EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000142676 (Gene tree)
Gene ID: 6135
Gene Symbol: RPL11
Alias: L11|uL5
Full Name: ribosomal protein L11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,094 bases
Position: chr1:23,691,742-23,696,835
Accession: 10301
RBP type: canonical RBP
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000398888	Ribosomal_L5_C	PF00673.21	5.9e-21	1	1
ENSP00000363676	Ribosomal_L5_C	PF00673.21	6.8e-21	1	1
ENSP00000496250	Ribosomal_L5_C	PF00673.21	6.9e-21	1	1
ENSP00000363676	Ribosomal_L5	PF00281.19	4.6e-22	1	1
ENSP00000496250	Ribosomal_L5	PF00281.19	4.7e-22	1	1
ENSP00000398888	Ribosomal_L5	PF00281.19	1.6e-20	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
386275	Binding of Escherichia coli ribosomal proteins to 23S RNA under reconstitution conditions for the 50S subunit.	Nucleic Acids Res	1979 Aug 10	Marquardt O	-
9398519	The RNA binding domain of ribosomal protein L11: three-dimensional structure of the RNA-bound form of the protein and its interaction with 23 S rRNA.	J Mol Biol	1997 Nov 21	Hinck AP	-
10325228	Crystal structure of a conserved ribosomal protein-RNA complex.	Science	1999 May 14	Conn GL	-
8989317	The RNA binding domain of ribosomal protein L11 is structurally similar to homeodomains.	Nat Struct Biol	1997 Jan	Xing Y	-
25849277	Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.	Nat Commun	2015 Apr 7	Calvino FR	doi: 10.1038/ncomms7510.
1923813	A chemical interference study on the interaction of ribosomal protein L11 from Escherichia coli with RNA molecules containing its binding site from 23S rRNA.	Nucleic Acids Res	1991 Oct 11	Karaoglu D	-
10734197	The RNA-binding domain of ribosomal protein L11 recognizes an rRNA tertiary structure stabilized by both thiostrepton and magnesium ion.	Nucleic Acids Res	2000 Apr 15	Blyn LB	-
16094695	Domain reorientation and induced fit upon RNA binding: solution structure and dynamics of ribosomal protein L11 from Thermotoga maritima.	Chembiochem	2005 Sep	Ilin S	-
22899071	Effect of salt stress on genes encoding translation-associated proteins in Arabidopsis thaliana.	Plant Signal Behav	2012 Sep 1	Omidbakhshfard MA	doi: 10.4161/psb.21218
2068110	Detection of a key tertiary interaction in the highly conserved GTPase center of large subunit ribosomal RNA.	Proc Natl Acad Sci U S A	1991 Jul 15	Ryan PC	-
1942050	Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton.	J Mol Biol	1991 Oct 20	Ryan PC	-
6271782	The binding site for ribosomal protein L11 within 23 S ribosomal RNA of Escherichia coli.	J Biol Chem	1981 Dec 10	Schmidt FJ	-
9718323	A functional ribosomal RNA tertiary structure involves a base triple interaction.	Biochemistry	1998 Aug 25	Conn GL	-
1692883	Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli.	J Mol Biol	1990 May 20	Egebjerg J	-
8989327	High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA.	Nat Struct Biol	1997 Jan	Markus MA	-
15492007	Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.	J Biol Chem	2005 Jan 28	Bowen WS	-
18380436	Mapping the binding site of thiopeptide antibiotics by proximity-induced covalent capture.	J Am Chem Soc	2008 Apr 30	Baumann S	doi: 10.1021/ja710608w

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374550	RPL11-201	660	-	ENSP00000363676	177 (aa)	-	P62913
ENST00000643754	RPL11-206	1017	-	ENSP00000496250	178 (aa)	-	P62913
ENST00000443624	RPL11-202	1600	-	-	- (aa)	-	-
ENST00000467075	RPL11-204	823	-	ENSP00000493634	44 (aa)	-	A0A2R8Y447
ENST00000458455	RPL11-203	879	-	ENSP00000398888	167 (aa)	-	Q5VVC8
ENST00000482370	RPL11-205	539	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000142676's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000142676	Tunica Media	4.6992723E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142676's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142676	RPL11	100	96.407	ENSAPOG00000004725	rpl11	100	96.067	Acanthochromis_polyacanthus
