EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000142453 (Gene tree)
Gene ID: 10498
Gene Symbol: CARM1
Alias: PRMT4
Full Name: coactivator associated arginine methyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 51,558 bases
Position: chr19:10,871,513-10,923,070
Accession: 23393
RBP type: canonical RBP
Summary: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000340934	MTS	PF05175.14	2.7e-07	1	1
ENSP00000325690	MTS	PF05175.14	2.9e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27577262	Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells.	Sci Signal	2016 Aug 30	Larsen SC	doi: 10.1126/scisignal.aaf7329.
23136128	A novel function for the survival motoneuron protein as a translational regulator.	Hum Mol Genet	2013 Feb 15	Sanchez G	doi: 10.1093/hmg/dds474
21088113	HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.	Hum Mol Genet	2011 Feb 1	Hubers L	doi: 10.1093/hmg/ddq500
20631301	Sirtuin 1 regulation of developmental genes during differentiation of stem cells.	Proc Natl Acad Sci U S A	2010 Aug 3	Calvanese V	doi: 10.1073/pnas.1001399107
30456381	CARM1 methylates MED12 to regulate its RNA-binding ability.	Life Sci Alliance	2018 Sep 19	Cheng D	doi: 10.26508/lsa.201800117
15525597	Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.	J Mol Endocrinol	2004 Oct	Klinge CM	-
21191649	P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.	Breast Cancer Res Treat	2011 Nov	Fuchs-Young R	doi: 10.1007/s10549-010-1308-y
25838539	CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.	Genes Dev	2015 Apr 1	Elbarbary RA	doi: 10.1101/gad.261438.115.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590699	CARM1-209	2240	-	ENSP00000467420	161 (aa)	-	K7EPK1
ENST00000344150	CARM1-202	2722	XM_005259708	ENSP00000340934	585 (aa)	XP_005259765	Q86X55
ENST00000589693	CARM1-207	601	-	ENSP00000468319	92 (aa)	-	K7ERM3
ENST00000327064	CARM1-201	3330	XM_011527638	ENSP00000325690	608 (aa)	XP_011525940	Q86X55
ENST00000586221	CARM1-203	2766	-	ENSP00000467746	343 (aa)	-	K7EQA8
ENST00000588947	CARM1-206	468	-	ENSP00000465417	120 (aa)	-	K7EK20
ENST00000592516	CARM1-210	696	-	-	- (aa)	-	-
ENST00000590039	CARM1-208	596	-	ENSP00000464852	111 (aa)	-	K7EIQ8
ENST00000586298	CARM1-204	674	-	ENSP00000467761	176 (aa)	-	K7EQB9
ENST00000586508	CARM1-205	1050	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000142453's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01522	Endocrine resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000142453	Cholesterol, LDL	8.973e-005	19060910
ENSG00000142453	Eosinophils	7.0470000E-005	-
ENSG00000142453	Platelet Function Tests	1.8150100E-005	-
ENSG00000142453	C-Reactive Protein	2E-8	27286809
ENSG00000142453	Cholesterol, LDL	2E-8	27286809
ENSG00000142453	C-Reactive Protein	3E-8	27286809
ENSG00000142453	Cholesterol	3E-8	27286809
ENSG00000142453	S-(3-hydroxypropyl)cysteine N-acetate	6E-7	26053186
ENSG00000142453	Smoking	6E-7	26053186

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000142453	rs1529711	19	10912758	T	C-reactive protein levels or total cholesterol levels (pleiotropy)	27286809			EFO_0004574\|EFO_0004458
ENSG00000142453	rs1529711	19	10912758	T	C-reactive protein levels or LDL-cholesterol levels (pleiotropy)	27286809			EFO_0004611\|EFO_0004458
ENSG00000142453	rs12710258	19	10879653	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit increase	0.1876	EFO_0004318\|EFO_0007014
