EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143374 (Gene tree)
Gene ID: 80222
Gene Symbol: TARS2
Alias: FLJ12528|TARSL1
Full Name: threonyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,246 bases
Position: chr1:150,487,364-150,507,609
Accession: 30740
RBP type: canonical RBP
Summary: This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000358060	tRNA_SAD	PF07973.14	2.1e-08	1	1
ENSP00000475847	tRNA_SAD	PF07973.14	5.4e-07	1	1
ENSP00000415002	tRNA_SAD	PF07973.14	3.1e-06	1	1
ENSP00000415002	HGTP_anticodon	PF03129.20	9.9e-19	1	1
ENSP00000358050	HGTP_anticodon	PF03129.20	1.2e-18	1	1
ENSP00000475847	HGTP_anticodon	PF03129.20	1.4e-18	1	1
ENSP00000358060	HGTP_anticodon	PF03129.20	1.6e-18	1	1
ENSP00000415002	tRNA-synt_2b	PF00587.25	2.7e-33	1	1
ENSP00000358050	tRNA-synt_2b	PF00587.25	5e-33	1	1
ENSP00000475847	tRNA-synt_2b	PF00587.25	5.4e-33	1	1
ENSP00000358060	tRNA-synt_2b	PF00587.25	7e-33	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000369051	TARS2-201	2106	-	ENSP00000358047	135 (aa)	-	Q5T5E9
ENST00000480070	TARS2-212	832	-	-	- (aa)	-	-
ENST00000369053	TARS2-202	628	-	-	- (aa)	-	-
ENST00000369054	TARS2-203	1998	-	ENSP00000358050	588 (aa)	-	Q9BW92
ENST00000462578	TARS2-207	609	-	-	- (aa)	-	-
ENST00000606933	TARS2-214	2162	XM_017002395	ENSP00000475847	636 (aa)	XP_016857884	U3KQG0
ENST00000438568	TARS2-205	2188	-	ENSP00000415002	443 (aa)	-	F6S7Q7
ENST00000463555	TARS2-208	852	-	-	- (aa)	-	-
ENST00000467982	TARS2-210	1855	-	ENSP00000475551	143 (aa)	-	U3KQ50
ENST00000466989	TARS2-209	427	-	-	- (aa)	-	-
ENST00000369064	TARS2-204	2729	XM_006711555	ENSP00000358060	718 (aa)	XP_006711618	Q9BW92
ENST00000479372	TARS2-211	850	-	-	- (aa)	-	-
ENST00000483046	TARS2-213	311	-	-	- (aa)	-	-
ENST00000460794	TARS2-206	568	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143374's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143374	Cerebrospinal Fluid	2E-10	28031287

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000143374	rs3754214	1	150506147	?	Cerebrospinal fluid biomarker levels	28031287		EFO_0006794
ENSG00000143374	rs9436119	1	150495277	A	Chronotype	30696823	1.0402905	EFO_0008328
ENSG00000143374	rs9436119	1	150495277	A	Morning person	30696823	1.041	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143374's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000143374	TARS2	96	55.759	ENSG00000185418	TARSL2	97	57.639
ENSG00000143374	TARS2	96	57.552	ENSG00000113407	TARS	93	54.124

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143374	TARS2	100	87.656	ENSAMEG00000001547	TARS2	100	87.656	Ailuropoda_melanoleuca
ENSG00000143374	TARS2	100	95.125	ENSANAG00000019620	TARS2	100	95.125	Aotus_nancymaae
ENSG00000143374	TARS2	100	88.022	ENSBTAG00000003799	TARS2	100	88.022	Bos_taurus
ENSG00000143374	TARS2	100	94.969	ENSCJAG00000006429	TARS2	100	94.969	Callithrix_jacchus
