EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143799 (Gene tree)
Gene ID: 142
Gene Symbol: PARP1
Alias: PARP|PPOL|ADPRT
Full Name: poly(ADP-ribose) polymerase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,410 bases
Position: chr1:226,360,691-226,408,100
Accession: 270
RBP type: canonical RBP
Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000355759	PARP	PF00644.20	9.2e-73	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29432179	PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability.	Proc Natl Acad Sci U S A	2018 Feb 20	Chen JK	doi: 10.1073/pnas.1713912115
29949139	STEEL participates in fracture healing through upregulating angiogenesis-related genes by recruiting PARP 1.	Eur Rev Med Pharmacol Sci	2018 Jun	Zhang SZ	doi: 10.26355/eurrev_201806_15245.
29387452	Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis.	Cell Discov	2017 Nov 28	Melikishvili M	doi: 10.1038/celldisc.2017.43
24335297	Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.	J Virol	2014 Feb	Atasheva S	doi: 10.1128/JVI.03443-13
22941645	PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.	Nucleic Acids Res	2012 Nov 1	Krietsch J	doi: 10.1093/nar/gks798
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
26927092	Roles of RNA-Binding Proteins in DNA Damage Response.	Int J Mol Sci	2016 Feb 27	Kai M	doi: 10.3390/ijms17030310.
30777121	Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing.	Epigenetics Chromatin	2019 Feb 18	Matveeva EA	doi: 10.1186/s13072-019-0261-1.
17785446	The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription.	Mol Cell Biol	2007 Nov	Wacker DA	-
9122182	Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro.	Proc Natl Acad Sci U S A	1997 Mar 18	Meisterernst M	-
16464859	Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene.	J Biol Chem	2006 Apr 7	Yu Z	-
16115861	Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.	J Biol Chem	2005 Oct 21	Tapodi A	-
15498776	Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex.	J Biol Chem	2005 Jan 7	Parent M	-
15302869	Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.	J Biol Chem	2004 Oct 8	Nakajima H	-
14715657	Camptothecin-sensitive relaxation of supercoiled DNA by the topoisomerase I-like activity associated with poly(ADP-ribose) polymerase-1.	J Biol Chem	2004 Mar 19	Yung TM	-
18258916	Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.	Science	2008 Feb 8	Krishnakumar R	doi: 10.1126/science.1149250.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490921	PARP1-207	3165	-	-	- (aa)	-	-
ENST00000491816	PARP1-208	416	-	-	- (aa)	-	-
ENST00000366792	PARP1-202	553	-	ENSP00000355757	108 (aa)	-	Q5VX84
ENST00000366790	PARP1-201	570	-	ENSP00000355755	155 (aa)	-	Q5VX85
ENST00000498787	PARP1-209	628	-	-	- (aa)	-	-
ENST00000463968	PARP1-204	830	-	-	- (aa)	-	-
ENST00000629232	PARP1-210	477	-	ENSP00000485852	108 (aa)	-	Q5VX84
ENST00000366794	PARP1-203	3958	-	ENSP00000355759	1014 (aa)	-	P09874
ENST00000469663	PARP1-206	542	-	-	- (aa)	-	-
ENST00000468608	PARP1-205	438	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143799's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG
hsa04064	NF-kappa B signaling pathway	KEGG
hsa04210	Apoptosis	KEGG
hsa04217	Necroptosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143799	Melanoma	9E-8	21983785

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143799	rs752307	1	226363828	?	Platelet count	29403010	[0.016-0.033] unit increase novel	0.02424	EFO_0004309
ENSG00000143799	rs3219090	1	226376990	C	Melanoma	21983785	[NR]	1.15	EFO_0000756

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143799's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143799	PARP1	100	70.381	ENSAPOG00000006414	parp1	100	70.479	Acanthochromis_polyacanthus
ENSG00000143799	PARP1	99	92.661	ENSAMEG00000014451	PARP1	100	92.661	Ailuropoda_melanoleuca
ENSG00000143799	PARP1	100	69.765	ENSACIG00000005651	parp1	100	69.540	Amphilophus_citrinellus
ENSG00000143799	PARP1	100	71.065	ENSAOCG00000021005	parp1	100	71.065	Amphiprion_ocellaris
ENSG00000143799	PARP1	100	71.163	ENSAPEG00000004784	parp1	100	71.163	Amphiprion_percula
ENSG00000143799	PARP1	99	70.993	ENSATEG00000010457	parp1	99	70.993	Anabas_testudineus
ENSG00000143799	PARP1	87	80.363	ENSAPLG00000014039	PARP1	100	80.363	Anas_platyrhynchos
ENSG00000143799	PARP1	100	76.824	ENSACAG00000006189	PARP1	100	77.120	Anolis_carolinensis
ENSG00000143799	PARP1	100	97.041	ENSANAG00000032699	PARP1	100	97.041	Aotus_nancymaae
ENSG00000143799	PARP1	100	71.386	ENSACLG00000015489	parp1	100	71.386	Astatotilapia_calliptera
ENSG00000143799	PARP1	100	69.366	ENSAMXG00000006465	parp1	100	69.620	Astyanax_mexicanus
ENSG00000143799	PARP1	100	90.757	ENSBTAG00000000837	PARP1	100	90.757	Bos_taurus
ENSG00000143799	PARP1	91	38.835	WBGene00004049	parp-1	100	45.594	Caenorhabditis_elegans
ENSG00000143799	PARP1	100	97.140	ENSCJAG00000012831	PARP1	100	97.140	Callithrix_jacchus
ENSG00000143799	PARP1	96	94.136	ENSCAFG00000016089	PARP1	100	94.136	Canis_familiaris
ENSG00000143799	PARP1	100	94.280	ENSCAFG00020001660	PARP1	100	94.280	Canis_lupus_dingo
ENSG00000143799	PARP1	100	90.954	ENSCHIG00000018072	PARP1	100	90.954	Capra_hircus
ENSG00000143799	PARP1	99	95.647	ENSTSYG00000003699	PARP1	100	95.647	Carlito_syrichta
ENSG00000143799	PARP1	87	93.103	ENSCAPG00000011113	-	100	76.561	Cavia_aperea
ENSG00000143799	PARP1	100	92.998	ENSCPOG00000015643	-	100	92.998	Cavia_porcellus
ENSG00000143799	PARP1	100	96.943	ENSCCAG00000033484	PARP1	100	96.943	Cebus_capucinus
ENSG00000143799	PARP1	100	98.225	ENSCATG00000038981	PARP1	100	98.225	Cercocebus_atys
ENSG00000143799	PARP1	100	93.097	ENSCLAG00000006637	PARP1	100	93.097	Chinchilla_lanigera
ENSG00000143799	PARP1	88	95.789	ENSCHOG00000003539	PARP1	66	95.312	Choloepus_hoffmanni
ENSG00000143799	PARP1	100	80.452	ENSCPBG00000011958	PARP1	100	80.433	Chrysemys_picta_bellii
ENSG00000143799	PARP1	99	97.639	ENSCANG00000041340	PARP1	100	97.639	Colobus_angolensis_palliatus
ENSG00000143799	PARP1	100	93.195	ENSCGRG00001020559	Parp1	100	93.195	Cricetulus_griseus_chok1gshd
ENSG00000143799	PARP1	99	93.224	ENSCGRG00000004864	Parp1	100	93.224	Cricetulus_griseus_crigri
ENSG00000143799	PARP1	100	69.667	ENSCSEG00000020665	parp1	99	77.733	Cynoglossus_semilaevis
