EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143486 (Gene tree)
Gene ID: 1939
Gene Symbol: EIF2D
Alias: LGTN
Full Name: eukaryotic translation initiation factor 2D
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 41,260 bases
Position: chr1:206,571,292-206,612,551
Accession: 6583
RBP type: canonical RBP
Summary: This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000356081	SUI1	PF01253.22	3.9e-18	1	1
ENSP00000271764	SUI1	PF01253.22	4e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28732596	Structural and Functional Insights into Human Re-initiation Complexes.	Mol Cell	2017 Aug 3	Weisser M	doi: 10.1016/j.molcel.2017.06.032

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000472709	EIF2D-206	750	-	ENSP00000484299	62 (aa)	-	A0A087X1L6
ENST00000271764	EIF2D-201	2005	XM_005277509	ENSP00000271764	584 (aa)	XP_005277566	P41214
ENST00000613435	EIF2D-209	437	-	ENSP00000484590	73 (aa)	-	A0A087X202
ENST00000620382	EIF2D-211	1274	-	-	- (aa)	-	-
ENST00000367114	EIF2D-202	1633	XM_017000530	ENSP00000356081	460 (aa)	XP_016856019	P41214
ENST00000617960	EIF2D-210	5224	-	-	- (aa)	-	-
ENST00000468891	EIF2D-205	542	-	-	- (aa)	-	-
ENST00000437518	EIF2D-203	920	XM_011509258	ENSP00000394685	270 (aa)	XP_011507560	Q5SY38
ENST00000484492	EIF2D-208	479	-	ENSP00000479327	66 (aa)	-	A0A087WVB6
ENST00000474408	EIF2D-207	484	-	-	- (aa)	-	-
ENST00000461334	EIF2D-204	411	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143486's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143486's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143486	EIF2D	100	69.886	ENSAPOG00000003524	eif2d	100	58.459	Acanthochromis_polyacanthus
ENSG00000143486	EIF2D	100	92.222	ENSAMEG00000011880	EIF2D	100	87.884	Ailuropoda_melanoleuca
ENSG00000143486	EIF2D	100	56.189	ENSACIG00000021785	eif2d	99	70.056	Amphilophus_citrinellus
ENSG00000143486	EIF2D	100	71.186	ENSAOCG00000017584	eif2d	90	71.186	Amphiprion_ocellaris
ENSG00000143486	EIF2D	100	69.444	ENSAPEG00000011347	eif2d	100	56.102	Amphiprion_percula
ENSG00000143486	EIF2D	100	67.614	ENSATEG00000007580	eif2d	100	57.383	Anabas_testudineus
ENSG00000143486	EIF2D	96	67.284	ENSAPLG00000014849	EIF2D	100	60.997	Anas_platyrhynchos
ENSG00000143486	EIF2D	100	72.727	ENSACAG00000007724	EIF2D	100	60.661	Anolis_carolinensis
ENSG00000143486	EIF2D	100	96.739	ENSANAG00000022240	EIF2D	100	96.739	Aotus_nancymaae
ENSG00000143486	EIF2D	100	68.182	ENSACLG00000024604	eif2d	100	56.419	Astatotilapia_calliptera
ENSG00000143486	EIF2D	98	65.556	ENSAMXG00000038035	eif2d	100	54.908	Astyanax_mexicanus
ENSG00000143486	EIF2D	100	92.222	ENSBTAG00000010432	EIF2D	82	88.356	Bos_taurus
ENSG00000143486	EIF2D	99	35.450	WBGene00016113	eif-2D	83	35.450	Caenorhabditis_elegans
ENSG00000143486	EIF2D	100	96.154	ENSCJAG00000018600	EIF2D	100	96.154	Callithrix_jacchus
ENSG00000143486	EIF2D	98	91.667	ENSCAFG00000010261	EIF2D	100	87.350	Canis_familiaris
ENSG00000143486	EIF2D	98	91.111	ENSCAFG00020004757	EIF2D	100	87.179	Canis_lupus_dingo
