EuRBPDB

Description

Ensembl ID: ENSG00000144048 (Gene tree)
Gene ID: 8446
Gene Symbol: DUSP11
Alias: PIR1
Full Name: dual specificity phosphatase 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,974 bases
Position: chr2:73,762,184-73,780,157
Accession: 3066
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14671117	The genome of canarypox virus.	J Virol	2004 Jan	Tulman ER	-
24447265	Structure of human PIR1, an atypical dual-specificity phosphatase.	Biochemistry	2014 Feb 11	Sankhala RS	doi: 10.1021/bi401240x

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000452812	DUSP11-203	672	-	ENSP00000394535	150 (aa)	-	H7C0E6
ENST00000480948	DUSP11-205	787	-	-	- (aa)	-	-
ENST00000272444	DUSP11-201	1653	-	ENSP00000272444	377 (aa)	-	O75319
ENST00000477458	DUSP11-204	588	-	-	- (aa)	-	-
ENST00000443070	DUSP11-202	2175	-	ENSP00000413444	273 (aa)	-	O75319

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144048	DUSP11	87	80.769	ENSMUSG00000030002	Dusp11	88	86.719	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	9685386.	IDA	Function
GO:0004651	polynucleotide 5'-phosphatase activity	21873635.	IBA	Function
GO:0004651	polynucleotide 5'-phosphatase activity	10347225.	IDA	Function
GO:0004725	protein tyrosine phosphatase activity	9685386.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0006396	RNA processing	9685386.	TAS	Process
GO:0006470	protein dephosphorylation	9685386.	IDA	Process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	-	IEA	Function
GO:0016070	RNA metabolic process	10347225.	IDA	Process
GO:0016607	nuclear speck	9685386.	IDA	Component
GO:0016791	phosphatase activity	24447265.	IDA	Function
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	Process
GO:0045171	intercellular bridge	-	IDA	Component
GO:0098507	polynucleotide 5' dephosphorylation	10347225.	IDA	Process
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	24447265.	IMP	Function