EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143970 (Gene tree)
Gene ID: 55252
Gene Symbol: ASXL2
Alias: ASXH2|FLJ10898|KIAA1685
Full Name: ASXL transcriptional regulator 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 144,764 bases
Position: chr2:25,733,753-25,878,516
Accession: 23805
RBP type: canonical RBP
Summary: This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000391447	HARE-HTH	PF05066.13	1.7e-20	1	1
ENSP00000337250	HARE-HTH	PF05066.13	1.8e-12	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435504	ASXL2-203	12878	XM_011532950	ENSP00000391447	1435 (aa)	XP_011531252	Q76L83
ENST00000404843	ASXL2-202	3299	XM_006712040	ENSP00000383920	918 (aa)	XP_006712103	Q76L83
ENST00000497092	ASXL2-204	549	-	-	- (aa)	-	-
ENST00000336112	ASXL2-201	8889	XM_006712039	ENSP00000337250	1407 (aa)	XP_006712102	E7EWD6

Gene Model

Click here to download ENSG00000143970's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143970	Leukoaraiosis	6.9438289E-005	-
ENSG00000143970	Leukoaraiosis	6.9462627E-005	-
ENSG00000143970	Leukoaraiosis	6.9260852E-005	-
ENSG00000143970	Leukoaraiosis	6.9481144E-005	-
ENSG00000143970	Leukoaraiosis	6.9450455E-005	-
ENSG00000143970	Leukoaraiosis	6.9494815E-005	-
ENSG00000143970	Leukoaraiosis	6.9450455E-005	-
ENSG00000143970	Leukoaraiosis	6.9462627E-005	-
ENSG00000143970	Leukoaraiosis	6.9573347E-005	-
ENSG00000143970	Insulin-Like Growth Factor I	3.4660000E-008	27329260
ENSG00000143970	Insulin-Like Growth Factor I	3.3100000E-008	27329260
ENSG00000143970	Insulin-Like Growth Factor I	3.5370000E-008	27329260
ENSG00000143970	Insulin-Like Growth Factor I	3.5860000E-008	27329260
ENSG00000143970	Insulin-Like Growth Factor I	3.2920000E-008	27329260
ENSG00000143970	Insulin-Like Growth Factor I	3.5120000E-008	27329260

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143970	rs115348265	2	25818009	T	CTACK levels	27989323	[0.19-0.45] SD units decrease	0.3199	EFO_0008082
ENSG00000143970	rs28562485	2	25776342	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000143970	rs28562485	2	25776342	?	Hair color	30595370			EFO_0007822
ENSG00000143970	rs13392329	2	25842723	T	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0043-0.0098] unit decrease	0.00706146	EFO_0007878
ENSG00000143970	rs11897652	2	25767112	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143970's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143970	ASXL2	100	89.337	ENSAMEG00000002397	ASXL2	99	85.575	Ailuropoda_melanoleuca
ENSG00000143970	ASXL2	56	56.667	ENSAOCG00000018354	asxl2	64	56.667	Amphiprion_ocellaris
ENSG00000143970	ASXL2	56	56.667	ENSAPEG00000009777	asxl2	64	56.667	Amphiprion_percula
ENSG00000143970	ASXL2	81	49.292	ENSATEG00000003374	asxl2	63	59.167	Anabas_testudineus
ENSG00000143970	ASXL2	100	95.480	ENSANAG00000030148	ASXL2	100	95.063	Aotus_nancymaae
