EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000143149 (Gene tree)
Gene ID: 223
Gene Symbol: ALDH9A1
Alias: E3|ALDH7|ALDH4|ALDH9
Full Name: aldehyde dehydrogenase 9 family member A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 36,652 bases
Position: chr1:165,662,212-165,698,863
Accession: 412
RBP type: non-canonical RBP
Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000354775	ALDH9A1-201	2696	XM_011509294	ENSP00000346827	518 (aa)	XP_011507596	P49189
ENST00000461664	ALDH9A1-202	899	-	-	- (aa)	-	-
ENST00000463610	ALDH9A1-203	559	-	-	- (aa)	-	-
ENST00000491436	ALDH9A1-205	819	-	-	- (aa)	-	-
ENST00000471457	ALDH9A1-204	568	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143149's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00053	Ascorbate and aldarate metabolism	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00330	Arginine and proline metabolism	KEGG
hsa00340	Histidine metabolism	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00410	beta-Alanine metabolism	KEGG
hsa00561	Glycerolipid metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143149	Leukoaraiosis	7.4391763E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143149's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004029	aldehyde dehydrogenase (NAD) activity	21873635.	IBA	Function
GO:0004029	aldehyde dehydrogenase (NAD) activity	2925663.	IDA	Function
GO:0005737	cytoplasm	2925663.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006081	cellular aldehyde metabolic process	8645224.	IDA	Process
GO:0019145	aminobutyraldehyde dehydrogenase activity	21873635.	IBA	Function
GO:0019145	aminobutyraldehyde dehydrogenase activity	2925663.8645224.	IDA	Function
GO:0033737	1-pyrroline dehydrogenase activity	-	IEA	Function
GO:0042136	neurotransmitter biosynthetic process	2925663.	IDA	Process
GO:0042445	hormone metabolic process	2925663.	TAS	Process
GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	-	IEA	Function
GO:0045329	carnitine biosynthetic process	-	IEA	Process
GO:0045329	carnitine biosynthetic process	-	TAS	Process
GO:0047105	4-trimethylammoniobutyraldehyde dehydrogenase activity	21873635.	IBA	Function
GO:0055114	oxidation-reduction process	2925663.	IDA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	165680537	Missense_Mutation	NA	P247S	0.16
BLCA	chr1	165683098	Missense_Mutation	novel	E114K	0.16
BLCA	chr1	165698559	5'UTR	novel		0.45
BLCA	chr1	165679569	Nonsense_Mutation	NA	S268*	0.15
BLCA	chr1	165680567	Nonsense_Mutation	novel	G236_A237ins*	0.46
BLCA	chr1	165669297	Nonsense_Mutation	NA	R362*	0.45
BLCA	chr1	165665076	Missense_Mutation	novel	F468L	0.38
BRCA	chr1	165682199	Missense_Mutation	novel	R167T	0.09
BRCA	chr1	165695359	Frame_Shift_Del	novel	*E74Sfs13**	0.22
BRCA	chr1	165698466	Silent	NA	V31V	0.19
BRCA	chr1	165665119	Missense_Mutation	rs142168163	R454Q	0.21
BRCA	chr1	165683091	Missense_Mutation	NA	A116V	0.26