ENSG00000142676	RPL11	100	100.000	ENSAMEG00000009704	RPL11	100	98.876	Ailuropoda_melanoleuca
ENSG00000142676	RPL11	95	96.203	ENSACIG00000001176	rpl11	85	94.675	Amphilophus_citrinellus
ENSG00000142676	RPL11	100	96.407	ENSAOCG00000002035	rpl11	97	96.045	Amphiprion_ocellaris
ENSG00000142676	RPL11	100	96.407	ENSAPEG00000016389	rpl11	97	96.045	Amphiprion_percula
ENSG00000142676	RPL11	100	97.006	ENSATEG00000003155	rpl11	100	97.006	Anabas_testudineus
ENSG00000142676	RPL11	100	99.401	ENSACAG00000005058	RPL11	99	98.295	Anolis_carolinensis
ENSG00000142676	RPL11	100	77.528	ENSANAG00000037822	RPL11	100	77.528	Aotus_nancymaae
ENSG00000142676	RPL11	100	95.808	ENSACLG00000022487	rpl11	99	95.455	Astatotilapia_calliptera
ENSG00000142676	RPL11	100	96.407	ENSAMXG00000034710	rpl11	100	96.067	Astyanax_mexicanus
ENSG00000142676	RPL11	100	100.000	ENSBTAG00000020905	RPL11	100	100.000	Bos_taurus
ENSG00000142676	RPL11	100	82.036	WBGene00004422	rpl-11.1	86	81.657	Caenorhabditis_elegans
ENSG00000142676	RPL11	100	82.635	WBGene00004423	rpl-11.2	86	82.249	Caenorhabditis_elegans
ENSG00000142676	RPL11	100	100.000	ENSCJAG00000020953	RPL11	100	100.000	Callithrix_jacchus
ENSG00000142676	RPL11	100	87.640	ENSCAFG00000012252	-	100	87.640	Canis_familiaris
ENSG00000142676	RPL11	100	100.000	ENSCAFG00000013232	RPL11	100	100.000	Canis_familiaris
ENSG00000142676	RPL11	100	62.011	ENSCAFG00000023440	-	100	62.011	Canis_familiaris
ENSG00000142676	RPL11	92	92.157	ENSCAFG00020004144	-	100	92.157	Canis_lupus_dingo
ENSG00000142676	RPL11	100	100.000	ENSCAFG00020020012	-	100	100.000	Canis_lupus_dingo
ENSG00000142676	RPL11	89	64.458	ENSCAFG00020024210	-	94	64.458	Canis_lupus_dingo
ENSG00000142676	RPL11	100	100.000	ENSCHIG00000020543	-	100	100.000	Capra_hircus
ENSG00000142676	RPL11	100	93.413	ENSCHIG00000023100	-	100	91.011	Capra_hircus
ENSG00000142676	RPL11	100	89.888	ENSCHIG00000023371	-	100	89.888	Capra_hircus
ENSG00000142676	RPL11	100	76.404	ENSTSYG00000027649	-	100	76.404	Carlito_syrichta
ENSG00000142676	RPL11	100	100.000	ENSTSYG00000001349	RPL11	100	100.000	Carlito_syrichta
ENSG00000142676	RPL11	100	75.281	ENSTSYG00000026668	-	100	75.281	Carlito_syrichta
ENSG00000142676	RPL11	100	51.124	ENSCAPG00000014256	-	100	51.124	Cavia_aperea
ENSG00000142676	RPL11	92	84.416	ENSCAPG00000015125	-	80	100.000	Cavia_aperea
ENSG00000142676	RPL11	100	100.000	ENSCPOG00000008432	RPL11	100	100.000	Cavia_porcellus
ENSG00000142676	RPL11	100	77.528	ENSCCAG00000002920	-	100	77.528	Cebus_capucinus
ENSG00000142676	RPL11	100	100.000	ENSCCAG00000027290	RPL11	100	100.000	Cebus_capucinus
ENSG00000142676	RPL11	96	86.957	ENSCATG00000038834	-	100	82.022	Cercocebus_atys
ENSG00000142676	RPL11	100	98.315	ENSCATG00000001301	-	100	98.315	Cercocebus_atys
ENSG00000142676	RPL11	100	100.000	ENSCATG00000021760	RPL11	100	100.000	Cercocebus_atys
ENSG00000142676	RPL11	100	100.000	ENSCLAG00000012453	Rpl11	100	100.000	Chinchilla_lanigera
ENSG00000142676	RPL11	100	71.910	ENSCLAG00000015055	-	100	71.910	Chinchilla_lanigera
ENSG00000142676	RPL11	100	100.000	ENSCSAG00000000929	RPL11	100	100.000	Chlorocebus_sabaeus
ENSG00000142676	RPL11	96	97.500	ENSCSAG00000019508	-	96	97.500	Chlorocebus_sabaeus
ENSG00000142676	RPL11	99	96.988	ENSCSAG00000000280	-	99	96.610	Chlorocebus_sabaeus
ENSG00000142676	RPL11	100	98.315	ENSCPBG00000000630	RPL11	100	98.315	Chrysemys_picta_bellii
ENSG00000142676	RPL11	100	79.641	ENSCING00000003326	-	100	77.528	Ciona_intestinalis
ENSG00000142676	RPL11	100	79.641	ENSCSAVG00000000639	-	100	77.528	Ciona_savignyi
ENSG00000142676	RPL11	100	89.888	ENSCANG00000019971	-	100	89.888	Colobus_angolensis_palliatus
