EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143862 (Gene tree)
Gene ID: 127829
Gene Symbol: ARL8A
Alias: FLJ45195|Gie2|ARL10B
Full Name: ADP ribosylation factor like GTPase 8A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 11,340 bases
Position: chr1:202,133,404-202,144,743
Accession: 25192
RBP type: canonical RBP
Summary: ARL8A (ADP Ribosylation Factor Like GTPase 8A) is a Protein Coding gene. Diseases associated with ARL8A include Drug-Induced Lupus Erythematosus. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL8B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000272217	MMR_HSR1	PF01926.23	4e-06	1	1
ENSP00000485023	MMR_HSR1	PF01926.23	8.1e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491358	ARL8A-203	355	-	-	- (aa)	-	-
ENST00000272217	ARL8A-201	1793	-	ENSP00000272217	186 (aa)	-	Q96BM9
ENST00000614750	ARL8A-204	1727	-	ENSP00000485023	147 (aa)	-	A0A087X2J2
ENST00000486225	ARL8A-202	431	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000143862's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143862	rs4342901	1	202134674	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143862's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143862	ARL8A	100	95.699	ENSAPOG00000023583	arl8a	99	95.699	Acanthochromis_polyacanthus
ENSG00000143862	ARL8A	100	100.000	ENSAMEG00000011970	ARL8A	98	100.000	Ailuropoda_melanoleuca
ENSG00000143862	ARL8A	100	96.237	ENSACIG00000000868	arl8a	99	96.237	Amphilophus_citrinellus
ENSG00000143862	ARL8A	100	95.699	ENSAOCG00000009256	arl8a	99	95.699	Amphiprion_ocellaris
ENSG00000143862	ARL8A	100	95.699	ENSAPEG00000023154	arl8a	99	95.699	Amphiprion_percula
ENSG00000143862	ARL8A	100	96.237	ENSATEG00000021432	arl8a	99	96.237	Anabas_testudineus
ENSG00000143862	ARL8A	100	98.387	ENSACAG00000004202	ARL8A	100	98.387	Anolis_carolinensis
ENSG00000143862	ARL8A	100	100.000	ENSANAG00000030745	ARL8A	100	100.000	Aotus_nancymaae
ENSG00000143862	ARL8A	100	96.237	ENSACLG00000011996	arl8a	99	96.237	Astatotilapia_calliptera
ENSG00000143862	ARL8A	100	96.774	ENSAMXG00000039062	arl8a	100	96.774	Astyanax_mexicanus
ENSG00000143862	ARL8A	100	100.000	ENSBTAG00000006574	ARL8A	100	100.000	Bos_taurus
ENSG00000143862	ARL8A	99	84.865	WBGene00000192	arl-8	100	84.865	Caenorhabditis_elegans
ENSG00000143862	ARL8A	100	100.000	ENSCJAG00000005865	ARL8A	100	100.000	Callithrix_jacchus
ENSG00000143862	ARL8A	100	100.000	ENSCAFG00020016164	ARL8A	100	100.000	Canis_lupus_dingo
ENSG00000143862	ARL8A	100	99.462	ENSCHIG00000003028	ARL8A	100	99.462	Capra_hircus
ENSG00000143862	ARL8A	100	100.000	ENSCCAG00000007022	ARL8A	100	100.000	Cebus_capucinus
ENSG00000143862	ARL8A	100	100.000	ENSCATG00000041869	ARL8A	100	100.000	Cercocebus_atys
ENSG00000143862	ARL8A	100	100.000	ENSCSAG00000014093	ARL8A	100	100.000	Chlorocebus_sabaeus