CESC	chr1	165669414	Missense_Mutation	rs755173841	E323Q	0.15
CESC	chr1	165682214	Missense_Mutation	rs760770069	S162L	0.11
CESC	chr1	165662842	3'UTR	novel		0.49
CESC	chr1	165680566	Missense_Mutation	novel	A237D	0.49
COAD	chr1	165667413	Missense_Mutation	NA	E415D	0.33
COAD	chr1	165669437	Missense_Mutation	NA	G315D	0.32
COAD	chr1	165679533	Missense_Mutation	NA	G280E	0.28
COAD	chr1	165680499	Silent	NA	P259P	0.26
COAD	chr1	165682111	Silent	NA	A196A	0.25
COAD	chr1	165663099	Missense_Mutation	NA	Q503R	0.33
COAD	chr1	165695289	Missense_Mutation	rs145012858	R97H	0.27
ESCA	chr1	165668940	Missense_Mutation	novel	R398K	0.19
GBM	chr1	165680666	Missense_Mutation	novel	K204Q	0.04
GBM	chr1	165667429	Missense_Mutation	novel	T410S	0.1
GBM	chr1	165668879	Intron	novel		0.42
GBM	chr1	165663112	Missense_Mutation	rs767836676	E499K	0.42
GBM	chr1	165669436	Silent	novel	G315G	0.09
HNSC	chr1	165698612	5'UTR	novel		0.36
HNSC	chr1	165669404	Missense_Mutation	novel	D326G	0.09
HNSC	chr1	165698438	Missense_Mutation	novel	G41R	0.33
HNSC	chr1	165695291	Missense_Mutation	novel	E96D	0.33
HNSC	chr1	165698478	Silent	novel	T27T	0.16
KIRC	chr1	165683000	Silent	NA	G146G	0.3
KIRP	chr1	165695249	Splice_Region	novel		0.53
LGG	chr1	165669439	Silent	novel	N314N	0.22
LUAD	chr1	165683047	Missense_Mutation	rs752528835	R131C	0.21
LUAD	chr1	165682205	Missense_Mutation	NA	Y165C	0.05
LUAD	chr1	165698391	Silent	NA	F56F	0.57
LUAD	chr1	165663038	3'UTR	novel		0.23
LUSC	chr1	165669004	Missense_Mutation	novel	V377L	0.24
LUSC	chr1	165695329	Missense_Mutation	novel	A84S	0.18
LUSC	chr1	165663050	Nonstop_Mutation	novel	519Cext27	0.21
LUSC	chr1	165698438	Missense_Mutation	novel	G41R	0.07
LUSC	chr1	165680560	Missense_Mutation	NA	T239I	0.39
LUSC	chr1	165698516	Missense_Mutation	NA	R15C	0.57
LUSC	chr1	165683053	Missense_Mutation	rs755836366	E129Q	0.07
MESO	chr1	165680617	Missense_Mutation	rs377384593	Y220C	0.56
OV	chr1	165667327	Missense_Mutation	novel	A444G	0.17
OV	chr1	165663002	3'UTR	novel		0.05
PAAD	chr1	165665049	Silent	novel	V477V	0.12
READ	chr1	165680670	Silent	NA	V202V	0.16
READ	chr1	165662982	3'UTR	novel		0.44
READ	chr1	165698397	Missense_Mutation	novel	K54N	0.53
SARC	chr1	165680624	Nonsense_Mutation	novel	E218*	0.28
SARC	chr1	165682190	Missense_Mutation	novel	P170L	0.26
SARC	chr1	165680517	Silent	novel	S253S	0.28
SKCM	chr1	165669291	Missense_Mutation	novel	L364F	0.4
SKCM	chr1	165682988	Silent	NA	S150S	0.64
SKCM	chr1	165682988	Silent	NA	S150S	0.35
SKCM	chr1	165680656	Missense_Mutation	novel	P207L	0.27
SKCM	chr1	165680663	Missense_Mutation	rs770756608	P205S	0.16
SKCM	chr1	165680677	Missense_Mutation	NA	A200V	0.27
SKCM	chr1	165680490	Missense_Mutation	novel	M262I	0.58
STAD	chr1	165669408	Missense_Mutation	NA	L325I	0.17
STAD	chr1	165695393	Silent	NA	R62R	0.26
STAD	chr1	165669431	Missense_Mutation	novel	R317I	0.36
STAD	chr1	165669297	Nonsense_Mutation	NA	R362*	0.29
