EuRBPDB

Description

Ensembl ID: ENSG00000143815 (Gene tree)
Gene ID: 3930
Gene Symbol: LBR
Alias: DHCR14B|TDRD18
Full Name: lamin B receptor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 27,424 bases
Position: chr1:225,401,502-225,428,925
Accession: 6518
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421383	LBR-203	736	-	ENSP00000416554	51 (aa)	-	C9JES9
ENST00000425080	LBR-205	874	-	ENSP00000388059	213 (aa)	-	C9JXK0
ENST00000424022	LBR-204	478	-	-	- (aa)	-	-
ENST00000487054	LBR-207	731	-	-	- (aa)	-	-
ENST00000272163	LBR-201	3745	XM_005273125	ENSP00000272163	615 (aa)	XP_005273182	Q14739
ENST00000441022	LBR-206	536	-	-	- (aa)	-	-
ENST00000338179	LBR-202	3812	-	ENSP00000339883	615 (aa)	-	Q14739
ENST00000488632	LBR-208	425	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143815	Platelet Function Tests	2.8308856E-006	-
ENSG00000143815	Child Development Disorders, Pervasive	3.5325700E-005	-
ENSG00000143815	Child Development Disorders, Pervasive	2.0387200E-005	-
ENSG00000143815	Immunoglobulins	4E-6	23382691
ENSG00000143815	Immunoglobulins	4E-6	23382691
ENSG00000143815	Immunoglobulins	6E-6	23382691

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143815	rs16844841	1	225402973	C	IgG glycosylation	23382691	[0.18-0.45] unit increase	0.3163	EFO_0005193
ENSG00000143815	rs16844846	1	225405225	G	IgG glycosylation	23382691	[0.18-0.45] unit decrease	0.311	EFO_0005193
ENSG00000143815	rs16844846	1	225405225	G	IgG glycosylation	23382691	[0.18-0.45] unit decrease	0.3154	EFO_0005193
ENSG00000143815	rs7406	1	225401771	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143815	LBR	100	92.157	ENSMUSG00000004880	Lbr	100	92.593	Mus_musculus
ENSG00000143815	LBR	67	39.819	YNL280C		98	39.819	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	8663349.	IPI	Function
GO:0005521	lamin binding	8157662.	TAS	Function
GO:0005634	nucleus	21327084.	IDA	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005637	nuclear inner membrane	21873635.	IBA	Component
GO:0005639	integral component of nuclear inner membrane	8157662.	TAS	Component
GO:0005737	cytoplasm	21327084.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	21327084.	IDA	Component
GO:0006695	cholesterol biosynthetic process	16784888.	IDA	Process
GO:0006695	cholesterol biosynthetic process	-	IEA	Process
GO:0006695	cholesterol biosynthetic process	27336722.	IMP	Process
GO:0006695	cholesterol biosynthetic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	15698635.	IDA	Component
GO:0016126	sterol biosynthetic process	21873635.	IBA	Process
GO:0030223	neutrophil differentiation	-	ISS	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0050613	delta14-sterol reductase activity	9630650.16784888.	IDA	Function
GO:0050613	delta14-sterol reductase activity	12618959.21327084.27336722.	IMP	Function
GO:0050613	delta14-sterol reductase activity	-	TAS	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070087	chromo shadow domain binding	15882967.	IPI	Function
GO:0070402	NADPH binding	27336722.	IMP	Function