EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000143742 (Gene tree)
Gene ID
6726
Gene Symbol
SRP9
Alias
N
Full Name
signal recognition particle 9
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
12,654 bases
Position
chr1:225,777,813-225,790,466
Accession
11304
RBP type
canonical RBP
Summary
(Signal Recognition Particle 9) is a Protein Coding gene. Diseases associated with SRP9 include Coffin-Siris Syndrome 1 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Protein export and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include RNA binding and signal recognition particle binding.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000305230SRP9-21PF05486.122.7e-1211
ENSP00000355803SRP9-21PF05486.123.4e-0511
ENSP00000485985SRP9-21PF05486.123.4e-0511
ENSP00000355804SRP9-21PF05486.120.0001611
ENSP00000485002SRP9-21PF05486.120.0001611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
1377027Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative.Biochemistry1992 Jun 30Janiak F-
7681065A cellular protein binds B1 and Alu small cytoplasmic RNAs in vitro.J Biol Chem1993 Mar 25Chang DY-
25336584Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.RNA2014 DecBousset Ldoi: 10.1261/rna.047209.114
28709002Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.Cell2017 Jul 13Nabet BYdoi: 10.1016/j.cell.2017.06.031.
9233785The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14.EMBO J1997 Jul 1Birse DE-
9214658Mutational analysis of the protein subunits of the signal recognition particle Alu-domain.RNA1997 JulBui N-
9032241The decline in human Alu retroposition was accompanied by an asymmetric decrease in SRP9/14 binding to dimeric Alu RNA and increased expression of small cytoplasmic Alu RNA.Mol Cell Biol1997 MarSarrowa J-
7730321Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.J Biol Chem1995 Apr 28Hsu K-
30664217Scutellaria barbata polysaccharides inhibit tumor growth and affect the serum proteomic profiling of hepatoma H22bearing mice.Mol Med Rep2019 MarLi Ldoi: 10.3892/mmr.2019.9862
1712900Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution.Mol Cell Biol1991 AugStrub K-
25200073Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.Nucleic Acids Res2014Berger Adoi: 10.1093/nar/gku822
9115358A truncation in the 14 kDa protein of the signal recognition particle leads to tertiary structure changes in the RNA and abolishes the elongation arrest activity of the particle.Nucleic Acids Res1997 May 15Thomas Y-
15383645Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain.Nucleic Acids Res2004 Sep 21Huck L-
10521474Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase.J Biol Chem1999 Oct 22Sinha K-
9092618A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14.Nucleic Acids Res1997 Mar 15Chang DY-
17175535Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners.Nucleic Acids Res2007Khanam T-
25697503Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.Nucleic Acids Res2015 Mar 11Ivanova Edoi: 10.1093/nar/gkv048
26503250Discovery and characterization of Alu repeat sequences via precise local read assembly.Nucleic Acids Res2015 Dec 2Wildschutte JHdoi: 10.1093/nar/gkv1089