STAD	chr1	165663018	3'UTR	rs368572095		0.37
STAD	chr1	165669259	Splice_Region	novel		0.6
STAD	chr1	165698604	5'UTR	novel		0.33
STAD	chr1	165668980	Frame_Shift_Ins	novel	*V385Mfs8**	0.14
STAD	chr1	165663129	Missense_Mutation	rs758256843	N493S	0.27
STAD	chr1	165663114	Missense_Mutation	NA	I498T	0.34
UCEC	chr1	165679466	Missense_Mutation	novel	M302I	0.31
UCEC	chr1	165667436	Missense_Mutation	NA	D408Y	0.33
UCEC	chr1	165662826	3'UTR	novel		0.4
UCEC	chr1	165669414	Nonsense_Mutation	NA	E323*	0.1
UCEC	chr1	165667391	Missense_Mutation	NA	I423V	0.07
UCEC	chr1	165695308	Missense_Mutation	novel	Q91K	0.29
UCEC	chr1	165663089	Silent	NA	T506T	0.32
UCEC	chr1	165695283	Missense_Mutation	rs771178170	R99Q	0.32
UCEC	chr1	165663124	Missense_Mutation	rs149646148	R495C	0.08
UCEC	chr1	165668918	Splice_Region	novel		0.52
UCEC	chr1	165669401	Missense_Mutation	novel	K327T	0.2
UCEC	chr1	165679559	Silent	novel	G271G	0.11
UCEC	chr1	165701722	5'Flank	novel		0.29
UCEC	chr1	165701945	5'Flank	novel		0.44
UCEC	chr1	165663017	3'UTR	rs376768135		0.42
UCEC	chr1	165663128	Silent	rs536182553	N493N	0.56
UCEC	chr1	165668823	Intron	novel		0.38
UCEC	chr1	165701970	5'Flank	novel		0.3
UCEC	chr1	165663079	Frame_Shift_Ins	novel	*E510Wfs15**	0.16
UCEC	chr1	165663113	Silent	rs139191905	I498I	0.51
UCEC	chr1	165668874	Intron	novel		0.47
UCEC	chr1	165669391	Missense_Mutation	novel	E330D	0.48
UCEC	chr1	165669408	Missense_Mutation	NA	L325I	0.33
UCEC	chr1	165679551	Missense_Mutation	novel	P274H	0.44
UCEC	chr1	165680577	Silent	rs561795333	V233V	0.47
UCEC	chr1	165683102	Missense_Mutation	novel	E112D	0.38
UCEC	chr1	165701942	5'Flank	novel		0.38
UCEC	chr1	165663012	3'UTR	novel		0.43
UCEC	chr1	165701845	5'Flank	novel		0.11
UCEC	chr1	165682214	Missense_Mutation	rs760770069	S162L	0.48
UCEC	chr1	165667388	Missense_Mutation	NA	L424I	0.28
UCEC	chr1	165701875	5'Flank	novel		0.21
UCEC	chr1	165698339	Intron	novel		0.22
UCEC	chr1	165683086	Nonsense_Mutation	novel	*M118Dfs4**	0.05
UCEC	chr1	165667320	Silent	rs551226422	G446G	0.23
UCEC	chr1	165669278	Missense_Mutation	novel	K368T	0.23
UCEC	chr1	165679574	Missense_Mutation	novel	E266D	0.17
UCEC	chr1	165695360	Missense_Mutation	novel	K73N	0.44
UCEC	chr1	165698443	Missense_Mutation	novel	R39H	0.35
UCEC	chr1	165662824	3'UTR	novel		0.14
UCEC	chr1	165662971	3'UTR	novel		0.18
UCEC	chr1	165695330	Silent	novel	K83K	0.38
UCEC	chr1	165701810	5'Flank	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.4185	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2174	0.085665
SKCM	AMP	0.4905	9.6912e-06
TGCT	AMP	0.3333	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
THYM	0.042	Kaplan-Meier Survival Analysis
KIRC	0.00015	Kaplan-Meier Survival Analysis
MESO	0.0085	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
PAAD	0.024	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0038	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742