemin7	96	50.394	Amphiprion_percula
ENSG00000142252	GEMIN7	93	52.419	ENSATEG00000012989	gemin7	96	52.419	Anabas_testudineus
ENSG00000142252	GEMIN7	96	54.688	ENSACAG00000004282	GEMIN7	95	54.688	Anolis_carolinensis
ENSG00000142252	GEMIN7	100	95.420	ENSANAG00000019968	GEMIN7	100	95.420	Aotus_nancymaae
ENSG00000142252	GEMIN7	93	53.226	ENSACLG00000017160	gemin7	88	53.226	Astatotilapia_calliptera
ENSG00000142252	GEMIN7	96	53.125	ENSAMXG00000025854	gemin7	99	53.125	Astyanax_mexicanus
ENSG00000142252	GEMIN7	100	78.626	ENSBTAG00000010668	GEMIN7	100	80.916	Bos_taurus
ENSG00000142252	GEMIN7	60	35.897	WBGene00007702	C24H11.5	85	35.897	Caenorhabditis_elegans
ENSG00000142252	GEMIN7	100	97.710	ENSCJAG00000022315	-	100	97.710	Callithrix_jacchus
ENSG00000142252	GEMIN7	100	96.947	ENSCJAG00000047637	-	100	96.947	Callithrix_jacchus
ENSG00000142252	GEMIN7	100	86.260	ENSCAFG00000004570	GEMIN7	100	86.260	Canis_familiaris
ENSG00000142252	GEMIN7	100	86.260	ENSCAFG00020012296	GEMIN7	100	86.260	Canis_lupus_dingo
ENSG00000142252	GEMIN7	100	83.969	ENSCHIG00000010022	GEMIN7	100	83.969	Capra_hircus
ENSG00000142252	GEMIN7	99	83.846	ENSCAPG00000016241	GEMIN7	99	83.846	Cavia_aperea
ENSG00000142252	GEMIN7	99	85.385	ENSCPOG00000037844	GEMIN7	99	85.385	Cavia_porcellus
ENSG00000142252	GEMIN7	100	79.389	ENSCATG00000029958	-	100	79.389	Cercocebus_atys
ENSG00000142252	GEMIN7	100	97.710	ENSCATG00000015354	GEMIN7	100	97.710	Cercocebus_atys
ENSG00000142252	GEMIN7	100	95.420	ENSCSAG00000019622	GEMIN7	100	95.420	Chlorocebus_sabaeus
ENSG00000142252	GEMIN7	100	85.496	ENSCHOG00000010012	GEMIN7	100	85.496	Choloepus_hoffmanni
ENSG00000142252	GEMIN7	99	58.015	ENSCPBG00000014394	GEMIN7	99	58.015	Chrysemys_picta_bellii
ENSG00000142252	GEMIN7	57	48.000	ENSCING00000018224	-	87	48.000	Ciona_intestinalis
ENSG00000142252	GEMIN7	56	41.892	ENSCSAVG00000004480	-	86	41.892	Ciona_savignyi
ENSG00000142252	GEMIN7	100	78.626	ENSCANG00000034839	-	100	78.626	Colobus_angolensis_palliatus
ENSG00000142252	GEMIN7	99	81.818	ENSCGRG00001013306	Gemin7	99	81.818	Cricetulus_griseus_chok1gshd
ENSG00000142252	GEMIN7	99	80.303	ENSCGRG00000019443	Gemin7	99	80.303	Cricetulus_griseus_crigri
ENSG00000142252	GEMIN7	93	54.032	ENSCSEG00000008152	gemin7	96	54.032	Cynoglossus_semilaevis
ENSG00000142252	GEMIN7	94	54.400	ENSCVAG00000005214	gemin7	97	54.400	Cyprinodon_variegatus
ENSG00000142252	GEMIN7	96	49.206	ENSDARG00000041011	gemin7	99	49.206	Danio_rerio
ENSG00000142252	GEMIN7	99	83.846	ENSDNOG00000019933	GEMIN7	96	83.846	Dasypus_novemcinctus
ENSG00000142252	GEMIN7	90	81.356	ENSDORG00000027339	Gemin7	99	78.030	Dipodomys_ordii
ENSG00000142252	GEMIN7	100	87.786	ENSEASG00005013777	GEMIN7	100	87.786	Equus_asinus_asinus
ENSG00000142252	GEMIN7	100	88.550	ENSECAG00000005915	GEMIN7	100	88.550	Equus_caballus
ENSG00000142252	GEMIN7	93	52.033	ENSELUG00000014034	gemin7	96	52.033	Esox_lucius
ENSG00000142252	GEMIN7	100	83.206	ENSFCAG00000043198	GEMIN7	100	83.206	Felis_catus
ENSG00000142252	GEMIN7	100	82.443	ENSFDAG00000004461	GEMIN7	100	82.443	Fukomys_damarensis