ENSG00000142453	rs2304088	19	10916950	C	Total cholesterol levels	29507422	unit increase	0.048	EFO_0004574
ENSG00000142453	rs2304088	19	10916950	C	Total cholesterol levels	29507422	unit increase	0.042	EFO_0004574
ENSG00000142453	rs2304088	19	10916950	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.055	EFO_0004611
ENSG00000142453	rs2304088	19	10916950	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.048	EFO_0004611
ENSG00000142453	rs4804540	19	10883726	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142453's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000142453	CARM1	61	40.758	ENSG00000126457	PRMT1	99	46.835

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142453	CARM1	95	87.423	ENSAPOG00000017897	carm1	99	85.690	Acanthochromis_polyacanthus
ENSG00000142453	CARM1	86	98.980	ENSAMEG00000011015	CARM1	100	94.086	Ailuropoda_melanoleuca
ENSG00000142453	CARM1	95	88.037	ENSACIG00000013700	carm1	91	85.862	Amphilophus_citrinellus
ENSG00000142453	CARM1	95	87.730	ENSAOCG00000024623	carm1	99	85.690	Amphiprion_ocellaris
ENSG00000142453	CARM1	95	87.730	ENSAPEG00000021106	carm1	99	85.690	Amphiprion_percula
ENSG00000142453	CARM1	95	86.503	ENSATEG00000008974	carm1	99	84.483	Anabas_testudineus
ENSG00000142453	CARM1	88	94.569	ENSACAG00000015347	CARM1	100	94.007	Anolis_carolinensis
ENSG00000142453	CARM1	99	97.529	ENSANAG00000027252	CARM1	99	97.529	Aotus_nancymaae
ENSG00000142453	CARM1	95	86.810	ENSACLG00000004610	carm1	99	85.517	Astatotilapia_calliptera
ENSG00000142453	CARM1	95	79.387	ENSAMXG00000018518	carm1	99	79.046	Astyanax_mexicanus
ENSG00000142453	CARM1	100	96.711	ENSBTAG00000012048	CARM1	100	96.711	Bos_taurus
ENSG00000142453	CARM1	99	98.517	ENSCJAG00000006228	CARM1	99	98.517	Callithrix_jacchus
ENSG00000142453	CARM1	89	97.417	ENSCAFG00000017621	CARM1	100	97.417	Canis_familiaris
ENSG00000142453	CARM1	100	94.728	ENSCAFG00020024515	-	100	94.728	Canis_lupus_dingo
ENSG00000142453	CARM1	100	96.875	ENSCHIG00000008507	CARM1	100	96.875	Capra_hircus
ENSG00000142453	CARM1	89	97.959	ENSTSYG00000001409	CARM1	100	98.630	Carlito_syrichta
ENSG00000142453	CARM1	88	97.753	ENSCAPG00000009042	CARM1	100	97.652	Cavia_aperea
ENSG00000142453	CARM1	91	95.307	ENSCPOG00000015465	CARM1	91	95.307	Cavia_porcellus
ENSG00000142453	CARM1	99	98.517	ENSCCAG00000020727	CARM1	99	98.517	Cebus_capucinus
ENSG00000142453	CARM1	99	99.010	ENSCATG00000034760	CARM1	100	99.463	Cercocebus_atys
ENSG00000142453	CARM1	88	98.692	ENSCLAG00000011012	CARM1	100	98.692	Chinchilla_lanigera
ENSG00000142453	CARM1	99	98.188	ENSCSAG00000006939	CARM1	99	98.188	Chlorocebus_sabaeus
ENSG00000142453	CARM1	89	95.098	ENSCPBG00000010065	CARM1	100	93.291	Chrysemys_picta_bellii
ENSG00000142453	CARM1	84	100.000	ENSCANG00000004191	CARM1	94	87.170	Colobus_angolensis_palliatus
ENSG00000142453	CARM1	99	97.858	ENSCGRG00001023212	Carm1	99	97.858	Cricetulus_griseus_chok1gshd
ENSG00000142453	CARM1	88	98.321	ENSCGRG00000008046	Carm1	99	98.321	Cricetulus_griseus_crigri
ENSG00000142453	CARM1	95	87.117	ENSCSEG00000013769	carm1	98	88.158	Cynoglossus_semilaevis
ENSG00000142453	CARM1	95	88.344	ENSCVAG00000010021	carm1	99	85.345	Cyprinodon_variegatus
ENSG00000142453	CARM1	95	87.423	ENSDARG00000018698	carm1	99	85.009	Danio_rerio
ENSG00000142453	CARM1	100	76.577	ENSDNOG00000018868	CARM1	100	97.987	Dasypus_novemcinctus