ENSG00000143486	EIF2D	100	92.222	ENSCHIG00000009380	EIF2D	100	88.396	Capra_hircus
ENSG00000143486	EIF2D	100	95.000	ENSTSYG00000007829	EIF2D	100	95.000	Carlito_syrichta
ENSG00000143486	EIF2D	99	89.444	ENSCPOG00000008935	EIF2D	100	82.847	Cavia_porcellus
ENSG00000143486	EIF2D	100	97.174	ENSCCAG00000026977	EIF2D	100	97.174	Cebus_capucinus
ENSG00000143486	EIF2D	100	98.043	ENSCATG00000030190	EIF2D	100	98.043	Cercocebus_atys
ENSG00000143486	EIF2D	100	91.111	ENSCLAG00000014401	EIF2D	100	84.075	Chinchilla_lanigera
ENSG00000143486	EIF2D	100	97.260	ENSCSAG00000014939	EIF2D	100	97.260	Chlorocebus_sabaeus
ENSG00000143486	EIF2D	100	90.136	ENSCHOG00000007330	EIF2D	100	79.452	Choloepus_hoffmanni
ENSG00000143486	EIF2D	100	75.568	ENSCPBG00000001908	EIF2D	100	63.322	Chrysemys_picta_bellii
ENSG00000143486	EIF2D	100	42.703	ENSCING00000000226	-	100	35.656	Ciona_intestinalis
ENSG00000143486	EIF2D	100	39.640	ENSCSAVG00000005731	-	100	38.024	Ciona_savignyi
ENSG00000143486	EIF2D	100	97.037	ENSCANG00000033926	EIF2D	100	92.637	Colobus_angolensis_palliatus
ENSG00000143486	EIF2D	99	89.444	ENSCGRG00001019105	Eif2d	100	82.333	Cricetulus_griseus_chok1gshd
ENSG00000143486	EIF2D	99	89.444	ENSCGRG00000014164	Eif2d	100	82.333	Cricetulus_griseus_crigri
ENSG00000143486	EIF2D	100	66.120	ENSCSEG00000021328	eif2d	100	54.305	Cynoglossus_semilaevis
ENSG00000143486	EIF2D	100	68.182	ENSCVAG00000016064	eif2d	100	57.239	Cyprinodon_variegatus
ENSG00000143486	EIF2D	100	69.886	ENSDARG00000012929	eif2d	100	56.926	Danio_rerio
ENSG00000143486	EIF2D	100	79.032	ENSDNOG00000009251	-	100	75.717	Dasypus_novemcinctus
ENSG00000143486	EIF2D	100	91.667	ENSDORG00000012925	Eif2d	100	84.615	Dipodomys_ordii
ENSG00000143486	EIF2D	98	43.889	FBgn0041588	eIF2D	99	36.227	Drosophila_melanogaster
ENSG00000143486	EIF2D	100	88.636	ENSETEG00000015298	EIF2D	100	83.590	Echinops_telfairi
ENSG00000143486	EIF2D	99	55.000	ENSEBUG00000011079	eif2d	100	43.598	Eptatretus_burgeri
ENSG00000143486	EIF2D	100	93.889	ENSEASG00005004921	EIF2D	100	91.453	Equus_asinus_asinus
ENSG00000143486	EIF2D	100	93.889	ENSECAG00000000127	EIF2D	80	90.769	Equus_caballus
ENSG00000143486	EIF2D	100	67.045	ENSELUG00000001790	eif2d	100	55.519	Esox_lucius
ENSG00000143486	EIF2D	100	90.476	ENSFCAG00000013786	-	100	90.476	Felis_catus
ENSG00000143486	EIF2D	99	90.556	ENSFDAG00000011373	EIF2D	100	81.709	Fukomys_damarensis
ENSG00000143486	EIF2D	100	65.909	ENSFHEG00000003474	eif2d	100	57.047	Fundulus_heteroclitus
ENSG00000143486	EIF2D	100	64.444	ENSGMOG00000016667	eif2d	100	55.196	Gadus_morhua
ENSG00000143486	EIF2D	100	70.000	ENSGALG00000000856	EIF2D	100	63.167	Gallus_gallus
ENSG00000143486	EIF2D	100	67.614	ENSGAFG00000021062	eif2d	100	55.041	Gambusia_affinis
ENSG00000143486	EIF2D	99	69.886	ENSGACG00000002815	eif2d	100	55.408	Gasterosteus_aculeatus
ENSG00000143486	EIF2D	100	76.136	ENSGAGG00000010058	EIF2D	100	63.993	Gopherus_agassizii
ENSG00000143486	EIF2D	100	98.913	ENSGGOG00000015270	EIF2D	100	98.913	Gorilla_gorilla