ENSG00000142676	RPL11	100	94.915	ENSCANG00000032092	-	100	94.915	Colobus_angolensis_palliatus
ENSG00000142676	RPL11	100	99.438	ENSCANG00000010609	RPL11	100	99.438	Colobus_angolensis_palliatus
ENSG00000142676	RPL11	100	93.413	ENSCGRG00001007720	-	99	93.220	Cricetulus_griseus_chok1gshd
ENSG00000142676	RPL11	100	77.528	ENSCGRG00001013740	-	100	77.528	Cricetulus_griseus_chok1gshd
ENSG00000142676	RPL11	100	90.449	ENSCGRG00001002780	-	100	90.449	Cricetulus_griseus_chok1gshd
ENSG00000142676	RPL11	100	84.431	ENSCGRG00001010099	-	100	84.270	Cricetulus_griseus_chok1gshd
ENSG00000142676	RPL11	100	84.431	ENSCGRG00000018726	-	100	84.270	Cricetulus_griseus_crigri
ENSG00000142676	RPL11	100	100.000	ENSCGRG00000007382	-	100	99.438	Cricetulus_griseus_crigri
ENSG00000142676	RPL11	100	77.528	ENSCGRG00000015986	-	100	77.528	Cricetulus_griseus_crigri
ENSG00000142676	RPL11	100	79.775	ENSCGRG00000000391	-	100	79.775	Cricetulus_griseus_crigri
ENSG00000142676	RPL11	100	97.006	ENSCSEG00000007952	rpl11	100	96.629	Cynoglossus_semilaevis
ENSG00000142676	RPL11	100	98.204	ENSCVAG00000019408	rpl11	100	97.753	Cyprinodon_variegatus
ENSG00000142676	RPL11	100	98.204	ENSDARG00000043509	rpl11	100	97.191	Danio_rerio
ENSG00000142676	RPL11	100	100.000	ENSDNOG00000011230	RPL11	100	100.000	Dasypus_novemcinctus
ENSG00000142676	RPL11	100	74.405	ENSDORG00000025287	-	100	73.410	Dipodomys_ordii
ENSG00000142676	RPL11	100	100.000	ENSDORG00000012496	-	100	98.876	Dipodomys_ordii
ENSG00000142676	RPL11	100	85.030	FBgn0013325	RpL11	92	84.706	Drosophila_melanogaster
ENSG00000142676	RPL11	62	100.000	ENSETEG00000014825	RPL11	100	100.000	Echinops_telfairi
ENSG00000142676	RPL11	100	91.617	ENSEBUG00000002312	-	100	91.617	Eptatretus_burgeri
ENSG00000142676	RPL11	100	100.000	ENSECAG00000021136	RPL11	100	100.000	Equus_caballus
ENSG00000142676	RPL11	100	100.000	ENSECAG00000038599	RPL11	100	100.000	Equus_caballus
ENSG00000142676	RPL11	53	100.000	ENSEEUG00000011673	-	53	100.000	Erinaceus_europaeus
ENSG00000142676	RPL11	100	96.407	ENSELUG00000023364	rpl11	100	96.407	Esox_lucius
ENSG00000142676	RPL11	65	72.222	ENSFCAG00000028651	-	81	72.222	Felis_catus
ENSG00000142676	RPL11	100	99.438	ENSFCAG00000042504	RPL11	81	99.438	Felis_catus
ENSG00000142676	RPL11	100	98.802	ENSFALG00000000520	RPL11	100	98.802	Ficedula_albicollis
ENSG00000142676	RPL11	100	100.000	ENSFDAG00000009821	RPL11	94	98.876	Fukomys_damarensis
ENSG00000142676	RPL11	100	97.006	ENSFHEG00000015082	rpl11	100	96.629	Fundulus_heteroclitus
ENSG00000142676	RPL11	100	94.012	ENSGMOG00000011990	rpl11	100	93.750	Gadus_morhua
ENSG00000142676	RPL11	100	98.876	ENSGALG00000030378	RPL11	100	98.876	Gallus_gallus
ENSG00000142676	RPL11	100	98.204	ENSGAFG00000014635	rpl11	100	97.753	Gambusia_affinis
ENSG00000142676	RPL11	100	96.407	ENSGACG00000002118	rpl11	100	96.407	Gasterosteus_aculeatus
ENSG00000142676	RPL11	100	85.629	ENSGAGG00000001266	-	100	84.831	Gopherus_agassizii
ENSG00000142676	RPL11	95	98.225	ENSGAGG00000000655	-	79	98.225	Gopherus_agassizii
ENSG00000142676	RPL11	100	100.000	ENSGGOG00000014628	RPL11	100	100.000	Gorilla_gorilla
ENSG00000142676	RPL11	99	92.121	ENSGGOG00000024275	-	100	88.764	Gorilla_gorilla
ENSG00000142676	RPL11	100	80.791	ENSGGOG00000022399	-	100	79.775	Gorilla_gorilla
ENSG00000142676	RPL11	100	95.808	ENSHBUG00000017027	rpl11	99	95.455	Haplochromis_burtoni
ENSG00000142676	RPL11	100	100.000	ENSHGLG00000014694	RPL11	100	100.000	Heterocephalus_glaber_female
ENSG00000142676	RPL11	100	71.348	ENSHGLG00000006006	-	100	71.348	Heterocephalus_glaber_female
ENSG00000142676	RPL11	100	71.348	ENSHGLG00000005322	-	100	71.348	Heterocephalus_glaber_female
ENSG00000142676	RPL11	100	71.348	ENSHGLG00100002671	-	100	71.348	Heterocephalus_glaber_male