ENSG00000143374	TARS2	100	87.467	ENSCAFG00000011941	TARS2	100	87.326	Canis_familiaris
ENSG00000143374	TARS2	100	87.467	ENSCAFG00020019615	TARS2	100	87.326	Canis_lupus_dingo
ENSG00000143374	TARS2	100	88.022	ENSCHIG00000018559	TARS2	100	88.022	Capra_hircus
ENSG00000143374	TARS2	100	91.922	ENSTSYG00000003903	TARS2	100	92.095	Carlito_syrichta
ENSG00000143374	TARS2	100	94.290	ENSCCAG00000034305	TARS2	100	94.290	Cebus_capucinus
ENSG00000143374	TARS2	100	96.769	ENSCATG00000034784	TARS2	100	96.769	Cercocebus_atys
ENSG00000143374	TARS2	98	84.615	ENSCLAG00000017274	TARS2	100	86.207	Chinchilla_lanigera
ENSG00000143374	TARS2	98	100.000	ENSCSAG00000018075	TARS2	100	97.354	Chlorocebus_sabaeus
ENSG00000143374	TARS2	72	88.350	ENSCHOG00000000796	-	82	87.402	Choloepus_hoffmanni
ENSG00000143374	TARS2	84	95.135	ENSCANG00000035036	TARS2	94	95.135	Colobus_angolensis_palliatus
ENSG00000143374	TARS2	100	84.371	ENSCGRG00001023517	Tars2	100	86.614	Cricetulus_griseus_chok1gshd
ENSG00000143374	TARS2	100	84.371	ENSCGRG00000007836	Tars2	100	86.614	Cricetulus_griseus_crigri
ENSG00000143374	TARS2	100	87.744	ENSDNOG00000005934	TARS2	100	87.744	Dasypus_novemcinctus
ENSG00000143374	TARS2	91	81.888	ENSDORG00000007569	Tars2	99	89.362	Dipodomys_ordii
ENSG00000143374	TARS2	98	88.462	ENSETEG00000008569	TARS2	100	79.387	Echinops_telfairi
ENSG00000143374	TARS2	100	89.817	ENSEASG00005001587	TARS2	100	88.997	Equus_asinus_asinus
ENSG00000143374	TARS2	100	90.339	ENSECAG00000014276	TARS2	100	89.276	Equus_caballus
ENSG00000143374	TARS2	89	86.592	ENSEEUG00000000186	-	78	86.592	Erinaceus_europaeus
ENSG00000143374	TARS2	100	88.095	ENSFCAG00000001702	TARS2	100	88.142	Felis_catus
ENSG00000143374	TARS2	100	81.723	ENSFDAG00000012739	TARS2	100	83.629	Fukomys_damarensis
ENSG00000143374	TARS2	100	94.183	ENSGGOG00000006311	TARS2	100	100.000	Gorilla_gorilla
ENSG00000143374	TARS2	100	81.241	ENSHGLG00000009219	TARS2	100	82.011	Heterocephalus_glaber_female
ENSG00000143374	TARS2	100	81.241	ENSHGLG00100008254	TARS2	100	81.379	Heterocephalus_glaber_male
ENSG00000143374	TARS2	100	87.467	ENSSTOG00000008311	TARS2	100	89.567	Ictidomys_tridecemlineatus
ENSG00000143374	TARS2	100	83.862	ENSJJAG00000021883	Tars2	100	85.433	Jaculus_jaculus
ENSG00000143374	TARS2	100	86.842	ENSLAFG00000004979	TARS2	100	86.842	Loxodonta_africana
ENSG00000143374	TARS2	98	100.000	ENSMFAG00000030387	TARS2	98	100.000	Macaca_fascicularis
ENSG00000143374	TARS2	98	100.000	ENSMMUG00000006256	TARS2	98	100.000	Macaca_mulatta
ENSG00000143374	TARS2	88	96.923	ENSMNEG00000042066	TARS2	90	96.923	Macaca_nemestrina
ENSG00000143374	TARS2	98	100.000	ENSMLEG00000030174	TARS2	98	100.000	Mandrillus_leucophaeus
ENSG00000143374	TARS2	93	59.466	ENSMGAG00000000718	TARS2	100	60.102	Meleagris_gallopavo
ENSG00000143374	TARS2	100	83.812	ENSMAUG00000008184	Tars2	99	88.571	Mesocricetus_auratus