ENSG00000142453	CARM1	86	98.639	ENSDORG00000013395	Carm1	91	94.325	Dipodomys_ordii
ENSG00000142453	CARM1	100	69.820	ENSETEG00000005386	-	86	90.244	Echinops_telfairi
ENSG00000142453	CARM1	92	81.388	ENSEBUG00000015598	carm1	99	69.901	Eptatretus_burgeri
ENSG00000142453	CARM1	100	97.109	ENSEASG00005007536	CARM1	100	97.109	Equus_asinus_asinus
ENSG00000142453	CARM1	100	97.697	ENSECAG00000013563	CARM1	100	97.697	Equus_caballus
ENSG00000142453	CARM1	95	88.957	ENSELUG00000023839	carm1	99	86.047	Esox_lucius
ENSG00000142453	CARM1	95	85.890	ENSELUG00000015993	-	99	77.397	Esox_lucius
ENSG00000142453	CARM1	100	98.026	ENSFCAG00000004893	CARM1	100	98.026	Felis_catus
ENSG00000142453	CARM1	88	99.064	ENSFDAG00000007838	CARM1	100	99.064	Fukomys_damarensis
ENSG00000142453	CARM1	95	87.423	ENSFHEG00000001930	carm1	99	84.740	Fundulus_heteroclitus
ENSG00000142453	CARM1	95	87.423	ENSGMOG00000009257	carm1	99	84.563	Gadus_morhua
ENSG00000142453	CARM1	95	88.344	ENSGAFG00000006197	carm1	99	85.517	Gambusia_affinis
ENSG00000142453	CARM1	95	86.810	ENSGACG00000005531	carm1	100	84.560	Gasterosteus_aculeatus
ENSG00000142453	CARM1	88	96.026	ENSGAGG00000016821	CARM1	100	94.130	Gopherus_agassizii
ENSG00000142453	CARM1	99	93.575	ENSGGOG00000000695	CARM1	99	93.575	Gorilla_gorilla
ENSG00000142453	CARM1	95	87.117	ENSHBUG00000009307	carm1	99	85.517	Haplochromis_burtoni
ENSG00000142453	CARM1	99	97.030	ENSHGLG00000007754	CARM1	99	97.030	Heterocephalus_glaber_female
ENSG00000142453	CARM1	88	98.876	ENSHGLG00100016789	CARM1	100	98.876	Heterocephalus_glaber_male
ENSG00000142453	CARM1	95	87.117	ENSHCOG00000007723	carm1	99	83.216	Hippocampus_comes
ENSG00000142453	CARM1	95	88.037	ENSIPUG00000000942	carm1	99	85.520	Ictalurus_punctatus
ENSG00000142453	CARM1	88	98.876	ENSSTOG00000007864	CARM1	100	98.826	Ictidomys_tridecemlineatus
ENSG00000142453	CARM1	97	97.635	ENSJJAG00000008047	Carm1	100	97.635	Jaculus_jaculus
ENSG00000142453	CARM1	95	88.344	ENSKMAG00000020575	carm1	99	86.034	Kryptolebias_marmoratus
ENSG00000142453	CARM1	95	86.810	ENSLBEG00000010071	carm1	99	84.655	Labrus_bergylta
ENSG00000142453	CARM1	87	90.909	ENSLACG00000015696	CARM1	100	81.883	Latimeria_chalumnae
ENSG00000142453	CARM1	95	88.957	ENSLOCG00000006077	carm1	100	84.201	Lepisosteus_oculatus
ENSG00000142453	CARM1	86	99.660	ENSLAFG00000004431	CARM1	100	91.840	Loxodonta_africana
ENSG00000142453	CARM1	98	99.494	ENSMFAG00000036898	CARM1	100	99.494	Macaca_fascicularis
ENSG00000142453	CARM1	100	99.507	ENSMMUG00000004401	CARM1	100	99.487	Macaca_mulatta
ENSG00000142453	CARM1	96	99.485	ENSMNEG00000031496	CARM1	100	99.485	Macaca_nemestrina
ENSG00000142453	CARM1	88	99.813	ENSMLEG00000006303	CARM1	100	99.813	Mandrillus_leucophaeus
ENSG00000142453	CARM1	95	86.503	ENSMAMG00000002021	carm1	99	85.000	Mastacembelus_armatus
ENSG00000142453	CARM1	95	87.117	ENSMZEG00005000446	carm1	99	85.517	Maylandia_zebra
ENSG00000142453	CARM1	96	98.628	ENSMICG00000009787	CARM1	100	98.628	Microcebus_murinus
ENSG00000142453	CARM1	99	95.008	ENSMOCG00000004215	Carm1	98	95.008	Microtus_ochrogaster
ENSG00000142453	CARM1	95	86.503	ENSMMOG00000017018	carm1	99	84.828	Mola_mola
ENSG00000142453	CARM1	87	96.990	ENSMODG00000006104	CARM1	99	89.667	Monodelphis_domestica
ENSG00000142453	CARM1	95	86.503	ENSMALG00000002150	carm1	99	85.000	Monopterus_albus
ENSG00000142453	CARM1	99	98.023	MGP_CAROLIEiJ_G0031876	Carm1	99	98.023	Mus_caroli