ENSG00000142676	RPL11	100	100.000	ENSHGLG00100008038	-	93	98.876	Heterocephalus_glaber_male
ENSG00000142676	RPL11	100	95.210	ENSHCOG00000008500	rpl11	91	93.750	Hippocampus_comes
ENSG00000142676	RPL11	100	95.808	ENSIPUG00000019795	rpl11	100	95.506	Ictalurus_punctatus
ENSG00000142676	RPL11	100	78.652	ENSJJAG00000020450	-	100	78.652	Jaculus_jaculus
ENSG00000142676	RPL11	100	99.438	ENSJJAG00000016031	Rpl11	100	99.438	Jaculus_jaculus
ENSG00000142676	RPL11	100	99.401	ENSJJAG00000022270	-	100	98.870	Jaculus_jaculus
ENSG00000142676	RPL11	100	97.006	ENSKMAG00000000381	rpl11	100	96.629	Kryptolebias_marmoratus
ENSG00000142676	RPL11	100	97.006	ENSLBEG00000002984	rpl11	100	96.067	Labrus_bergylta
ENSG00000142676	RPL11	100	98.802	ENSLACG00000010502	RPL11	100	97.175	Latimeria_chalumnae
ENSG00000142676	RPL11	100	97.605	ENSLOCG00000000953	rpl11	100	96.629	Lepisosteus_oculatus
ENSG00000142676	RPL11	100	81.006	ENSLAFG00000030853	RPL11	99	81.006	Loxodonta_africana
ENSG00000142676	RPL11	100	92.697	ENSMFAG00000033318	-	99	94.340	Macaca_fascicularis
ENSG00000142676	RPL11	100	100.000	ENSMFAG00000017384	RPL11	100	100.000	Macaca_fascicularis
ENSG00000142676	RPL11	100	100.000	ENSMMUG00000002445	RPL11	100	100.000	Macaca_mulatta
ENSG00000142676	RPL11	99	96.988	ENSMNEG00000005892	-	99	96.988	Macaca_nemestrina
ENSG00000142676	RPL11	100	100.000	ENSMNEG00000029303	RPL11	100	100.000	Macaca_nemestrina
ENSG00000142676	RPL11	100	100.000	ENSMLEG00000032521	RPL11	100	100.000	Mandrillus_leucophaeus
ENSG00000142676	RPL11	93	85.455	ENSMLEG00000038432	-	83	85.455	Mandrillus_leucophaeus
ENSG00000142676	RPL11	100	97.006	ENSMAMG00000007767	rpl11	100	97.006	Mastacembelus_armatus
ENSG00000142676	RPL11	100	95.808	ENSMZEG00005026109	rpl11	99	95.455	Maylandia_zebra
ENSG00000142676	RPL11	100	98.802	ENSMGAG00000005572	RPL11	99	98.864	Meleagris_gallopavo
ENSG00000142676	RPL11	100	91.018	ENSMAUG00000002975	-	100	91.011	Mesocricetus_auratus
ENSG00000142676	RPL11	100	88.764	ENSMAUG00000012828	-	100	88.764	Mesocricetus_auratus
ENSG00000142676	RPL11	100	78.090	ENSMAUG00000002256	-	92	87.162	Mesocricetus_auratus
ENSG00000142676	RPL11	92	88.344	ENSMAUG00000015589	-	100	88.344	Mesocricetus_auratus
ENSG00000142676	RPL11	99	86.826	ENSMAUG00000014028	-	99	82.955	Mesocricetus_auratus
ENSG00000142676	RPL11	96	87.500	ENSMAUG00000006096	-	100	87.500	Mesocricetus_auratus
ENSG00000142676	RPL11	100	78.652	ENSMAUG00000010575	-	90	90.278	Mesocricetus_auratus
ENSG00000142676	RPL11	100	100.000	ENSMICG00000044631	-	100	100.000	Microcebus_murinus
ENSG00000142676	RPL11	100	85.556	ENSMICG00000009582	-	99	85.556	Microcebus_murinus
ENSG00000142676	RPL11	100	94.611	ENSMOCG00000020573	-	100	94.382	Microtus_ochrogaster
ENSG00000142676	RPL11	100	90.449	ENSMOCG00000009548	-	100	90.449	Microtus_ochrogaster
ENSG00000142676	RPL11	100	98.802	ENSMOCG00000002378	-	100	98.315	Microtus_ochrogaster
ENSG00000142676	RPL11	99	91.515	ENSMOCG00000004581	-	100	87.079	Microtus_ochrogaster
ENSG00000142676	RPL11	100	100.000	ENSMOCG00000021255	-	100	100.000	Microtus_ochrogaster
ENSG00000142676	RPL11	99	89.697	ENSMOCG00000000648	-	100	85.955	Microtus_ochrogaster
ENSG00000142676	RPL11	100	97.006	ENSMMOG00000001098	rpl11	99	96.591	Mola_mola
ENSG00000142676	RPL11	100	99.438	ENSMODG00000012828	RPL11	100	99.438	Monodelphis_domestica
ENSG00000142676	RPL11	100	96.407	ENSMALG00000010547	rpl11	100	96.067	Monopterus_albus
ENSG00000142676	RPL11	100	75.281	MGP_CAROLIEiJ_G0026654	-	100	75.281	Mus_caroli
ENSG00000142676	RPL11	100	100.000	ENSMUSG00000059291	Rpl11	100	100.000	Mus_musculus
ENSG00000142676	RPL11	100	100.000	MGP_PahariEiJ_G0028987	Rpl11	100	100.000	Mus_pahari
ENSG00000142676	RPL11	100	100.000	MGP_SPRETEiJ_G0027634	Rpl11	100	100.000	Mus_spretus
ENSG00000142676	RPL11	86	96.078	MGP_SPRETEiJ_G0028655	-	77	96.078	Mus_spretus
