EuRBPDB

Ensembl ID

ENSG00000143702 (Gene tree)

Gene ID

9859

Gene Symbol

CEP170

Alias

KAB|FAM68A|KIAA0470

Full Name

centrosomal protein 170

Gene Type

protein_coding

Species

Homo_sapiens

Status

putative

Strand

Minus strand

Length

130,979 bases

Position

chr1:243,124,428-243,255,406

Accession

28920

RBP type

non-canonical RBP

Summary

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]