EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143624 (Gene tree)
Gene ID: 65123
Gene Symbol: INTS3
Alias: FLJ21919|INT3|SOSS-A|C1orf60
Full Name: integrator complex subunit 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 46,759 bases
Position: chr1:153,728,050-153,774,808
Accession: 26153
RBP type: canonical RBP
Summary: The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425437	Ints3	PF10189.9	3.8e-106	1	1
ENSP00000318641	Ints3	PF10189.9	3.9e-106	1	1
ENSP00000404290	Ints3	PF10189.9	3.9e-106	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29150435	Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.	Biochem J	2018 Jan 2	Vidhyasagar V	doi: 10.1042/BCJ20170351.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512605	INTS3-210	3442	-	ENSP00000425437	902 (aa)	-	Q68E01
ENST00000503133	INTS3-209	1896	-	ENSP00000422616	49 (aa)	-	H0Y8Z1
ENST00000491790	INTS3-208	2116	-	-	- (aa)	-	-
ENST00000318967	INTS3-201	5235	-	ENSP00000318641	1042 (aa)	-	Q68E01
ENST00000435409	INTS3-204	3597	-	ENSP00000404290	1042 (aa)	-	Q68E01
ENST00000368670	INTS3-203	3047	-	-	- (aa)	-	-
ENST00000624515	INTS3-211	478	-	ENSP00000485502	41 (aa)	-	A0A096LPB9
ENST00000476843	INTS3-205	3404	-	ENSP00000485263	280 (aa)	-	A0A096LNW8
ENST00000480659	INTS3-206	866	-	-	- (aa)	-	-
ENST00000368669	INTS3-202	2889	-	-	- (aa)	-	-
ENST00000481797	INTS3-207	5741	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143624's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143624	Monocytes	2.5030000E-005	-
ENSG00000143624	Monocytes	2.5650000E-005	-
ENSG00000143624	Monocytes	2.5030000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143624's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143624	INTS3	88	97.674	ENSAPOG00000018838	ints3	99	84.524	Acanthochromis_polyacanthus
ENSG00000143624	INTS3	100	100.000	ENSAMEG00000012085	INTS3	100	98.656	Ailuropoda_melanoleuca
ENSG00000143624	INTS3	86	100.000	ENSACIG00000007094	ints3	95	82.584	Amphilophus_citrinellus
ENSG00000143624	INTS3	88	97.674	ENSAOCG00000013168	ints3	99	84.425	Amphiprion_ocellaris
ENSG00000143624	INTS3	88	97.674	ENSAPEG00000018538	ints3	99	81.349	Amphiprion_percula
ENSG00000143624	INTS3	86	100.000	ENSATEG00000010938	ints3	94	76.111	Anabas_testudineus
ENSG00000143624	INTS3	100	100.000	ENSANAG00000037379	INTS3	100	100.000	Aotus_nancymaae
ENSG00000143624	INTS3	88	97.674	ENSACLG00000006786	ints3	99	84.722	Astatotilapia_calliptera
ENSG00000143624	INTS3	88	97.674	ENSAMXG00000011437	ints3	100	85.451	Astyanax_mexicanus
ENSG00000143624	INTS3	100	100.000	ENSBTAG00000006235	INTS3	100	99.232	Bos_taurus
ENSG00000143624	INTS3	100	100.000	ENSCJAG00000010155	INTS3	100	100.000	Callithrix_jacchus
ENSG00000143624	INTS3	100	100.000	ENSCAFG00000017453	INTS3	97	91.292	Canis_familiaris
ENSG00000143624	INTS3	100	100.000	ENSCAFG00020010273	INTS3	100	98.987	Canis_lupus_dingo