ENSG00000142676	RPL11	100	100.000	ENSMPUG00000020149	-	100	100.000	Mustela_putorius_furo
ENSG00000142676	RPL11	100	97.006	ENSMPUG00000020092	-	96	97.076	Mustela_putorius_furo
ENSG00000142676	RPL11	100	100.000	ENSMLUG00000008868	RPL11	99	100.000	Myotis_lucifugus
ENSG00000142676	RPL11	100	100.000	ENSNGAG00000018109	Rpl11	100	100.000	Nannospalax_galili
ENSG00000142676	RPL11	100	66.854	ENSNGAG00000000298	-	100	66.854	Nannospalax_galili
ENSG00000142676	RPL11	100	72.472	ENSNGAG00000011953	-	100	72.472	Nannospalax_galili
ENSG00000142676	RPL11	100	88.690	ENSNGAG00000016385	-	100	88.690	Nannospalax_galili
ENSG00000142676	RPL11	91	72.840	ENSNGAG00000014180	-	89	72.840	Nannospalax_galili
ENSG00000142676	RPL11	74	78.195	ENSNBRG00000009835	-	72	78.788	Neolamprologus_brichardi
ENSG00000142676	RPL11	100	100.000	ENSNLEG00000028203	RPL11	100	100.000	Nomascus_leucogenys
ENSG00000142676	RPL11	100	77.401	ENSNLEG00000028212	-	96	77.401	Nomascus_leucogenys
ENSG00000142676	RPL11	100	99.438	ENSMEUG00000013738	RPL11	100	99.438	Notamacropus_eugenii
ENSG00000142676	RPL11	54	100.000	ENSOPRG00000014983	-	59	100.000	Ochotona_princeps
ENSG00000142676	RPL11	100	100.000	ENSODEG00000014876	-	100	100.000	Octodon_degus
ENSG00000142676	RPL11	100	73.034	ENSODEG00000010047	-	100	73.034	Octodon_degus
ENSG00000142676	RPL11	100	92.262	ENSODEG00000002269	-	100	92.179	Octodon_degus
ENSG00000142676	RPL11	100	85.393	ENSODEG00000001032	-	92	95.973	Octodon_degus
ENSG00000142676	RPL11	100	80.899	ENSODEG00000016649	-	100	80.899	Octodon_degus
ENSG00000142676	RPL11	99	86.667	ENSODEG00000001783	-	89	86.667	Octodon_degus
ENSG00000142676	RPL11	100	95.808	ENSONIG00000017753	rpl11	99	95.455	Oreochromis_niloticus
ENSG00000142676	RPL11	100	99.438	ENSOANG00000000321	RPL11	100	99.438	Ornithorhynchus_anatinus
ENSG00000142676	RPL11	100	100.000	ENSOCUG00000022928	RPL11	100	100.000	Oryctolagus_cuniculus
ENSG00000142676	RPL11	100	95.808	ENSORLG00000007578	rpl11	100	94.944	Oryzias_latipes
ENSG00000142676	RPL11	100	95.808	ENSORLG00020011962	rpl11	100	94.944	Oryzias_latipes_hni
ENSG00000142676	RPL11	100	95.808	ENSORLG00015002266	rpl11	99	94.886	Oryzias_latipes_hsok
ENSG00000142676	RPL11	100	96.407	ENSOMEG00000018186	-	100	96.407	Oryzias_melastigma
ENSG00000142676	RPL11	100	100.000	ENSOGAG00000032741	RPL11	100	98.876	Otolemur_garnettii
ENSG00000142676	RPL11	100	100.000	ENSOARG00000007306	RPL11	100	98.876	Ovis_aries
ENSG00000142676	RPL11	100	75.706	ENSPPAG00000011196	-	91	75.706	Pan_paniscus
ENSG00000142676	RPL11	100	100.000	ENSPPAG00000032945	RPL11	100	100.000	Pan_paniscus
ENSG00000142676	RPL11	100	100.000	ENSPPRG00000007647	RPL11	100	100.000	Panthera_pardus
ENSG00000142676	RPL11	100	100.000	ENSPTIG00000004366	RPL11	100	99.438	Panthera_tigris_altaica
ENSG00000142676	RPL11	99	66.265	ENSPTIG00000007650	-	96	66.102	Panthera_tigris_altaica
ENSG00000142676	RPL11	100	80.240	ENSPTRG00000045554	-	100	79.775	Pan_troglodytes
ENSG00000142676	RPL11	100	100.000	ENSPTRG00000000334	RPL11	100	100.000	Pan_troglodytes
ENSG00000142676	RPL11	96	98.125	ENSPANG00000010235	-	100	98.125	Papio_anubis
ENSG00000142676	RPL11	100	100.000	ENSPANG00000033920	RPL11	100	100.000	Papio_anubis
ENSG00000142676	RPL11	100	96.407	ENSPKIG00000022899	rpl11	100	96.407	Paramormyrops_kingsleyae
ENSG00000142676	RPL11	68	94.737	ENSPKIG00000022926	rpl11	99	94.737	Paramormyrops_kingsleyae
ENSG00000142676	RPL11	100	98.315	ENSPSIG00000008253	RPL11	100	98.315	Pelodiscus_sinensis
ENSG00000142676	RPL11	95	96.835	ENSPMGG00000023894	rpl11	97	96.450	Periophthalmus_magnuspinnatus
ENSG00000142676	RPL11	100	100.000	ENSPEMG00000009906	-	100	99.438	Peromyscus_maniculatus_bairdii
ENSG00000142676	RPL11	75	92.857	ENSPMAG00000009481	-	100	92.857	Petromyzon_marinus