ENSG00000143862	ARL8A	100	97.849	ENSCPBG00000010155	ARL8A	100	97.849	Chrysemys_picta_bellii
ENSG00000143862	ARL8A	100	99.462	ENSCGRG00001020777	Arl8a	100	99.462	Cricetulus_griseus_chok1gshd
ENSG00000143862	ARL8A	100	91.156	ENSCSEG00000018609	arl8a	97	97.647	Cynoglossus_semilaevis
ENSG00000143862	ARL8A	100	97.312	ENSDARG00000078686	arl8a	100	97.312	Danio_rerio
ENSG00000143862	ARL8A	100	100.000	ENSDNOG00000048007	ARL8A	98	100.000	Dasypus_novemcinctus
ENSG00000143862	ARL8A	100	90.323	ENSEBUG00000010483	-	100	90.323	Eptatretus_burgeri
ENSG00000143862	ARL8A	99	75.676	ENSEBUG00000016029	-	83	75.676	Eptatretus_burgeri
ENSG00000143862	ARL8A	100	88.710	ENSEBUG00000016527	-	83	88.710	Eptatretus_burgeri
ENSG00000143862	ARL8A	100	100.000	ENSECAG00000021194	ARL8A	100	100.000	Equus_caballus
ENSG00000143862	ARL8A	100	96.237	ENSELUG00000010736	arl8a	99	96.237	Esox_lucius
ENSG00000143862	ARL8A	100	95.699	ENSELUG00000003770	arl8a	99	95.699	Esox_lucius
ENSG00000143862	ARL8A	100	100.000	ENSFCAG00000018232	ARL8A	100	100.000	Felis_catus
ENSG00000143862	ARL8A	100	94.624	ENSGMOG00000013490	arl8a	99	94.624	Gadus_morhua
ENSG00000143862	ARL8A	100	98.925	ENSGALG00000000606	ARL8A	100	98.925	Gallus_gallus
ENSG00000143862	ARL8A	84	97.581	ENSGAFG00000017776	arl8a	78	97.778	Gambusia_affinis
ENSG00000143862	ARL8A	100	91.710	ENSGACG00000000273	arl8a	99	91.710	Gasterosteus_aculeatus
ENSG00000143862	ARL8A	100	100.000	ENSGGOG00000027790	ARL8A	100	100.000	Gorilla_gorilla
ENSG00000143862	ARL8A	100	96.237	ENSHBUG00000000964	arl8a	99	96.237	Haplochromis_burtoni
ENSG00000143862	ARL8A	100	100.000	ENSHGLG00000004366	ARL8A	100	100.000	Heterocephalus_glaber_female
ENSG00000143862	ARL8A	100	100.000	ENSHGLG00100016670	ARL8A	100	100.000	Heterocephalus_glaber_male
ENSG00000143862	ARL8A	100	95.699	ENSHCOG00000005512	-	99	95.699	Hippocampus_comes
ENSG00000143862	ARL8A	100	100.000	ENSSTOG00000013990	-	100	100.000	Ictidomys_tridecemlineatus
ENSG00000143862	ARL8A	100	100.000	ENSJJAG00000023105	Arl8a	100	100.000	Jaculus_jaculus
ENSG00000143862	ARL8A	100	96.237	ENSKMAG00000002898	arl8a	99	96.237	Kryptolebias_marmoratus
ENSG00000143862	ARL8A	100	96.774	ENSLACG00000014881	ARL8A	100	96.774	Latimeria_chalumnae
ENSG00000143862	ARL8A	100	96.257	ENSLOCG00000012467	arl8a	100	96.257	Lepisosteus_oculatus
ENSG00000143862	ARL8A	100	99.462	ENSLAFG00000015043	ARL8A	100	99.462	Loxodonta_africana
ENSG00000143862	ARL8A	100	100.000	ENSMFAG00000000767	ARL8A	100	100.000	Macaca_fascicularis
ENSG00000143862	ARL8A	100	100.000	ENSMMUG00000031357	ARL8A	100	100.000	Macaca_mulatta
ENSG00000143862	ARL8A	100	100.000	ENSMNEG00000039827	ARL8A	100	100.000	Macaca_nemestrina
ENSG00000143862	ARL8A	100	96.237	ENSMAMG00000013640	arl8a	99	96.237	Mastacembelus_armatus
