EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144231 (Gene tree)
Gene ID: 5433
Gene Symbol: POLR2D
Alias: RBP4
Full Name: RNA polymerase II subunit D
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 14,607 bases
Position: chr2:127,843,551-127,858,157
Accession: 9191
RBP type: canonical RBP
Summary: This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000272645	RNA_pol_Rpb4	PF03874.16	1.8e-24	1	1
ENSP00000387117	RNA_pol_Rpb4	PF03874.16	1.6e-23	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409955	POLR2D-203	1758	-	ENSP00000387323	110 (aa)	-	E9PHV4
ENST00000409698	POLR2D-202	806	-	ENSP00000387117	104 (aa)	-	E9PB93
ENST00000487079	POLR2D-204	1037	-	-	- (aa)	-	-
ENST00000272645	POLR2D-201	5042	-	ENSP00000272645	142 (aa)	-	O15514

Gene Model

Click here to download ENSG00000144231's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa05016	Huntington disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144231's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144231	POLR2D	100	95.192	ENSAPOG00000023553	polr2d	100	90.179	Acanthochromis_polyacanthus
ENSG00000144231	POLR2D	100	100.000	ENSAMEG00000011746	POLR2D	100	98.611	Ailuropoda_melanoleuca
ENSG00000144231	POLR2D	100	95.192	ENSAOCG00000007295	polr2d	98	90.071	Amphiprion_ocellaris
ENSG00000144231	POLR2D	100	95.192	ENSAPEG00000018714	polr2d	100	90.179	Amphiprion_percula
ENSG00000144231	POLR2D	100	95.192	ENSATEG00000020416	polr2d	100	90.972	Anabas_testudineus
ENSG00000144231	POLR2D	100	99.038	ENSACAG00000005255	POLR2D	100	96.479	Anolis_carolinensis
ENSG00000144231	POLR2D	100	100.000	ENSANAG00000019959	POLR2D	100	100.000	Aotus_nancymaae
ENSG00000144231	POLR2D	100	95.192	ENSACLG00000009919	polr2d	100	90.179	Astatotilapia_calliptera
ENSG00000144231	POLR2D	100	97.115	ENSAMXG00000008954	polr2d	100	90.210	Astyanax_mexicanus
ENSG00000144231	POLR2D	100	100.000	ENSBTAG00000053244	POLR2D	100	99.296	Bos_taurus
ENSG00000144231	POLR2D	99	61.165	WBGene00018391	rpb-4	100	57.639	Caenorhabditis_elegans
ENSG00000144231	POLR2D	100	99.296	ENSCJAG00000021814	-	100	99.296	Callithrix_jacchus
ENSG00000144231	POLR2D	100	100.000	ENSCJAG00000042216	-	100	100.000	Callithrix_jacchus
ENSG00000144231	POLR2D	100	100.000	ENSCAFG00000004311	POLR2D	100	100.000	Canis_familiaris
ENSG00000144231	POLR2D	100	100.000	ENSCAFG00020003617	POLR2D	100	100.000	Canis_lupus_dingo
ENSG00000144231	POLR2D	100	100.000	ENSCHIG00000025995	POLR2D	100	98.592	Capra_hircus
ENSG00000144231	POLR2D	100	99.038	ENSTSYG00000036021	POLR2D	100	99.145	Carlito_syrichta
ENSG00000144231	POLR2D	100	99.038	ENSCPOG00000002571	POLR2D	100	98.592	Cavia_porcellus
ENSG00000144231	POLR2D	100	100.000	ENSCCAG00000037709	POLR2D	100	100.000	Cebus_capucinus
ENSG00000144231	POLR2D	100	100.000	ENSCATG00000036749	POLR2D	100	99.296	Cercocebus_atys
ENSG00000144231	POLR2D	100	99.296	ENSCLAG00000004449	POLR2D	100	99.296	Chinchilla_lanigera
ENSG00000144231	POLR2D	100	100.000	ENSCSAG00000016861	POLR2D	100	99.296	Chlorocebus_sabaeus