ENSG00000143799	PARP1	99	69.746	ENSCVAG00000021372	parp1	99	69.746	Cyprinodon_variegatus
ENSG00000143799	PARP1	100	70.479	ENSDARG00000019529	parp1	100	70.939	Danio_rerio
ENSG00000143799	PARP1	96	91.770	ENSDNOG00000012059	PARP1	100	92.181	Dasypus_novemcinctus
ENSG00000143799	PARP1	99	90.862	ENSDORG00000005234	Parp1	100	90.862	Dipodomys_ordii
ENSG00000143799	PARP1	99	41.708	FBgn0010247	Parp	99	41.609	Drosophila_melanogaster
ENSG00000143799	PARP1	87	96.094	ENSETEG00000013254	PARP1	88	96.094	Echinops_telfairi
ENSG00000143799	PARP1	99	58.191	ENSEBUG00000005820	parp1	100	58.074	Eptatretus_burgeri
ENSG00000143799	PARP1	98	94.980	ENSEASG00005013275	PARP1	99	94.885	Equus_asinus_asinus
ENSG00000143799	PARP1	100	95.168	ENSECAG00000019207	PARP1	100	95.168	Equus_caballus
ENSG00000143799	PARP1	100	88.692	ENSEEUG00000012253	PARP1	100	88.692	Erinaceus_europaeus
ENSG00000143799	PARP1	99	71.654	ENSELUG00000017336	parp1	100	71.034	Esox_lucius
ENSG00000143799	PARP1	97	91.939	ENSFCAG00000005777	PARP1	100	92.551	Felis_catus
ENSG00000143799	PARP1	99	78.403	ENSFALG00000011578	PARP1	100	79.017	Ficedula_albicollis
ENSG00000143799	PARP1	99	93.018	ENSFDAG00000017662	PARP1	100	93.018	Fukomys_damarensis
ENSG00000143799	PARP1	99	70.305	ENSFHEG00000001117	parp1	99	70.305	Fundulus_heteroclitus
ENSG00000143799	PARP1	99	69.951	ENSGMOG00000014929	parp1	99	69.813	Gadus_morhua
ENSG00000143799	PARP1	100	78.466	ENSGALG00000009228	PARP1	100	79.371	Gallus_gallus
ENSG00000143799	PARP1	100	70.059	ENSGAFG00000010450	parp1	100	70.059	Gambusia_affinis
ENSG00000143799	PARP1	100	69.141	ENSGACG00000011280	parp1	100	69.434	Gasterosteus_aculeatus
ENSG00000143799	PARP1	100	79.528	ENSGAGG00000010066	PARP1	100	79.626	Gopherus_agassizii
ENSG00000143799	PARP1	100	99.606	ENSGGOG00000006308	PARP1	100	99.606	Gorilla_gorilla
ENSG00000143799	PARP1	100	71.359	ENSHBUG00000010490	parp1	100	71.359	Haplochromis_burtoni
ENSG00000143799	PARP1	96	91.897	ENSHGLG00000003992	PARP1	93	91.897	Heterocephalus_glaber_female
ENSG00000143799	PARP1	96	91.897	ENSHGLG00100016965	PARP1	93	91.897	Heterocephalus_glaber_male
ENSG00000143799	PARP1	100	69.268	ENSHCOG00000011619	parp1	100	69.659	Hippocampus_comes
ENSG00000143799	PARP1	100	68.738	ENSIPUG00000020250	parp1	99	69.336	Ictalurus_punctatus
ENSG00000143799	PARP1	100	95.562	ENSSTOG00000016000	PARP1	100	95.562	Ictidomys_tridecemlineatus
ENSG00000143799	PARP1	100	91.330	ENSJJAG00000023497	Parp1	100	91.330	Jaculus_jaculus
ENSG00000143799	PARP1	100	71.024	ENSKMAG00000011627	parp1	100	70.996	Kryptolebias_marmoratus
ENSG00000143799	PARP1	100	70.841	ENSLBEG00000013376	parp1	100	70.841	Labrus_bergylta
ENSG00000143799	PARP1	99	58.333	ENSLACG00000002735	PARP1	100	58.984	Latimeria_chalumnae
ENSG00000143799	PARP1	100	72.576	ENSLOCG00000015798	parp1	100	73.307	Lepisosteus_oculatus
ENSG00000143799	PARP1	99	91.376	ENSLAFG00000007830	PARP1	100	91.376	Loxodonta_africana
ENSG00000143799	PARP1	100	98.126	ENSMFAG00000002526	PARP1	100	98.126	Macaca_fascicularis
ENSG00000143799	PARP1	100	98.225	ENSMMUG00000021820	PARP1	100	98.225	Macaca_mulatta
ENSG00000143799	PARP1	100	98.225	ENSMNEG00000034074	PARP1	100	98.225	Macaca_nemestrina
ENSG00000143799	PARP1	100	95.969	ENSMLEG00000012344	PARP1	100	95.969	Mandrillus_leucophaeus
ENSG00000143799	PARP1	100	71.583	ENSMAMG00000020652	parp1	100	71.583	Mastacembelus_armatus
ENSG00000143799	PARP1	100	71.554	ENSMZEG00005016907	parp1	100	71.554	Maylandia_zebra
ENSG00000143799	PARP1	99	78.710	ENSMGAG00000007760	PARP1	100	79.141	Meleagris_gallopavo
ENSG00000143799	PARP1	100	93.097	ENSMAUG00000008306	Parp1	100	93.097	Mesocricetus_auratus
ENSG00000143799	PARP1	100	92.012	ENSMICG00000017076	PARP1	100	92.012	Microcebus_murinus
ENSG00000143799	PARP1	100	92.702	ENSMOCG00000014315	Parp1	100	92.702	Microtus_ochrogaster
ENSG00000143799	PARP1	100	70.069	ENSMMOG00000015966	parp1	100	70.069	Mola_mola
ENSG00000143799	PARP1	100	83.776	ENSMODG00000006076	PARP1	100	84.676	Monodelphis_domestica
ENSG00000143799	PARP1	100	68.560	ENSMALG00000004057	parp1	100	68.560	Monopterus_albus
ENSG00000143799	PARP1	100	92.315	MGP_CAROLIEiJ_G0014978	Parp1	100	93.878	Mus_caroli
ENSG00000143799	PARP1	100	92.315	ENSMUSG00000026496	Parp1	99	93.878	Mus_musculus
ENSG00000143799	PARP1	100	92.315	MGP_SPRETEiJ_G0015777	Parp1	100	93.878	Mus_spretus
ENSG00000143799	PARP1	100	92.801	ENSMPUG00000004585	PARP1	100	92.801	Mustela_putorius_furo
ENSG00000143799	PARP1	76	94.118	ENSMLUG00000012285	PARP1	100	75.791	Myotis_lucifugus
ENSG00000143799	PARP1	100	92.110	ENSNGAG00000003885	Parp1	100	92.604	Nannospalax_galili
ENSG00000143799	PARP1	100	71.386	ENSNBRG00000017434	parp1	100	71.386	Neolamprologus_brichardi
ENSG00000143799	PARP1	95	98.451	ENSNLEG00000013905	PARP1	100	98.451	Nomascus_leucogenys
ENSG00000143799	PARP1	67	91.642	ENSMEUG00000007720	PARP1	87	91.642	Notamacropus_eugenii
ENSG00000143799	PARP1	100	93.590	ENSOPRG00000011722	PARP1	100	93.590	Ochotona_princeps
ENSG00000143799	PARP1	100	90.434	ENSODEG00000007424	PARP1	100	90.434	Octodon_degus
ENSG00000143799	PARP1	100	71.457	ENSONIG00000013486	parp1	100	71.457	Oreochromis_niloticus
ENSG00000143799	PARP1	99	82.600	ENSOANG00000001488	PARP1	100	83.521	Ornithorhynchus_anatinus
ENSG00000143799	PARP1	100	94.286	ENSOCUG00000017820	PARP1	100	94.286	Oryctolagus_cuniculus
ENSG00000143799	PARP1	100	69.765	ENSORLG00000013691	parp1	100	69.765	Oryzias_latipes
ENSG00000143799	PARP1	99	69.161	ENSORLG00020001074	parp1	99	69.161	Oryzias_latipes_hni
ENSG00000143799	PARP1	100	69.863	ENSORLG00015007090	parp1	100	69.863	Oryzias_latipes_hsok
ENSG00000143799	PARP1	100	93.590	ENSOGAG00000016206	PARP1	100	93.590	Otolemur_garnettii
ENSG00000143799	PARP1	100	91.150	ENSOARG00000000811	PARP1	100	91.150	Ovis_aries
ENSG00000143799	PARP1	100	99.408	ENSPPAG00000040862	PARP1	100	99.408	Pan_paniscus
ENSG00000143799	PARP1	96	91.684	ENSPPRG00000003528	PARP1	100	92.402	Panthera_pardus
ENSG00000143799	PARP1	87	100.000	ENSPTIG00000009102	PARP1	98	78.421	Panthera_tigris_altaica
ENSG00000143799	PARP1	100	99.408	ENSPTRG00000002049	PARP1	100	99.408	Pan_troglodytes
ENSG00000143799	PARP1	100	98.030	ENSPANG00000011198	PARP1	100	98.030	Papio_anubis
ENSG00000143799	PARP1	100	70.629	ENSPKIG00000006039	parp1	100	71.246	Paramormyrops_kingsleyae