ENSG00000142676	RPL11	100	99.401	ENSPCIG00000004594	-	100	99.401	Phascolarctos_cinereus
ENSG00000142676	RPL11	100	98.204	ENSPFOG00000003710	rpl11	100	97.753	Poecilia_formosa
ENSG00000142676	RPL11	100	98.204	ENSPLAG00000004334	rpl11	100	97.753	Poecilia_latipinna
ENSG00000142676	RPL11	100	98.204	ENSPMEG00000001017	rpl11	98	96.648	Poecilia_mexicana
ENSG00000142676	RPL11	100	98.204	ENSPREG00000008204	rpl11	100	97.753	Poecilia_reticulata
ENSG00000142676	RPL11	100	100.000	ENSPPYG00000001736	RPL11	100	100.000	Pongo_abelii
ENSG00000142676	RPL11	100	83.708	ENSPCAG00000004489	RPL11	100	83.708	Procavia_capensis
ENSG00000142676	RPL11	71	86.885	ENSPCOG00000023926	-	91	86.885	Propithecus_coquereli
ENSG00000142676	RPL11	100	73.653	ENSPCOG00000019164	-	99	73.373	Propithecus_coquereli
ENSG00000142676	RPL11	100	98.876	ENSPCOG00000025449	RPL11	100	98.876	Propithecus_coquereli
ENSG00000142676	RPL11	100	100.000	ENSPVAG00000004282	RPL11	100	100.000	Pteropus_vampyrus
ENSG00000142676	RPL11	100	95.808	ENSPNYG00000007331	rpl11	100	95.506	Pundamilia_nyererei
ENSG00000142676	RPL11	100	95.808	ENSPNAG00000026061	rpl11	100	95.506	Pygocentrus_nattereri
ENSG00000142676	RPL11	100	71.856	ENSRNOG00000004163	AABR07064667.1	99	70.930	Rattus_norvegicus
ENSG00000142676	RPL11	100	100.000	ENSRNOG00000026260	Rpl11	100	100.000	Rattus_norvegicus
ENSG00000142676	RPL11	99	93.220	ENSRBIG00000032677	-	96	97.605	Rhinopithecus_bieti
ENSG00000142676	RPL11	100	97.191	ENSRBIG00000001691	-	100	97.191	Rhinopithecus_bieti
ENSG00000142676	RPL11	100	92.697	ENSRBIG00000019645	-	100	92.697	Rhinopithecus_bieti
ENSG00000142676	RPL11	100	100.000	ENSRBIG00000027604	RPL11	100	100.000	Rhinopithecus_bieti
ENSG00000142676	RPL11	100	97.753	ENSRROG00000021726	-	100	97.753	Rhinopithecus_roxellana
ENSG00000142676	RPL11	100	99.435	ENSRROG00000039209	-	100	99.435	Rhinopithecus_roxellana
ENSG00000142676	RPL11	98	72.561	YGR085C	RPL11B	96	72.455	Saccharomyces_cerevisiae
ENSG00000142676	RPL11	98	72.561	YPR102C	RPL11A	96	72.455	Saccharomyces_cerevisiae
ENSG00000142676	RPL11	100	98.315	ENSSBOG00000035179	-	100	98.315	Saimiri_boliviensis_boliviensis
ENSG00000142676	RPL11	100	79.661	ENSSBOG00000020669	RPL11	100	79.661	Saimiri_boliviensis_boliviensis
ENSG00000142676	RPL11	100	99.401	ENSSHAG00000006767	RPL11	100	98.315	Sarcophilus_harrisii
ENSG00000142676	RPL11	100	95.210	ENSSFOG00015022461	rpl11	100	94.944	Scleropages_formosus
ENSG00000142676	RPL11	100	95.210	ENSSMAG00000018435	rpl11	99	94.350	Scophthalmus_maximus
ENSG00000142676	RPL11	99	96.386	ENSSDUG00000008255	rpl11	89	96.045	Seriola_dumerili
ENSG00000142676	RPL11	100	96.407	ENSSLDG00000019043	-	100	96.067	Seriola_lalandi_dorsalis
ENSG00000142676	RPL11	98	67.683	ENSSLDG00000001556	-	97	68.047	Seriola_lalandi_dorsalis
ENSG00000142676	RPL11	89	98.658	ENSSARG00000010904	RPL11	100	98.101	Sorex_araneus
ENSG00000142676	RPL11	100	99.438	ENSSPUG00000001317	RPL11	100	99.438	Sphenodon_punctatus
ENSG00000142676	RPL11	100	96.407	ENSSPAG00000001672	rpl11	100	96.067	Stegastes_partitus
ENSG00000142676	RPL11	100	70.225	ENSSSCG00000035389	-	100	70.225	Sus_scrofa
ENSG00000142676	RPL11	100	77.246	ENSSSCG00000028670	-	100	76.966	Sus_scrofa
ENSG00000142676	RPL11	99	64.773	ENSSSCG00000036398	-	95	64.773	Sus_scrofa
ENSG00000142676	RPL11	100	99.438	ENSSSCG00000024260	RPL11	100	99.438	Sus_scrofa
ENSG00000142676	RPL11	100	98.802	ENSTGUG00000001210	RPL11	100	98.864	Taeniopygia_guttata
ENSG00000142676	RPL11	100	96.407	ENSTRUG00000020944	rpl11	100	96.407	Takifugu_rubripes
ENSG00000142676	RPL11	100	96.407	ENSTNIG00000002616	rpl11	100	96.067	Tetraodon_nigroviridis
ENSG00000142676	RPL11	100	78.652	ENSTBEG00000007838	RPL11	100	78.652	Tupaia_belangeri
ENSG00000142676	RPL11	100	100.000	ENSTTRG00000016115	RPL11	100	100.000	Tursiops_truncatus
