EuRBPDB

Description

Ensembl ID: ENSG00000143776 (Gene tree)
Gene ID: 8476
Gene Symbol: CDC42BPA
Alias: MRCKA|PK428|FLJ23347|KIAA0451|MRCK
Full Name: CDC42 binding protein kinase alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 328,635 bases
Position: chr1:226,989,858-227,318,492
Accession: 1737
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000366767	CDC42BPA-204	9320	-	ENSP00000355729	1638 (aa)	-	Q5VT25
ENST00000366766	CDC42BPA-203	10610	-	ENSP00000355728	1018 (aa)	-	A0A0A0MRJ1
ENST00000429440	CDC42BPA-206	2501	-	ENSP00000407120	546 (aa)	-	H0Y6R0
ENST00000366764	CDC42BPA-202	10445	-	ENSP00000355726	1699 (aa)	-	A0A0A0MRJ0
ENST00000334218	CDC42BPA-201	10134	XM_005273318	ENSP00000335341	1732 (aa)	XP_005273375	Q5VT25
ENST00000442054	CDC42BPA-208	3786	-	ENSP00000401051	1048 (aa)	-	H0Y5V1
ENST00000366769	CDC42BPA-205	10855	XM_005273317	ENSP00000355731	1719 (aa)	XP_005273374	Q5VT25
ENST00000466538	CDC42BPA-211	568	-	-	- (aa)	-	-
ENST00000462553	CDC42BPA-210	430	-	-	- (aa)	-	-
ENST00000488131	CDC42BPA-213	1859	-	-	- (aa)	-	-
ENST00000478573	CDC42BPA-212	599	-	-	- (aa)	-	-
ENST00000441725	CDC42BPA-207	2183	-	ENSP00000408165	728 (aa)	-	H0Y6V3
ENST00000448940	CDC42BPA-209	7355	-	ENSP00000415388	984 (aa)	-	H0Y7V8

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143776	Cholesterol, HDL	4.22168387819166E-5	17903299
ENSG00000143776	Heart Failure	7.0399331E-004	-
ENSG00000143776	Heart Failure	6.9802696E-004	-
ENSG00000143776	Heart Rate	2.609e-005	-
ENSG00000143776	Heart Rate	2.609e-005	-
ENSG00000143776	Heart Rate	2.609e-005	-
ENSG00000143776	Heart Rate	2.609e-005	-
ENSG00000143776	Monocytes	6.6710000E-006	-
ENSG00000143776	Platelet Function Tests	3.4601900E-005	-
ENSG00000143776	Platelet Function Tests	2.4633500E-005	-
ENSG00000143776	Platelet Function Tests	7.4800000E-006	-
ENSG00000143776	Platelet Function Tests	6.8100000E-006	-
ENSG00000143776	Platelet Function Tests	5.1500000E-006	-
ENSG00000143776	Dextroamphetamine	6.6483000E-005	-
ENSG00000143776	Dextroamphetamine	6.9910000E-005	-
ENSG00000143776	Dextroamphetamine	2.6477000E-005	-
ENSG00000143776	Dextroamphetamine	6.9910000E-005	-
ENSG00000143776	Optic Disk	2E-7	25631615
ENSG00000143776	Optic Disk	4E-14	25631615
ENSG00000143776	Optic Disk	2E-12	25631615
ENSG00000143776	Optic Disk	4E-16	28073927
ENSG00000143776	Optic Disk	1E-14	28073927

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143776	rs6671926	1	227199270	A	Optic disc area	25631615	[0.049-0.085] unit decrease	0.067	EFO_0006937
ENSG00000143776	rs6671926	1	227199270	A	Optic disc area	25631615	[0.047-0.087] unit decrease	0.067	EFO_0006937
ENSG00000143776	rs6671926	1	227199270	A	Optic cup area	25631615	[0.015-0.035] unit increase	0.025	EFO_0006940
ENSG00000143776	rs6665290	1	227013405	T	Myeloid white cell count	27863252	[0.017-0.031] unit decrease	0.02398569	EFO_0007988
ENSG00000143776	rs10916082	1	227064925	A	Diastolic blood pressure	28135244	[0.12-0.24] unit decrease	0.177	EFO_0006336
ENSG00000143776	rs11806180	1	227315768	?	Blond vs. brown/black hair color	30531825	NR	1.0485477	EFO_0003924
ENSG00000143776	rs112779011	1	227193355	?	Hair color	30595370			EFO_0007822
ENSG00000143776	rs76132272	1	227268364	T	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0098-0.0182] unit increase	0.0139991	EFO_0006527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143776	CDC42BPA	98	60.910	ENSG00000198752	CDC42BPB	88	85.965	Homo_sapiens
ENSG00000143776	CDC42BPA	73	32.820	ENSG00000122966	CIT	90	40.136	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	9092543.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	9092543.11340065.11399775.21457715.	IDA	Function
GO:0005515	protein binding	9418861.10644344.15194684.20936779.	IPI	Function
GO:0005524	ATP binding	9092543.	IDA	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0006468	protein phosphorylation	9092543.	IDA	Process
GO:0016477	cell migration	18854160.	IMP	Process
GO:0030027	lamellipodium	-	ISS	Component
GO:0031032	actomyosin structure organization	18854160.	IMP	Process
GO:0031252	cell leading edge	-	ISS	Component
GO:0031532	actin cytoskeleton reorganization	9418861.	IDA	Process
GO:0035556	intracellular signal transduction	-	IEA	Process
GO:0042641	actomyosin	18854160.	IDA	Component
GO:0042802	identical protein binding	11283256.23414517.	IPI	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component