ENSG00000143799	PARP1	99	78.491	ENSPSIG00000016374	PARP1	100	79.328	Pelodiscus_sinensis
ENSG00000143799	PARP1	100	67.121	ENSPMGG00000008936	parp1	100	67.121	Periophthalmus_magnuspinnatus
ENSG00000143799	PARP1	100	92.801	ENSPEMG00000020230	Parp1	100	92.801	Peromyscus_maniculatus_bairdii
ENSG00000143799	PARP1	100	82.776	ENSPCIG00000006436	PARP1	100	87.758	Phascolarctos_cinereus
ENSG00000143799	PARP1	99	70.079	ENSPFOG00000002342	parp1	99	70.079	Poecilia_formosa
ENSG00000143799	PARP1	99	70.768	ENSPLAG00000000909	parp1	99	70.768	Poecilia_latipinna
ENSG00000143799	PARP1	99	70.866	ENSPMEG00000013979	parp1	99	70.866	Poecilia_mexicana
ENSG00000143799	PARP1	99	70.768	ENSPREG00000001114	parp1	99	70.768	Poecilia_reticulata
ENSG00000143799	PARP1	99	99.383	ENSPPYG00000000164	PARP1	100	99.383	Pongo_abelii
ENSG00000143799	PARP1	65	95.062	ENSPCAG00000005558	-	65	95.062	Procavia_capensis
ENSG00000143799	PARP1	100	94.773	ENSPCOG00000016918	PARP1	100	94.773	Propithecus_coquereli
ENSG00000143799	PARP1	92	94.340	ENSPVAG00000005543	PARP1	92	94.340	Pteropus_vampyrus
ENSG00000143799	PARP1	100	71.386	ENSPNYG00000009702	parp1	100	71.386	Pundamilia_nyererei
ENSG00000143799	PARP1	100	70.594	ENSPNAG00000002787	parp1	100	70.789	Pygocentrus_nattereri
ENSG00000143799	PARP1	100	91.626	ENSRNOG00000003084	Parp1	100	91.429	Rattus_norvegicus
ENSG00000143799	PARP1	100	97.929	ENSRBIG00000044893	PARP1	100	97.929	Rhinopithecus_bieti
ENSG00000143799	PARP1	100	97.929	ENSRROG00000029280	PARP1	100	97.929	Rhinopithecus_roxellana
ENSG00000143799	PARP1	100	68.701	ENSRROG00000040615	-	100	69.586	Rhinopithecus_roxellana
ENSG00000143799	PARP1	100	96.548	ENSSBOG00000010144	PARP1	100	96.548	Saimiri_boliviensis_boliviensis
ENSG00000143799	PARP1	99	84.000	ENSSHAG00000001991	PARP1	100	84.631	Sarcophilus_harrisii
ENSG00000143799	PARP1	100	70.732	ENSSFOG00015020017	parp1	100	70.732	Scleropages_formosus
ENSG00000143799	PARP1	100	70.772	ENSSMAG00000013799	parp1	100	70.772	Scophthalmus_maximus
ENSG00000143799	PARP1	100	70.127	ENSSDUG00000016626	parp1	100	70.127	Seriola_dumerili
ENSG00000143799	PARP1	100	70.127	ENSSLDG00000006384	parp1	100	70.127	Seriola_lalandi_dorsalis
ENSG00000143799	PARP1	53	97.222	ENSSARG00000009436	-	59	97.222	Sorex_araneus
ENSG00000143799	PARP1	100	75.862	ENSSPUG00000007790	PARP1	100	76.552	Sphenodon_punctatus
ENSG00000143799	PARP1	100	69.080	ENSSPAG00000019074	parp1	100	70.256	Stegastes_partitus
ENSG00000143799	PARP1	100	93.688	ENSSSCG00000023660	PARP1	100	93.688	Sus_scrofa
ENSG00000143799	PARP1	97	79.245	ENSTGUG00000004260	-	100	79.578	Taeniopygia_guttata
ENSG00000143799	PARP1	100	69.902	ENSTRUG00000014490	parp1	100	69.902	Takifugu_rubripes
ENSG00000143799	PARP1	100	69.561	ENSTNIG00000016384	parp1	100	69.561	Tetraodon_nigroviridis
ENSG00000143799	PARP1	82	97.872	ENSTBEG00000002364	PARP1	92	97.872	Tupaia_belangeri
ENSG00000143799	PARP1	100	88.560	ENSTTRG00000000188	PARP1	100	88.560	Tursiops_truncatus
ENSG00000143799	PARP1	99	93.641	ENSUAMG00000014388	PARP1	100	93.641	Ursus_americanus
ENSG00000143799	PARP1	84	98.113	ENSUMAG00000014555	PARP1	99	83.590	Ursus_maritimus
ENSG00000143799	PARP1	88	98.947	ENSVPAG00000011411	PARP1	84	97.744	Vicugna_pacos
ENSG00000143799	PARP1	96	94.239	ENSVVUG00000001655	PARP1	100	94.239	Vulpes_vulpes
ENSG00000143799	PARP1	98	72.954	ENSXETG00000022610	parp1	99	73.848	Xenopus_tropicalis
ENSG00000143799	PARP1	99	69.783	ENSXMAG00000003632	parp1	99	69.783	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	TAS	Process
GO:0000723	telomere maintenance	25749521.	TAS	Process
GO:0000724	double-strand break repair via homologous recombination	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	11112786.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	11112786.	IDA	Function
GO:0003677	DNA binding	2513174.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	21873635.	IBA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	7852410.16107709.17396150.19470756.19764761.23275542.	IDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	22504299.	IMP	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	-	TAS	Function
GO:0005515	protein binding	7596430.9518481.11248244.14596914.14627987.14734561.15044383.15555565.16490787.17167422.17396150.18172500.18971944.19661379.19666485.19710015.19779455.20064938.20098424.20133863.21266351.21549307.21575865.21577210.22504299.22863007.23230272.23396353.23481255.23966166.24778456.25533949.25640309.25749521.26344098.27067600.27248496.27728808.28190768.30356214.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	17177976.22504299.	IDA	Component
GO:0005635	nuclear envelope	9518481.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	19303849.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	9518481.16107709.	IDA	Component
GO:0005739	mitochondrion	25378300.	IDA	Component
GO:0006281	DNA repair	17396150.	TAS	Process
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	Process
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	Process
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006302	double-strand break repair	21873635.	IBA	Process
GO:0006302	double-strand break repair	23230272.	IMP	Process
GO:0006366	transcription by RNA polymerase II	10944198.	TAS	Process
GO:0006471	protein ADP-ribosylation	7852410.17396150.26344098.27067600.	IDA	Process
GO:0006471	protein ADP-ribosylation	22504299.	IMP	Process
GO:0006915	apoptotic process	15565177.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	24289924.24550317.27067600.27248496.	IMP	Process
GO:0007005	mitochondrion organization	25378300.	IMP	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IEA	Process
GO:0008134	transcription factor binding	19303849.	IPI	Function
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010332	response to gamma radiation	-	IEA	Process
GO:0010613	positive regulation of cardiac muscle hypertrophy	-	ISS	Process
GO:0010990	regulation of SMAD protein complex assembly	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016540	protein autoprocessing	-	IEA	Process
GO:0018312	peptidyl-serine ADP-ribosylation	28190768.	IDA	Process
GO:0018424	peptidyl-glutamic acid poly-ADP-ribosylation	19764761.	IDA	Process
GO:0019899	enzyme binding	23382074.	IPI	Function
GO:0019901	protein kinase binding	17177976.	IPI	Function
