EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143614 (Gene tree)
Gene ID: 57459
Gene Symbol: GATAD2B
Alias: P66beta
Full Name: GATA zinc finger domain containing 2B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 134,331 bases
Position: chr1:153,789,030-153,923,360
Accession: 30778
RBP type: non-canonical RBP
Summary: This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000637918	GATAD2B-211	1027	-	ENSP00000490724	190 (aa)	-	A0A1B0GW07
ENST00000634544	GATAD2B-204	2342	-	ENSP00000489184	593 (aa)	-	Q8WXI9
ENST00000636008	GATAD2B-208	100	-	-	- (aa)	-	-
ENST00000634564	GATAD2B-205	788	-	ENSP00000489309	263 (aa)	-	A0A0U1RR30
ENST00000637331	GATAD2B-210	145	-	ENSP00000490635	27 (aa)	-	A0A1B0GVS4
ENST00000634645	GATAD2B-206	507	-	-	- (aa)	-	-
ENST00000636014	GATAD2B-209	187	-	-	- (aa)	-	-
ENST00000634791	GATAD2B-207	642	-	ENSP00000489566	149 (aa)	-	A0A0U1RRK3
ENST00000638051	GATAD2B-212	112	-	-	- (aa)	-	-
ENST00000634401	GATAD2B-202	867	-	ENSP00000489313	187 (aa)	-	A0A0U1RR34
ENST00000368655	GATAD2B-201	7478	XM_005245364	ENSP00000357644	593 (aa)	XP_005245421	Q8WXI9
ENST00000634408	GATAD2B-203	1825	-	ENSP00000489595	577 (aa)	-	A0A0U1RRM1

Gene Model

Click here to download ENSG00000143614's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143614	Lipoprotein(a)	3.2030000E-005	-
ENSG00000143614	Forced Expiratory Volume	3.7230000E-006	24983941
ENSG00000143614	Emotions	9E-6	27089181
ENSG00000143614	Corpus Striatum	3E-6	22903471
ENSG00000143614	Emotions	3E-9	27089181

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143614	rs11264567	1	153903213	G	Empathy quotient	29527006	[0.45-0.99] unit increase	0.72	EFO_0009183
ENSG00000143614	rs67881926	1	153858753	C	Subjective well-being	27089181	[0.017-0.043] unit decrease	0.030060733	EFO_0007869
ENSG00000143614	rs7554469	1	153855076	A	Life satisfaction	27089181	[0.015-0.029] unit increase	0.0218	EFO_0007869
ENSG00000143614	rs7414227	1	153876520	G	Lentiform nucleus volume	22903471	[NR] unit decrease	99.5	EFO_0004913
ENSG00000143614	rs9426935	1	153796924	C	Lentiform nucleus volume	22903471	[NR] unit decrease	96.63	EFO_0004913
ENSG00000143614	rs4434872	1	153801800	T	Conduct disorder (symptom count)	20585324	[NR] unit increase	0.08	EFO_0004216
ENSG00000143614	rs112780312	1	153824539	A	Cognitive performance	30038396	[0.015-0.027] unit decrease	0.0212	EFO_0008354
ENSG00000143614	rs4595397	1	153855604	T	Self-reported math ability	30038396	[0.01-0.018] unit increase	0.0143	EFO_0004875
ENSG00000143614	rs12033835	1	153914397	T	Educational attainment (MTAG)	30038396	[0.0073-0.0127] unit increase	0.01	EFO_0004784
ENSG00000143614	rs4612664	1	153850197	T	Highest math class taken	30038396	[0.011-0.02] unit increase	0.0156	EFO_0004875
ENSG00000143614	rs4612664	1	153850197	T	Self-reported math ability (MTAG)	30038396	[0.012-0.02] unit increase	0.016	EFO_0004875
ENSG00000143614	rs4391701	1	153825652	T	Highest math class taken (MTAG)	30038396	[0.012-0.019] unit decrease	0.0153	EFO_0004875
ENSG00000143614	rs112780312	1	153824539	A	Cognitive performance (MTAG)	30038396	[0.016-0.026] unit decrease	0.0209	EFO_0008354
ENSG00000143614	rs112780312	1	153824539	A	General cognitive ability	29844566	z-score decrease	5.736	EFO_0004337
ENSG00000143614	rs112780312	1	153824539	A	Intelligence	29942086	z-score decrease	5.899	EFO_0004337
ENSG00000143614	rs112780312	1	153824539	?	Balding type 1	30595370			EFO_0007825
ENSG00000143614	rs7537691	1	153886244	T	Male-pattern baldness	30573740	[0.016-0.029] unit decrease	0.0223196	EFO_0007825
ENSG00000143614	rs78053957	1	153843573	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143614's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143614	GATAD2B	100	100.000	ENSMUSG00000042390	Gatad2b	100	98.443	Mus_musculus
ENSG00000143614	GATAD2B	99	39.091	ENSMUSG00000036180	Gatad2a	99	39.939	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16217013.	HDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	16217013.	HDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0005515	protein binding	25123934.25150861.25416956.26816381.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016581	NuRD complex	21873635.	IBA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process