ENSG00000142676	RPL11	100	100.000	ENSUAMG00000008926	RPL11	89	98.876	Ursus_americanus
ENSG00000142676	RPL11	100	100.000	ENSUMAG00000013210	RPL11	89	98.876	Ursus_maritimus
ENSG00000142676	RPL11	89	64.375	ENSVVUG00000018614	-	94	64.375	Vulpes_vulpes
ENSG00000142676	RPL11	100	100.000	ENSVVUG00000026887	-	91	98.876	Vulpes_vulpes
ENSG00000142676	RPL11	100	97.605	ENSXETG00000001178	rpl11	99	96.023	Xenopus_tropicalis
ENSG00000142676	RPL11	100	98.204	ENSXCOG00000013397	rpl11	100	98.204	Xiphophorus_couchianus
ENSG00000142676	RPL11	100	98.204	ENSXMAG00000016325	rpl11	100	97.753	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0000027	ribosomal large subunit assembly	24120868.	IMP	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0002181	cytoplasmic translation	25957688.	IDA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	12962325.	NAS	Function
GO:0005515	protein binding	15195100.15314173.17110929.17310983.17373842.17599065.18274552.18560357.19417104.19713960.21399665.21988832.23507139.23776465.24556985.24965446.25416956.25910212.27829214.	IPI	Function
GO:0005654	nucleoplasm	23776465.24120868.	IDA	Component
GO:0005730	nucleolus	16791210.	HDA	Component
GO:0005730	nucleolus	15195100.23776465.	IDA	Component
GO:0005737	cytoplasm	16791210.	HDA	Component
GO:0005737	cytoplasm	15314173.24120868.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	18697920.	IMP	Process
GO:0006412	translation	12962325.	NAS	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006605	protein targeting	15195100.	IMP	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	Process
GO:0008097	5S rRNA binding	18560357.	IMP	Function
GO:0010628	positive regulation of gene expression	18560357.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019083	viral transcription	-	TAS	Process
GO:0022625	cytosolic large ribosomal subunit	12962325.	HDA	Component
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0022625	cytosolic large ribosomal subunit	25957688.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	18560357.	IPI	Function
GO:0032092	positive regulation of protein binding	18560357.	IMP	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	-	ISS	Process
GO:0032991	protein-containing complex	15314173.	IDA	Component
GO:0034504	protein localization to nucleus	-	ISS	Process
GO:0042273	ribosomal large subunit biogenesis	18697920.	IMP	Process
GO:0042788	polysomal ribosome	25957688.	IDA	Component
GO:0050821	protein stabilization	18560357.	IMP	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:1901796	regulation of signal transduction by p53 class mediator	24120868.	IMP	Process
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	-	IEA	Process
GO:1904667	negative regulation of ubiquitin protein ligase activity	18560357.	IMP	Process
GO:1990948	ubiquitin ligase inhibitor activity	18560357.	IMP	Function
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	18560357.	IMP	Process
GO:2000435	negative regulation of protein neddylation	18560357.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24061479	Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.	Mol Cell Biol	2013 Dec	Teng T	doi: 10.1128/MCB.01174-13
17116689	Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.	Mol Cell Biol	2007 Feb	Lindstrm MS	-
24045667	PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.	Br J Cancer	2013 Oct 15	Uchi R	doi: 10.1038/bjc.2013.561

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	23692612	Missense_Mutation	novel	D4N	0.43	Ribosomal_L5_C
BLCA	chr1	23696394	3'UTR	novel		0.18
BLCA	chr1	23692648	Missense_Mutation	NA	R16C	0.3	Ribosomal_L5_C
BLCA	chr1	23693823	Silent	rs752965630	R58R	0.19
BRCA	chr1	23696341	Splice_Region	novel		0.58
BRCA	chr1	23696006	Intron	novel		0.63