ENSG00000142453	CARM1	99	98.023	ENSMUSG00000032185	Carm1	99	98.023	Mus_musculus
ENSG00000142453	CARM1	99	98.023	MGP_PahariEiJ_G0014742	Carm1	99	98.023	Mus_pahari
ENSG00000142453	CARM1	99	98.023	MGP_SPRETEiJ_G0033000	Carm1	99	98.023	Mus_spretus
ENSG00000142453	CARM1	86	98.980	ENSMPUG00000005752	CARM1	100	98.922	Mustela_putorius_furo
ENSG00000142453	CARM1	87	97.000	ENSMLUG00000011075	CARM1	99	91.901	Myotis_lucifugus
ENSG00000142453	CARM1	97	98.472	ENSNGAG00000001362	Carm1	97	98.472	Nannospalax_galili
ENSG00000142453	CARM1	94	99.381	ENSNLEG00000012371	CARM1	100	99.467	Nomascus_leucogenys
ENSG00000142453	CARM1	91	96.370	ENSODEG00000015950	CARM1	100	99.064	Octodon_degus
ENSG00000142453	CARM1	95	87.117	ENSONIG00000006259	carm1	98	85.517	Oreochromis_niloticus
ENSG00000142453	CARM1	84	97.403	ENSOCUG00000003368	CARM1	100	82.709	Oryctolagus_cuniculus
ENSG00000142453	CARM1	95	87.117	ENSORLG00000017315	carm1	99	84.456	Oryzias_latipes
ENSG00000142453	CARM1	95	87.117	ENSORLG00020017371	carm1	99	84.173	Oryzias_latipes_hni
ENSG00000142453	CARM1	95	87.117	ENSORLG00015009932	carm1	99	84.283	Oryzias_latipes_hsok
ENSG00000142453	CARM1	95	87.117	ENSOMEG00000013937	carm1	99	87.059	Oryzias_melastigma
ENSG00000142453	CARM1	87	98.662	ENSOGAG00000016835	CARM1	100	92.215	Otolemur_garnettii
ENSG00000142453	CARM1	88	98.315	ENSOARG00000017317	CARM1	97	98.315	Ovis_aries
ENSG00000142453	CARM1	88	100.000	ENSPPAG00000030586	CARM1	100	100.000	Pan_paniscus
ENSG00000142453	CARM1	88	98.689	ENSPPRG00000007534	CARM1	88	98.689	Panthera_pardus
ENSG00000142453	CARM1	86	89.831	ENSPTIG00000020631	CARM1	89	93.172	Panthera_tigris_altaica
ENSG00000142453	CARM1	100	99.836	ENSPTRG00000010485	CARM1	100	99.836	Pan_troglodytes
ENSG00000142453	CARM1	100	99.507	ENSPANG00000021071	CARM1	100	99.507	Papio_anubis
ENSG00000142453	CARM1	95	89.264	ENSPKIG00000003610	-	98	87.020	Paramormyrops_kingsleyae
ENSG00000142453	CARM1	95	88.344	ENSPKIG00000005227	carm1	99	85.637	Paramormyrops_kingsleyae
ENSG00000142453	CARM1	95	88.344	ENSPMGG00000005086	carm1	96	85.172	Periophthalmus_magnuspinnatus
ENSG00000142453	CARM1	88	98.502	ENSPEMG00000023286	Carm1	100	98.502	Peromyscus_maniculatus_bairdii
ENSG00000142453	CARM1	94	78.899	ENSPMAG00000003740	carm1	92	72.469	Petromyzon_marinus
ENSG00000142453	CARM1	95	97.546	ENSPCIG00000017124	CARM1	96	94.521	Phascolarctos_cinereus
ENSG00000142453	CARM1	95	87.730	ENSPFOG00000019570	carm1	99	84.642	Poecilia_formosa
ENSG00000142453	CARM1	96	87.273	ENSPLAG00000011942	carm1	99	85.517	Poecilia_latipinna
ENSG00000142453	CARM1	96	87.273	ENSPMEG00000012879	carm1	99	85.345	Poecilia_mexicana
ENSG00000142453	CARM1	95	88.037	ENSPREG00000007471	carm1	99	85.198	Poecilia_reticulata
ENSG00000142453	CARM1	95	99.693	ENSPPYG00000009565	CARM1	96	84.492	Pongo_abelii
ENSG00000142453	CARM1	88	99.438	ENSPCOG00000018916	CARM1	100	99.413	Propithecus_coquereli
ENSG00000142453	CARM1	88	97.393	ENSPVAG00000012161	CARM1	88	97.393	Pteropus_vampyrus
ENSG00000142453	CARM1	95	86.810	ENSPNYG00000022506	carm1	99	85.517	Pundamilia_nyererei
ENSG00000142453	CARM1	95	87.117	ENSPNAG00000023691	carm1	99	85.484	Pygocentrus_nattereri
ENSG00000142453	CARM1	99	98.023	ENSRNOG00000031129	Carm1	99	98.023	Rattus_norvegicus
ENSG00000142453	CARM1	93	94.903	ENSRBIG00000029213	CARM1	98	94.903	Rhinopithecus_bieti
ENSG00000142453	CARM1	88	99.627	ENSRROG00000033867	CARM1	100	99.804	Rhinopithecus_roxellana