GO:0023019	signal transduction involved in regulation of gene expression	-	IEA	Process
GO:0030225	macrophage differentiation	18309324.	TAS	Process
GO:0030331	estrogen receptor binding	-	IEA	Function
GO:0030592	DNA ADP-ribosylation	27471034.	IDA	Process
GO:0032042	mitochondrial DNA metabolic process	25378300.	IMP	Process
GO:0032869	cellular response to insulin stimulus	19303849.	IDA	Process
GO:0032991	protein-containing complex	22504299.25378300.	IDA	Component
GO:0032993	protein-DNA complex	22504299.	IDA	Component
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	-	IEA	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0034599	cellular response to oxidative stress	25378300.	IMP	Process
GO:0034644	cellular response to UV	24289924.	IMP	Process
GO:0035861	site of double-strand break	26344098.30356214.	IDA	Component
GO:0036211	protein modification process	25378300.	IMP	Process
GO:0042769	DNA damage response, detection of DNA damage	-	IEA	Process
GO:0042802	identical protein binding	14734561.23481255.	IPI	Function
GO:0042826	histone deacetylase binding	-	IEA	Function
GO:0043504	mitochondrial DNA repair	25378300.	IMP	Process
GO:0044030	regulation of DNA methylation	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	11112786.	IDA	Process
GO:0047485	protein N-terminus binding	16107709.	IPI	Function
GO:0050790	regulation of catalytic activity	25749521.	IDA	Process
GO:0051287	NAD binding	-	IEA	Function
GO:0051901	positive regulation of mitochondrial depolarization	-	IEA	Process
GO:0060391	positive regulation of SMAD protein signal transduction	-	IEA	Process
GO:0070212	protein poly-ADP-ribosylation	21873635.	IBA	Process
GO:0070212	protein poly-ADP-ribosylation	15674325.19470756.25043379.	IDA	Process
GO:0070213	protein auto-ADP-ribosylation	19764761.	IDA	Process
GO:0070412	R-SMAD binding	-	IEA	Function
GO:0070911	global genome nucleotide-excision repair	-	TAS	Process
GO:0071294	cellular response to zinc ion	-	IEA	Process
GO:0090734	site of DNA damage	27248496.	IMP	Component
GO:1900182	positive regulation of protein localization to nucleus	-	IEA	Process
GO:1901216	positive regulation of neuron death	-	IEA	Process
GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	-	IEA	Process
GO:1903518	positive regulation of single strand break repair	28002403.	IGI	Process
GO:1903827	regulation of cellular protein localization	24550317.	IMP	Process
GO:1904044	response to aldosterone	-	IEA	Process
GO:1904357	negative regulation of telomere maintenance via telomere lengthening	-	ISS	Process
GO:1904646	cellular response to amyloid-beta	-	IEA	Process
GO:1904762	positive regulation of myofibroblast differentiation	-	IEA	Process
GO:1905168	positive regulation of double-strand break repair via homologous recombination	26344098.30356214.	IDA	Process
GO:1990404	protein ADP-ribosylase activity	21873635.	IBA	Function
GO:1990404	protein ADP-ribosylase activity	7852410.19764761.25043379.26344098.28190768.	IDA	Function
GO:1990966	ATP generation from poly-ADP-D-ribose	27257257.	IDA	Process
GO:2000679	positive regulation of transcription regulatory region DNA binding	-	IEA	Process
GO:2001170	negative regulation of ATP biosynthetic process	24289924.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23275151	PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.	Carcinogenesis	2013 Apr	Cheng H	doi: 10.1093/carcin/bgs393
22993403	Dual roles of PARP-1 promote cancer growth and progression.	Cancer Discov	2012 Dec	Schiewer MJ	doi: 10.1158/2159-8290.CD-12-0120
21612407	Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2.	DNA Cell Biol	2011 Dec	Kim J	doi: 10.1089/dna.2011.1250
24939750	Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription.	Oncotarget	2014 Nov 15	Ciccarone F	-
28167507	PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.	Clin Cancer Res	2017 Jul 15	Jiao S	doi: 10.1158/1078-0432.CCR-16-3215
29684820	Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.	Redox Biol	2018 Jul	Hou D	doi: 10.1016/j.redox.2018.03.016
26920250	Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.	Biochem Pharmacol	2016 May 1	Zhou Q	doi: 10.1016/j.bcp.2016.02.015
29632181	PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.	Proc Natl Acad Sci U S A	2018 Apr 24	Drsam B	doi: 10.1073/pnas.1712345115
14557488	Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.	J Clin Endocrinol Metab	2003 Oct	Huang SC	-
24535833	Inherited variation in the PARP1 gene and survival from melanoma.	Int J Cancer	2014 Oct 1	Davies JR	doi: 10.1002/ijc.28796
22472897	PARP-1 protein expression in glioblastoma multiforme.	Eur J Histochem	2012 Feb 27	Galia A	doi: 10.4081/ejh.2012.e9.
19655414	The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.	Am J Chin Med	2009	Li SL	-
22864776	Colorectal cancers differ in respect of PARP-1 protein expression.	Pol J Pathol	2012 Jun	Sulzyc-Bielicka V	-
25257171	Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.	Cell Death Differ	2015 Feb	Kumari A	doi: 10.1038/cdd.2014.146
22392482	Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.	Apoptosis	2012 Jul	Warrener P	doi: 10.1007/s10495-012-0707-4.
18314489	Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.	Mol Cancer Res	2008 Feb	Elser M	doi: 10.1158/1541-7786.MCR-07-0377.
19784808	Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.	Cell Mol Life Sci	2009 Dec	Gopinath S	doi: 10.1007/s00018-009-0157-5
15286704	Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.	Oncogene	2004 Sep 23	Veuger SJ	-
20113831	Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.	Cancer Genet Cytogenet	2010 Feb	Ogino H	doi: 10.1016/j.cancergencyto.2009.10.012.
21555554	Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.	Proc Natl Acad Sci U S A	2011 Jun 14	Krawczyk PM	doi: 10.1073/pnas.1101053108
15564335	The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.	Endocrinology	2005 Mar	Newton CJ	-
27440880	Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1.	J Virol	2016 Sep 12	Martin KA	doi: 10.1128/JVI.01180-16
27787517	PARP1 regulates the protein stability and proapoptotic function of HIPK2.	Cell Death Dis	2016 Oct 27	Choi JR	doi: 10.1038/cddis.2016.345.
28454547	PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.	Mol Cancer	2017 Apr 28	Pignochino Y	doi: 10.1186/s12943-017-0652-5.