ENSG00000144231	POLR2D	100	100.000	ENSCHOG00000013850	POLR2D	100	100.000	Choloepus_hoffmanni
ENSG00000144231	POLR2D	100	99.038	ENSCPBG00000019132	POLR2D	51	95.775	Chrysemys_picta_bellii
ENSG00000144231	POLR2D	99	87.379	ENSCING00000011474	-	96	86.719	Ciona_intestinalis
ENSG00000144231	POLR2D	99	87.379	ENSCSAVG00000008353	-	88	86.719	Ciona_savignyi
ENSG00000144231	POLR2D	100	100.000	ENSCANG00000043665	POLR2D	100	100.000	Colobus_angolensis_palliatus
ENSG00000144231	POLR2D	100	100.000	ENSCGRG00001013608	Polr2d	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000144231	POLR2D	100	100.000	ENSCGRG00000012624	Polr2d	100	100.000	Cricetulus_griseus_crigri
ENSG00000144231	POLR2D	100	95.192	ENSCSEG00000006147	polr2d	100	90.278	Cynoglossus_semilaevis
ENSG00000144231	POLR2D	100	94.231	ENSCVAG00000000779	polr2d	100	90.972	Cyprinodon_variegatus
ENSG00000144231	POLR2D	100	97.115	ENSDARG00000076509	polr2d	100	92.254	Danio_rerio
ENSG00000144231	POLR2D	100	100.000	ENSDNOG00000008527	POLR2D	100	97.887	Dasypus_novemcinctus
ENSG00000144231	POLR2D	100	100.000	ENSDORG00000026897	Polr2d	100	99.296	Dipodomys_ordii
ENSG00000144231	POLR2D	100	77.885	FBgn0263757	Rpb4	94	77.692	Drosophila_melanogaster
ENSG00000144231	POLR2D	100	97.115	ENSEBUG00000007675	polr2d	100	92.254	Eptatretus_burgeri
ENSG00000144231	POLR2D	100	100.000	ENSEASG00005007103	POLR2D	100	99.296	Equus_asinus_asinus
ENSG00000144231	POLR2D	100	100.000	ENSECAG00000000556	POLR2D	100	100.000	Equus_caballus
ENSG00000144231	POLR2D	100	96.154	ENSELUG00000005928	polr2d	99	91.489	Esox_lucius
ENSG00000144231	POLR2D	100	100.000	ENSFCAG00000027816	POLR2D	100	100.000	Felis_catus
ENSG00000144231	POLR2D	100	99.038	ENSFALG00000003528	POLR2D	100	97.887	Ficedula_albicollis
ENSG00000144231	POLR2D	100	99.038	ENSFDAG00000007217	POLR2D	100	98.592	Fukomys_damarensis
ENSG00000144231	POLR2D	100	97.115	ENSGMOG00000001823	polr2d	99	93.706	Gadus_morhua
ENSG00000144231	POLR2D	100	99.038	ENSGALG00000002057	POLR2D	100	97.183	Gallus_gallus
ENSG00000144231	POLR2D	100	95.192	ENSGAFG00000016932	polr2d	71	91.667	Gambusia_affinis
ENSG00000144231	POLR2D	100	94.231	ENSGACG00000004639	polr2d	100	90.278	Gasterosteus_aculeatus
ENSG00000144231	POLR2D	100	99.038	ENSGAGG00000021308	POLR2D	100	95.775	Gopherus_agassizii
ENSG00000144231	POLR2D	100	100.000	ENSGGOG00000004723	POLR2D	100	100.000	Gorilla_gorilla
ENSG00000144231	POLR2D	100	99.296	ENSHGLG00000016570	Polr2d	100	99.296	Heterocephalus_glaber_female
ENSG00000144231	POLR2D	100	99.296	ENSHGLG00100013785	Polr2d	100	99.296	Heterocephalus_glaber_male
ENSG00000144231	POLR2D	100	93.269	ENSHCOG00000006425	polr2d	100	88.732	Hippocampus_comes
ENSG00000144231	POLR2D	100	97.115	ENSIPUG00000011192	polr2d	100	91.549	Ictalurus_punctatus
ENSG00000144231	POLR2D	100	97.887	ENSSTOG00000023329	POLR2D	100	97.887	Ictidomys_tridecemlineatus
ENSG00000144231	POLR2D	100	100.000	ENSJJAG00000015053	-	100	98.592	Jaculus_jaculus