ENSG00000143970	ASXL2	66	71.605	ENSACLG00000008337	asxl2	79	55.833	Astatotilapia_calliptera
ENSG00000143970	ASXL2	64	69.444	ENSAMXG00000040278	asxl2	80	57.500	Astyanax_mexicanus
ENSG00000143970	ASXL2	99	89.049	ENSBTAG00000019983	ASXL2	100	85.842	Bos_taurus
ENSG00000143970	ASXL2	100	94.792	ENSCJAG00000008396	ASXL2	100	94.375	Callithrix_jacchus
ENSG00000143970	ASXL2	99	88.761	ENSCAFG00000004241	ASXL2	100	85.744	Canis_familiaris
ENSG00000143970	ASXL2	99	88.761	ENSCAFG00020025120	ASXL2	100	85.577	Canis_lupus_dingo
ENSG00000143970	ASXL2	100	91.837	ENSTSYG00000010372	ASXL2	100	88.835	Carlito_syrichta
ENSG00000143970	ASXL2	100	84.003	ENSCPOG00000007343	ASXL2	100	84.141	Cavia_porcellus
ENSG00000143970	ASXL2	100	95.335	ENSCCAG00000028549	ASXL2	100	94.514	Cebus_capucinus
ENSG00000143970	ASXL2	100	97.003	ENSCATG00000041653	ASXL2	100	97.003	Cercocebus_atys
ENSG00000143970	ASXL2	100	86.880	ENSCLAG00000011428	ASXL2	100	82.929	Chinchilla_lanigera
ENSG00000143970	ASXL2	86	98.113	ENSCHOG00000010181	-	82	84.874	Choloepus_hoffmanni
ENSG00000143970	ASXL2	100	60.163	ENSCPBG00000010779	ASXL2	100	59.379	Chrysemys_picta_bellii
ENSG00000143970	ASXL2	100	96.934	ENSCANG00000038929	ASXL2	100	96.934	Colobus_angolensis_palliatus
ENSG00000143970	ASXL2	100	83.090	ENSCGRG00001024434	Asxl2	100	80.111	Cricetulus_griseus_chok1gshd
ENSG00000143970	ASXL2	100	83.090	ENSCGRG00000018294	Asxl2	100	80.111	Cricetulus_griseus_crigri
ENSG00000143970	ASXL2	81	45.012	ENSCSEG00000006512	asxl2	90	48.567	Cynoglossus_semilaevis
ENSG00000143970	ASXL2	65	63.636	ENSCVAG00000022430	asxl2	64	54.167	Cyprinodon_variegatus
ENSG00000143970	ASXL2	85	51.631	ENSDARG00000076501	asxl2	63	57.265	Danio_rerio
ENSG00000143970	ASXL2	100	87.172	ENSDORG00000013989	Asxl2	100	81.207	Dipodomys_ordii
ENSG00000143970	ASXL2	93	98.113	ENSETEG00000012061	-	91	88.040	Echinops_telfairi
ENSG00000143970	ASXL2	99	89.625	ENSEASG00005011580	ASXL2	100	86.501	Equus_asinus_asinus
ENSG00000143970	ASXL2	99	89.625	ENSECAG00000010885	ASXL2	100	86.501	Equus_caballus
ENSG00000143970	ASXL2	75	92.188	ENSEEUG00000014459	-	84	74.586	Erinaceus_europaeus
ENSG00000143970	ASXL2	100	90.379	ENSFCAG00000003836	ASXL2	100	85.795	Felis_catus
ENSG00000143970	ASXL2	56	86.822	ENSFALG00000012449	ASXL2	61	77.807	Ficedula_albicollis
ENSG00000143970	ASXL2	100	85.131	ENSFDAG00000008670	ASXL2	100	84.501	Fukomys_damarensis
ENSG00000143970	ASXL2	100	59.207	ENSGALG00000016531	ASXL2	100	56.855	Gallus_gallus
ENSG00000143970	ASXL2	52	78.788	ENSGAFG00000018677	asxl2	67	62.406	Gambusia_affinis
ENSG00000143970	ASXL2	100	99.125	ENSGGOG00000011013	-	100	99.094	Gorilla_gorilla
ENSG00000143970	ASXL2	66	71.605	ENSHBUG00000017227	asxl2	79	55.833	Haplochromis_burtoni
ENSG00000143970	ASXL2	100	87.464	ENSHGLG00000006048	ASXL2	97	84.397	Heterocephalus_glaber_female
ENSG00000143970	ASXL2	100	87.464	ENSHGLG00100010557	ASXL2	100	83.782	Heterocephalus_glaber_male