28450901Insertion and deletion polymorphisms of the ancient AluS family in the human genome.Mob DNA2017 Apr 24Kryatova MSdoi: 10.1186/s13100-017-0089-9
29103173A Role for the Mutagenic DNA Self-Catalyzed Depurination Mechanism in the Evolution of 7SL-Derived RNAs.J Mol Evol2017 OctGold MPdoi: 10.1007/s00239-017-9811-y
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000626563SRP9-205329-ENSP0000048598566 (aa)-E9PE20
ENST00000366839SRP9-2031596-ENSP0000035580482 (aa)-P49458
ENST00000304786SRP9-2011480-ENSP0000030523086 (aa)-P49458
ENST00000366838SRP9-202540-ENSP0000035580366 (aa)-E9PE20
ENST00000619790SRP9-204377-ENSP0000048500282 (aa)-P49458
Gene Model
Click here to download ENSG00000143742's gene model file
Pathways
Pathway IDPathway NameSource
hsa03060Protein exportKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143742's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000143742SRP910076.744ENSAPOG00000006089srp910076.744Acanthochromis_polyacanthus
ENSG00000143742SRP910091.860ENSAMEG00000014744SRP910091.860Ailuropoda_melanoleuca
ENSG00000143742SRP910056.977ENSACIG00000022298srp910056.977Amphilophus_citrinellus
ENSG00000143742SRP910076.744ENSAOCG00000014643srp910076.744Amphiprion_ocellaris
ENSG00000143742SRP910076.744ENSAPEG00000004398srp910076.744Amphiprion_percula
ENSG00000143742SRP910077.907ENSATEG00000014339srp910077.907Anabas_testudineus
ENSG00000143742SRP98181.429ENSAPLG00000015368SRP910081.429Anas_platyrhynchos
ENSG00000143742SRP910083.721ENSACAG00000005788SRP910083.721Anolis_carolinensis
ENSG00000143742SRP910094.186ENSANAG00000022626SRP910094.186Aotus_nancymaae
ENSG00000143742SRP910077.907ENSACLG00000018392srp910077.907Astatotilapia_calliptera
ENSG00000143742SRP910077.907ENSAMXG00000010366srp910077.907Astyanax_mexicanus
ENSG00000143742SRP910091.860ENSBTAG00000033322SRP910091.860Bos_taurus
ENSG00000143742SRP98851.316WBGene00013984ZK512.410051.316Caenorhabditis_elegans
ENSG00000143742SRP910094.186ENSCJAG00000040095SRP910094.186Callithrix_jacchus
ENSG00000143742SRP910091.860ENSCAFG00000016162SRP910091.860Canis_familiaris
ENSG00000143742SRP910091.860ENSCAFG00020003285SRP910091.860Canis_lupus_dingo
ENSG00000143742SRP910091.860ENSCHIG00000006407SRP910091.860Capra_hircus
ENSG00000143742SRP910091.860ENSTSYG00000026832SRP910091.860Carlito_syrichta
ENSG00000143742SRP910094.186ENSCPOG00000033454SRP910094.186Cavia_porcellus
ENSG00000143742SRP910095.349ENSCCAG00000034464SRP910095.349Cebus_capucinus
ENSG00000143742SRP910098.485ENSCATG00000041813SRP910098.485Cercocebus_atys
ENSG00000143742SRP910093.023ENSCLAG00000001368-10093.023Chinchilla_lanigera
ENSG00000143742SRP99983.529ENSCLAG00000017687-9983.529Chinchilla_lanigera
ENSG00000143742SRP910091.860ENSCHOG00000006096-10091.860Choloepus_hoffmanni
ENSG00000143742SRP95886.000ENSCHOG00000008435-10086.000Choloepus_hoffmanni
ENSG00000143742SRP97195.745ENSCHOG00000012912-10059.302Choloepus_hoffmanni
ENSG00000143742SRP910084.884ENSCPBG00000011999SRP910084.884Chrysemys_picta_bellii
ENSG00000143742SRP910097.674ENSCANG00000030765-10097.674Colobus_angolensis_palliatus
ENSG00000143742SRP910096.512ENSCANG00000012015-10096.512Colobus_angolensis_palliatus
ENSG00000143742SRP910090.698ENSCGRG00001008910Srp910090.698Cricetulus_griseus_chok1gshd
ENSG00000143742SRP97485.938ENSCGRG00000009651Srp98485.938Cricetulus_griseus_crigri