ENSG00000143624	INTS3	100	100.000	ENSCHIG00000025770	INTS3	100	99.328	Capra_hircus
ENSG00000143624	INTS3	100	100.000	ENSTSYG00000037547	INTS3	100	99.616	Carlito_syrichta
ENSG00000143624	INTS3	100	100.000	ENSCAPG00000013132	INTS3	85	100.000	Cavia_aperea
ENSG00000143624	INTS3	100	100.000	ENSCPOG00000009450	INTS3	100	95.494	Cavia_porcellus
ENSG00000143624	INTS3	100	100.000	ENSCCAG00000024830	INTS3	100	100.000	Cebus_capucinus
ENSG00000143624	INTS3	100	100.000	ENSCATG00000043517	INTS3	100	100.000	Cercocebus_atys
ENSG00000143624	INTS3	100	100.000	ENSCLAG00000003620	INTS3	100	99.041	Chinchilla_lanigera
ENSG00000143624	INTS3	100	100.000	ENSCSAG00000001872	INTS3	100	100.000	Chlorocebus_sabaeus
ENSG00000143624	INTS3	94	95.038	ENSCPBG00000024695	INTS3	100	95.050	Chrysemys_picta_bellii
ENSG00000143624	INTS3	88	76.744	ENSCING00000002537	-	99	49.231	Ciona_intestinalis
ENSG00000143624	INTS3	88	74.419	ENSCSAVG00000011100	-	100	50.567	Ciona_savignyi
ENSG00000143624	INTS3	100	100.000	ENSCANG00000025992	INTS3	100	99.808	Colobus_angolensis_palliatus
ENSG00000143624	INTS3	100	98.656	ENSCGRG00001024236	Ints3	100	98.656	Cricetulus_griseus_chok1gshd
ENSG00000143624	INTS3	100	98.656	ENSCGRG00000004920	Ints3	100	98.656	Cricetulus_griseus_crigri
ENSG00000143624	INTS3	98	80.531	ENSCSEG00000018322	ints3	99	80.952	Cynoglossus_semilaevis
ENSG00000143624	INTS3	88	97.674	ENSCVAG00000004832	ints3	99	83.730	Cyprinodon_variegatus
ENSG00000143624	INTS3	88	97.674	ENSDARG00000016811	ints3	99	85.516	Danio_rerio
ENSG00000143624	INTS3	100	100.000	ENSDNOG00000013903	INTS3	100	97.793	Dasypus_novemcinctus
ENSG00000143624	INTS3	100	100.000	ENSDORG00000001484	Ints3	100	99.040	Dipodomys_ordii
ENSG00000143624	INTS3	90	65.909	FBgn0262117	IntS3	78	53.533	Drosophila_melanogaster
ENSG00000143624	INTS3	100	100.000	ENSETEG00000002204	INTS3	88	98.230	Echinops_telfairi
ENSG00000143624	INTS3	88	90.698	ENSEBUG00000003412	ints3	96	65.327	Eptatretus_burgeri
ENSG00000143624	INTS3	100	100.000	ENSEASG00005000830	INTS3	100	99.328	Equus_asinus_asinus
ENSG00000143624	INTS3	100	100.000	ENSECAG00000022270	INTS3	100	99.328	Equus_caballus
ENSG00000143624	INTS3	100	97.561	ENSEEUG00000004649	INTS3	100	96.161	Erinaceus_europaeus
ENSG00000143624	INTS3	88	97.674	ENSELUG00000000616	ints3	99	84.344	Esox_lucius
ENSG00000143624	INTS3	100	98.560	ENSFCAG00000002744	INTS3	100	98.560	Felis_catus
ENSG00000143624	INTS3	94	93.916	ENSFALG00000008898	INTS3	100	90.476	Ficedula_albicollis
ENSG00000143624	INTS3	100	100.000	ENSFDAG00000005767	INTS3	100	98.660	Fukomys_damarensis
ENSG00000143624	INTS3	91	79.692	ENSFHEG00000016968	ints3	98	80.139	Fundulus_heteroclitus
ENSG00000143624	INTS3	88	97.674	ENSGMOG00000004467	ints3	99	80.276	Gadus_morhua
ENSG00000143624	INTS3	94	95.038	ENSGALG00000027046	INTS3	98	90.275	Gallus_gallus