ENSG00000143374	TARS2	100	89.524	ENSMICG00000008016	TARS2	100	90.119	Microcebus_murinus
ENSG00000143374	TARS2	100	84.856	ENSMOCG00000018432	Tars2	100	87.205	Microtus_ochrogaster
ENSG00000143374	TARS2	91	84.615	ENSMODG00000018792	TARS2	99	74.334	Monodelphis_domestica
ENSG00000143374	TARS2	100	83.541	MGP_CAROLIEiJ_G0025352	Tars2	99	92.143	Mus_caroli
ENSG00000143374	TARS2	100	83.679	ENSMUSG00000028107	Tars2	99	90.714	Mus_musculus
ENSG00000143374	TARS2	100	82.988	MGP_PahariEiJ_G0026796	Tars2	99	91.429	Mus_pahari
ENSG00000143374	TARS2	100	83.541	MGP_SPRETEiJ_G0026296	Tars2	99	90.714	Mus_spretus
ENSG00000143374	TARS2	100	88.488	ENSMPUG00000004795	TARS2	100	88.488	Mustela_putorius_furo
ENSG00000143374	TARS2	100	87.933	ENSMLUG00000013123	TARS2	100	87.933	Myotis_lucifugus
ENSG00000143374	TARS2	100	98.571	ENSNLEG00000009858	TARS2	100	98.571	Nomascus_leucogenys
ENSG00000143374	TARS2	91	84.615	ENSMEUG00000014226	TARS2	99	69.986	Notamacropus_eugenii
ENSG00000143374	TARS2	93	84.127	ENSOPRG00000010194	TARS2	86	85.301	Ochotona_princeps
ENSG00000143374	TARS2	100	82.621	ENSODEG00000011883	TARS2	100	84.252	Octodon_degus
ENSG00000143374	TARS2	100	85.446	ENSOGAG00000005360	TARS2	100	74.480	Otolemur_garnettii
ENSG00000143374	TARS2	100	87.535	ENSOARG00000020814	TARS2	100	87.535	Ovis_aries
ENSG00000143374	TARS2	100	100.000	ENSPPAG00000042011	TARS2	100	100.000	Pan_paniscus
ENSG00000143374	TARS2	100	87.831	ENSPPRG00000019975	TARS2	100	87.747	Panthera_pardus
ENSG00000143374	TARS2	100	87.566	ENSPTIG00000008079	TARS2	100	86.907	Panthera_tigris_altaica
ENSG00000143374	TARS2	100	100.000	ENSPTRG00000001256	TARS2	100	100.000	Pan_troglodytes
ENSG00000143374	TARS2	98	100.000	ENSPANG00000016774	TARS2	98	100.000	Papio_anubis
ENSG00000143374	TARS2	99	77.285	ENSPCIG00000008884	TARS2	99	74.895	Phascolarctos_cinereus
ENSG00000143374	TARS2	100	98.607	ENSPPYG00000000898	TARS2	100	98.607	Pongo_abelii
ENSG00000143374	TARS2	92	78.635	ENSPCAG00000016619	TARS2	100	73.991	Procavia_capensis
ENSG00000143374	TARS2	100	91.667	ENSPCOG00000017247	TARS2	100	91.667	Propithecus_coquereli
ENSG00000143374	TARS2	100	88.372	ENSPVAG00000004340	TARS2	100	83.148	Pteropus_vampyrus
ENSG00000143374	TARS2	100	82.573	ENSRNOG00000057194	Tars2	100	82.573	Rattus_norvegicus
ENSG00000143374	TARS2	100	96.084	ENSRBIG00000044518	TARS2	100	96.084	Rhinopithecus_bieti
ENSG00000143374	TARS2	98	100.000	ENSRROG00000030946	TARS2	98	100.000	Rhinopithecus_roxellana
ENSG00000143374	TARS2	97	93.211	ENSSBOG00000001108	TARS2	100	93.211	Saimiri_boliviensis_boliviensis
ENSG00000143374	TARS2	93	84.615	ENSSHAG00000010286	TARS2	100	76.341	Sarcophilus_harrisii
ENSG00000143374	TARS2	98	79.772	ENSSARG00000013133	TARS2	100	79.358	Sorex_araneus
ENSG00000143374	TARS2	91	89.817	ENSSSCG00000026395	TARS2	99	89.238	Sus_scrofa
ENSG00000143374	TARS2	82	85.417	ENSTBEG00000003968	TARS2	82	85.417	Tupaia_belangeri
