EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000143641 (Gene tree)
Gene ID: 2590
Gene Symbol: GALNT2
Alias: GalNAc-T2
Full Name: polypeptide N-acetylgalactosaminyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 224,342 bases
Position: chr1:230,057,789-230,282,130
Accession: 4124
RBP type: non-canonical RBP
Summary: This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485438	GALNT2-202	4030	-	-	- (aa)	-	-
ENST00000488903	GALNT2-203	593	NR_120373	-	- (aa)	-	-
ENST00000492568	GALNT2-204	2766	-	-	- (aa)	-	-
ENST00000494106	GALNT2-205	692	-	-	- (aa)	-	-
ENST00000366672	GALNT2-201	4454	XM_017000963	ENSP00000355632	571 (aa)	XP_016856452	Q10471

Gene Model

Click here to download ENSG00000143641's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00512	Mucin type O-glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143641	Cholesterol, HDL	4.929e-006	19060910
ENSG00000143641	Cholesterol, HDL	3.858e-005	19060910
ENSG00000143641	Cholesterol, HDL	2.859e-006	19060910
ENSG00000143641	Peroxidases	3E-6	23620142
ENSG00000143641	Schizophrenia	8E-7	26198764
ENSG00000143641	Cholesterol, HDL	4E-8	19060906
ENSG00000143641	Cholesterol, HDL	4E-41	24097068
ENSG00000143641	Triglycerides	2E-14	20686565
ENSG00000143641	Cholesterol, HDL	3E-14	18193043
ENSG00000143641	Alzheimer Disease	2E-6	25188341
ENSG00000143641	Dementia	2E-6	25188341
ENSG00000143641	Fibrinogen	8E-7	28107422
ENSG00000143641	Fibrinogen	1E-8	28107422
ENSG00000143641	Lipoproteins	2E-9	27005778
ENSG00000143641	Metabolism	2E-9	27005778
ENSG00000143641	Alzheimer Disease	4E-6	25188341
ENSG00000143641	Dementia	4E-6	25188341
ENSG00000143641	Cholesterol, HDL	1E-16	25961943
ENSG00000143641	Blood Proteins	8E-6	23303382
ENSG00000143641	Cholesterol, HDL	4E-21	20686565
ENSG00000143641	Triglycerides	7E-31	24097068
ENSG00000143641	Cholesterol, HDL	2E-13	18193044
ENSG00000143641	Triglycerides	7E-15	18193044
ENSG00000143641	Triglycerides	8E-7	18193043
ENSG00000143641	Metabolic Syndrome X	4E-8	22399527
ENSG00000143641	Vascular Calcification	1E-9	22916037
ENSG00000143641	Cholesterol, HDL	4E-9	20864672
ENSG00000143641	Triglycerides	5E-16	25961943

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143641	rs7549029	1	230117659	A	Blood protein levels	29875488	[0.13-0.25] unit increase	0.19	EFO_0007937
ENSG00000143641	rs16850871	1	230083723	?	Circulating odd-numbered chain saturated fatty acid levels (C23:0)	29738550	[0.01-0.022] unit decrease	0.0164	EFO_0005110
ENSG00000143641	rs7513659	1	230090639	?	Circulating odd-numbered chain saturated fatty acid levels (C23:0)	29738550	[0.01-0.022] unit increase	0.0164	EFO_0005110
ENSG00000143641	rs10864728	1	230169168	G	Blood protein levels	29875488	[0.13-0.25] unit increase	0.19	EFO_0007937
ENSG00000143641	rs17315646	1	230159560	G	Blood protein levels	29875488	[0.23-0.31] unit decrease	0.27	EFO_0007937
ENSG00000143641	rs590820	1	230173873	G	Metabolite levels (lipoprotein measures)	27005778	[0.04-0.08] unit decrease	0.06	EFO_0004732\|EFO_0005664
ENSG00000143641	rs4846914	1	230159944	G	HDL cholesterol	24097068	[NR] unit decrease	0.048	EFO_0004612
ENSG00000143641	rs12040273	1	230063651	?	Carotid intima media thickness	26343869			EFO_0007117
ENSG00000143641	rs2144300	1	230159169	T	HDL cholesterol	18193043	[NR] mg/dl increase	1.11	EFO_0004612
ENSG00000143641	rs4846923	1	230171476	G	HDL cholesterol	25961943	[0.041-0.069] s.d. increase	0.055	EFO_0004612
ENSG00000143641	rs10864728	1	230169168	A	Triglycerides	25961943	[0.04-0.064] s.d. increase	0.052	EFO_0004530
ENSG00000143641	rs11807834	1	230136877	A	Schizophrenia	26198764	[NR]	1.06	EFO_0000692
ENSG00000143641	rs3761944	1	230253243	C	Hematology traits	23303382	[0.0082-0.0238] unit increase	0.016	EFO_0005128