ENSG00000142252	GEMIN7	93	54.839	ENSFHEG00000006645	gemin7	96	54.839	Fundulus_heteroclitus
ENSG00000142252	GEMIN7	95	50.781	ENSGMOG00000019844	gemin7	96	50.781	Gadus_morhua
ENSG00000142252	GEMIN7	93	54.839	ENSGAFG00000012101	gemin7	96	54.839	Gambusia_affinis
ENSG00000142252	GEMIN7	95	48.837	ENSGACG00000009619	gemin7	95	48.837	Gasterosteus_aculeatus
ENSG00000142252	GEMIN7	100	99.237	ENSGGOG00000037037	GEMIN7	100	99.237	Gorilla_gorilla
ENSG00000142252	GEMIN7	100	84.733	ENSGGOG00000025251	-	100	84.733	Gorilla_gorilla
ENSG00000142252	GEMIN7	93	53.226	ENSHBUG00000002286	gemin7	96	53.226	Haplochromis_burtoni
ENSG00000142252	GEMIN7	100	85.496	ENSHGLG00000019901	GEMIN7	100	85.496	Heterocephalus_glaber_female
ENSG00000142252	GEMIN7	100	85.496	ENSHGLG00100020531	GEMIN7	100	85.496	Heterocephalus_glaber_male
ENSG00000142252	GEMIN7	94	50.000	ENSHCOG00000007043	gemin7	97	50.400	Hippocampus_comes
ENSG00000142252	GEMIN7	99	53.030	ENSIPUG00000004094	gemin7	99	53.030	Ictalurus_punctatus
ENSG00000142252	GEMIN7	99	90.000	ENSSTOG00000033006	GEMIN7	99	90.000	Ictidomys_tridecemlineatus
ENSG00000142252	GEMIN7	96	50.794	ENSJJAG00000000292	Gemin7	99	50.794	Jaculus_jaculus
ENSG00000142252	GEMIN7	93	53.226	ENSKMAG00000021331	gemin7	96	53.226	Kryptolebias_marmoratus
ENSG00000142252	GEMIN7	93	53.226	ENSLBEG00000020367	gemin7	96	53.226	Labrus_bergylta
ENSG00000142252	GEMIN7	96	49.606	ENSLACG00000000843	-	96	49.606	Latimeria_chalumnae
ENSG00000142252	GEMIN7	96	55.118	ENSLACG00000005844	gemin7	98	55.118	Latimeria_chalumnae
ENSG00000142252	GEMIN7	96	54.762	ENSLOCG00000017726	gemin7	94	54.762	Lepisosteus_oculatus
ENSG00000142252	GEMIN7	99	86.923	ENSLAFG00000016380	GEMIN7	99	86.923	Loxodonta_africana
ENSG00000142252	GEMIN7	100	98.473	ENSMFAG00000030305	GEMIN7	100	98.473	Macaca_fascicularis
ENSG00000142252	GEMIN7	100	70.229	ENSMFAG00000002457	-	100	70.229	Macaca_fascicularis
ENSG00000142252	GEMIN7	100	96.947	ENSMMUG00000039904	GEMIN7	100	96.947	Macaca_mulatta
ENSG00000142252	GEMIN7	100	96.183	ENSMMUG00000037567	-	100	96.183	Macaca_mulatta
ENSG00000142252	GEMIN7	100	70.229	ENSMMUG00000043051	-	100	70.229	Macaca_mulatta
ENSG00000142252	GEMIN7	100	97.710	ENSMNEG00000022258	GEMIN7	100	97.710	Macaca_nemestrina
ENSG00000142252	GEMIN7	100	60.902	ENSMNEG00000033837	-	100	60.902	Macaca_nemestrina
ENSG00000142252	GEMIN7	100	96.947	ENSMLEG00000028032	GEMIN7	100	96.947	Mandrillus_leucophaeus
ENSG00000142252	GEMIN7	100	74.809	ENSMLEG00000029956	-	100	74.809	Mandrillus_leucophaeus
ENSG00000142252	GEMIN7	93	50.000	ENSMAMG00000011153	gemin7	96	50.000	Mastacembelus_armatus
ENSG00000142252	GEMIN7	93	53.226	ENSMZEG00005016459	gemin7	96	53.226	Maylandia_zebra
ENSG00000142252	GEMIN7	99	82.576	ENSMAUG00000018897	Gemin7	99	82.576	Mesocricetus_auratus
ENSG00000142252	GEMIN7	91	83.193	ENSMOCG00000019633	Gemin7	99	81.818	Microtus_ochrogaster
ENSG00000142252	GEMIN7	94	52.800	ENSMMOG00000012350	gemin7	97	52.800	Mola_mola
ENSG00000142252	GEMIN7	94	53.600	ENSMMOG00000016733	-	97	53.600	Mola_mola
ENSG00000142252	GEMIN7	94	53.600	ENSMMOG00000012348	gemin7	97	53.600	Mola_mola