25225750	PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer.	Genet Test Mol Biomarkers	2014 Nov	Wang HT	doi: 10.1089/gtmb.2014.0106
23254695	Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADPribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells.	Int J Oncol	2013 Feb	Feng X	doi: 10.3892/ijo.2012.1740
22166496	The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.	Carcinogenesis	2012 Mar	Teo MT	doi: 10.1093/carcin/bgr300
24436031	Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.	Int Urol Nephrol	2014 Jul	Wu W	doi: 10.1007/s11255-014-0642-0
18716896	PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population.	Mol Biol Rep	2009 Jul	Zhang Q	doi: 10.1007/s11033-008-9336-y
22127734	Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.	Genet Epidemiol	2012 Jan	Yu H	doi: 10.1002/gepi.20663
29393407	PARP1-siRNA suppresses human prostate cancer cell growth and progression.	Oncol Rep	2018 Apr	Lai Y	doi: 10.3892/or.2018.6238
24726141	The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells.	Neoplasia	2014 Mar	Piao L	doi: 10.1016/j.neo.2014.03.002
22221038	PARP1 polymorphisms increase the risk of gastric cancer in a Chinese population.	Mol Diagn Ther	2012 Feb 1	He W	doi: 10.2165/11595630-000000000-00000.
25037599	PARP-1 and CASP3 genes are up-regulated in LNCaP and PC-3 prostate cancer cell lines.	Hum Cell	2014 Oct	Salemi M	doi: 10.1007/s13577-013-0076-5
20218899	Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.	DNA Cell Biol	2010 Jun	Wang M	doi: 10.1089/dna.2009.0969.
23244082	XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy.	Asian Pac J Cancer Prev	2012	Ye S	-
27871924	MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.	Gene	2017 Feb 5	Luo Y	doi: 10.1016/j.gene.2016.11.031
23510475	Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.	Cell Prolif	2013 Apr	Loganathan R	doi: 10.1111/cpr.12014.
19109787	Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.	Methods Mol Biol	2009	Jiang J	doi: 10.1007/978-1-59745-416-2_16.
22660976	The role of PARP1 in the DNA damage response and its application in tumor therapy.	Front Med	2012 Jun	Wang Z	doi: 10.1007/s11684-012-0197-3
22384823	High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.	Histopathology	2012 Sep	Klauschen F	doi: 10.1111/j.1365-2559.2012.04225.x
27466483	Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.	Anticancer Res	2016 Aug	Tome Y	-
25738796	Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.	Int J Mol Med	2015 May	Zheng B	doi: 10.3892/ijmm.2015.2125
16328064	Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.	Oncol Rep	2006 Jan	Zhai X	-
20823142	Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer.	Clin Cancer Res	2010 Sep 15	Annunziata CM	doi: 10.1158/1078-0432.CCR-10-0526
23430444	Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population.	Med Oncol	2013 Jun	Li Y	doi: 10.1007/s12032-013-0505-z
17560163	Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.	Mutat Res	2007 Aug 15	Cao WH	-
24866151	Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.	Cancer Discov	2014 Aug	Gonz??lez-Billalabeitia E	doi: 10.1158/2159-8290.CD-13-0230
27055253	Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.	PLoS One	2016 Apr 7	Cardnell RJ	doi: 10.1371/journal.pone.0152584
24448423	Poly (ADP-ribose) polymerase 1 transcriptional regulation: a novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer.	Oncotarget	2014 Jan 15	Li D	-
23644255	Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1.	Gene	2013 Jul 25	Tang LY	doi: 10.1016/j.gene.2013.04.064
26826460	Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients.	Gene	2016 May 10	Batar B	doi: 10.1016/j.gene.2016.01.040
23548269	Germline mutations of BRCA1 gene exon 11 are not associated with platinum response neither with survival advantage in patients with primary ovarian cancer: understanding the clinical importance of one of the biggest human exons. A study of the Tumor Bank Ovarian Cancer (TOC) Consortium.	Tumour Biol	2016 Sep	Dimitrova D	-
25128455	Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.	Eur J Cancer	2014 Oct	Garc??a-Parra J	doi: 10.1016/j.ejca.2014.07.004
25883215	Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.	Oncotarget	2015 May 10	Frankum J	-
23633189	Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women.	Mol Diagn Ther	2013 Aug	Roszak A	doi: 10.1007/s40291-013-0036-5.
26091341	Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.	Mol Cell	2015 Jun 18	Feng FY	doi: 10.1016/j.molcel.2015.04.016.
21532888	p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.	Neoplasia	2011 May	Meng F	-
24535158	Nuclear-cytoplasmic PARP-1 expression as an unfavorable prognostic marker in lymph nodenegative early breast cancer: 15-year follow-up.	Oncol Rep	2014 Apr	Donizy P	doi: 10.3892/or.2014.3024
25480692	The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity.	Pathol Res Pract	2015 Feb	Zhai L	doi: 10.1016/j.prp.2014.11.004
26540566	Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications.	Oncotarget	2015 Dec 29	Park SH	doi: 10.18632/oncotarget.6264.
25400754	Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.	Int J Clin Exp Pathol	2014 Sep 15	Kim HC	-
19568233	Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.	Br J Cancer	2009 Jul 21	Zaremba T	doi: 10.1038/sj.bjc.6605166
25611238	The prognostic and predictive significance of PARP-1 in locally advanced breast cancer of Egyptian patients receiving neoadjuvant chemotherapy.	Appl Immunohistochem Mol Morphol	2015 Sep	Aiad HA	doi: 10.1097/PAI.0000000000000124.
28118040	PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy.	Cancer Biother Radiopharm	2017 Feb	Sander Effron S	doi: 10.1089/cbr.2016.2133
25333575	Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.	Oncol Rep	2014 Dec	Jiang X	doi: 10.3892/or.2014.3533
17943227	Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer.	J Hum Genet	2007	Durocher F	-
25526641	PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.	PLoS One	2014 Dec 19	Dziaman T	doi: 10.1371/journal.pone.0115558
20373286	Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.	EMBO Mol Med	2010 Apr	Sourisseau T	doi: 10.1002/emmm.201000068.
21434873	Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.	Biochem J	2011 Jun 15	Zaremba T	doi: 10.1042/BJ20101723.
21037106	Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.	Cancer Epidemiol Biomarkers Prev	2010 Dec	Brevik A	doi: 10.1158/1055-9965.EPI-10-0606
22134241	Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.	Cell Cycle	2011 Dec 15	Vance S	doi: 10.4161/cc.10.24.18661
21908496	Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.	Ann Oncol	2012 May	Rojo F	doi: 10.1093/annonc/mdr361
17975135	Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.	Clin Cancer Res	2007 Nov 1	Plummer ER	-
26356822	Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.	Oncotarget	2015 Oct 13	Brodie SA	doi: 10.18632/oncotarget.5040.
23479135	Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer.	Cancer Chemother Pharmacol	2013 May	Zhao W	doi: 10.1007/s00280-013-2127-8
24870775	Novel mutations of the PARP-1 gene associated with colorectal cancer in the Saudi population.	Asian Pac J Cancer Prev	2014	Alshammari AH	-
24489833	Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.	PLoS One	2014 Jan 28	Hua RX	doi: 10.1371/journal.pone.0087057
24761869	Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy.	Asian Pac J Cancer Prev	2014	Xie KJ	-
25528020	Biological and clinical significance of PARP1 protein expression in breast cancer.	Breast Cancer Res Treat	2015 Jan	Green AR	doi: 10.1007/s10549-014-3230-1
26387143	Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer.	Ann Oncol	2015 Dec	Michels J	doi: 10.1093/annonc/mdv393
22982218	The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines.	Mol Cell Endocrinol	2013 Jan 5	Lavarone E	doi: 10.1016/j.mce.2012.08.019
27746584	The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort.	Dis Markers	2016	Alhadheq AM	-
23317230	Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study.	Asian Pac J Cancer Prev	2012	Pan XF	-
21575865	Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.	Cancer Cell	2011 May 17	Brenner JC	doi: 10.1016/j.ccr.2011.04.010.