ENSG00000143641	rs2144300	1	230159169	C	Circulating myeloperoxidase levels (serum)	23620142	[0.030-0.070] unit decrease	0.05	EFO_0005243
ENSG00000143641	rs10127775	1	230160042	?	Metabolite levels	22916037			EFO_0004723
ENSG00000143641	rs4846914	1	230159944	G	Triglycerides	24097068	[NR] mg/dL increase	0.04	EFO_0004530
ENSG00000143641	rs4846914	1	230159944	G	HDL cholesterol	19060906	[0.01-0.09] s.d. decrease	0.05	EFO_0004612
ENSG00000143641	rs10127775	1	230160042	A	Blood protein levels	28240269	[0.24-0.41] unit increase	0.3248	EFO_0008113
ENSG00000143641	rs6541297	1	230147759	A	Coronary artery disease	29212778	[0.019-0.051] unit decrease	0.035	EFO_0000378
ENSG00000143641	rs2281719	1	230161913	T	Coronary artery disease	29212778	[0.018-0.04] unit decrease	0.0289	EFO_0000378
ENSG00000143641	rs2144300	1	230159169	?	Triglyceride levels	29403010	[0.019-0.041] unit decrease novel	0.02985	EFO_0004530
ENSG00000143641	rs7022	1	230281918	G	Blood protein levels	29875488	[0.14-0.26] unit increase	0.2	EFO_0007937
ENSG00000143641	rs2144300	1	230159169	?	High density lipoprotein cholesterol levels	29403010	[0.024-0.05] unit increase novel	0.03663	EFO_0004612
ENSG00000143641	rs11122449	1	230164735	T	Red cell distribution width	27863252	[0.029-0.045] unit increase	0.03728932	EFO_0005192
ENSG00000143641	rs4631704	1	230157783	T	Platelet count	27863252	[0.016-0.031] unit increase	0.02382391	EFO_0004309
ENSG00000143641	rs4846914	1	230159944	G	HDL cholesterol	20686565	[0.47-0.75] mg/dL decrease	0.61	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	G	Triglycerides	20686565	[2.02-3.5] mg/dL increase	2.76	EFO_0004530
ENSG00000143641	rs10489615	1	230169242	G	HDL cholesterol	20864672	[0.01-0.03] unit increase	0.02	EFO_0004612
ENSG00000143641	rs4846922	1	230171436	T	Metabolic syndrome	22399527	[NR] mmol/l decrease	0.08	EFO_0000195
ENSG00000143641	rs4846914	1	230159944	G	HDL cholesterol	18193044	[0.05-0.09] unit decrease	0.07	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	G	Triglycerides	18193044	[0.06-0.10] unit increase	0.08	EFO_0004530
ENSG00000143641	rs2144300	1	230159169	C	Triglycerides	18193043	[NR] mg/dl increase	4.25	EFO_0004530
ENSG00000143641	rs10489615	1	230169242	?	Fibrinogen levels	28107422	unit increase	0.0052	EFO_0004623
ENSG00000143641	rs10864726	1	230160406	?	Fibrinogen levels	28107422	unit increase	0.0059	EFO_0004623
ENSG00000143641	rs4846835	1	230145409	A	Dementia and core Alzheimer's disease neuropathologic changes	25188341	[0.23-0.56] unit decrease	0.3966	HP_0000726\|EFO_0006801
ENSG00000143641	rs4846835	1	230145409	A	Dementia and core Alzheimer's disease neuropathologic changes	25188341	[0.26-0.66] unit decrease	0.4595	HP_0000726\|EFO_0006801
ENSG00000143641	rs2144300	1	230159169	T	HDL cholesterol levels	28334899	[0.036-0.076] unit increase	0.056	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	A	HDL cholesterol levels	28334899	[0.041-0.055] unit increase (EA Beta values)	0.0479	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	A	Triglyceride levels	28334899	[0.033-0.047] unit decrease (EA Beta values)	0.0401	EFO_0004530
ENSG00000143641	rs1546954	1	230168102	G	Red cell distribution width	28957414	[0.022-0.038] unit increase	0.0300215	EFO_0005192
ENSG00000143641	rs2144300	1	230159169	C	High density lipoprotein cholesterol levels	29507422	unit decrease	0.043	EFO_0004612
ENSG00000143641	rs2144300	1	230159169	C	High density lipoprotein cholesterol levels	29507422	unit decrease	0.043	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.042	EFO_0004612
ENSG00000143641	rs4846914	1	230159944	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.041	EFO_0004612