ENSG00000142453	CARM1	88	98.876	ENSSBOG00000031852	CARM1	99	98.876	Saimiri_boliviensis_boliviensis
ENSG00000142453	CARM1	88	96.040	ENSSHAG00000005586	CARM1	100	94.107	Sarcophilus_harrisii
ENSG00000142453	CARM1	95	88.957	ENSSFOG00015010235	carm1	89	86.379	Scleropages_formosus
ENSG00000142453	CARM1	95	88.650	ENSSFOG00015018537	-	99	84.925	Scleropages_formosus
ENSG00000142453	CARM1	95	87.423	ENSSMAG00000016701	carm1	98	85.172	Scophthalmus_maximus
ENSG00000142453	CARM1	95	88.037	ENSSDUG00000023353	carm1	99	85.517	Seriola_dumerili
ENSG00000142453	CARM1	95	87.423	ENSSLDG00000011328	carm1	99	85.172	Seriola_lalandi_dorsalis
ENSG00000142453	CARM1	91	93.312	ENSSPUG00000004517	CARM1	99	90.794	Sphenodon_punctatus
ENSG00000142453	CARM1	95	88.037	ENSSPAG00000008826	carm1	99	85.690	Stegastes_partitus
ENSG00000142453	CARM1	100	97.533	ENSSSCG00000013633	CARM1	100	97.533	Sus_scrofa
ENSG00000142453	CARM1	95	86.810	ENSTRUG00000012690	carm1	99	84.483	Takifugu_rubripes
ENSG00000142453	CARM1	95	86.810	ENSTNIG00000014008	carm1	99	83.966	Tetraodon_nigroviridis
ENSG00000142453	CARM1	99	90.264	ENSTTRG00000016644	CARM1	99	90.264	Tursiops_truncatus
ENSG00000142453	CARM1	93	94.340	ENSUAMG00000005865	CARM1	96	97.191	Ursus_americanus
ENSG00000142453	CARM1	86	98.734	ENSUMAG00000024981	CARM1	96	91.231	Ursus_maritimus
ENSG00000142453	CARM1	99	95.270	ENSVVUG00000017717	CARM1	98	95.270	Vulpes_vulpes
ENSG00000142453	CARM1	95	89.264	ENSXETG00000009357	carm1	99	82.867	Xenopus_tropicalis
ENSG00000142453	CARM1	95	88.344	ENSXCOG00000010644	carm1	96	85.862	Xiphophorus_couchianus
ENSG00000142453	CARM1	95	88.344	ENSXMAG00000002542	carm1	99	85.690	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003420	regulation of growth plate cartilage chondrocyte proliferation	-	IEA	Process
GO:0003713	transcription coactivator activity	-	ISS	Function
GO:0005515	protein binding	16938873.20111005.21911467.23455924.24434208.24498420.26267537.	IPI	Function
GO:0005634	nucleus	15221992.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	15221992.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	ISS	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006355	regulation of transcription, DNA-templated	-	ISS	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0007568	aging	-	IEA	Process
GO:0008013	beta-catenin binding	16344550.	TAS	Function
GO:0008276	protein methyltransferase activity	-	ISS	Function
GO:0008284	positive regulation of cell proliferation	-	IEA	Process
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0008469	histone-arginine N-methyltransferase activity	23980157.	IDA	Function
GO:0016032	viral process	-	IEA	Process
GO:0016274	protein-arginine N-methyltransferase activity	18495660.	IDA	Function
GO:0016274	protein-arginine N-methyltransferase activity	-	ISS	Function
GO:0016274	protein-arginine N-methyltransferase activity	-	TAS	Function
GO:0016571	histone methylation	19405910.	IDA	Process
GO:0016571	histone methylation	-	ISS	Process
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	21873635.	IBA	Process
GO:0030374	nuclear receptor transcription coactivator activity	-	ISS	Function
GO:0030520	intracellular estrogen receptor signaling pathway	-	IEA	Process
GO:0032091	negative regulation of protein binding	-	IEA	Process
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	-	ISS	Process