ENSG00000144231	POLR2D	100	93.269	ENSJJAG00000005723	-	94	94.017	Jaculus_jaculus
ENSG00000144231	POLR2D	100	92.308	ENSJJAG00000000783	-	100	89.437	Jaculus_jaculus
ENSG00000144231	POLR2D	99	94.175	ENSKMAG00000010677	polr2d	68	90.909	Kryptolebias_marmoratus
ENSG00000144231	POLR2D	100	98.077	ENSLACG00000017253	POLR2D	100	96.479	Latimeria_chalumnae
ENSG00000144231	POLR2D	100	96.154	ENSLOCG00000009106	polr2d	100	91.667	Lepisosteus_oculatus
ENSG00000144231	POLR2D	100	100.000	ENSLAFG00000001848	POLR2D	100	99.296	Loxodonta_africana
ENSG00000144231	POLR2D	100	100.000	ENSMFAG00000031937	POLR2D	100	99.296	Macaca_fascicularis
ENSG00000144231	POLR2D	100	100.000	ENSMMUG00000001989	POLR2D	100	99.296	Macaca_mulatta
ENSG00000144231	POLR2D	100	100.000	ENSMNEG00000035505	POLR2D	100	99.296	Macaca_nemestrina
ENSG00000144231	POLR2D	100	100.000	ENSMLEG00000035827	POLR2D	100	99.296	Mandrillus_leucophaeus
ENSG00000144231	POLR2D	100	99.038	ENSMGAG00000001248	POLR2D	100	97.183	Meleagris_gallopavo
ENSG00000144231	POLR2D	100	99.296	ENSMAUG00000014518	Polr2d	100	99.296	Mesocricetus_auratus
ENSG00000144231	POLR2D	100	99.296	ENSMICG00000009931	POLR2D	100	99.296	Microcebus_murinus
ENSG00000144231	POLR2D	100	97.183	ENSMOCG00000019367	Polr2d	100	97.183	Microtus_ochrogaster
ENSG00000144231	POLR2D	100	99.038	ENSMODG00000018653	-	100	98.592	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.769	ENSMODG00000025032	-	100	80.282	Monodelphis_domestica
ENSG00000144231	POLR2D	100	81.731	ENSMODG00000025027	-	100	81.690	Monodelphis_domestica
ENSG00000144231	POLR2D	100	81.731	ENSMODG00000025026	-	100	81.690	Monodelphis_domestica
ENSG00000144231	POLR2D	100	81.731	ENSMODG00000025028	-	100	81.690	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.986	ENSMODG00000025036	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	81.731	ENSMODG00000025034	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.986	ENSMODG00000025035	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.986	ENSMODG00000025033	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	81.731	ENSMODG00000025030	-	100	81.690	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.986	ENSMODG00000025031	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	80.986	ENSMODG00000025029	-	100	80.986	Monodelphis_domestica
ENSG00000144231	POLR2D	100	95.192	ENSMALG00000018266	polr2d	100	90.972	Monopterus_albus
ENSG00000144231	POLR2D	100	100.000	MGP_CAROLIEiJ_G0022066	Polr2d	100	100.000	Mus_caroli
ENSG00000144231	POLR2D	100	100.000	ENSMUSG00000024258	Polr2d	100	100.000	Mus_musculus
ENSG00000144231	POLR2D	100	100.000	MGP_PahariEiJ_G0018800	Polr2d	100	100.000	Mus_pahari
ENSG00000144231	POLR2D	100	100.000	MGP_SPRETEiJ_G0022977	Polr2d	100	100.000	Mus_spretus
ENSG00000144231	POLR2D	100	100.000	ENSMPUG00000016685	POLR2D	100	100.000	Mustela_putorius_furo
ENSG00000144231	POLR2D	100	100.000	ENSMLUG00000006862	POLR2D	100	100.000	Myotis_lucifugus