ENSG00000143641	rs10864728	1	230169168	A	High density lipoprotein cholesterol levels	29507422	unit decrease	0.043	EFO_0004612
ENSG00000143641	rs10864728	1	230169168	A	High density lipoprotein cholesterol levels	29507422	unit decrease	0.04	EFO_0004612
ENSG00000143641	rs1321257	1	230169566	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.043	EFO_0004612
ENSG00000143641	rs1321257	1	230169566	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.04	EFO_0004612
ENSG00000143641	rs4846923	1	230171476	T	High density lipoprotein cholesterol levels	29507422	unit decrease	0.048	EFO_0004612
ENSG00000143641	rs4846923	1	230171476	T	High density lipoprotein cholesterol levels	29507422	unit decrease	0.044	EFO_0004612
ENSG00000143641	rs2144300	1	230159169	C	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs2144300	1	230159169	C	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs4846914	1	230159944	G	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs4846914	1	230159944	G	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs10864728	1	230169168	A	Triglycerides	29507422	unit increase	0.038	EFO_0004530
ENSG00000143641	rs10864728	1	230169168	A	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs1321257	1	230169566	G	Triglycerides	29507422	unit increase	0.038	EFO_0004530
ENSG00000143641	rs1321257	1	230169566	G	Triglycerides	29507422	unit increase	0.036	EFO_0004530
ENSG00000143641	rs4846923	1	230171476	T	Triglycerides	29507422	unit increase	0.043	EFO_0004530
ENSG00000143641	rs4846923	1	230171476	T	Triglycerides	29507422	unit increase	0.039	EFO_0004530
ENSG00000143641	rs4846913	1	230158968	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000143641	rs1043897	1	230280653	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000143641	rs6703306	1	230216083	G	Postburn scar pliability	30595539	[0.49-1.18] unit increase	0.8324	EFO_0007747
ENSG00000143641	rs10746509	1	230101535	T	Neuroticism	30643256	[0.0059-0.0118] unit increase	0.008847726	EFO_0007660
ENSG00000143641	rs10746509	1	230101535	T	Depressive symptoms	30643256	[0.0037-0.0075] unit increase	0.005638635	EFO_0007006
ENSG00000143641	rs3811489	1	230103512	?	Neuroticism	30595370			EFO_0007660
ENSG00000143641	rs10746509	1	230101535	T	Well-being spectrum (multivariate analysis)	30643256	[0.0036-0.0073] unit increase	0.005454711	EFO_0007869
ENSG00000143641	rs10864726	1	230160406	T	HDL cholesterol x physical activity interaction (2df test)	30670697			EFO_0007805\|EFO_0003940

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143641's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0002378	immunoglobulin biosynthetic process	12438318.	IDA	Process
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	9295285.12438318.16434399.18562306.19460755.	IDA	Function
GO:0005515	protein binding	21699783.25416956.	IPI	Function
GO:0005576	extracellular region	-	IEA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005794	Golgi apparatus	9852147.	IDA	Component
GO:0005794	Golgi apparatus	12506059.	IDA	Component
GO:0005795	Golgi stack	9852147.	IDA	Component
GO:0006493	protein O-linked glycosylation	16434399.19460755.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016266	O-glycan processing	18562306.	IDA	Process
GO:0016266	O-glycan processing	-	TAS	Process
GO:0018242	protein O-linked glycosylation via serine	9295285.12438318.	IDA	Process
GO:0018243	protein O-linked glycosylation via threonine	9295285.12438318.18562306.	IDA	Process
GO:0030145	manganese ion binding	9295285.16434399.	IDA	Function
GO:0030173	integral component of Golgi membrane	9852147.	NAS	Component
GO:0030246	carbohydrate binding	-	IEA	Function
GO:0032580	Golgi cisterna membrane	-	IEA	Component
GO:0048471	perinuclear region of cytoplasm	12506059.	IDA	Component