ENSG00000143624	INTS3	88	97.674	ENSGAFG00000012876	ints3	92	83.487	Gambusia_affinis
ENSG00000143624	INTS3	88	97.674	ENSGACG00000010341	ints3	99	82.725	Gasterosteus_aculeatus
ENSG00000143624	INTS3	96	95.319	ENSGAGG00000000206	INTS3	99	95.437	Gopherus_agassizii
ENSG00000143624	INTS3	100	100.000	ENSGGOG00000003835	INTS3	100	100.000	Gorilla_gorilla
ENSG00000143624	INTS3	88	97.674	ENSHBUG00000015312	ints3	99	80.971	Haplochromis_burtoni
ENSG00000143624	INTS3	100	98.177	ENSHGLG00000008354	INTS3	100	98.177	Heterocephalus_glaber_female
ENSG00000143624	INTS3	99	98.264	ENSHGLG00100018661	INTS3	100	98.264	Heterocephalus_glaber_male
ENSG00000143624	INTS3	88	97.674	ENSHCOG00000009084	ints3	99	82.953	Hippocampus_comes
ENSG00000143624	INTS3	88	97.674	ENSIPUG00000016699	ints3	99	83.874	Ictalurus_punctatus
ENSG00000143624	INTS3	100	100.000	ENSSTOG00000000670	INTS3	100	99.232	Ictidomys_tridecemlineatus
ENSG00000143624	INTS3	100	97.313	ENSJJAG00000019885	Ints3	100	97.313	Jaculus_jaculus
ENSG00000143624	INTS3	88	97.674	ENSKMAG00000001336	ints3	99	85.317	Kryptolebias_marmoratus
ENSG00000143624	INTS3	88	97.674	ENSLBEG00000024260	ints3	99	84.028	Labrus_bergylta
ENSG00000143624	INTS3	88	97.674	ENSLACG00000004421	INTS3	99	88.218	Latimeria_chalumnae
ENSG00000143624	INTS3	100	100.000	ENSLAFG00000002663	INTS3	100	98.848	Loxodonta_africana
ENSG00000143624	INTS3	100	100.000	ENSMFAG00000008338	INTS3	100	99.904	Macaca_fascicularis
ENSG00000143624	INTS3	100	100.000	ENSMMUG00000019482	INTS3	100	100.000	Macaca_mulatta
ENSG00000143624	INTS3	100	100.000	ENSMNEG00000042397	INTS3	100	100.000	Macaca_nemestrina
ENSG00000143624	INTS3	100	100.000	ENSMLEG00000041804	INTS3	100	99.904	Mandrillus_leucophaeus
ENSG00000143624	INTS3	88	97.674	ENSMAMG00000022219	ints3	99	85.119	Mastacembelus_armatus
ENSG00000143624	INTS3	88	97.674	ENSMZEG00005012255	ints3	99	84.722	Maylandia_zebra
ENSG00000143624	INTS3	86	100.000	ENSMGAG00000000752	INTS3	95	91.404	Meleagris_gallopavo
ENSG00000143624	INTS3	100	98.560	ENSMAUG00000003190	Ints3	100	98.560	Mesocricetus_auratus
ENSG00000143624	INTS3	100	100.000	ENSMICG00000008832	INTS3	100	100.000	Microcebus_murinus
ENSG00000143624	INTS3	100	98.369	ENSMOCG00000013737	Ints3	100	98.369	Microtus_ochrogaster
ENSG00000143624	INTS3	88	97.674	ENSMMOG00000017619	ints3	99	84.028	Mola_mola
ENSG00000143624	INTS3	100	100.000	ENSMODG00000017354	INTS3	100	97.505	Monodelphis_domestica
ENSG00000143624	INTS3	88	97.674	ENSMALG00000011873	ints3	99	85.317	Monopterus_albus
ENSG00000143624	INTS3	100	100.000	MGP_CAROLIEiJ_G0025235	Ints3	100	98.656	Mus_caroli
ENSG00000143624	INTS3	100	100.000	ENSMUSG00000027933	Ints3	100	98.656	Mus_musculus
ENSG00000143624	INTS3	100	100.000	MGP_PahariEiJ_G0026679	Ints3	100	96.161	Mus_pahari
ENSG00000143624	INTS3	100	100.000	MGP_SPRETEiJ_G0026178	Ints3	100	98.560	Mus_spretus