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0034970	histone H3-R2 methylation	17898714.	IMP	Process
GO:0034971	histone H3-R17 methylation	-	ISS	Process
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	21873635.	IBA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	-	ISS	Function
GO:0035642	histone methyltransferase activity (H3-R17 specific)	-	ISS	Function
GO:0042054	histone methyltransferase activity	19405910.	IDA	Function
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0044212	transcription regulatory region DNA binding	-	ISS	Function
GO:0045600	positive regulation of fat cell differentiation	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IEA	Process
GO:0051591	response to cAMP	-	IEA	Process
GO:0060350	endochondral bone morphogenesis	-	IEA	Process
GO:0070577	lysine-acetylated histone binding	-	ISS	Function
GO:0071168	protein localization to chromatin	-	IEA	Process
GO:0090575	RNA polymerase II transcription factor complex	-	IEA	Component
GO:1902415	regulation of mRNA binding	-	IEA	Process
GO:2000171	negative regulation of dendrite development	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24211191	CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.	Biochimie	2014 Feb	Elakoum R	doi: 10.1016/j.biochi.2013.10.021
25348716	PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.	Mol Cell Biol	2015 Jan	Kim KY	doi: 10.1128/MCB.00945-14
26030442	Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.	PLoS One	2015 Jun 1	Shlensky D	doi: 10.1371/journal.pone.0128143
16705743	Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability.	Prostate	2006 Sep 1	Majumder S	-
23915145	Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.	Diagn Pathol	2013 Aug 2	Cheng H	doi: 10.1186/1746-1596-8-129.
21282336	CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells.	Cancer Res	2011 Mar 15	Al-Dhaheri M	doi: 10.1158/0008-5472.CAN-10-2426
18172323	CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.	Cancer Res	2008 Jan 1	Frietze S	doi: 10.1158/0008-5472.CAN-07-1983.
21478268	A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression.	Mol Cancer Res	2011 May	Ou CY	doi: 10.1158/1541-7786.MCR-10-0223
27840030	Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.	Mol Cell	2016 Nov 17	Wang YP	doi: 10.1016/j.molcel.2016.09.028
29628309	JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.	Mol Cell	2018 Apr 19	Gao WW	doi: 10.1016/j.molcel.2018.03.006

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	10921872	3'UTR	novel		0.25
BLCA	chr19	10916407	Missense_Mutation	novel	G283E	0.92	MTS
BLCA	chr19	10908088	Silent	novel	L132L	0.14
BLCA	chr19	10908089	Nonsense_Mutation	novel	E133*	0.14
BLCA	chr19	10921763	3'UTR	rs576714524		0.09
BLCA	chr19	10921705	Missense_Mutation	NA	S592Y	0.17
BLCA	chr19	10909198	Missense_Mutation	novel	F183L	0.49	MTS
BLCA	chr19	10921095	Missense_Mutation	NA	S528C	0.22
BLCA	chr19	10921106	Missense_Mutation	novel	H532N	0.12
BLCA	chr19	10921072	Missense_Mutation	NA	L520F	0.44
BLCA	chr19	10921409	Silent	novel	R550R	0.51
BLCA	chr19	10920674	Silent	NA	I450I	0.23
BLCA	chr19	10908116	Missense_Mutation	NA	E142K	0.39
BRCA	chr19	10916707	Missense_Mutation	NA	S317F	0.23
BRCA	chr19	10905063	Silent	rs573080689	F111F	0.22
BRCA	chr19	10921072	Missense_Mutation	NA	L520F	0.19
BRCA	chr19	10920924	Silent	rs780775044	L505L	0.32
BRCA	chr19	10922150	3'UTR	novel		0.23