ENSG00000143862	ARL8A	100	96.237	ENSMZEG00005026811	arl8a	99	96.237	Maylandia_zebra
ENSG00000143862	ARL8A	100	99.462	ENSMAUG00000005741	Arl8a	100	99.462	Mesocricetus_auratus
ENSG00000143862	ARL8A	100	100.000	ENSMICG00000038748	ARL8A	100	100.000	Microcebus_murinus
ENSG00000143862	ARL8A	100	99.462	ENSMOCG00000011687	Arl8a	100	99.462	Microtus_ochrogaster
ENSG00000143862	ARL8A	100	96.237	ENSMMOG00000010753	arl8a	99	96.237	Mola_mola
ENSG00000143862	ARL8A	91	100.000	ENSMODG00000000562	ARL8A	99	100.000	Monodelphis_domestica
ENSG00000143862	ARL8A	100	96.237	ENSMALG00000019198	arl8a	99	96.237	Monopterus_albus
ENSG00000143862	ARL8A	100	99.462	MGP_CAROLIEiJ_G0014632	Arl8a	100	99.462	Mus_caroli
ENSG00000143862	ARL8A	100	99.462	ENSMUSG00000026426	Arl8a	100	99.462	Mus_musculus
ENSG00000143862	ARL8A	100	99.462	MGP_PahariEiJ_G0027868	Arl8a	100	99.462	Mus_pahari
ENSG00000143862	ARL8A	100	99.462	MGP_SPRETEiJ_G0015439	Arl8a	100	99.462	Mus_spretus
ENSG00000143862	ARL8A	100	100.000	ENSNGAG00000007576	Arl8a	100	100.000	Nannospalax_galili
ENSG00000143862	ARL8A	100	96.237	ENSNBRG00000010663	arl8a	99	96.237	Neolamprologus_brichardi
ENSG00000143862	ARL8A	100	100.000	ENSODEG00000011676	ARL8A	100	100.000	Octodon_degus
ENSG00000143862	ARL8A	100	96.237	ENSONIG00000014667	arl8a	99	96.237	Oreochromis_niloticus
ENSG00000143862	ARL8A	100	96.237	ENSORLG00000028909	arl8a	99	96.237	Oryzias_latipes
ENSG00000143862	ARL8A	100	96.237	ENSORLG00020004126	arl8a	99	96.237	Oryzias_latipes_hni
ENSG00000143862	ARL8A	100	96.237	ENSORLG00015018698	-	99	96.237	Oryzias_latipes_hsok
ENSG00000143862	ARL8A	100	100.000	ENSOGAG00000030870	ARL8A	100	100.000	Otolemur_garnettii
ENSG00000143862	ARL8A	100	100.000	ENSPPAG00000031562	ARL8A	100	100.000	Pan_paniscus
ENSG00000143862	ARL8A	100	100.000	ENSPPRG00000003884	ARL8A	100	100.000	Panthera_pardus
ENSG00000143862	ARL8A	100	100.000	ENSPTRG00000001846	ARL8A	100	100.000	Pan_troglodytes
ENSG00000143862	ARL8A	100	100.000	ENSPANG00000006549	ARL8A	100	100.000	Papio_anubis
ENSG00000143862	ARL8A	100	96.237	ENSPKIG00000005234	-	99	96.237	Paramormyrops_kingsleyae
ENSG00000143862	ARL8A	100	96.237	ENSPKIG00000005327	arl8a	100	96.237	Paramormyrops_kingsleyae
ENSG00000143862	ARL8A	89	95.783	ENSPMGG00000006369	arl8a	99	95.783	Periophthalmus_magnuspinnatus
ENSG00000143862	ARL8A	100	99.462	ENSPEMG00000009150	Arl8a	100	99.462	Peromyscus_maniculatus_bairdii
ENSG00000143862	ARL8A	100	100.000	ENSPCIG00000004915	ARL8A	100	100.000	Phascolarctos_cinereus
ENSG00000143862	ARL8A	100	96.237	ENSPFOG00000012465	arl8a	99	96.237	Poecilia_formosa
ENSG00000143862	ARL8A	100	96.237	ENSPLAG00000004167	arl8a	99	96.237	Poecilia_latipinna
ENSG00000143862	ARL8A	100	96.237	ENSPMEG00000017237	arl8a	99	96.237	Poecilia_mexicana