ENSG00000143486	EIF2D	100	68.182	ENSHBUG00000006298	eif2d	100	56.419	Haplochromis_burtoni
ENSG00000143486	EIF2D	99	89.444	ENSHGLG00000008498	EIF2D	100	80.822	Heterocephalus_glaber_female
ENSG00000143486	EIF2D	99	89.444	ENSHGLG00100006825	EIF2D	100	80.651	Heterocephalus_glaber_male
ENSG00000143486	EIF2D	100	53.578	ENSHCOG00000009140	eif2d	95	66.071	Hippocampus_comes
ENSG00000143486	EIF2D	100	68.333	ENSIPUG00000012330	eif2d	100	56.376	Ictalurus_punctatus
ENSG00000143486	EIF2D	100	94.444	ENSSTOG00000006329	EIF2D	100	90.940	Ictidomys_tridecemlineatus
ENSG00000143486	EIF2D	100	66.477	ENSKMAG00000016689	eif2d	100	56.449	Kryptolebias_marmoratus
ENSG00000143486	EIF2D	100	67.045	ENSLBEG00000009691	eif2d	100	54.817	Labrus_bergylta
ENSG00000143486	EIF2D	99	68.182	ENSLACG00000008651	EIF2D	100	58.725	Latimeria_chalumnae
ENSG00000143486	EIF2D	100	71.591	ENSLOCG00000012230	eif2d	100	57.072	Lepisosteus_oculatus
ENSG00000143486	EIF2D	100	93.333	ENSLAFG00000000517	EIF2D	100	87.350	Loxodonta_africana
ENSG00000143486	EIF2D	100	98.261	ENSMFAG00000033925	EIF2D	100	98.261	Macaca_fascicularis
ENSG00000143486	EIF2D	100	98.261	ENSMMUG00000002528	EIF2D	100	98.261	Macaca_mulatta
ENSG00000143486	EIF2D	100	98.043	ENSMNEG00000028643	EIF2D	100	98.043	Macaca_nemestrina
ENSG00000143486	EIF2D	100	98.043	ENSMLEG00000030616	EIF2D	100	98.043	Mandrillus_leucophaeus
ENSG00000143486	EIF2D	100	67.778	ENSMAMG00000012055	eif2d	100	57.426	Mastacembelus_armatus
ENSG00000143486	EIF2D	100	68.182	ENSMZEG00005023738	eif2d	100	56.588	Maylandia_zebra
ENSG00000143486	EIF2D	100	65.193	ENSMGAG00000003648	EIF2D	100	60.500	Meleagris_gallopavo
ENSG00000143486	EIF2D	99	87.778	ENSMAUG00000008390	Eif2d	100	81.475	Mesocricetus_auratus
ENSG00000143486	EIF2D	100	94.444	ENSMICG00000017696	EIF2D	100	94.348	Microcebus_murinus
ENSG00000143486	EIF2D	99	88.333	ENSMOCG00000015872	Eif2d	100	82.333	Microtus_ochrogaster
ENSG00000143486	EIF2D	100	70.455	ENSMMOG00000020867	eif2d	100	55.668	Mola_mola
ENSG00000143486	EIF2D	76	84.000	ENSMODG00000002070	EIF2D	99	69.006	Monodelphis_domestica
ENSG00000143486	EIF2D	100	66.477	ENSMALG00000020271	eif2d	100	55.705	Monopterus_albus
ENSG00000143486	EIF2D	99	87.222	MGP_CAROLIEiJ_G0014568	Eif2d	100	81.304	Mus_caroli
ENSG00000143486	EIF2D	99	87.222	ENSMUSG00000026427	Eif2d	100	80.961	Mus_musculus
ENSG00000143486	EIF2D	99	87.778	MGP_PahariEiJ_G0027802	Eif2d	100	80.961	Mus_pahari
ENSG00000143486	EIF2D	99	87.222	MGP_SPRETEiJ_G0015372	Eif2d	100	81.132	Mus_spretus
ENSG00000143486	EIF2D	100	91.667	ENSMPUG00000012089	EIF2D	100	86.177	Mustela_putorius_furo
ENSG00000143486	EIF2D	100	94.014	ENSMLUG00000001410	-	100	89.060	Myotis_lucifugus
ENSG00000143486	EIF2D	100	90.000	ENSMLUG00000013479	-	100	88.205	Myotis_lucifugus
ENSG00000143486	EIF2D	100	90.556	ENSNGAG00000017892	Eif2d	100	84.589	Nannospalax_galili
ENSG00000143486	EIF2D	100	68.750	ENSNBRG00000017231	eif2d	100	56.757	Neolamprologus_brichardi
ENSG00000143486	EIF2D	100	98.696	ENSNLEG00000000648	EIF2D	100	98.696	Nomascus_leucogenys