BRCA	chr19	10912233	Missense_Mutation	NA	A203V	0.29	MTS
CESC	chr19	10922400	3'UTR	novel		0.41
CESC	chr19	10920494	Missense_Mutation	novel	R419W	0.2
CESC	chr19	10905060	Missense_Mutation	NA	Q110H	0.27
CESC	chr19	10921993	3'UTR	novel		0.63
CESC	chr19	10913903	Silent	novel	T232T	0.09
COAD	chr19	10916432	Silent	rs375369228	D291D	0.42
COAD	chr19	10904958	Frame_Shift_Del	novel	*C78Sfs46**	0.1
COAD	chr19	10912249	Silent	novel	R208R	0.32
COAD	chr19	10919904	Missense_Mutation	novel	M378I	0.52
COAD	chr19	10921093	Silent	NA	G527G	0.21
COAD	chr19	10920839	Missense_Mutation	novel	T477M	0.37
COAD	chr19	10920679	Frame_Shift_Del	novel	*I452Sfs12**	0.18
COAD	chr19	10912289	Missense_Mutation	novel	A222T	0.23	MTS
COAD	chr19	10919853	Intron	novel		0.26
COAD	chr19	10921813	3'UTR	novel		0.26
ESCA	chr19	10922196	3'UTR	novel		0.37
ESCA	chr19	10922348	3'UTR	novel		0.26
ESCA	chr19	10908111	Missense_Mutation	NA	R140Q	0.18
ESCA	chr19	10922180	3'UTR	novel		0.2
ESCA	chr19	10922195	3'UTR	novel		0.31
GBM	chr19	10905011	Missense_Mutation	novel	G94V	0.12
GBM	chr19	10904987	Missense_Mutation	rs373397887	R86Q	0.16
GBM	chr19	10913951	Silent	novel	P248P	0.14
GBM	chr19	10908075	Missense_Mutation	NA	R128Q	0.75
GBM	chr19	10920738	Missense_Mutation	novel	P472S	0.23
HNSC	chr19	10921651	Missense_Mutation	rs139191688	T574M	0.25
HNSC	chr19	10921652	Silent	novel	T574T	0.24
HNSC	chr19	10908142	Frame_Shift_Del	novel	*Q151Sfs12**	0.6
HNSC	chr19	10919922	Silent	novel	V384V	0.11
HNSC	chr19	10921424	Missense_Mutation	novel	M555I	0.29
HNSC	chr19	10908114	Missense_Mutation	novel	T141M	0.15
HNSC	chr19	10916435	Silent	rs148487813	V292V	0.15
KIRP	chr19	10909180	Silent	NA	L177L	0.34
LUAD	chr19	10913904	Missense_Mutation	novel	D233N	0.17	MTS
LUAD	chr19	10914029	Silent	rs764313465	H274H	0.27
LUAD	chr19	10921730	Silent	rs763545329	P600P	0.09
LUAD	chr19	10912184	Missense_Mutation	rs549040186	I187V	0.25	MTS
LUAD	chr19	10912232	Missense_Mutation	NA	A203P	0.44	MTS
LUSC	chr19	10909152	Missense_Mutation	novel	R168Q	0.07
LUSC	chr19	10919633	Silent	novel	V353V	0.22
LUSC	chr19	10908145	Splice_Region	novel	Q151Q	0.3
LUSC	chr19	10921424	Missense_Mutation	NA	M555I	0.3
LUSC	chr19	10921835	3'UTR	novel		0.13
OV	chr19	10921716	Missense_Mutation	novel	P596S	0.13
OV	chr19	10912255	Missense_Mutation	NA	I210M	0.32	MTS
OV	chr19	10919595	Missense_Mutation	NA	D341N	0.19
OV	chr19	10919926	Missense_Mutation	NA	G386S	0.48
OV	chr19	10921843	3'UTR	novel		0.42
OV	chr19	10904962	Missense_Mutation	novel	C78S	0.07
OV	chr19	10919950	Missense_Mutation	novel	A394P	0.08
OV	chr19	10919951	Missense_Mutation	novel	A394D	0.07
PAAD	chr19	10909115	Missense_Mutation	novel	L156M	0.17
PAAD	chr19	10914029	Silent	rs764313465	H274H	0.22
PAAD	chr19	10919861	Intron	novel		0.19
PRAD	chr19	10914007	Missense_Mutation	novel	R267H	0.44	MTS
PRAD	chr19	10921058	Missense_Mutation	novel	T516A	0.31
SARC	chr19	10922309	3'UTR	novel		0.47
SKCM	chr19	10921771	3'UTR	rs749553998		0.43
SKCM	chr19	10921772	3'UTR	novel		0.43
SKCM	chr19	10909100	Splice_Region	novel		0.32
SKCM	chr19	10908112	Silent	rs141502552	R140R	0.24
SKCM	chr19	10920712	Missense_Mutation	NA	S463F	0.16
SKCM	chr19	10921822	3'UTR	novel		0.21
SKCM	chr19	10920706	Missense_Mutation	NA	S461F	0.14
SKCM	chr19	10913969	Silent	NA	I254I	0.25
SKCM	chr19	10920747	Splice_Region	novel	R475R	0.16
SKCM	chr19	10908142	Silent	NA	F150F	0.43
SKCM	chr19	10904957	Missense_Mutation	NA	D76V	0.33
