EuRBPDB

Description

Ensembl ID: ENSG00000142546 (Gene tree)
Gene ID: 51070
Gene Symbol: NOSIP
Alias: CGI-25
Full Name: nitric oxide synthase interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 34,795 bases
Position: chr19:49,555,468-49,590,262
Accession: 17946
RBP type: non-canonical RBP
Summary: The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000601107	NOSIP-215	671	-	-	- (aa)	-	-
ENST00000601340	NOSIP-216	2197	-	-	- (aa)	-	-
ENST00000339093	NOSIP-201	1000	XM_005258964	ENSP00000343497	304 (aa)	XP_005259021	A0A075B6F9
ENST00000601015	NOSIP-214	697	-	ENSP00000470450	232 (aa)	-	A0A075B797
ENST00000599537	NOSIP-212	833	-	ENSP00000473109	241 (aa)	-	M0R3B2
ENST00000598544	NOSIP-207	429	-	ENSP00000468974	96 (aa)	-	M0QX85
ENST00000600019	NOSIP-213	1167	-	ENSP00000471291	63 (aa)	-	M0R1T7
ENST00000598820	NOSIP-209	2615	-	-	- (aa)	-	-
ENST00000598839	NOSIP-210	753	-	-	- (aa)	-	-
ENST00000598296	NOSIP-206	529	-	ENSP00000471929	176 (aa)	-	M0R1K2
ENST00000598550	NOSIP-208	771	-	-	- (aa)	-	-
ENST00000596477	NOSIP-205	865	-	-	- (aa)	-	-
ENST00000593345	NOSIP-202	933	-	-	- (aa)	-	-
ENST00000599425	NOSIP-211	872	-	-	- (aa)	-	-
ENST00000596358	NOSIP-204	1005	XM_011527017	ENSP00000470034	301 (aa)	XP_011525319	Q9Y314
ENST00000594932	NOSIP-203	602	-	ENSP00000472103	63 (aa)	-	M0R1T7

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000142546	rs111544199	19	49587965	G	Red blood cell count	27863252	[0.021-0.037] unit increase	0.02880154	EFO_0004305
ENSG00000142546	rs56873913	19	49587942	T	Schizophrenia	25056061	[1.045-1.098]	1.071	EFO_0000692
ENSG00000142546	rs56873913	19	49587942	T	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000142546	rs56873913	19	49587942	T	Schizophrenia	28991256	[1.04-1.08]	1.061	EFO_0000692
ENSG00000142546	rs552708909	19	49587166	CT	Hematocrit	27863252	[0.019-0.036] unit increase	0.02767996	EFO_0004348
ENSG00000142546	rs56873913	19	49587942	T	Schizophrenia	30285260	[1.04-1.09]	1.0679	EFO_0000692
ENSG00000142546	rs56873913	19	49587942	T	Schizophrenia	30285260	[1.05-1.09]	1.069	EFO_0000692

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142546	NOSIP	100	96.875	ENSMUSG00000003421	Nosip	100	90.698	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	11149895.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15548660.	IDA	Component
GO:0005737	cytoplasm	15548660.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0043086	negative regulation of catalytic activity	11149895.	IDA	Process
GO:0050999	regulation of nitric-oxide synthase activity	-	TAS	Process
GO:0051001	negative regulation of nitric-oxide synthase activity	11149895.	IDA	Process
GO:0061630	ubiquitin protein ligase activity	-	IEA	Function