ENSG00000143742SRP910076.744ENSCSEG00000018438srp910076.744Cynoglossus_semilaevis
ENSG00000143742SRP910079.070ENSCVAG00000001083srp910079.070Cyprinodon_variegatus
ENSG00000143742SRP910077.907ENSDARG00000042851srp910077.907Danio_rerio
ENSG00000143742SRP910091.860ENSDNOG00000013412-10091.860Dasypus_novemcinctus
ENSG00000143742SRP98541.096FBgn0035827Srp99541.096Drosophila_melanogaster
ENSG00000143742SRP910081.395ENSETEG00000012291SRP910081.395Echinops_telfairi
ENSG00000143742SRP99866.667ENSEBUG00000009080srp910066.667Eptatretus_burgeri
ENSG00000143742SRP910091.860ENSECAG00000033839SRP910091.860Equus_caballus
ENSG00000143742SRP910084.884ENSEEUG00000001344SRP910084.884Erinaceus_europaeus
ENSG00000143742SRP910079.070ENSELUG00000001506srp910079.070Esox_lucius
ENSG00000143742SRP910091.860ENSFCAG00000010275SRP96291.860Felis_catus
ENSG00000143742SRP910081.395ENSFALG00000011689SRP910081.395Ficedula_albicollis
ENSG00000143742SRP910094.186ENSFDAG00000020469SRP910094.186Fukomys_damarensis
ENSG00000143742SRP910079.070ENSFHEG00000011666srp910079.070Fundulus_heteroclitus
ENSG00000143742SRP910076.744ENSGMOG00000003565srp910076.744Gadus_morhua
ENSG00000143742SRP910082.558ENSGALG00000026009SRP910082.558Gallus_gallus
ENSG00000143742SRP910079.070ENSGAFG00000009506srp910079.070Gambusia_affinis
ENSG00000143742SRP910075.581ENSGACG00000004110srp910075.581Gasterosteus_aculeatus
ENSG00000143742SRP910084.884ENSGAGG00000017129SRP910084.884Gopherus_agassizii
ENSG00000143742SRP9100100.000ENSGGOG00000011555SRP9100100.000Gorilla_gorilla
ENSG00000143742SRP910077.907ENSHBUG00000021430srp910077.907Haplochromis_burtoni
ENSG00000143742SRP99883.333ENSHGLG00000006535-9983.333Heterocephalus_glaber_female
ENSG00000143742SRP99393.750ENSHGLG00000020925-10093.750Heterocephalus_glaber_female
ENSG00000143742SRP910086.047ENSHGLG00000020168-10086.047Heterocephalus_glaber_female
ENSG00000143742SRP910090.698ENSHGLG00000002329SRP910090.698Heterocephalus_glaber_female
ENSG00000143742SRP98188.571ENSHGLG00000019830-10088.571Heterocephalus_glaber_female
ENSG00000143742SRP99883.333ENSHGLG00100009760-9983.333Heterocephalus_glaber_male
ENSG00000143742SRP910086.047ENSHGLG00100020800-10086.047Heterocephalus_glaber_male
ENSG00000143742SRP910093.023ENSHGLG00100019986-10093.023Heterocephalus_glaber_male
ENSG00000143742SRP99587.805ENSHGLG00100016521-10087.805Heterocephalus_glaber_male
ENSG00000143742SRP910075.581ENSHGLG00100011806-10075.581Heterocephalus_glaber_male
ENSG00000143742SRP910055.814ENSHCOG00000006978srp910055.814Hippocampus_comes
ENSG00000143742SRP910079.070ENSIPUG00000020674srp910079.070Ictalurus_punctatus
ENSG00000143742SRP910091.860ENSSTOG00000026827SRP910091.860Ictidomys_tridecemlineatus
ENSG00000143742SRP910087.209ENSJJAG00000016583Srp910087.209Jaculus_jaculus
ENSG00000143742SRP910079.070ENSKMAG00000014117srp910079.070Kryptolebias_marmoratus
ENSG00000143742SRP910077.907ENSLBEG00000020620srp910077.907Labrus_bergylta
ENSG00000143742SRP910081.395ENSLACG00000007546SRP910081.395Latimeria_chalumnae
ENSG00000143742SRP910081.395ENSLOCG00000015903srp910081.395Lepisosteus_oculatus
ENSG00000143742SRP910089.535ENSLAFG00000004081SRP910089.535Loxodonta_africana
ENSG00000143742SRP910098.485ENSMFAG00000002641SRP910098.485Macaca_fascicularis
