EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000142684 (Gene tree)
Gene ID
51042
Gene Symbol
ZNF593
Alias
ZT86
Full Name
zinc finger protein 593
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
1,003 bases
Position
chr1:26,169,871-26,170,873
Accession
30943
RBP type
canonical RBP
Summary
(Zinc Finger Protein 593) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is NDUFAB1.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000363384zf-C2H2_jazPF12171.84.5e-0711
ENSP00000270812zf-C2H2_jazPF12171.85.3e-0711
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18287285The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.Protein Sci2008 MarHayes PLdoi: 10.1110/ps.073290408.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000270812ZNF593-201698-ENSP00000270812156 (aa)-A9J4F5
ENST00000374266ZNF593-202675-ENSP00000363384134 (aa)-O00488
Gene Model
Click here to download ENSG00000142684's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142684's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000142684ZNF5939150.400ENSAPOG00000014046znf5938650.400Acanthochromis_polyacanthus
ENSG00000142684ZNF5939989.474ENSAMEG00000010410ZNF5939889.474Ailuropoda_melanoleuca
ENSG00000142684ZNF5939150.400ENSACIG00000004744znf5939550.400Amphilophus_citrinellus
ENSG00000142684ZNF5939150.400ENSAOCG00000014030znf5939550.400Amphiprion_ocellaris
ENSG00000142684ZNF5939150.400ENSAPEG00000018888znf5939550.400Amphiprion_percula
ENSG00000142684ZNF5939850.746ENSATEG00000012876znf59310050.746Anabas_testudineus
ENSG00000142684ZNF5939362.400ENSACAG00000017787ZNF5939462.400Anolis_carolinensis
ENSG00000142684ZNF59310094.776ENSANAG00000034118ZNF59310094.776Aotus_nancymaae
ENSG00000142684ZNF5939150.400ENSACLG00000016796znf5939550.400Astatotilapia_calliptera
ENSG00000142684ZNF5939846.269ENSAMXG00000039647znf59310046.269Astyanax_mexicanus
ENSG00000142684ZNF59310093.284ENSBTAG00000009562ZNF59310093.284Bos_taurus
ENSG00000142684ZNF5937838.318WBGene00013236Y56A3A.187938.318Caenorhabditis_elegans
ENSG00000142684ZNF59310089.552ENSCJAG00000009624ZNF59310089.552Callithrix_jacchus
ENSG00000142684ZNF5939987.970ENSCAFG00000030699ZNF5937387.970Canis_familiaris
ENSG00000142684ZNF5939987.970ENSCAFG00020021225ZNF5939787.970Canis_lupus_dingo
ENSG00000142684ZNF59310094.030ENSCHIG00000011277ZNF59310094.030Capra_hircus
ENSG00000142684ZNF5938180.734ENSTSYG00000031897ZNF5939380.734Carlito_syrichta
ENSG00000142684ZNF59310093.284ENSCPOG00000035949ZNF59310093.284Cavia_porcellus
ENSG00000142684ZNF59310097.015ENSCATG00000015417-10097.015Cercocebus_atys
ENSG00000142684ZNF59310092.537ENSCLAG00000011066ZNF59310092.537Chinchilla_lanigera
ENSG00000142684ZNF59310095.522ENSCSAG00000000966ZNF59310095.522Chlorocebus_sabaeus
ENSG00000142684ZNF59310076.282ENSCHOG00000004944ZNF59310076.282Choloepus_hoffmanni
ENSG00000142684ZNF5939760.769ENSCPBG00000025034ZNF5939560.769Chrysemys_picta_bellii
ENSG00000142684ZNF59310087.313ENSCANG00000029027ZNF59310087.313Colobus_angolensis_palliatus
ENSG00000142684ZNF59310088.806ENSCGRG00001010679Zfp59310088.806Cricetulus_griseus_chok1gshd