ENSG00000143970	ASXL2	100	91.254	ENSSTOG00000013729	ASXL2	100	86.902	Ictidomys_tridecemlineatus
ENSG00000143970	ASXL2	100	87.172	ENSJJAG00000020150	Asxl2	100	79.917	Jaculus_jaculus
ENSG00000143970	ASXL2	66	62.617	ENSKMAG00000013630	asxl2	87	57.522	Kryptolebias_marmoratus
ENSG00000143970	ASXL2	51	78.947	ENSLBEG00000006710	asxl2	57	61.905	Labrus_bergylta
ENSG00000143970	ASXL2	100	47.865	ENSLACG00000002221	ASXL2	100	46.950	Latimeria_chalumnae
ENSG00000143970	ASXL2	81	46.973	ENSLOCG00000016319	asxl2	59	45.908	Lepisosteus_oculatus
ENSG00000143970	ASXL2	100	96.793	ENSMFAG00000039252	ASXL2	100	96.655	Macaca_fascicularis
ENSG00000143970	ASXL2	100	96.793	ENSMMUG00000001377	ASXL2	100	96.655	Macaca_mulatta
ENSG00000143970	ASXL2	100	96.934	ENSMNEG00000030154	ASXL2	100	96.934	Macaca_nemestrina
ENSG00000143970	ASXL2	100	96.864	ENSMLEG00000042828	ASXL2	100	96.864	Mandrillus_leucophaeus
ENSG00000143970	ASXL2	80	49.569	ENSMAMG00000000263	asxl2	64	58.333	Mastacembelus_armatus
ENSG00000143970	ASXL2	66	71.605	ENSMZEG00005015122	asxl2	79	55.833	Maylandia_zebra
ENSG00000143970	ASXL2	95	82.090	ENSMGAG00000014086	ASXL2	100	82.090	Meleagris_gallopavo
ENSG00000143970	ASXL2	99	84.012	ENSMAUG00000017967	Asxl2	100	77.670	Mesocricetus_auratus
ENSG00000143970	ASXL2	100	93.586	ENSMICG00000038141	ASXL2	100	91.054	Microcebus_murinus
ENSG00000143970	ASXL2	100	82.267	ENSMOCG00000003954	Asxl2	100	77.232	Microtus_ochrogaster
ENSG00000143970	ASXL2	100	71.955	ENSMODG00000015832	-	100	71.429	Monodelphis_domestica
ENSG00000143970	ASXL2	100	81.341	MGP_CAROLIEiJ_G0017573	Asxl2	95	94.764	Mus_caroli
ENSG00000143970	ASXL2	100	80.466	ENSMUSG00000037486	Asxl2	100	93.333	Mus_musculus
ENSG00000143970	ASXL2	100	81.341	MGP_SPRETEiJ_G0018417	Asxl2	95	92.932	Mus_spretus
ENSG00000143970	ASXL2	100	88.473	ENSMPUG00000014077	ASXL2	100	82.393	Mustela_putorius_furo
ENSG00000143970	ASXL2	100	88.184	ENSMLUG00000014831	ASXL2	100	85.396	Myotis_lucifugus
ENSG00000143970	ASXL2	99	86.297	ENSNGAG00000017809	Asxl2	100	81.068	Nannospalax_galili
ENSG00000143970	ASXL2	100	84.548	ENSODEG00000009627	ASXL2	100	81.319	Octodon_degus
ENSG00000143970	ASXL2	66	71.605	ENSONIG00000001036	asxl2	79	55.833	Oreochromis_niloticus
ENSG00000143970	ASXL2	100	82.216	ENSOCUG00000017108	ASXL2	99	80.538	Oryctolagus_cuniculus
ENSG00000143970	ASXL2	100	92.733	ENSOGAG00000002435	ASXL2	100	90.076	Otolemur_garnettii
ENSG00000143970	ASXL2	99	90.202	ENSOARG00000018413	ASXL2	99	84.107	Ovis_aries
ENSG00000143970	ASXL2	100	99.480	ENSPPAG00000040962	-	100	99.373	Pan_paniscus
ENSG00000143970	ASXL2	99	89.914	ENSPPRG00000000239	ASXL2	100	86.593	Panthera_pardus
ENSG00000143970	ASXL2	100	99.480	ENSPTRG00000011726	ASXL2	100	99.373	Pan_troglodytes
ENSG00000143970	ASXL2	100	96.934	ENSPANG00000007355	ASXL2	100	96.934	Papio_anubis
ENSG00000143970	ASXL2	100	58.403	ENSPSIG00000012140	ASXL2	100	57.597	Pelodiscus_sinensis