ENSG00000143486	EIF2D	100	81.818	ENSMEUG00000008777	EIF2D	99	74.617	Notamacropus_eugenii
ENSG00000143486	EIF2D	83	90.556	ENSOPRG00000000585	EIF2D	87	86.275	Ochotona_princeps
ENSG00000143486	EIF2D	99	83.959	ENSODEG00000005533	EIF2D	100	82.705	Octodon_degus
ENSG00000143486	EIF2D	98	67.614	ENSONIG00000017293	eif2d	100	55.912	Oreochromis_niloticus
ENSG00000143486	EIF2D	74	87.755	ENSOANG00000002339	EIF2D	100	58.465	Ornithorhynchus_anatinus
ENSG00000143486	EIF2D	100	93.333	ENSOCUG00000015451	EIF2D	100	85.445	Oryctolagus_cuniculus
ENSG00000143486	EIF2D	100	67.045	ENSORLG00000010491	eif2d	100	53.795	Oryzias_latipes
ENSG00000143486	EIF2D	100	65.909	ENSORLG00020021017	eif2d	100	54.915	Oryzias_latipes_hni
ENSG00000143486	EIF2D	100	67.045	ENSORLG00015016577	eif2d	100	55.424	Oryzias_latipes_hsok
ENSG00000143486	EIF2D	100	64.773	ENSOMEG00000010533	eif2d	100	55.892	Oryzias_melastigma
ENSG00000143486	EIF2D	100	94.444	ENSOGAG00000010156	EIF2D	100	91.111	Otolemur_garnettii
ENSG00000143486	EIF2D	100	92.222	ENSOARG00000005917	EIF2D	100	89.384	Ovis_aries
ENSG00000143486	EIF2D	100	98.973	ENSPPAG00000034016	EIF2D	100	98.973	Pan_paniscus
ENSG00000143486	EIF2D	100	93.696	ENSPPRG00000010958	EIF2D	100	93.696	Panthera_pardus
ENSG00000143486	EIF2D	100	79.032	ENSPTIG00000012728	EIF2D	100	93.634	Panthera_tigris_altaica
ENSG00000143486	EIF2D	100	98.801	ENSPTRG00000001913	EIF2D	100	98.801	Pan_troglodytes
ENSG00000143486	EIF2D	100	98.043	ENSPANG00000012287	EIF2D	100	98.043	Papio_anubis
ENSG00000143486	EIF2D	100	68.750	ENSPKIG00000012100	eif2d	100	57.500	Paramormyrops_kingsleyae
ENSG00000143486	EIF2D	100	76.630	ENSPSIG00000003547	EIF2D	100	63.875	Pelodiscus_sinensis
ENSG00000143486	EIF2D	100	65.909	ENSPMGG00000011913	eif2d	100	54.958	Periophthalmus_magnuspinnatus
ENSG00000143486	EIF2D	99	89.444	ENSPEMG00000010082	Eif2d	100	82.676	Peromyscus_maniculatus_bairdii
ENSG00000143486	EIF2D	100	82.955	ENSPCIG00000001093	EIF2D	100	74.617	Phascolarctos_cinereus
ENSG00000143486	EIF2D	99	67.045	ENSPFOG00000012940	eif2d	99	55.184	Poecilia_formosa
ENSG00000143486	EIF2D	100	67.045	ENSPLAG00000019930	eif2d	100	56.463	Poecilia_latipinna
ENSG00000143486	EIF2D	100	66.477	ENSPMEG00000007895	eif2d	100	55.316	Poecilia_mexicana
ENSG00000143486	EIF2D	100	67.614	ENSPREG00000015967	eif2d	100	56.126	Poecilia_reticulata
ENSG00000143486	EIF2D	100	98.288	ENSPPYG00000000285	EIF2D	100	98.288	Pongo_abelii
ENSG00000143486	EIF2D	100	91.111	ENSPCAG00000010685	EIF2D	100	77.778	Procavia_capensis
ENSG00000143486	EIF2D	100	95.000	ENSPCOG00000028365	EIF2D	100	94.348	Propithecus_coquereli
ENSG00000143486	EIF2D	100	94.444	ENSPVAG00000008053	EIF2D	100	89.744	Pteropus_vampyrus
ENSG00000143486	EIF2D	85	65.190	ENSPNYG00000004459	eif2d	73	65.190	Pundamilia_nyererei
ENSG00000143486	EIF2D	100	67.222	ENSPNAG00000000143	eif2d	100	56.208	Pygocentrus_nattereri
ENSG00000143486	EIF2D	99	88.889	ENSRNOG00000004910	Eif2d	100	81.304	Rattus_norvegicus
ENSG00000143486	EIF2D	100	97.826	ENSRBIG00000011644	EIF2D	100	97.826	Rhinopithecus_bieti