ENSG00000143742SRP910098.485ENSMMUG00000000134SRP910098.485Macaca_mulatta
ENSG00000143742SRP910098.485ENSMNEG00000043512SRP910098.485Macaca_nemestrina
ENSG00000143742SRP910098.485ENSMLEG00000037309SRP910098.485Mandrillus_leucophaeus
ENSG00000143742SRP910077.907ENSMAMG00000004755srp910077.907Mastacembelus_armatus
ENSG00000143742SRP910077.907ENSMZEG00005015517srp910077.907Maylandia_zebra
ENSG00000143742SRP910082.558ENSMGAG00000008061SRP910082.558Meleagris_gallopavo
ENSG00000143742SRP910090.698ENSMAUG00000017552Srp910090.698Mesocricetus_auratus
ENSG00000143742SRP910089.394ENSMICG00000030104-10089.394Microcebus_murinus
ENSG00000143742SRP910090.698ENSMOCG00000012590Srp910090.698Microtus_ochrogaster
ENSG00000143742SRP910074.713ENSMMOG00000014838srp910074.713Mola_mola
ENSG00000143742SRP910091.860ENSMODG00000025664SRP910091.860Monodelphis_domestica
ENSG00000143742SRP910075.581ENSMALG00000004262srp910075.581Monopterus_albus
ENSG00000143742SRP910093.023MGP_CAROLIEiJ_G0014997Srp910093.023Mus_caroli
ENSG00000143742SRP910093.023ENSMUSG00000026511Srp910093.023Mus_musculus
ENSG00000143742SRP910090.698MGP_PahariEiJ_G0028229Srp910090.698Mus_pahari
ENSG00000143742SRP910093.023MGP_SPRETEiJ_G0015797Srp910093.023Mus_spretus
ENSG00000143742SRP910090.698ENSMLUG00000014914SRP910090.698Myotis_lucifugus
ENSG00000143742SRP910091.860ENSNGAG00000019936Srp910091.860Nannospalax_galili
ENSG00000143742SRP910077.907ENSNBRG00000010915srp910077.907Neolamprologus_brichardi
ENSG00000143742SRP9100100.000ENSNLEG00000013740SRP9100100.000Nomascus_leucogenys
ENSG00000143742SRP910091.860ENSOPRG00000012133SRP910091.860Ochotona_princeps
ENSG00000143742SRP910085.227ENSODEG00000010125-7685.227Octodon_degus
ENSG00000143742SRP910087.209ENSODEG00000015075-10087.209Octodon_degus
ENSG00000143742SRP910076.744ENSONIG00000011409srp910076.744Oreochromis_niloticus
ENSG00000143742SRP910089.535ENSOANG00000001472SRP910089.535Ornithorhynchus_anatinus
ENSG00000143742SRP910091.860ENSOCUG00000010791SRP910091.860Oryctolagus_cuniculus
ENSG00000143742SRP910074.419ENSORLG00020003090srp910074.419Oryzias_latipes_hni
ENSG00000143742SRP910074.419ENSORLG00015001636srp98974.419Oryzias_latipes_hsok
ENSG00000143742SRP910075.581ENSOMEG00000020548srp910075.581Oryzias_melastigma
ENSG00000143742SRP910094.186ENSOGAG00000001752-10094.186Otolemur_garnettii
ENSG00000143742SRP910094.186ENSOGAG00000031299-10094.186Otolemur_garnettii
ENSG00000143742SRP9100100.000ENSPPAG00000042680SRP9100100.000Pan_paniscus
ENSG00000143742SRP910091.860ENSPPRG00000011732SRP910091.860Panthera_pardus
ENSG00000143742SRP97288.710ENSPTIG00000014838SRP97288.710Panthera_tigris_altaica
ENSG00000143742SRP9100100.000ENSPTRG00000002038SRP9100100.000Pan_troglodytes
ENSG00000143742SRP910098.485ENSPANG00000030164SRP910098.485Papio_anubis
ENSG00000143742SRP910077.907ENSPKIG00000015012srp910077.907Paramormyrops_kingsleyae
ENSG00000143742SRP910084.884ENSPSIG00000014842SRP910084.884Pelodiscus_sinensis
ENSG00000143742SRP910055.814ENSPMGG00000002318srp910055.814Periophthalmus_magnuspinnatus
ENSG00000143742SRP910090.698ENSPEMG00000022774Srp910090.698Peromyscus_maniculatus_bairdii
ENSG00000143742SRP910091.860ENSPCIG00000017399SRP910091.860Phascolarctos_cinereus