ENSG00000143374	TARS2	85	90.741	ENSTTRG00000010627	TARS2	80	90.741	Tursiops_truncatus
ENSG00000143374	TARS2	93	87.500	ENSUAMG00000023983	TARS2	95	88.571	Ursus_americanus
ENSG00000143374	TARS2	100	88.773	ENSUMAG00000003705	TARS2	100	88.579	Ursus_maritimus
ENSG00000143374	TARS2	85	87.069	ENSVPAG00000005427	TARS2	74	87.069	Vicugna_pacos
ENSG00000143374	TARS2	100	87.728	ENSVVUG00000009226	TARS2	100	86.963	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002161	aminoacyl-tRNA editing activity	26811336.	IDA	Function
GO:0004829	threonine-tRNA ligase activity	21873635.	IBA	Function
GO:0004829	threonine-tRNA ligase activity	26811336.	IDA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0006435	threonyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0042803	protein homodimerization activity	26811336.	IDA	Function
GO:0070159	mitochondrial threonyl-tRNA aminoacylation	15779907.	TAS	Process
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	150490708	Missense_Mutation	novel	F165L	0.18
BLCA	chr1	150487909	Missense_Mutation	NA	E40K	0.12
BLCA	chr1	150491410	Missense_Mutation	NA	E177Q	0.11
BLCA	chr1	150507022	Missense_Mutation	novel	E705D	0.36
BLCA	chr1	150491497	Missense_Mutation	rs780461008	R206C	0.56
BLCA	chr1	150499293	Missense_Mutation	NA	K539N	0.38	tRNA_SAD
BLCA	chr1	150487903	Missense_Mutation	novel	L38V	0.19
BLCA	chr1	150489044	Missense_Mutation	novel	S115C	0.18
BLCA	chr1	150490606	Missense_Mutation	NA	F131L	0.14
BLCA	chr1	150491430	Silent	NA	R183R	0.17
BLCA	chr1	150505633	Missense_Mutation	NA	D646H	0.17
BRCA	chr1	150504338	Missense_Mutation	NA	D541H	0.54	tRNA_SAD
BRCA	chr1	150507053	Missense_Mutation	NA	E716K	0.29
BRCA	chr1	150496867	Nonsense_Mutation	novel	R327*	0.05
BRCA	chr1	150499231	Missense_Mutation	novel	L519M	0.06	tRNA_SAD
BRCA	chr1	150498646	Missense_Mutation	NA	I461M	0.23	tRNA_SAD
BRCA	chr1	150491430	Silent	NA	R183R	0.24
BRCA	chr1	150492439	Missense_Mutation	NA	G242S	0.32
BRCA	chr1	150497548	Missense_Mutation	novel	G347C	0.12
BRCA	chr1	150496546	Missense_Mutation	NA	S280F	0.17
BRCA	chr1	150497565	Frame_Shift_Ins	novel	*T353Sfs65**	0.1
BRCA	chr1	150499013	Silent	NA	C506C	0.41
BRCA	chr1	150505643	Missense_Mutation	NA	S649C	0.3
BRCA	chr1	150491652	Missense_Mutation	novel	T229P	0.1
BRCA	chr1	150497689	Missense_Mutation	NA	S394P	0.23
CESC	chr1	150490637	Missense_Mutation	NA	A142T	0.18
CESC	chr1	150496868	Missense_Mutation	rs367984492	R327Q	0.16
CESC	chr1	150504976	Missense_Mutation	NA	E631Q	0.27
CESC	chr1	150491497	Missense_Mutation	rs780461008	R206C	0.12
CESC	chr1	150504644	Silent	NA	A577A	0.28
CESC	chr1	150507034	Silent	rs774814779	T709T	0.08
CESC	chr1	150491508	Silent	novel	F209F	0.25
CESC	chr1	150492333	Intron	NA		0.27
COAD	chr1	150504337	Missense_Mutation	NA	I540M	0.32	tRNA_SAD
COAD	chr1	150491445	Silent	novel	L188L	0.26
COAD	chr1	150496883	Missense_Mutation	novel	Y332C	0.57