ENSG00000143486	EIF2D	100	97.826	ENSRROG00000034152	EIF2D	100	97.826	Rhinopithecus_roxellana
ENSG00000143486	EIF2D	92	30.811	YDR117C	TMA64	65	30.811	Saccharomyces_cerevisiae
ENSG00000143486	EIF2D	100	96.957	ENSSBOG00000018387	EIF2D	100	96.957	Saimiri_boliviensis_boliviensis
ENSG00000143486	EIF2D	86	82.456	ENSSHAG00000016470	-	99	59.524	Sarcophilus_harrisii
ENSG00000143486	EIF2D	100	84.091	ENSSHAG00000017769	-	100	73.254	Sarcophilus_harrisii
ENSG00000143486	EIF2D	100	69.886	ENSSFOG00015014988	eif2d	100	58.209	Scleropages_formosus
ENSG00000143486	EIF2D	100	70.330	ENSSMAG00000010879	eif2d	100	57.454	Scophthalmus_maximus
ENSG00000143486	EIF2D	100	67.778	ENSSDUG00000014517	eif2d	100	57.596	Seriola_dumerili
ENSG00000143486	EIF2D	100	67.778	ENSSLDG00000006671	eif2d	100	57.095	Seriola_lalandi_dorsalis
ENSG00000143486	EIF2D	76	94.000	ENSSARG00000012911	EIF2D	100	77.092	Sorex_araneus
ENSG00000143486	EIF2D	100	76.705	ENSSPUG00000008418	EIF2D	100	64.489	Sphenodon_punctatus
ENSG00000143486	EIF2D	100	67.778	ENSSPAG00000002966	eif2d	100	57.095	Stegastes_partitus
ENSG00000143486	EIF2D	98	93.407	ENSSSCG00000015648	EIF2D	96	90.657	Sus_scrofa
ENSG00000143486	EIF2D	96	72.152	ENSTGUG00000001092	EIF2D	100	64.499	Taeniopygia_guttata
ENSG00000143486	EIF2D	100	71.591	ENSTRUG00000012383	eif2d	100	56.876	Takifugu_rubripes
ENSG00000143486	EIF2D	100	60.181	ENSTNIG00000017906	eif2d	100	56.345	Tetraodon_nigroviridis
ENSG00000143486	EIF2D	83	92.045	ENSTBEG00000017584	EIF2D	72	94.737	Tupaia_belangeri
ENSG00000143486	EIF2D	100	95.556	ENSTTRG00000012099	EIF2D	100	85.788	Tursiops_truncatus
ENSG00000143486	EIF2D	100	92.778	ENSUAMG00000022745	EIF2D	100	88.225	Ursus_americanus
ENSG00000143486	EIF2D	100	87.415	ENSUMAG00000004182	EIF2D	98	86.931	Ursus_maritimus
ENSG00000143486	EIF2D	86	96.491	ENSVPAG00000007046	EIF2D	67	93.827	Vicugna_pacos
ENSG00000143486	EIF2D	98	92.778	ENSVVUG00000013525	EIF2D	100	87.009	Vulpes_vulpes
ENSG00000143486	EIF2D	100	71.429	ENSXETG00000023678	eif2d	100	58.472	Xenopus_tropicalis
ENSG00000143486	EIF2D	100	66.477	ENSXCOG00000011402	eif2d	100	56.208	Xiphophorus_couchianus
ENSG00000143486	EIF2D	99	67.045	ENSXMAG00000014696	eif2d	99	56.176	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001731	formation of translation preinitiation complex	21873635.	IBA	Process
GO:0001731	formation of translation preinitiation complex	20713520.	IDA	Process
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	20566627.	IDA	Function
GO:0005737	cytoplasm	20566627.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006886	intracellular protein transport	2482295.	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0022627	cytosolic small ribosomal subunit	21873635.	IBA	Component
GO:0022627	cytosolic small ribosomal subunit	20713520.	IDA	Component
GO:0032790	ribosome disassembly	20713520.	IDA	Process
GO:0038023	signaling receptor activity	2482295.	TAS	Function
GO:0075522	IRES-dependent viral translational initiation	20713520.	IDA	Process