ENSG00000143742SRP910079.070ENSPREG00000020242srp910079.070Poecilia_reticulata
ENSG00000143742SRP997100.000ENSPPYG00000000174SRP9100100.000Pongo_abelii
ENSG00000143742SRP910089.535ENSPCAG00000014886SRP910089.535Procavia_capensis
ENSG00000143742SRP97285.484ENSPCOG00000021743-10085.484Propithecus_coquereli
ENSG00000143742SRP910070.787ENSPCOG00000012531-10070.787Propithecus_coquereli
ENSG00000143742SRP910091.860ENSPVAG00000008142SRP910091.860Pteropus_vampyrus
ENSG00000143742SRP910077.907ENSPNYG00000010536srp910077.907Pundamilia_nyererei
ENSG00000143742SRP910077.907ENSPNAG00000008264srp910077.907Pygocentrus_nattereri
ENSG00000143742SRP910090.698ENSRNOG00000003211Srp910090.698Rattus_norvegicus
ENSG00000143742SRP910097.674ENSRBIG00000040480SRP910097.674Rhinopithecus_bieti
ENSG00000143742SRP910097.674ENSRROG00000028703SRP910097.674Rhinopithecus_roxellana
ENSG00000143742SRP910094.186ENSSBOG00000034573SRP910094.186Saimiri_boliviensis_boliviensis
ENSG00000143742SRP910091.860ENSSHAG00000013504SRP910091.860Sarcophilus_harrisii
ENSG00000143742SRP910079.070ENSSFOG00015000310srp910079.070Scleropages_formosus
ENSG00000143742SRP910077.907ENSSMAG00000001318srp910077.907Scophthalmus_maximus
ENSG00000143742SRP910077.907ENSSDUG00000008772srp910077.907Seriola_dumerili
ENSG00000143742SRP98782.667ENSSLDG00000019141srp99582.667Seriola_lalandi_dorsalis
ENSG00000143742SRP910061.628ENSSPUG00000014436SRP910061.628Sphenodon_punctatus
ENSG00000143742SRP910077.907ENSSPAG00000017244srp910077.907Stegastes_partitus
ENSG00000143742SRP910091.860ENSSSCG00000031664-10091.860Sus_scrofa
ENSG00000143742SRP910081.395ENSTGUG00000004123SRP910081.395Taeniopygia_guttata
ENSG00000143742SRP910075.581ENSTRUG00000024107srp910075.581Takifugu_rubripes
ENSG00000143742SRP910076.744ENSTNIG00000007254srp910076.744Tetraodon_nigroviridis
ENSG00000143742SRP910089.535ENSTBEG00000005634SRP910089.535Tupaia_belangeri
ENSG00000143742SRP97288.710ENSTTRG00000010081SRP910088.710Tursiops_truncatus
ENSG00000143742SRP910091.860ENSUAMG00000020489SRP910091.860Ursus_americanus
ENSG00000143742SRP910091.860ENSUMAG00000015908SRP910091.860Ursus_maritimus
ENSG00000143742SRP97288.710ENSVPAG00000001698SRP910088.710Vicugna_pacos
ENSG00000143742SRP910091.860ENSVVUG00000002065SRP910091.860Vulpes_vulpes
ENSG00000143742SRP910077.907ENSXCOG00000000662srp910077.907Xiphophorus_couchianus
ENSG00000143742SRP910077.907ENSXMAG00000029514srp910077.907Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding7730321.TASFunction
GO:0005047signal recognition particle binding7730321.TASFunction
GO:0005515protein binding24965446.25910212.30021884.IPIFunction
GO:0005785signal recognition particle receptor complex7730321.TASComponent
GO:0005786signal recognition particle, endoplasmic reticulum targeting21873635.IBAComponent
GO:0005786signal recognition particle, endoplasmic reticulum targeting17154533.NASComponent
GO:0005829cytosol-TASComponent
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TASProcess
GO:0006616SRP-dependent cotranslational protein targeting to membrane, translocation21873635.IBAProcess
GO:00083127S RNA binding-IEAFunction
GO:0045900negative regulation of translational elongation-IEAProcess

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