ENSG00000142684ZNF59310088.806ENSCGRG00000014971Zfp59310088.806Cricetulus_griseus_crigri
ENSG00000142684ZNF5939051.240ENSCSEG00000002614znf5939451.240Cynoglossus_semilaevis
ENSG00000142684ZNF5939849.254ENSCVAG00000020798znf59310049.254Cyprinodon_variegatus
ENSG00000142684ZNF5939850.000ENSDARG00000044102znf59310050.000Danio_rerio
ENSG00000142684ZNF5939989.474ENSDNOG00000034363ZNF5939889.474Dasypus_novemcinctus
ENSG00000142684ZNF59310087.313ENSDORG00000028366Zfp59310087.313Dipodomys_ordii
ENSG00000142684ZNF5935954.430FBgn0029885CG32247445.161Drosophila_melanogaster
ENSG00000142684ZNF59310091.045ENSETEG00000019920ZNF59310091.045Echinops_telfairi
ENSG00000142684ZNF59310094.030ENSEASG00005004029ZNF59310094.030Equus_asinus_asinus
ENSG00000142684ZNF59310094.030ENSECAG00000023934ZNF59310094.030Equus_caballus
ENSG00000142684ZNF59310091.045ENSEEUG00000010536ZNF59310091.045Erinaceus_europaeus
ENSG00000142684ZNF5939147.200ENSELUG00000014408znf5939547.200Esox_lucius
ENSG00000142684ZNF5939990.226ENSFCAG00000023239ZNF5939990.226Felis_catus
ENSG00000142684ZNF59310091.045ENSFDAG00000013333ZNF59310091.045Fukomys_damarensis
ENSG00000142684ZNF5939150.400ENSFHEG00000004200znf5939550.400Fundulus_heteroclitus
ENSG00000142684ZNF5939146.400ENSGMOG00000010720znf5939446.400Gadus_morhua
ENSG00000142684ZNF5939865.649ENSGALG00000000542ZNF5939665.649Gallus_gallus
ENSG00000142684ZNF5939149.600ENSGAFG00000007635znf5939549.600Gambusia_affinis
ENSG00000142684ZNF5939446.512ENSGACG00000009279znf5939846.512Gasterosteus_aculeatus
ENSG00000142684ZNF5939760.769ENSGAGG00000000323ZNF5939560.769Gopherus_agassizii
ENSG00000142684ZNF59310097.761ENSGGOG00000006573ZNF59310097.761Gorilla_gorilla
ENSG00000142684ZNF5939150.400ENSHBUG00000023229znf5939550.400Haplochromis_burtoni
ENSG00000142684ZNF59310089.552ENSHGLG00000011938ZNF59310089.552Heterocephalus_glaber_female
ENSG00000142684ZNF59310089.552ENSHGLG00100016960ZNF59310089.552Heterocephalus_glaber_male
ENSG00000142684ZNF5939151.200ENSHCOG00000007954znf5939551.200Hippocampus_comes
ENSG00000142684ZNF5939150.400ENSIPUG00000015389znf5939550.400Ictalurus_punctatus
ENSG00000142684ZNF5939990.226ENSSTOG00000022153ZNF5939990.226Ictidomys_tridecemlineatus
ENSG00000142684ZNF59310091.791ENSJJAG00000006095Zfp59310091.791Jaculus_jaculus
ENSG00000142684ZNF5939150.400ENSKMAG00000008952znf5939550.400Kryptolebias_marmoratus
ENSG00000142684ZNF5939847.015ENSLBEG00000005765znf59310047.015Labrus_bergylta
ENSG00000142684ZNF5939148.000ENSLACG00000004262znf5939548.000Latimeria_chalumnae
ENSG00000142684ZNF5939149.600ENSLOCG00000004338znf5939549.600Lepisosteus_oculatus
ENSG00000142684ZNF5939992.481ENSLAFG00000022048ZNF59310092.481Loxodonta_africana
ENSG00000142684ZNF59310091.791ENSMFAG00000025982-7791.791Macaca_fascicularis
ENSG00000142684ZNF59310096.269ENSMFAG00000044001-10096.269Macaca_fascicularis
ENSG00000142684ZNF59310088.462ENSMMUG00000004682ZNF59310088.462Macaca_mulatta
ENSG00000142684ZNF59310091.791ENSMMUG00000030530-7791.791Macaca_mulatta
ENSG00000142684ZNF59310096.269ENSMNEG00000028267ZNF59310096.269Macaca_nemestrina
ENSG00000142684ZNF59310094.776ENSMLEG00000035715ZNF59310094.776Mandrillus_leucophaeus