ENSG00000143862	ARL8A	100	96.237	ENSPREG00000004992	arl8a	99	96.237	Poecilia_reticulata
ENSG00000143862	ARL8A	100	100.000	ENSPPYG00000000352	ARL8A	100	100.000	Pongo_abelii
ENSG00000143862	ARL8A	100	99.462	ENSPCAG00000007412	ARL8A	100	99.462	Procavia_capensis
ENSG00000143862	ARL8A	100	100.000	ENSPCOG00000024352	ARL8A	100	100.000	Propithecus_coquereli
ENSG00000143862	ARL8A	100	96.237	ENSPVAG00000014931	ARL8A	100	96.237	Pteropus_vampyrus
ENSG00000143862	ARL8A	100	99.462	ENSRNOG00000005988	Arl8a	100	99.462	Rattus_norvegicus
ENSG00000143862	ARL8A	89	100.000	ENSRROG00000039378	ARL8A	100	99.206	Rhinopithecus_roxellana
ENSG00000143862	ARL8A	100	96.774	ENSSFOG00015021537	arl8a	100	96.774	Scleropages_formosus
ENSG00000143862	ARL8A	100	94.086	ENSSMAG00000015087	arl8a	99	94.086	Scophthalmus_maximus
ENSG00000143862	ARL8A	100	96.237	ENSSDUG00000000578	arl8a	99	96.237	Seriola_dumerili
ENSG00000143862	ARL8A	100	96.237	ENSSLDG00000011226	arl8a	99	96.237	Seriola_lalandi_dorsalis
ENSG00000143862	ARL8A	100	97.849	ENSSPUG00000007980	ARL8A	100	97.849	Sphenodon_punctatus
ENSG00000143862	ARL8A	100	95.699	ENSSPAG00000015869	arl8a	99	95.699	Stegastes_partitus
ENSG00000143862	ARL8A	100	100.000	ENSSSCG00000036967	ARL8A	100	100.000	Sus_scrofa
ENSG00000143862	ARL8A	100	96.237	ENSTRUG00000013912	arl8a	99	96.237	Takifugu_rubripes
ENSG00000143862	ARL8A	91	100.000	ENSUAMG00000020350	ARL8A	56	100.000	Ursus_americanus
ENSG00000143862	ARL8A	100	97.312	ENSXETG00000000910	arl8a	97	97.312	Xenopus_tropicalis
ENSG00000143862	ARL8A	100	92.473	ENSXCOG00000016886	arl8a	99	92.473	Xiphophorus_couchianus
ENSG00000143862	ARL8A	100	96.237	ENSXMAG00000025580	arl8a	99	96.237	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	15331635.	NAS	Function
GO:0005515	protein binding	24955142.25416956.25898167.	IPI	Function
GO:0005525	GTP binding	15331635.	IDA	Function
GO:0005737	cytoplasm	15331635.	IDA	Component
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005765	lysosomal membrane	21873635.	IBA	Component
GO:0005774	vacuolar membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0007059	chromosome segregation	14871887.	ISS	Process
GO:0008089	anterograde axonal transport	-	IEA	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030496	midbody	15331635.	IDA	Component
GO:0031902	late endosome membrane	-	IEA	Component
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0043014	alpha-tubulin binding	15331635.	ISS	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045202	synapse	-	IEA	Component
GO:0048487	beta-tubulin binding	15331635.	ISS	Function
GO:0051233	spindle midzone	15331635.	IDA	Component
GO:0051301	cell division	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component
GO:1904115	axon cytoplasm	-	IEA	Component