ENSG00000142252	GEMIN7	93	53.226	ENSMALG00000011818	gemin7	96	53.226	Monopterus_albus
ENSG00000142252	GEMIN7	99	81.343	MGP_CAROLIEiJ_G0029297	Gemin7	99	81.343	Mus_caroli
ENSG00000142252	GEMIN7	99	81.343	ENSMUSG00000044709	Gemin7	99	81.343	Mus_musculus
ENSG00000142252	GEMIN7	99	80.597	MGP_PahariEiJ_G0021157	Gemin7	99	80.597	Mus_pahari
ENSG00000142252	GEMIN7	99	81.343	MGP_SPRETEiJ_G0030381	Gemin7	99	81.343	Mus_spretus
ENSG00000142252	GEMIN7	100	86.260	ENSMPUG00000019379	GEMIN7	100	86.260	Mustela_putorius_furo
ENSG00000142252	GEMIN7	94	84.553	ENSMLUG00000002175	GEMIN7	97	84.553	Myotis_lucifugus
ENSG00000142252	GEMIN7	99	85.606	ENSNGAG00000018443	Gemin7	99	85.606	Nannospalax_galili
ENSG00000142252	GEMIN7	93	53.226	ENSNBRG00000005377	gemin7	96	53.226	Neolamprologus_brichardi
ENSG00000142252	GEMIN7	97	77.165	ENSNLEG00000001923	-	92	77.165	Nomascus_leucogenys
ENSG00000142252	GEMIN7	100	98.473	ENSNLEG00000001846	GEMIN7	100	98.473	Nomascus_leucogenys
ENSG00000142252	GEMIN7	95	64.000	ENSMEUG00000010052	GEMIN7	96	64.000	Notamacropus_eugenii
ENSG00000142252	GEMIN7	100	82.443	ENSODEG00000009107	GEMIN7	100	82.443	Octodon_degus
ENSG00000142252	GEMIN7	93	53.226	ENSONIG00000020468	gemin7	92	53.226	Oreochromis_niloticus
ENSG00000142252	GEMIN7	94	60.163	ENSOANG00000008945	GEMIN7	92	60.163	Ornithorhynchus_anatinus
ENSG00000142252	GEMIN7	93	55.645	ENSORLG00000006826	gemin7	96	55.645	Oryzias_latipes
ENSG00000142252	GEMIN7	93	54.839	ENSORLG00020002840	gemin7	96	54.839	Oryzias_latipes_hni
ENSG00000142252	GEMIN7	93	55.645	ENSORLG00015004977	gemin7	96	55.645	Oryzias_latipes_hsok
ENSG00000142252	GEMIN7	93	54.839	ENSOMEG00000009758	gemin7	96	54.839	Oryzias_melastigma
ENSG00000142252	GEMIN7	100	90.840	ENSOGAG00000014987	GEMIN7	100	90.840	Otolemur_garnettii
ENSG00000142252	GEMIN7	95	72.581	ENSOARG00000011421	GEMIN7	93	72.581	Ovis_aries
ENSG00000142252	GEMIN7	100	99.237	ENSPPAG00000023831	GEMIN7	100	99.237	Pan_paniscus
ENSG00000142252	GEMIN7	100	83.206	ENSPPAG00000032293	-	100	83.206	Pan_paniscus
ENSG00000142252	GEMIN7	100	83.969	ENSPPRG00000014746	GEMIN7	100	83.969	Panthera_pardus
ENSG00000142252	GEMIN7	100	83.969	ENSPTIG00000000303	GEMIN7	100	83.969	Panthera_tigris_altaica
ENSG00000142252	GEMIN7	100	99.237	ENSPTRG00000044428	GEMIN7	100	99.237	Pan_troglodytes
ENSG00000142252	GEMIN7	100	97.710	ENSPANG00000012354	GEMIN7	100	97.710	Papio_anubis
ENSG00000142252	GEMIN7	100	77.863	ENSPANG00000032589	-	100	77.863	Papio_anubis
ENSG00000142252	GEMIN7	96	56.693	ENSPKIG00000010356	gemin7	99	56.693	Paramormyrops_kingsleyae
ENSG00000142252	GEMIN7	94	49.600	ENSPMGG00000014207	gemin7	95	49.600	Periophthalmus_magnuspinnatus
ENSG00000142252	GEMIN7	79	72.381	ENSPEMG00000003653	-	100	65.909	Peromyscus_maniculatus_bairdii
ENSG00000142252	GEMIN7	99	65.152	ENSPCIG00000022911	GEMIN7	99	65.152	Phascolarctos_cinereus
ENSG00000142252	GEMIN7	93	54.839	ENSPFOG00000009309	gemin7	96	54.839	Poecilia_formosa
ENSG00000142252	GEMIN7	93	54.839	ENSPLAG00000020214	gemin7	96	54.839	Poecilia_latipinna