ENSG00000142684ZNF5939147.200ENSMAMG00000007484znf5939547.200Mastacembelus_armatus
ENSG00000142684ZNF5939150.400ENSMZEG00005005052znf5939550.400Maylandia_zebra
ENSG00000142684ZNF59310090.299ENSMAUG00000022183Zfp59310090.299Mesocricetus_auratus
ENSG00000142684ZNF59310092.537ENSMICG00000017472ZNF59310092.537Microcebus_murinus
ENSG00000142684ZNF59310088.060ENSMOCG00000013349Zfp59310088.060Microtus_ochrogaster
ENSG00000142684ZNF5939152.459ENSMMOG00000010269znf5939452.459Mola_mola
ENSG00000142684ZNF5939148.800ENSMALG00000012702znf5939548.800Monopterus_albus
ENSG00000142684ZNF59310089.552MGP_CAROLIEiJ_G0026613Zfp59310089.552Mus_caroli
ENSG00000142684ZNF59310090.299ENSMUSG00000028840Zfp59310090.299Mus_musculus
ENSG00000142684ZNF59310088.806MGP_PahariEiJ_G0028946Zfp59310088.806Mus_pahari
ENSG00000142684ZNF59310088.806MGP_SPRETEiJ_G0027593Zfp59310088.806Mus_spretus
ENSG00000142684ZNF59310090.299ENSMLUG00000010172ZNF59310090.299Myotis_lucifugus
ENSG00000142684ZNF59310089.552ENSNGAG00000011656Zfp59310089.552Nannospalax_galili
ENSG00000142684ZNF5939150.400ENSNBRG00000000263znf5939550.400Neolamprologus_brichardi
ENSG00000142684ZNF59310097.015ENSNLEG00000009197-10097.015Nomascus_leucogenys
ENSG00000142684ZNF59310063.750ENSMEUG00000012390-9963.750Notamacropus_eugenii
ENSG00000142684ZNF59310089.552ENSOPRG00000001439ZNF59310089.552Ochotona_princeps
ENSG00000142684ZNF59310089.552ENSODEG00000003869ZNF59310089.552Octodon_degus
ENSG00000142684ZNF5939150.400ENSONIG00000003571znf5939550.400Oreochromis_niloticus
ENSG00000142684ZNF5939070.833ENSOANG00000012304ZNF5939072.000Ornithorhynchus_anatinus
ENSG00000142684ZNF59310089.552ENSOCUG00000013999ZNF59310089.552Oryctolagus_cuniculus
ENSG00000142684ZNF5939150.820ENSORLG00000014641znf5939450.820Oryzias_latipes
ENSG00000142684ZNF5939150.820ENSORLG00020012989znf5939450.820Oryzias_latipes_hni
ENSG00000142684ZNF5939150.820ENSORLG00015011478znf5939450.820Oryzias_latipes_hsok
ENSG00000142684ZNF5939152.459ENSOMEG00000010097znf5939452.459Oryzias_melastigma
ENSG00000142684ZNF59310091.045ENSOGAG00000016334-9991.045Otolemur_garnettii
ENSG00000142684ZNF5939375.806ENSOGAG00000024080-9475.806Otolemur_garnettii
ENSG00000142684ZNF59310084.328ENSOARG00000005342ZNF59310084.328Ovis_aries
ENSG00000142684ZNF593100100.000ENSPPAG00000030063ZNF593100100.000Pan_paniscus
ENSG00000142684ZNF5939990.226ENSPPRG00000023304ZNF5939990.226Panthera_pardus
ENSG00000142684ZNF5936195.122ENSPTIG00000015187ZNF5939775.472Panthera_tigris_altaica
ENSG00000142684ZNF593100100.000ENSPTRG00000000375ZNF593100100.000Pan_troglodytes
ENSG00000142684ZNF59310092.949ENSPANG00000034030-10092.949Papio_anubis
ENSG00000142684ZNF59310091.791ENSPANG00000002484-10091.791Papio_anubis
ENSG00000142684ZNF5939150.400ENSPKIG00000000619znf5939550.400Paramormyrops_kingsleyae
ENSG00000142684ZNF5939149.600ENSPMGG00000010674znf5939549.600Periophthalmus_magnuspinnatus
ENSG00000142684ZNF59310090.299ENSPEMG00000011884Zfp59310090.299Peromyscus_maniculatus_bairdii
ENSG00000142684ZNF59310079.104ENSPCIG00000011911ZNF59310079.104Phascolarctos_cinereus
ENSG00000142684ZNF5939148.800ENSPFOG00000013615znf5939548.800Poecilia_formosa