ENSG00000143970	ASXL2	81	49.564	ENSPLAG00000017569	asxl2	91	47.639	Poecilia_latipinna
ENSG00000143970	ASXL2	53	64.912	ENSPMEG00000002877	asxl2	67	62.060	Poecilia_mexicana
ENSG00000143970	ASXL2	100	97.959	ENSPPYG00000012589	-	100	95.749	Pongo_abelii
ENSG00000143970	ASXL2	78	94.602	ENSPCAG00000006325	-	79	94.472	Procavia_capensis
ENSG00000143970	ASXL2	100	93.294	ENSPCOG00000027270	ASXL2	99	90.616	Propithecus_coquereli
ENSG00000143970	ASXL2	99	90.490	ENSPVAG00000014375	ASXL2	100	87.282	Pteropus_vampyrus
ENSG00000143970	ASXL2	66	71.605	ENSPNYG00000004178	asxl2	79	55.833	Pundamilia_nyererei
ENSG00000143970	ASXL2	71	57.500	ENSPNAG00000016179	asxl2	77	57.500	Pygocentrus_nattereri
ENSG00000143970	ASXL2	100	97.015	ENSRBIG00000030906	ASXL2	100	97.015	Rhinopithecus_bieti
ENSG00000143970	ASXL2	100	97.003	ENSRROG00000034489	ASXL2	100	97.003	Rhinopithecus_roxellana
ENSG00000143970	ASXL2	100	94.715	ENSSBOG00000001902	ASXL2	100	94.715	Saimiri_boliviensis_boliviensis
ENSG00000143970	ASXL2	100	72.286	ENSSHAG00000012066	-	98	69.931	Sarcophilus_harrisii
ENSG00000143970	ASXL2	50	64.750	ENSSMAG00000013191	asxl2	80	57.983	Scophthalmus_maximus
ENSG00000143970	ASXL2	54	71.154	ENSSDUG00000009262	asxl2	64	55.833	Seriola_dumerili
ENSG00000143970	ASXL2	54	71.154	ENSSLDG00000022018	asxl2	64	56.667	Seriola_lalandi_dorsalis
ENSG00000143970	ASXL2	98	70.317	ENSSARG00000000609	-	93	71.004	Sorex_araneus
ENSG00000143970	ASXL2	100	55.218	ENSSPUG00000000020	ASXL2	100	55.655	Sphenodon_punctatus
ENSG00000143970	ASXL2	56	55.285	ENSSPAG00000021847	asxl2	64	57.500	Stegastes_partitus
ENSG00000143970	ASXL2	99	85.960	ENSSSCG00000008575	ASXL2	94	84.547	Sus_scrofa
ENSG00000143970	ASXL2	60	54.310	ENSTRUG00000023287	asxl2	74	54.310	Takifugu_rubripes
ENSG00000143970	ASXL2	74	59.483	ENSTNIG00000019288	asxl2	88	59.483	Tetraodon_nigroviridis
ENSG00000143970	ASXL2	99	91.354	ENSTTRG00000010215	ASXL2	99	85.123	Tursiops_truncatus
ENSG00000143970	ASXL2	75	84.694	ENSVPAG00000006574	-	67	85.381	Vicugna_pacos
ENSG00000143970	ASXL2	99	88.473	ENSVVUG00000015856	ASXL2	99	85.508	Vulpes_vulpes
ENSG00000143970	ASXL2	100	42.236	ENSXETG00000003167	asxl2	54	48.201	Xenopus_tropicalis
ENSG00000143970	ASXL2	63	63.294	ENSXMAG00000015679	asxl2	69	60.849	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006351	transcription, DNA-templated	-	IEA	Process
GO:0009887	animal organ morphogenesis	21873635.	IBA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	21047783.	IDA	Process
GO:0035517	PR-DUB complex	21873635.	IBA	Component
GO:0042975	peroxisome proliferator activated receptor binding	21873635.	IBA	Function
GO:0042975	peroxisome proliferator activated receptor binding	21047783.	IDA	Function
GO:0045600	positive regulation of fat cell differentiation	21047783.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21047783.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function