22337872	CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.	J Biol Chem	2012 Apr 13	Kashima L	doi: 10.1074/jbc.M111.321828
24853559	PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.	PLoS One	2014 May 22	Qin Q	doi: 10.1371/journal.pone.0098022
27323894	Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.	Biomarkers	2017 Feb	Nogueira A	doi: 10.1080/1354750X.2016.1204006
24889936	Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.	J Pathol	2014 Oct	Mart??nez-Bosch N	doi: 10.1002/path.4384
23803078	The C allele of a synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a risk factor for susceptibility to breast cancer in Saudi patients.	Asian Pac J Cancer Prev	2013	Alanazi M	-
23073772	Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis.	Mol Biol Rep	2012 Dec	Pabalan N	doi: 10.1007/s11033-012-2009-x
24191908	BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.	BMC Cancer	2013 Nov 5	Jacot W	doi: 10.1186/1471-2407-13-523.
26900125	Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.	Sci Rep	2016 Feb 22	Kossatz S	doi: 10.1038/srep21371.
22983827	Association between polymorphisms of XRCC1 and ADPRT genes and ovarian cancer survival with platinum-based chemotherapy in Chinese population.	Mol Cell Biochem	2013 Jan	Li K	doi: 10.1007/s11010-012-1442-4
19513550	gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids.	Int J Oncol	2009 Jul	Qvarnstrm OF	-
27362900	The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.	Int J Gynecol Pathol	2017 Mar	Hjortkjr M	doi: 10.1097/PGP.0000000000000310.
28212434	Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis.	PLoS One	2017 Feb 17	Qiao W	doi: 10.1371/journal.pone.0172413
27847302	Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.	Cancer Lett	2017 Feb 1	Yuan B	doi: 10.1016/j.canlet.2016.11.010
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28031413	Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors.	Mol Cancer Res	2017 Mar	Wielgos ME	doi: 10.1158/1541-7786.MCR-16-0287-T
28985359	PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.	Nucleic Acids Res	2017 Oct 13	Hsieh MH	doi: 10.1093/nar/gkx683.
29063620	Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance.	Prostate	2017 Dec	Stark TW	doi: 10.1002/pros.23435
28713983	MalforminA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway.	Int J Oncol	2017 Sep	Park SY	doi: 10.3892/ijo.2017.4070
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29048575	MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis.	Mutagenesis	2017 Oct 17	Schneiderova M	doi: 10.1093/mutage/gex026.
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29973717	CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.	Nature	2018 Jul	Zimmermann M	doi: 10.1038/s41586-018-0291-z
29950726	High speed of fork progression induces DNA replication stress and genomic instability.	Nature	2018 Jul	Maya-Mendoza A	doi: 10.1038/s41586-018-0261-5
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Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	226385565	Missense_Mutation	novel	A317V	0.05
ACC	chr1	226367490	Missense_Mutation	novel	T799I	0.23
ACC	chr1	226379260	Missense_Mutation	rs200485374	A543T	0.22
BLCA	chr1	226377176	Missense_Mutation	rs577466994	A625T	0.25
BLCA	chr1	226379994	Missense_Mutation	novel	E491K	0.16
BLCA	chr1	226402253	Nonsense_Mutation	novel	Q83*	0.18
BLCA	chr1	226361508	Silent	novel	L999L	0.44
BLCA	chr1	226408003	5'UTR	novel		0.36
BLCA	chr1	226377194	Missense_Mutation	novel	E619K	0.6
BLCA	chr1	226366046	Missense_Mutation	novel	D805N	0.25
BLCA	chr1	226367590	Missense_Mutation	NA	D766N	0.33
BLCA	chr1	226379209	Missense_Mutation	NA	V560L	0.35
BLCA	chr1	226383103	Silent	rs761844848	S364S	0.18
BLCA	chr1	226388665	Frame_Shift_Del	novel	*A237Pfs2**	0.13
BLCA	chr1	226364018	Missense_Mutation	NA	S904T	0.51	PARP
BLCA	chr1	226367590	Missense_Mutation	NA	D766N	0.26
BLCA	chr1	226380165	Splice_Site	NA	X434_splice	0.11
BLCA	chr1	226392940	Intron	novel		0.62
BRCA	chr1	226383034	Splice_Site	NA	X387_splice	0.08
BRCA	chr1	226385597	Silent	rs755443483	S306S	0.16
BRCA	chr1	226402232	Missense_Mutation	novel	E90K	0.09
BRCA	chr1	226407828	Silent	novel	R34R	0.11
BRCA	chr1	226374264	Missense_Mutation	NA	D678H	0.12
BRCA	chr1	226385596	Missense_Mutation	rs377195931	D307N	0.08
BRCA	chr1	226379184	Missense_Mutation	NA	S568C	0.56
BRCA	chr1	226407902	Missense_Mutation	novel	R10G	0.05
BRCA	chr1	226383089	Missense_Mutation	NA	P369L	0.18
BRCA	chr1	226390478	Silent	novel	G183G	0.05
BRCA	chr1	226361440	3'UTR	novel		0.62
BRCA	chr1	226367488	Missense_Mutation	NA	D800N	0.27
BRCA	chr1	226392289	Missense_Mutation	NA	S104R	0.35
BRCA	chr1	226385596	Missense_Mutation	rs377195931	D307N	0.11
BRCA	chr1	226365136	Missense_Mutation	novel	E842K	0.1	PARP
BRCA	chr1	226361534	Missense_Mutation	novel	V991L	0.07	PARP
BRCA	chr1	226383093	Missense_Mutation	novel	T368P	0.31
BRCA	chr1	226377245	Nonsense_Mutation	novel	E602*	0.07
BRCA	chr1	226381159	Silent	rs776889972	R403R	0.15
CESC	chr1	226408003	5'UTR	novel		0.27
CESC	chr1	226364135	Intron	NA		0.18
CESC	chr1	226408003	5'UTR	novel		0.14
CESC	chr1	226390456	Missense_Mutation	NA	D191H	0.13
CESC	chr1	226365005	Silent	rs373903460	P885P	0.33
CESC	chr1	226374258	Missense_Mutation	NA	E680Q	0.22
CESC	chr1	226408003	5'UTR	novel		0.31
CESC	chr1	226407995	5'UTR	novel		0.17
CESC	chr1	226402251	Silent	NA	Q83Q	0.3
COAD	chr1	226364044	Silent	NA	I895I	0.41
COAD	chr1	226365097	Missense_Mutation	NA	H855N	0.39	PARP