ENSG00000142252	GEMIN7	93	54.839	ENSPMEG00000013022	gemin7	96	54.839	Poecilia_mexicana
ENSG00000142252	GEMIN7	93	54.032	ENSPREG00000022938	gemin7	96	54.032	Poecilia_reticulata
ENSG00000142252	GEMIN7	100	99.237	ENSPPYG00000010106	GEMIN7	100	99.237	Pongo_abelii
ENSG00000142252	GEMIN7	100	82.443	ENSPCAG00000011080	GEMIN7	100	82.443	Procavia_capensis
ENSG00000142252	GEMIN7	99	86.154	ENSPVAG00000015956	GEMIN7	99	86.154	Pteropus_vampyrus
ENSG00000142252	GEMIN7	94	52.800	ENSPNYG00000005509	gemin7	97	52.800	Pundamilia_nyererei
ENSG00000142252	GEMIN7	95	55.118	ENSPNAG00000029101	gemin7	98	55.118	Pygocentrus_nattereri
ENSG00000142252	GEMIN7	96	82.812	ENSRNOG00000034168	Gemin7l1	92	82.812	Rattus_norvegicus
ENSG00000142252	GEMIN7	96	83.594	ENSRNOG00000049772	Gemin7	85	83.594	Rattus_norvegicus
ENSG00000142252	GEMIN7	96	73.016	ENSRROG00000040650	-	92	72.441	Rhinopithecus_roxellana
ENSG00000142252	GEMIN7	100	96.183	ENSRROG00000044813	GEMIN7	90	96.183	Rhinopithecus_roxellana
ENSG00000142252	GEMIN7	96	51.969	ENSSFOG00015006881	gemin7	98	51.969	Scleropages_formosus
ENSG00000142252	GEMIN7	93	52.381	ENSSMAG00000014017	gemin7	96	52.381	Scophthalmus_maximus
ENSG00000142252	GEMIN7	86	51.304	ENSSDUG00000005677	gemin7	96	51.304	Seriola_dumerili
ENSG00000142252	GEMIN7	94	52.000	ENSSLDG00000000173	gemin7	97	52.000	Seriola_lalandi_dorsalis
ENSG00000142252	GEMIN7	96	56.349	ENSSPUG00000010715	GEMIN7	93	56.349	Sphenodon_punctatus
ENSG00000142252	GEMIN7	93	53.226	ENSSPAG00000019464	gemin7	96	53.226	Stegastes_partitus
ENSG00000142252	GEMIN7	99	84.615	ENSSSCG00000033194	GEMIN7	99	84.615	Sus_scrofa
ENSG00000142252	GEMIN7	95	53.968	ENSTRUG00000011620	gemin7	98	53.968	Takifugu_rubripes
ENSG00000142252	GEMIN7	100	87.023	ENSUAMG00000026410	GEMIN7	100	87.023	Ursus_americanus
ENSG00000142252	GEMIN7	100	86.260	ENSUMAG00000023443	GEMIN7	100	86.260	Ursus_maritimus
ENSG00000142252	GEMIN7	100	88.550	ENSVPAG00000000513	GEMIN7	100	88.550	Vicugna_pacos
ENSG00000142252	GEMIN7	100	86.260	ENSVVUG00000008153	GEMIN7	100	86.260	Vulpes_vulpes
ENSG00000142252	GEMIN7	98	45.802	ENSXETG00000009880	gemin7	95	45.802	Xenopus_tropicalis
ENSG00000142252	GEMIN7	93	54.839	ENSXCOG00000012659	gemin7	96	54.839	Xiphophorus_couchianus
ENSG00000142252	GEMIN7	93	54.032	ENSXMAG00000019556	gemin7	96	54.032	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000387	spliceosomal snRNP assembly	18984161.	IDA	Process
GO:0000387	spliceosomal snRNP assembly	12065586.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	12065586.	TAS	Process
GO:0005515	protein binding	12065586.15939020.16189514.25416956.26496610.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	12065586.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	12065586.	IDA	Component
GO:0005829	cytosol	18984161.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0016604	nuclear body	12065586.	IDA	Component
GO:0032797	SMN complex	18984161.	IDA	Component
GO:0034719	SMN-Sm protein complex	18984161.	IDA	Component
GO:0051170	import into nucleus	-	TAS	Process
GO:0097504	Gemini of coiled bodies	20513430.	IDA	Component