CESC	chr1	23696373	Nonstop_Mutation	NA	179Yext?	0.39
CESC	chr1	23696355	Silent	NA	I173I	0.38
COAD	chr1	23696402	3'UTR	novel		0.33
COAD	chr1	23691808	5'UTR	rs369231011		0.28
COAD	chr1	23695821	Silent	novel	S140S	0.18
COAD	chr1	23695825	Missense_Mutation	NA	A142T	0.22
COAD	chr1	23694914	Intron	novel		0.17
ESCA	chr1	23692666	Missense_Mutation	novel	L22V	0.19	Ribosomal_L5_C
GBM	chr1	23694735	Missense_Mutation	novel	D114N	0.23
HNSC	chr1	23692629	Silent	novel	E9E	0.21
KIRC	chr1	23695852	Missense_Mutation	NA	I151F	0.25
KIRP	chr1	23694714	Missense_Mutation	NA	F107V	0.33
KIRP	chr1	23694797	Splice_Region	novel		0.26
LAML	chr1	23694817	Intron	novel		0.08
LIHC	chr1	23693905	Missense_Mutation	novel	G86C	0.45
LUAD	chr1	23694719	Silent	novel	G108G	0.19
LUAD	chr1	23694673	Missense_Mutation	novel	E93V	0.38
LUSC	chr1	23692668	Silent	NA	L22L	0.36
OV	chr1	23691819	5'UTR	novel		0.91
OV	chr1	23694757	Missense_Mutation	novel	P121L	0.05
OV	chr1	23692726	Frame_Shift_Ins	novel	*Q42Lfs13**	0.05	Ribosomal_L5_C
PRAD	chr1	23692622	Frame_Shift_Del	novel	*K8Rfs26**	0.15	Ribosomal_L5_C
PRAD	chr1	23693863	Missense_Mutation	novel	C72R	0.45
READ	chr1	23694781	Missense_Mutation	NA	D129V	0.28
READ	chr1	23695897	Missense_Mutation	novel	F166L	0.5
SARC	chr1	23691826	Splice_Site	novel	X2_splice	0.41
SKCM	chr1	23693825	Missense_Mutation	NA	S59F	0.31
SKCM	chr1	23696389	3'UTR	novel		0.28
SKCM	chr1	23691819	5'UTR	novel		0.22
SKCM	chr1	23694748	Missense_Mutation	NA	K118T	0.24
SKCM	chr1	23691811	5'UTR	novel		0.32
SKCM	chr1	23691808	5'UTR	rs369231011		0.4
SKCM	chr1	23691808	5'UTR	rs369231011		0.36
SKCM	chr1	23695899	Silent	novel	F166F	0.44
SKCM	chr1	23695900	Nonsense_Mutation	novel	Q167*	0.44
SKCM	chr1	23696377	3'UTR	novel		0.27
SKCM	chr1	23692699	Missense_Mutation	NA	L33M	0.28	Ribosomal_L5_C
SKCM	chr1	23691811	5'UTR	novel		0.41
STAD	chr1	23691830	Splice_Site	NA	X2_splice	0.19
THYM	chr1	23692745	Missense_Mutation	novel	P48R	0.1	Ribosomal_L5_C
UCEC	chr1	23696349	Silent	rs759437708	D171D	0.44
UCEC	chr1	23695891	Missense_Mutation	rs777313952	R164C	0.44
UCEC	chr1	23695814	Missense_Mutation	novel	G138D	0.04
UCEC	chr1	23694760	Missense_Mutation	novel	S122I	0.04
UCEC	chr1	23695838	Missense_Mutation	rs770776620	R146H	0.23
UCEC	chr1	23696351	Missense_Mutation	novel	G172E	0.18
UCEC	chr1	23692639	Missense_Mutation	NA	R13W	0.39	Ribosomal_L5_C
UCEC	chr1	23696402	3'UTR	novel		0.41
UCEC	chr1	23695825	Missense_Mutation	NA	A142T	0.3
UCEC	chr1	23692649	Missense_Mutation	novel	R16H	0.43	Ribosomal_L5_C
UCEC	chr1	23695979	Intron	novel		0.47
UCEC	chr1	23695825	Missense_Mutation	NA	A142T	0.42
UCEC	chr1	23691829	Splice_Region	novel	A2A	0.56
UCEC	chr1	23693884	Missense_Mutation	novel	A79T	0.33
UCEC	chr1	23692715	Missense_Mutation	novel	K38T	0.21	Ribosomal_L5_C
UCEC	chr1	23695825	Missense_Mutation	NA	A142T	0.13
UCEC	chr1	23696081	Intron	novel		0.54
UCEC	chr1	23692608	Splice_Site	novel	X3_splice	0.25
UCEC	chr1	23694679	Frame_Shift_Ins	novel	*N97Kfs24**	0.52
UVM	chr1	23692738	Frame_Shift_Ins	novel	*T47Rfs42**	0.44	Ribosomal_L5_C

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0949	0.00029523
CHOL	DEL	0.7778	3.3987e-23
DLBC	DEL	0.125	0.011841
ESCA	DEL	0.2663	0.0012162
HNSC	DEL	0.1341	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LIHC	DEL	0.3459	1.6679e-20
LUAD	DEL	0.1609	0.0024765
LUSC	DEL	0.3713	2.5882e-07
MESO	DEL	0.3103	2.434e-07
READ	DEL	0.3939	2.1758e-10
TGCT	DEL	0.16	0.00046313
UVM	DEL	0.3	0.00034394

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0048	Kaplan-Meier Survival Analysis
MESO	0.008	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
BRCA	0.00096	Kaplan-Meier Survival Analysis
KIRP	0.041	Kaplan-Meier Survival Analysis
LIHC	0.009	Kaplan-Meier Survival Analysis
UVM	0.0087	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742