COAD	chr1	226362076	Silent	NA	G952G	0.21
COAD	chr1	226407948	5'UTR	novel		0.26
COAD	chr1	226367491	Frame_Shift_Del	novel	*T799Lfs41**	0.39
COAD	chr1	226377153	Silent	rs200966933	T632T	0.11
COAD	chr1	226383118	Frame_Shift_Ins	NA	*E360Rfs29**	0.22
COAD	chr1	226402258	Missense_Mutation	NA	D81G	0.24
COAD	chr1	226365090	Missense_Mutation	rs190105316	R857Q	0.26	PARP
COAD	chr1	226377177	Silent	rs147221209	N624N	0.18
COAD	chr1	226377277	Missense_Mutation	rs377397890	R591H	0.28
COAD	chr1	226388728	Silent	NA	G215G	0.26
COAD	chr1	226362013	Silent	rs759984608	T973T	0.1
COAD	chr1	226383139	Frame_Shift_Del	novel	*K352Nfs29**	0.12
COAD	chr1	226379946	Frame_Shift_Del	NA	*S507Afs17**	0.17
COAD	chr1	226379946	Frame_Shift_Del	NA	*S507Afs17**	0.39
COAD	chr1	226392288	Missense_Mutation	novel	K105E	0.24
COAD	chr1	226380076	Silent	rs564778763	S463S	0.38
COAD	chr1	226363153	Silent	NA	L932L	0.13
COAD	chr1	226388714	Missense_Mutation	rs139232092	A220V	0.22
COAD	chr1	226377177	Silent	rs147221209	N624N	0.29
COAD	chr1	226379581	Missense_Mutation	NA	P535H	0.36
COAD	chr1	226366028	Missense_Mutation	NA	A811T	0.33	PARP
COAD	chr1	226362060	Missense_Mutation	rs779988758	P958S	0.08	PARP
COAD	chr1	226365074	Silent	rs767353446	H862H	0.25
COAD	chr1	226379957	Missense_Mutation	NA	L503R	0.1
ESCA	chr1	226383092	Missense_Mutation	rs749502012	T368M	0.04
ESCA	chr1	226388687	Missense_Mutation	novel	D229V	0.4
GBM	chr1	226392272	Missense_Mutation	novel	L110Q	0.03
GBM	chr1	226402317	Silent	novel	G61G	0.06
GBM	chr1	226363950	Nonsense_Mutation	novel	G927*	0.12	PARP
GBM	chr1	226390411	Missense_Mutation	novel	G206R	0.29
GBM	chr1	226379965	Silent	novel	G500G	0.05
GBM	chr1	226365028	Missense_Mutation	rs746139482	R878W	0.57	PARP
GBM	chr1	226370515	Splice_Region	rs377495505	I691I	0.45
GBM	chr1	226374350	Missense_Mutation	novel	E649G	0.56
GBM	chr1	226377268	Missense_Mutation	rs776941221	T594M	0.1
GBM	chr1	226363144	Missense_Mutation	rs759579130	A935T	0.37	PARP
HNSC	chr1	226380099	Missense_Mutation	novel	E456Q	0.29
HNSC	chr1	226390507	Missense_Mutation	novel	P174T	0.55
HNSC	chr1	226386339	Missense_Mutation	novel	S274F	0.24
HNSC	chr1	226380079	Silent	novel	V462V	0.12
HNSC	chr1	226361517	Silent	novel	Q996Q	0.87
KIRC	chr1	226364045	Missense_Mutation	NA	I895T	0.24	PARP
KIRC	chr1	226377266	Missense_Mutation	NA	V595L	0.05
KIRC	chr1	226377144	Silent	NA	P635P	0.21
KIRP	chr1	226368296	In_Frame_Del	novel	S727del	0.26
KIRP	chr1	226383116	Missense_Mutation	NA	E360V	0.42
KIRP	chr1	226383108	Missense_Mutation	rs779486158	A363T	0.46
LGG	chr1	226365131	Silent	rs148631906	G843G	0.48
LGG	chr1	226366001	Missense_Mutation	NA	N820D	0.13	PARP
LIHC	chr1	226368317	Missense_Mutation	novel	V720E	0.3
LIHC	chr1	226407931	5'UTR	novel		0.23
LIHC	chr1	226402305	Silent	NA	R65R	0.79
LIHC	chr1	226383147	Missense_Mutation	novel	V350I	0.13
LUAD	chr1	226379228	Missense_Mutation	novel	F553L	0.13
LUAD	chr1	226365993	Silent	novel	H822H	0.12
LUAD	chr1	226366049	Missense_Mutation	NA	V804F	0.24
LUAD	chr1	226388734	Silent	NA	V213V	0.06
LUAD	chr1	226361482	Missense_Mutation	NA	N1008S	0.29
LUAD	chr1	226386373	Nonsense_Mutation	novel	E263*	0.35
LUSC	chr1	226368262	Silent	NA	T738T	0.42
LUSC	chr1	226377131	Missense_Mutation	novel	P640S	0.29
LUSC	chr1	226363130	Silent	NA	S939S	0.2
LUSC	chr1	226379931	Missense_Mutation	novel	K512E	0.15
LUSC	chr1	226368322	Splice_Site	NA	X719_splice	0.43
LUSC	chr1	226407995	5'UTR	novel		0.16
LUSC	chr1	226379964	Missense_Mutation	NA	A501T	0.04
LUSC	chr1	226379934	Missense_Mutation	NA	V511I	0.14
LUSC	chr1	226402215	Splice_Region	novel	T95T	0.36
LUSC	chr1	226408044	5'UTR	novel		0.26
LUSC	chr1	226379971	Silent	NA	K498K	0.31
OV	chr1	226379996	Frame_Shift_Ins	novel	*V490Afs2**	0.06
OV	chr1	226379197	Missense_Mutation	novel	K564E	0.11
OV	chr1	226379219	Silent	NA	T556T	0.33
OV	chr1	226364034	Missense_Mutation	NA	D899N	0.17	PARP
OV	chr1	226364046	Missense_Mutation	NA	I895V	0.22	PARP
PAAD	chr1	226366051	Missense_Mutation	novel	V803A	0.21
PAAD	chr1	226379201	Silent	rs534105862	I562I	0.26
PAAD	chr1	226385597	Silent	rs755443483	S306S	0.23
PAAD	chr1	226402268	Missense_Mutation	rs770918209	R78W	0.15
PRAD	chr1	226367554	Missense_Mutation	NA	L778F	0.35
PRAD	chr1	226383089	Missense_Mutation	NA	P369L	0.25
PRAD	chr1	226363999	Silent	rs756963125	T910T	0.22
READ	chr1	226390494	Missense_Mutation	rs202057244	A178V	0.25
READ	chr1	226377255	Missense_Mutation	novel	S598R	0.09
READ	chr1	226386377	Silent	novel	L261L	0.2
SARC	chr1	226361164	3'UTR	rs139052323		0.46
SARC	chr1	226408046	5'UTR	novel		0.56
SKCM	chr1	226392944	Intron	novel		0.18
SKCM	chr1	226361470	Missense_Mutation	NA	S1012F	0.15
SKCM	chr1	226377232	Missense_Mutation	NA	S606F	0.26
SKCM	chr1	226383103	Silent	rs761844848	S364S	0.23
SKCM	chr1	226383071	Missense_Mutation	novel	S375L	0.27
SKCM	chr1	226367516	Silent	rs148234314	I790I	0.2
SKCM	chr1	226368273	Missense_Mutation	rs766670559	R735C	0.42
SKCM	chr1	226377156	Silent	NA	F631F	0.33
SKCM	chr1	226379184	Missense_Mutation	NA	S568F	0.13
SKCM	chr1	226390430	Silent	NA	L199L	0.18
SKCM	chr1	226368310	Silent	novel	Q722Q	0.4
SKCM	chr1	226385528	Silent	rs770845304	N329N	0.57
SKCM	chr1	226379264	Silent	NA	H541H	0.18
SKCM	chr1	226374321	Missense_Mutation	NA	P659S	0.82
SKCM	chr1	226379209	Missense_Mutation	NA	V560M	0.16
SKCM	chr1	226361484	Silent	NA	F1007F	0.83
SKCM	chr1	226388721	Missense_Mutation	NA	E218K	0.1
SKCM	chr1	226365031	Missense_Mutation	novel	L877F	0.47	PARP