ENSG00000144231	POLR2D	100	100.000	ENSNGAG00000014862	Polr2d	100	100.000	Nannospalax_galili
ENSG00000144231	POLR2D	100	100.000	ENSNLEG00000027191	POLR2D	100	100.000	Nomascus_leucogenys
ENSG00000144231	POLR2D	100	99.038	ENSOPRG00000005327	POLR2D	100	99.145	Ochotona_princeps
ENSG00000144231	POLR2D	100	99.296	ENSODEG00000005262	POLR2D	100	99.296	Octodon_degus
ENSG00000144231	POLR2D	100	95.192	ENSONIG00000017290	polr2d	100	90.972	Oreochromis_niloticus
ENSG00000144231	POLR2D	100	99.038	ENSOANG00000013216	POLR2D	100	99.153	Ornithorhynchus_anatinus
ENSG00000144231	POLR2D	100	92.308	ENSOCUG00000021449	-	100	92.308	Oryctolagus_cuniculus
ENSG00000144231	POLR2D	100	99.038	ENSOCUG00000023403	-	100	97.183	Oryctolagus_cuniculus
ENSG00000144231	POLR2D	100	94.231	ENSORLG00000005266	polr2d	100	88.194	Oryzias_latipes
ENSG00000144231	POLR2D	100	94.231	ENSORLG00020006647	polr2d	100	88.194	Oryzias_latipes_hni
ENSG00000144231	POLR2D	100	94.231	ENSORLG00015003222	polr2d	100	88.194	Oryzias_latipes_hsok
ENSG00000144231	POLR2D	100	94.231	ENSOMEG00000018915	polr2d	100	88.889	Oryzias_melastigma
ENSG00000144231	POLR2D	100	99.038	ENSOGAG00000017118	POLR2D	100	97.917	Otolemur_garnettii
ENSG00000144231	POLR2D	100	100.000	ENSOARG00000015995	POLR2D	100	98.592	Ovis_aries
ENSG00000144231	POLR2D	100	100.000	ENSPPRG00000020222	POLR2D	100	100.000	Panthera_pardus
ENSG00000144231	POLR2D	100	100.000	ENSPTIG00000018618	POLR2D	100	100.000	Panthera_tigris_altaica
ENSG00000144231	POLR2D	100	100.000	ENSPTRG00000012436	POLR2D	100	100.000	Pan_troglodytes
ENSG00000144231	POLR2D	100	100.000	ENSPANG00000018602	POLR2D	100	99.296	Papio_anubis
ENSG00000144231	POLR2D	100	97.115	ENSPKIG00000012166	polr2d	99	92.958	Paramormyrops_kingsleyae
ENSG00000144231	POLR2D	100	99.038	ENSPSIG00000002873	POLR2D	100	99.153	Pelodiscus_sinensis
ENSG00000144231	POLR2D	100	100.000	ENSPEMG00000018244	Polr2d	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000144231	POLR2D	100	93.269	ENSPMAG00000005021	polr2d	99	88.028	Petromyzon_marinus
ENSG00000144231	POLR2D	100	95.192	ENSPFOG00000008969	polr2d	100	91.667	Poecilia_formosa
ENSG00000144231	POLR2D	100	95.192	ENSPLAG00000017210	polr2d	100	91.667	Poecilia_latipinna
ENSG00000144231	POLR2D	100	95.192	ENSPMEG00000005160	polr2d	100	91.667	Poecilia_mexicana
ENSG00000144231	POLR2D	100	95.192	ENSPREG00000021862	polr2d	100	95.192	Poecilia_reticulata
ENSG00000144231	POLR2D	100	100.000	ENSPPYG00000012759	POLR2D	100	100.000	Pongo_abelii
ENSG00000144231	POLR2D	100	100.000	ENSPCAG00000001396	POLR2D	100	99.296	Procavia_capensis
ENSG00000144231	POLR2D	100	99.296	ENSPCOG00000022076	POLR2D	100	99.296	Propithecus_coquereli
ENSG00000144231	POLR2D	100	100.000	ENSPVAG00000004002	POLR2D	100	99.296	Pteropus_vampyrus
ENSG00000144231	POLR2D	100	97.115	ENSPNAG00000018246	polr2d	100	91.608	Pygocentrus_nattereri
ENSG00000144231	POLR2D	100	100.000	ENSRNOG00000016231	Polr2d	100	100.000	Rattus_norvegicus