ENSG00000143624	INTS3	100	100.000	ENSMPUG00000008221	INTS3	100	98.886	Mustela_putorius_furo
ENSG00000143624	INTS3	100	100.000	ENSMLUG00000001857	INTS3	100	98.035	Myotis_lucifugus
ENSG00000143624	INTS3	100	100.000	ENSNGAG00000023917	Ints3	100	99.040	Nannospalax_galili
ENSG00000143624	INTS3	88	97.674	ENSNBRG00000021301	ints3	99	82.738	Neolamprologus_brichardi
ENSG00000143624	INTS3	100	100.000	ENSNLEG00000010578	INTS3	100	96.272	Nomascus_leucogenys
ENSG00000143624	INTS3	100	97.561	ENSMEUG00000006202	INTS3	100	90.979	Notamacropus_eugenii
ENSG00000143624	INTS3	100	97.561	ENSOPRG00000003801	INTS3	100	93.378	Ochotona_princeps
ENSG00000143624	INTS3	98	97.500	ENSODEG00000012581	INTS3	100	95.324	Octodon_degus
ENSG00000143624	INTS3	88	97.674	ENSONIG00000007567	ints3	99	84.425	Oreochromis_niloticus
ENSG00000143624	INTS3	100	98.944	ENSOCUG00000005436	INTS3	100	98.944	Oryctolagus_cuniculus
ENSG00000143624	INTS3	88	97.674	ENSORLG00000001502	ints3	99	84.028	Oryzias_latipes
ENSG00000143624	INTS3	88	97.674	ENSORLG00020010774	ints3	99	84.226	Oryzias_latipes_hni
ENSG00000143624	INTS3	88	97.674	ENSORLG00015017985	ints3	99	84.127	Oryzias_latipes_hsok
ENSG00000143624	INTS3	88	97.674	ENSOMEG00000009881	ints3	99	84.623	Oryzias_melastigma
ENSG00000143624	INTS3	100	100.000	ENSOGAG00000001080	INTS3	100	98.944	Otolemur_garnettii
ENSG00000143624	INTS3	100	100.000	ENSOARG00000001095	INTS3	100	99.328	Ovis_aries
ENSG00000143624	INTS3	100	100.000	ENSPPAG00000034436	INTS3	100	100.000	Pan_paniscus
ENSG00000143624	INTS3	100	98.560	ENSPPRG00000023995	INTS3	100	98.560	Panthera_pardus
ENSG00000143624	INTS3	99	98.835	ENSPTIG00000012061	INTS3	99	98.835	Panthera_tigris_altaica
ENSG00000143624	INTS3	100	100.000	ENSPTRG00000001360	INTS3	100	100.000	Pan_troglodytes
ENSG00000143624	INTS3	100	99.335	ENSPANG00000016455	INTS3	100	99.335	Papio_anubis
ENSG00000143624	INTS3	96	91.667	ENSPKIG00000014552	ints3	99	85.728	Paramormyrops_kingsleyae
ENSG00000143624	INTS3	88	97.674	ENSPMGG00000008191	ints3	99	83.597	Periophthalmus_magnuspinnatus
ENSG00000143624	INTS3	100	98.369	ENSPEMG00000009736	Ints3	100	98.369	Peromyscus_maniculatus_bairdii
ENSG00000143624	INTS3	88	93.023	ENSPMAG00000008569	ints3	100	73.952	Petromyzon_marinus
ENSG00000143624	INTS3	100	100.000	ENSPCIG00000029360	INTS3	100	97.313	Phascolarctos_cinereus
ENSG00000143624	INTS3	88	97.674	ENSPFOG00000009261	ints3	99	83.333	Poecilia_formosa
ENSG00000143624	INTS3	88	97.674	ENSPLAG00000006426	ints3	99	84.821	Poecilia_latipinna
ENSG00000143624	INTS3	88	97.674	ENSPMEG00000015206	ints3	99	84.821	Poecilia_mexicana
ENSG00000143624	INTS3	88	97.674	ENSPREG00000015731	ints3	99	84.623	Poecilia_reticulata
ENSG00000143624	INTS3	100	100.000	ENSPPYG00000000797	INTS3	100	99.904	Pongo_abelii
ENSG00000143624	INTS3	100	97.561	ENSPCAG00000016615	INTS3	100	96.257	Procavia_capensis