SKCM	chr1	226377146	Missense_Mutation	novel	P635S	0.32
STAD	chr1	226381103	Missense_Mutation	rs751338176	T422M	0.1
STAD	chr1	226379946	Frame_Shift_Del	NA	*S507Afs17**	0.22
STAD	chr1	226407982	5'UTR	novel		0.2
STAD	chr1	226368261	Frame_Shift_Del	novel	L739*	0.17
STAD	chr1	226374329	Missense_Mutation	NA	T656I	0.36
STAD	chr1	226385597	Silent	rs755443483	S306S	0.39
STAD	chr1	226383139	Frame_Shift_Del	novel	*K352Nfs29**	0.3
STAD	chr1	226379212	Missense_Mutation	NA	L559M	0.21
STAD	chr1	226383102	Missense_Mutation	rs774530658	V365M	0.19
STAD	chr1	226365131	Silent	rs148631906	G843G	0.51
STAD	chr1	226381174	Silent	rs373462891	L398L	0.51
STAD	chr1	226363139	Silent	NA	S936S	0.1
STAD	chr1	226381139	Missense_Mutation	NA	A410V	0.34
STAD	chr1	226381109	Missense_Mutation	rs757100394	T420M	0.15
STAD	chr1	226366037	Missense_Mutation	NA	S808T	0.07	PARP
STAD	chr1	226374297	Missense_Mutation	novel	K667E	0.33
STAD	chr1	226379924	Missense_Mutation	NA	E514G	0.25
STAD	chr1	226368250	Silent	rs761046396	H742H	0.15
STAD	chr1	226361435	3'UTR	novel		0.35
STAD	chr1	226377278	Missense_Mutation	rs752905479	R591C	0.32
STAD	chr1	226365121	Missense_Mutation	rs750773674	R847C	0.21	PARP
STAD	chr1	226388743	Silent	rs372233336	G210G	0.3
UCEC	chr1	226380046	Missense_Mutation	NA	F473L	0.33
UCEC	chr1	226361321	3'UTR	novel		0.25
UCEC	chr1	226364038	Silent	rs758785140	F897F	0.27
UCEC	chr1	226361465	Missense_Mutation	novel	W1014G	0.28
UCEC	chr1	226363971	Silent	novel	L920L	0.28
UCEC	chr1	226365070	Missense_Mutation	novel	S864P	0.15	PARP
UCEC	chr1	226365976	Missense_Mutation	rs147825810	A828V	0.36	PARP
UCEC	chr1	226367487	Missense_Mutation	novel	D800G	0.38
UCEC	chr1	226368272	Missense_Mutation	rs780595440	R735H	0.31
UCEC	chr1	226361405	3'UTR	novel		0.61
UCEC	chr1	226364026	Silent	novel	V901V	0.14
UCEC	chr1	226402338	Missense_Mutation	novel	F54L	0.33
UCEC	chr1	226361255	3'UTR	novel		0.5
UCEC	chr1	226361371	3'UTR	novel		0.09
UCEC	chr1	226362031	Silent	NA	V967V	0.45
UCEC	chr1	226362077	Missense_Mutation	novel	G952D	0.4	PARP
UCEC	chr1	226365085	Missense_Mutation	novel	L859V	0.34	PARP
UCEC	chr1	226361321	3'UTR	novel		0.35
UCEC	chr1	226365956	Missense_Mutation	NA	D835N	0.13	PARP
UCEC	chr1	226361225	3'UTR	novel		0.11
UCEC	chr1	226380082	Silent	rs369942072	D461D	0.2
UCEC	chr1	226377161	Missense_Mutation	NA	N630H	0.37
UCEC	chr1	226377278	Missense_Mutation	NA	R591S	0.31
UCEC	chr1	226381123	Silent	rs61731503	L415L	0.28
UCEC	chr1	226386327	Missense_Mutation	rs201777393	A278V	0.27
UCEC	chr1	226377176	Missense_Mutation	rs577466994	A625T	0.16
UCEC	chr1	226364038	Silent	rs758785140	F897F	0.31
UCEC	chr1	226379156	Silent	rs753320007	D577D	0.51
UCEC	chr1	226379616	Missense_Mutation	novel	M523I	0.41
UCEC	chr1	226381109	Missense_Mutation	rs757100394	T420M	0.3
UCEC	chr1	226380018	Frame_Shift_Del	NA	*A483Qfs3**	0.18
UCEC	chr1	226365139	Missense_Mutation	rs376334288	R841C	0.23	PARP
UCEC	chr1	226380041	Missense_Mutation	novel	A475V	0.36
UCEC	chr1	226385630	Silent	rs745779414	C295C	0.26
UCEC	chr1	226407919	Missense_Mutation	novel	S4Y	0.32
UCEC	chr1	226374282	Missense_Mutation	novel	L672I	0.43
UCEC	chr1	226390615	Missense_Mutation	rs193238922	R138C	0.3
UCEC	chr1	226367516	Silent	rs148234314	I790I	0.51
UCEC	chr1	226383118	Frame_Shift_Ins	NA	*E360Rfs29**	0.36
UCEC	chr1	226377133	Missense_Mutation	NA	Y639C	0.25
UCEC	chr1	226377160	Missense_Mutation	novel	N630T	0.45
UCEC	chr1	226361146	3'UTR	novel		0.48
UCEC	chr1	226385630	Silent	rs745779414	C295C	0.22
UCEC	chr1	226379265	Missense_Mutation	novel	H541R	0.28
UCEC	chr1	226381125	Missense_Mutation	novel	L415F	0.19
UCEC	chr1	226383169	Silent	novel	I342I	0.18
UCEC	chr1	226370463	Missense_Mutation	rs758506201	A709T	0.37
UCEC	chr1	226368320	Missense_Mutation	rs759524114	A719V	0.21
UCEC	chr1	226379945	Frame_Shift_Ins	novel	*S507Kfs14**	0.33
UCEC	chr1	226402278	Missense_Mutation	rs759516960	F74L	0.51
UCEC	chr1	226379187	Missense_Mutation	rs201570154	N567S	0.07
UCEC	chr1	226361155	3'UTR	novel		0.24
UCEC	chr1	226362029	Missense_Mutation	rs199689226	D968G	0.47	PARP
UCEC	chr1	226361030	3'UTR	novel		0.15
UCEC	chr1	226377278	Missense_Mutation	rs752905479	R591C	0.21
UCEC	chr1	226385597	Silent	rs755443483	S306S	0.09
UCEC	chr1	226379945	Frame_Shift_Ins	novel	*S507Kfs14**	0.41
UCEC	chr1	226361468	Silent	NA	L1013L	0.19
UCEC	chr1	226380152	Frame_Shift_Del	novel	*K438Rfs2**	0.29
UCEC	chr1	226402264	Missense_Mutation	NA	W79L	0.24
UCEC	chr1	226368226	Silent	rs200978353	P750P	0.45
UCEC	chr1	226402378	Missense_Mutation	rs768342881	S41L	0.27
UCEC	chr1	226365125	Silent	novel	C845C	0.38
UCEC	chr1	226365975	Silent	rs140555704	A828A	0.62
UCEC	chr1	226385619	Missense_Mutation	rs374381502	S299L	0.39
UCEC	chr1	226388670	Nonsense_Mutation	novel	E235*	0.39
UCEC	chr1	226385618	Silent	NA	S299S	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.076	0.033566
DLBC	DEL	0.1458	0.0017831
GBM	DEL	0.0503	0.00056261
KIRC	DEL	0.0644	0.018371
LGG	DEL	0.0312	0.11599
PCPG	DEL	0.0802	0.12617
PRAD	DEL	0.0691	0.00015401
READ	AMP	0.2545	0.14328
SARC	DEL	0.2957	2.6086e-08
TGCT	DEL	0.0333	0.16985
THYM	AMP	0.1789	0.24554
UCEC	AMP	0.3785	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0069	Kaplan-Meier Survival Analysis
MESO	0.0023	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.002	Kaplan-Meier Survival Analysis
KIRP	0.00018	Kaplan-Meier Survival Analysis
LAML	0.0007	Kaplan-Meier Survival Analysis
KICH	0.00024	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742