ENSG00000142684ZNF5939148.800ENSPLAG00000016005znf5939548.800Poecilia_latipinna
ENSG00000142684ZNF5939148.800ENSPMEG00000018232znf5939548.800Poecilia_mexicana
ENSG00000142684ZNF5939148.000ENSPREG00000020251znf5939548.000Poecilia_reticulata
ENSG00000142684ZNF59310097.761ENSPPYG00000001693ZNF59310097.761Pongo_abelii
ENSG00000142684ZNF59310073.718ENSPCAG00000005336ZNF59310073.718Procavia_capensis
ENSG00000142684ZNF59310091.791ENSPCOG00000016991ZNF59310091.791Propithecus_coquereli
ENSG00000142684ZNF59310082.051ENSPVAG00000017253ZNF59310082.051Pteropus_vampyrus
ENSG00000142684ZNF5939150.400ENSPNYG00000019886znf5939550.400Pundamilia_nyererei
ENSG00000142684ZNF5939148.800ENSPNAG00000023494znf5939548.800Pygocentrus_nattereri
ENSG00000142684ZNF59310088.806ENSRNOG00000016392Zfp59310088.806Rattus_norvegicus
ENSG00000142684ZNF59310095.522ENSRBIG00000042051ZNF59310095.522Rhinopithecus_bieti
ENSG00000142684ZNF59310095.522ENSRROG00000042522ZNF59310095.522Rhinopithecus_roxellana
ENSG00000142684ZNF5936941.304YLR074C-5441.304Saccharomyces_cerevisiae
ENSG00000142684ZNF59310094.030ENSSBOG00000030845ZNF59310094.030Saimiri_boliviensis_boliviensis
ENSG00000142684ZNF5939149.600ENSSFOG00015002115znf5939449.600Scleropages_formosus
ENSG00000142684ZNF5939447.287ENSSMAG00000020125znf5939847.287Scophthalmus_maximus
ENSG00000142684ZNF5939847.761ENSSDUG00000017282znf59310047.761Seriola_dumerili
ENSG00000142684ZNF5939148.800ENSSLDG00000002876znf5939548.800Seriola_lalandi_dorsalis
ENSG00000142684ZNF5939989.474ENSSARG00000003139-9989.474Sorex_araneus
ENSG00000142684ZNF5939559.843ENSSPUG00000010623ZNF5939559.843Sphenodon_punctatus
ENSG00000142684ZNF5939850.000ENSSPAG00000022301znf5939850.000Stegastes_partitus
ENSG00000142684ZNF59310092.537ENSSSCG00000036593-10092.537Sus_scrofa
ENSG00000142684ZNF5939561.417ENSTGUG00000001050ZNF5939361.417Taeniopygia_guttata
ENSG00000142684ZNF5939451.938ENSTRUG00000008269znf5939851.938Takifugu_rubripes
ENSG00000142684ZNF5939451.163ENSTNIG00000017288znf5939851.163Tetraodon_nigroviridis
ENSG00000142684ZNF5939989.474ENSUAMG00000007146ZNF5939989.474Ursus_americanus
ENSG00000142684ZNF5936988.172ENSUMAG00000012751ZNF5939888.172Ursus_maritimus
ENSG00000142684ZNF5939988.722ENSVVUG00000011698ZNF5939788.722Vulpes_vulpes
ENSG00000142684ZNF59310047.482ENSXETG00000009189znf59310047.482Xenopus_tropicalis
ENSG00000142684ZNF5939149.600ENSXCOG00000004628znf5939549.600Xiphophorus_couchianus
ENSG00000142684ZNF5939149.600ENSXMAG00000007785znf5939549.600Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000055ribosomal large subunit export from nucleus21873635.IBAProcess
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction
GO:0003677DNA binding-IEAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0008270zinc ion binding18287285.IMPFunction
GO:0030687preribosome, large subunit precursor21873635.IBAComponent
GO:0043023ribosomal large subunit binding21873635.IBAFunction
GO:0045944positive regulation of transcription by RNA polymerase II9115366.IGIProcess
GO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding9115366.IGIProcess