COAD	chr1	150489064	Missense_Mutation	NA	F122V	0.11
COAD	chr1	150487921	Missense_Mutation	NA	A44T	0.41
COAD	chr1	150497644	Nonsense_Mutation	NA	Q379*	0.12
COAD	chr1	150498628	Silent	rs373939663	Q455Q	0.33
COAD	chr1	150490708	Silent	NA	F165F	0.24
COAD	chr1	150504689	Silent	NA	V592V	0.29
COAD	chr1	150499029	Missense_Mutation	rs776799586	E512K	0.17	tRNA_SAD
COAD	chr1	150507095	3'UTR	rs754720456		0.34
COAD	chr1	150496617	Missense_Mutation	NA	R304C	0.22
COAD	chr1	150506974	Silent	NA	R689R	0.37
COAD	chr1	150498637	Silent	rs762924252	D458D	0.22
COAD	chr1	150498569	Missense_Mutation	novel	L436V	0.26	tRNA_SAD
ESCA	chr1	150497555	Missense_Mutation	novel	S349C	0.24
ESCA	chr1	150487951	Missense_Mutation	novel	A54T	0.16
GBM	chr1	150490708	Missense_Mutation	novel	F165L	0.1
GBM	chr1	150487868	Missense_Mutation	novel	S26L	0.2
GBM	chr1	150496586	Nonsense_Mutation	novel	W293*	0.12
GBM	chr1	150504924	Silent	novel	P613P	0.06
GBM	chr1	150490649	Missense_Mutation	novel	F146V	0.05
HNSC	chr1	150505618	Missense_Mutation	NA	L641M	0.39
HNSC	chr1	150491429	Missense_Mutation	rs762368446	R183Q	0.22
HNSC	chr1	150487977	Missense_Mutation	novel	K62N	0.12
HNSC	chr1	150487964	Missense_Mutation	novel	P58R	0.25
KIRC	chr1	150504362	Missense_Mutation	novel	G549S	0.17	tRNA_SAD
KIRC	chr1	150487454	Missense_Mutation	rs756811374	A2T	0.26
KIRC	chr1	150497677	Frame_Shift_Del	novel	Q390*	0.21
KIRP	chr1	150487445	5'UTR	novel		0.28
KIRP	chr1	150507193	3'UTR	novel		0.25
LAML	chr1	150498986	Silent	novel	R497R	0.09
LGG	chr1	150496584	Missense_Mutation	novel	W293R	0.52
LGG	chr1	150504662	Frame_Shift_Del	novel	*I584Vfs62**	0.04	tRNA_SAD
LIHC	chr1	150488975	Missense_Mutation	NA	A92G	0.18
LIHC	chr1	150497615	Missense_Mutation	novel	E369G	0.2
LIHC	chr1	150499231	Missense_Mutation	novel	L519V	0.48	tRNA_SAD
LIHC	chr1	150498977	Silent	novel	L494L	0.45
LUAD	chr1	150496840	Missense_Mutation	NA	S318C	0.09
LUAD	chr1	150499035	Splice_Site	NA	X513_splice	0.12
LUAD	chr1	150497629	Missense_Mutation	NA	D374N	0.19
LUAD	chr1	150506972	Missense_Mutation	rs778879320	R689C	0.39
LUAD	chr1	150504714	Missense_Mutation	NA	E601K	0.05	tRNA_SAD
LUAD	chr1	150499283	Missense_Mutation	novel	Y536C	0.32	tRNA_SAD
LUAD	chr1	150491476	Missense_Mutation	NA	E199K	0.32
LUAD	chr1	150487447	5'UTR	novel		0.11
LUAD	chr1	150499022	Missense_Mutation	novel	D509E	0.06	tRNA_SAD
LUAD	chr1	150491476	Missense_Mutation	NA	E199K	0.11
LUAD	chr1	150499019	Missense_Mutation	novel	W508C	0.12	tRNA_SAD
LUAD	chr1	150491663	Splice_Site	NA	X232_splice	0.19
LUSC	chr1	150504932	Missense_Mutation	NA	V616A	0.25
LUSC	chr1	150496560	Missense_Mutation	NA	E285K	0.19
LUSC	chr1	150498499	Splice_Region	novel		0.11
LUSC	chr1	150505664	Missense_Mutation	NA	R656T	0.16
LUSC	chr1	150505677	Silent	NA	A660A	0.2
LUSC	chr1	150504927	Silent	NA	F614F	0.15
LUSC	chr1	150507006	Missense_Mutation	novel	V700G	0.31