SKCM	chr19	10921051	Splice_Region	novel	G513G	0.38
SKCM	chr19	10921052	Missense_Mutation	novel	M514L	0.38
SKCM	chr19	10920520	Silent	rs201626054	F427F	0.39
SKCM	chr19	10913922	Missense_Mutation	novel	P239S	0.34	MTS
SKCM	chr19	10913923	Missense_Mutation	rs776086779	P239L	0.36	MTS
STAD	chr19	10905018	Frame_Shift_Ins	novel	*S97Ifs30**	0.05
STAD	chr19	10904957	Frame_Shift_Ins	novel	*F80Sfs46**	0.5
STAD	chr19	10912186	Splice_Region	NA	I187I	0.38
STAD	chr19	10921808	3'UTR	novel		0.32
STAD	chr19	10920495	Missense_Mutation	novel	R419Q	0.22
STAD	chr19	10921434	Missense_Mutation	NA	I559V	0.13
STAD	chr19	10913902	Missense_Mutation	rs527617157	T232M	0.29	MTS
STAD	chr19	10921717	Missense_Mutation	novel	P596L	0.3
STAD	chr19	10920450	Missense_Mutation	novel	L404R	0.14
UCEC	chr19	10919596	Missense_Mutation	novel	D341V	0.5
UCEC	chr19	10920442	Silent	rs370080653	T401T	0.43
UCEC	chr19	10908136	Silent	novel	Q148Q	0.7
UCEC	chr19	10913912	Silent	rs771934231	I235I	0.4
UCEC	chr19	10922224	3'UTR	novel		0.33
UCEC	chr19	10905070	Missense_Mutation	novel	P114S	0.23
UCEC	chr19	10920938	Missense_Mutation	NA	A510D	0.14
UCEC	chr19	10920931	Missense_Mutation	novel	G508R	0.57
UCEC	chr19	10922323	3'UTR	novel		0.55
UCEC	chr19	10919887	Missense_Mutation	NA	P373S	0.38
UCEC	chr19	10922951	3'UTR	novel		0.35
UCEC	chr19	10920520	Silent	rs201626054	F427F	0.47
UCEC	chr19	10922207	3'UTR	novel		0.5
UCEC	chr19	10922183	3'UTR	rs770180715		0.5
UCEC	chr19	10922264	3'UTR	novel		0.59
UCEC	chr19	10920669	Missense_Mutation	rs752773089	D449N	0.33
UCEC	chr19	10922528	3'UTR	novel		0.71
UCEC	chr19	10920885	Silent	rs143753697	P492P	0.09
UCEC	chr19	10913952	Missense_Mutation	novel	E249K	0.11	MTS
UCEC	chr19	10908094	Silent	novel	R134R	0.46
UCEC	chr19	10920906	Silent	rs111988493	T499T	0.47
UCEC	chr19	10922142	3'UTR	rs536948923		0.47
UCEC	chr19	10922196	3'UTR	novel		0.17
UCEC	chr19	10920839	Missense_Mutation	novel	T477M	0.27
UCEC	chr19	10920494	Missense_Mutation	novel	R419W	0.39
UCEC	chr19	10923026	3'UTR	novel		0.19
UCEC	chr19	10922343	3'UTR	novel		0.39
UCEC	chr19	10905076	Missense_Mutation	NA	D116N	0.52
UCEC	chr19	10921755	Nonstop_Mutation	NA	609Qext58	0.38
UCEC	chr19	10905063	Silent	rs573080689	F111F	0.37
UCEC	chr19	10908106	Silent	rs777132228	S138S	0.47
UCEC	chr19	10921433	Silent	novel	G558G	0.41
UCEC	chr19	10922320	3'UTR	novel		0.46
UCEC	chr19	10912248	Missense_Mutation	NA	R208Q	0.41	MTS
UCEC	chr19	10920442	Silent	rs370080653	T401T	0.16
UCEC	chr19	10921809	3'UTR	rs377501641		0.57
UCEC	chr19	10923008	3'UTR	novel		0.43
UCEC	chr19	10921915	3'UTR	novel		0.34
UCEC	chr19	10922327	3'UTR	rs190617590		0.31
UCEC	chr19	10922931	3'UTR	novel		0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0788	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0013	Kaplan-Meier Survival Analysis
STAD	0.0074	Kaplan-Meier Survival Analysis
SARC	0.033	Kaplan-Meier Survival Analysis
MESO	0.00018	Kaplan-Meier Survival Analysis
ACC	0.0026	Kaplan-Meier Survival Analysis
HNSC	0.029	Kaplan-Meier Survival Analysis
SKCM	0.00036	Kaplan-Meier Survival Analysis
ESCA	0.047	Kaplan-Meier Survival Analysis
KIRP	0.0011	Kaplan-Meier Survival Analysis
BLCA	0.00059	Kaplan-Meier Survival Analysis
LAML	0.0058	Kaplan-Meier Survival Analysis
LIHC	0.0049	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
LUAD	0.04	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742