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr126170591Frame_Shift_DelnovelE95Rfs*400.33
CESCchr126170522IntronNA0.29
CESCchr126170073Missense_MutationNAE30D0.3
COADchr126170648Frame_Shift_DelNAR115Gfs*240.49
COADchr1261707353'UTRnovel0.3
LIHCchr1261699575'UTRnovel0.33
LUSCchr126170687Missense_MutationnovelE126K0.81
MESOchr1261699595'UTRnovel0.22
OVchr126170607Missense_MutationnovelQ99P0.22
OVchr126170474Missense_MutationnovelK86M0.07zf-C2H2_jaz
READchr1261708713'UTRnovel0.5
READchr126170475Missense_MutationnovelK86N0.16zf-C2H2_jaz
TGCTchr126170456Frame_Shift_InsnovelR81Pfs*460.11zf-C2H2_jaz
UCECchr1261707273'UTRnovel0.3
UCECchr1261707413'UTRnovel0.5
UCECchr126170040Missense_MutationnovelM19I0.16
UCECchr126170616Missense_Mutationrs749150132A102V0.29
UCECchr126170475Missense_MutationnovelK86N0.33zf-C2H2_jaz
UCECchr126170431Missense_Mutationrs757730721D72N0.19zf-C2H2_jaz
UCECchr126170686SilentnovelT125T0.29
UCECchr1261707633'UTRnovel0.38
UCECchr126170617Silentrs770629776A102A0.56
UCECchr1261707823'UTRnovel0.29
UCECchr1261707943'UTRnovel0.47

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.09150.00029523
CHOLDEL0.77783.3987e-23
DLBCDEL0.10420.011841
ESCADEL0.29350.0012162
HNSCDEL0.1367.0766e-07
KIRCDEL0.14962.3538e-09
KIRPDEL0.17361.462e-09
LIHCDEL0.34861.6679e-20
LUADDEL0.17050.0024765
LUSCDEL0.37332.5882e-07
MESODEL0.26442.434e-07
READDEL0.42.1758e-10
TGCTDEL0.160.00046313

Survival Analysis
CancerP-value Q-value
KIRC0.00017

Kaplan-Meier Survival Analysis

SARC0.0063

Kaplan-Meier Survival Analysis

ACC0.0089

Kaplan-Meier Survival Analysis

SKCM0.019

Kaplan-Meier Survival Analysis

BRCA0.014

Kaplan-Meier Survival Analysis

LIHC0.015

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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