ENSG00000144231	POLR2D	100	100.000	ENSRBIG00000039326	POLR2D	100	100.000	Rhinopithecus_bieti
ENSG00000144231	POLR2D	100	100.000	ENSRROG00000023289	POLR2D	100	100.000	Rhinopithecus_roxellana
ENSG00000144231	POLR2D	100	99.038	ENSSHAG00000014817	-	100	97.887	Sarcophilus_harrisii
ENSG00000144231	POLR2D	100	97.115	ENSSFOG00015024204	polr2d	100	91.667	Scleropages_formosus
ENSG00000144231	POLR2D	100	95.192	ENSSDUG00000006060	polr2d	100	90.972	Seriola_dumerili
ENSG00000144231	POLR2D	100	95.192	ENSSLDG00000024485	polr2d	100	90.345	Seriola_lalandi_dorsalis
ENSG00000144231	POLR2D	100	99.038	ENSSARG00000009037	POLR2D	100	99.145	Sorex_araneus
ENSG00000144231	POLR2D	100	99.038	ENSSPUG00000014915	POLR2D	100	97.183	Sphenodon_punctatus
ENSG00000144231	POLR2D	100	95.192	ENSSPAG00000013386	polr2d	100	90.972	Stegastes_partitus
ENSG00000144231	POLR2D	100	100.000	ENSSSCG00000039230	POLR2D	100	100.000	Sus_scrofa
ENSG00000144231	POLR2D	100	99.038	ENSTGUG00000005773	POLR2D	99	97.183	Taeniopygia_guttata
ENSG00000144231	POLR2D	100	95.192	ENSTRUG00000004740	polr2d	100	90.845	Takifugu_rubripes
ENSG00000144231	POLR2D	100	95.192	ENSTNIG00000011210	polr2d	99	92.199	Tetraodon_nigroviridis
ENSG00000144231	POLR2D	100	100.000	ENSTBEG00000006081	POLR2D	100	100.000	Tupaia_belangeri
ENSG00000144231	POLR2D	100	100.000	ENSTTRG00000010055	POLR2D	100	100.000	Tursiops_truncatus
ENSG00000144231	POLR2D	100	100.000	ENSUAMG00000024374	POLR2D	98	99.231	Ursus_americanus
ENSG00000144231	POLR2D	100	100.000	ENSUMAG00000008280	POLR2D	100	100.000	Ursus_maritimus
ENSG00000144231	POLR2D	100	100.000	ENSVPAG00000007239	POLR2D	100	100.000	Vicugna_pacos
ENSG00000144231	POLR2D	100	100.000	ENSVVUG00000008616	POLR2D	100	100.000	Vulpes_vulpes
ENSG00000144231	POLR2D	100	95.192	ENSXETG00000002955	polr2d	100	90.845	Xenopus_tropicalis
ENSG00000144231	POLR2D	100	95.192	ENSXCOG00000012668	polr2d	100	95.192	Xiphophorus_couchianus
ENSG00000144231	POLR2D	100	95.192	ENSXMAG00000014031	polr2d	100	95.192	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0003727	single-stranded RNA binding	21873635.	IBA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	9528765.	IMP	Function
GO:0005634	nucleus	9852112.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005665	RNA polymerase II, core complex	21873635.	IBA	Component
GO:0005665	RNA polymerase II, core complex	9528765.9852112.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	9528765.	IMP	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0031369	translation initiation factor binding	21873635.	IBA	Function
GO:0031990	mRNA export from nucleus in response to heat stress	21873635.	IBA	Process
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	21873635.	IBA	Process
GO:0035019	somatic stem cell population maintenance	-	TAS	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0045948	positive regulation of translational initiation	21873635.	IBA	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process