ENSG00000143624	INTS3	100	100.000	ENSPCOG00000022153	INTS3	100	100.000	Propithecus_coquereli
ENSG00000143624	INTS3	100	95.122	ENSPVAG00000011079	INTS3	97	92.194	Pteropus_vampyrus
ENSG00000143624	INTS3	88	97.674	ENSPNYG00000010499	ints3	99	84.623	Pundamilia_nyererei
ENSG00000143624	INTS3	88	97.674	ENSPNAG00000027555	ints3	99	85.828	Pygocentrus_nattereri
ENSG00000143624	INTS3	100	98.464	ENSRNOG00000015153	Ints3	100	98.464	Rattus_norvegicus
ENSG00000143624	INTS3	100	100.000	ENSRBIG00000034979	INTS3	100	99.224	Rhinopithecus_bieti
ENSG00000143624	INTS3	100	100.000	ENSRROG00000032561	INTS3	100	99.904	Rhinopithecus_roxellana
ENSG00000143624	INTS3	100	100.000	ENSSBOG00000027353	INTS3	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000143624	INTS3	100	100.000	ENSSHAG00000010628	INTS3	99	97.986	Sarcophilus_harrisii
ENSG00000143624	INTS3	88	97.674	ENSSFOG00015009936	ints3	100	86.270	Scleropages_formosus
ENSG00000143624	INTS3	88	97.674	ENSSMAG00000014949	ints3	99	78.671	Scophthalmus_maximus
ENSG00000143624	INTS3	88	97.674	ENSSDUG00000000498	ints3	99	84.821	Seriola_dumerili
ENSG00000143624	INTS3	88	97.674	ENSSLDG00000000547	ints3	99	84.722	Seriola_lalandi_dorsalis
ENSG00000143624	INTS3	88	97.674	ENSSPAG00000005927	ints3	99	84.425	Stegastes_partitus
ENSG00000143624	INTS3	100	99.040	ENSSSCG00000006571	INTS3	100	99.040	Sus_scrofa
ENSG00000143624	INTS3	88	97.674	ENSTGUG00000016930	INTS3	100	93.811	Taeniopygia_guttata
ENSG00000143624	INTS3	86	100.000	ENSTRUG00000000794	ints3	94	77.340	Takifugu_rubripes
ENSG00000143624	INTS3	88	97.674	ENSTNIG00000019793	ints3	99	82.069	Tetraodon_nigroviridis
ENSG00000143624	INTS3	100	100.000	ENSTBEG00000016928	INTS3	81	100.000	Tupaia_belangeri
ENSG00000143624	INTS3	100	100.000	ENSTTRG00000014769	INTS3	100	94.242	Tursiops_truncatus
ENSG00000143624	INTS3	100	100.000	ENSUAMG00000019821	INTS3	100	98.656	Ursus_americanus
ENSG00000143624	INTS3	100	100.000	ENSUMAG00000020431	INTS3	100	98.656	Ursus_maritimus
ENSG00000143624	INTS3	86	100.000	ENSXETG00000014292	ints3	99	87.246	Xenopus_tropicalis
ENSG00000143624	INTS3	88	97.674	ENSXMAG00000017462	ints3	99	84.921	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16239144.19683501.25416956.	IPI	Function
GO:0005634	nucleus	19683501.23904267.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	23904267.	IDA	Component
GO:0006281	DNA repair	19605351.19683501.	IMP	Process
GO:0006974	cellular response to DNA damage stimulus	19683501.	IMP	Process
GO:0007093	mitotic cell cycle checkpoint	19683501.	IMP	Process
GO:0010212	response to ionizing radiation	19605351.19683501.	IMP	Process
GO:0016180	snRNA processing	16239144.	IDA	Process
GO:0032039	integrator complex	16239144.	IDA	Component
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0070876	SOSS complex	18449195.19683501.	IDA	Component