LUSC	chr1	150496599	Missense_Mutation	novel	E298K	0.31
LUSC	chr1	150496486	Nonsense_Mutation	novel	S260*	0.11
LUSC	chr1	150505668	Silent	novel	I657I	0.1
OV	chr1	150498528	Missense_Mutation	NA	S422F	0.13	tRNA_SAD
OV	chr1	150487919	Frame_Shift_Del	novel	*A44Lfs4**	0.28
OV	chr1	150496557	Missense_Mutation	rs748946128	T284A	0.06
OV	chr1	150487866	Nonsense_Mutation	novel	*S26Efs6**	0.1
OV	chr1	150497608	Missense_Mutation	NA	H367Y	0.24
PAAD	chr1	150507095	3'UTR	rs754720456		0.28
PRAD	chr1	150496510	Missense_Mutation	novel	G268V	0.05
PRAD	chr1	150498550	Silent	NA	R429R	0.06
PRAD	chr1	150492434	Missense_Mutation	novel	C240Y	0.38
READ	chr1	150508065	3'Flank	novel		0.08
READ	chr1	150490708	Missense_Mutation	novel	F165L	0.42
SARC	chr1	150504677	Silent	novel	V588V	0.09
SARC	chr1	150496868	Missense_Mutation	rs367984492	R327Q	0.15
SARC	chr1	150491434	Missense_Mutation	novel	C185S	0.63
SKCM	chr1	150492451	Missense_Mutation	NA	R246W	0.09
SKCM	chr1	150496810	Missense_Mutation	NA	E308K	0.47
SKCM	chr1	150498995	Silent	NA	G500G	0.06
SKCM	chr1	150498998	Silent	NA	F501F	0.08
SKCM	chr1	150498912	Nonsense_Mutation	NA	Q473*	0.41	tRNA_SAD
SKCM	chr1	150490621	Silent	NA	T136T	0.48
SKCM	chr1	150498980	Silent	novel	S495S	0.18
SKCM	chr1	150498962	Silent	NA	S489S	0.56
SKCM	chr1	150499218	Splice_Region	NA	V514V	0.33
SKCM	chr1	150499029	Missense_Mutation	rs776799586	E512K	0.23	tRNA_SAD
SKCM	chr1	150490614	Missense_Mutation	NA	S134F	0.21
SKCM	chr1	150491499	Silent	novel	R206R	0.12
SKCM	chr1	150491500	Nonsense_Mutation	novel	Q207*	0.12
SKCM	chr1	150498529	Silent	NA	S422S	0.81
SKCM	chr1	150487460	Missense_Mutation	novel	Y4D	0.2
SKCM	chr1	150498528	Missense_Mutation	NA	S422F	0.18	tRNA_SAD
SKCM	chr1	150490676	Missense_Mutation	NA	P155S	0.45
SKCM	chr1	150496550	Silent	NA	F281F	0.18
SKCM	chr1	150496484	Missense_Mutation	NA	N259K	0.12
STAD	chr1	150504723	Frame_Shift_Del	novel	*K606Nfs46**	0.18
STAD	chr1	150504365	Missense_Mutation	rs749517234	R550W	0.16	tRNA_SAD
STAD	chr1	150506939	Missense_Mutation	NA	K678E	0.27
STAD	chr1	150490616	Missense_Mutation	NA	S135G	0.16
STAD	chr1	150504387	Missense_Mutation	novel	I557N	0.11	tRNA_SAD
STAD	chr1	150491470	Missense_Mutation	NA	R197G	0.24
STAD	chr1	150487969	Missense_Mutation	novel	T60A	0.1
STAD	chr1	150496617	Missense_Mutation	NA	R304C	0.34
STAD	chr1	150490659	Missense_Mutation	novel	A149D	0.56
STAD	chr1	150487947	Silent	NA	S52S	0.16
STAD	chr1	150497716	Missense_Mutation	rs587685186	A403T	0.17	tRNA_SAD
STAD	chr1	150504426	Missense_Mutation	NA	Q570R	0.31	tRNA_SAD
STAD	chr1	150507143	3'UTR	rs770019083		0.26
STAD	chr1	150504729	Missense_Mutation	NA	K606E	0.21
STAD	chr1	150497647	Frame_Shift_Del	novel	*P381Qfs27**	0.31
STAD	chr1	150499292	Missense_Mutation	novel	K539T	0.16	tRNA_SAD
STAD	chr1	150504357	Missense_Mutation	novel	A547V	0.5	tRNA_SAD
STAD	chr1	150504359	In_Frame_Del	novel	L548_R550del	0.45	tRNA_SAD
UCEC	chr1	150497716	Missense_Mutation	rs587685186	A403T	0.23	tRNA_SAD
UCEC	chr1	150507053	Nonsense_Mutation	NA	E716*	0.28
UCEC	chr1	150487988	Missense_Mutation	NA	P66H	0.29
UCEC	chr1	150498939	Missense_Mutation	rs775749716	V482I	0.24	tRNA_SAD
UCEC	chr1	150490646	Missense_Mutation	NA	Q145E	0.3
UCEC	chr1	150506975	Missense_Mutation	rs777829295	R690C	0.11
UCEC	chr1	150491649	Missense_Mutation	novel	A228S	0.1
UCEC	chr1	150497716	Missense_Mutation	rs587685186	A403T	0.16	tRNA_SAD
UCEC	chr1	150498581	Missense_Mutation	rs781477512	E440K	0.39	tRNA_SAD
UCEC	chr1	150497600	Missense_Mutation	NA	Q364R	0.35
UCEC	chr1	150489066	Silent	rs376600610	F122F	0.34
UCEC	chr1	150497644	Nonsense_Mutation	NA	Q379*	0.3
UCEC	chr1	150504678	Missense_Mutation	novel	L589F	0.3	tRNA_SAD
UCEC	chr1	150504922	Missense_Mutation	novel	P613S	0.29
UCEC	chr1	150506989	Missense_Mutation	NA	W694C	0.33
UCEC	chr1	150491655	Missense_Mutation	novel	V230L	0.61
UCEC	chr1	150496501	Missense_Mutation	novel	R265M	0.22
UCEC	chr1	150507169	3'UTR	novel		0.31
UCEC	chr1	150490669	Silent	rs764569077	C152C	0.33
UCEC	chr1	150498987	Missense_Mutation	novel	P498S	0.3	tRNA_SAD
UCEC	chr1	150497686	Missense_Mutation	rs756030195	D393N	0.23
UCEC	chr1	150498611	Nonsense_Mutation	novel	R450*	0.13	tRNA_SAD
UCEC	chr1	150506958	Missense_Mutation	novel	R684Q	0.4
UCEC	chr1	150488985	Silent	novel	A95A	0.3
UCEC	chr1	150499281	Missense_Mutation	novel	F535L	0.24	tRNA_SAD
UCEC	chr1	150506972	Missense_Mutation	rs778879320	R689C	0.32
UCEC	chr1	150504365	Missense_Mutation	rs749517234	R550W	0.21	tRNA_SAD
UCEC	chr1	150504722	Silent	rs752424999	C603C	0.42
UCEC	chr1	150489066	Silent	rs376600610	F122F	0.21
UCEC	chr1	150491428	Missense_Mutation	rs768821693	R183W	0.37
UCEC	chr1	150504980	Splice_Site	novel	X631_splice	0.35
UCEC	chr1	150506976	Missense_Mutation	rs368552858	R690H	0.21
UCEC	chr1	150488007	Silent	NA	D72D	0.18
UCEC	chr1	150497607	Silent	NA	G366G	0.17
UCEC	chr1	150504682	Missense_Mutation	novel	G590D	0.31	tRNA_SAD
UCEC	chr1	150504915	Nonsense_Mutation	novel	W610*	0.4
UCEC	chr1	150507014	Silent	novel	L703L	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1556	0.11282
BRCA	AMP	0.6694	4.7504e-42
CESC	AMP	0.478	3.2002e-05
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3913	0.0022446
KIRC	AMP	0.0928	0.059566
LUSC	AMP	0.4271	1.6618e-06
PAAD	AMP	0.2174	0.085665
PCPG	AMP	0.1481	0.00029562
READ	AMP	0.2727	0.025154
SARC	AMP	0.3424	4.3422e-08
SKCM	AMP	0.4823	9.6912e-06
STAD	AMP	0.2562	1.12e-06
TGCT	AMP	0.3533	0.088103
UCEC	AMP	0.4249	3.1683e-22

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.042	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
PCPG	0.027	Kaplan-Meier Survival Analysis
KICH	0.0017	Kaplan-Meier Survival Analysis
UCEC	0.006	Kaplan-Meier Survival Analysis
UVM	0.00022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742