EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144635 (Gene tree)
Gene ID: 51143
Gene Symbol: DYNC1LI1
Alias: DNCLI1
Full Name: dynein cytoplasmic 1 light intermediate chain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 44,904 bases
Position: chr3:32,525,971-32,570,874
Accession: 18745
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474077	DYNC1LI1-206	605	-	-	- (aa)	-	-
ENST00000432458	DYNC1LI1-204	1827	-	ENSP00000407279	407 (aa)	-	E9PHI6
ENST00000273130	DYNC1LI1-201	2504	-	ENSP00000273130	523 (aa)	-	Q9Y6G9
ENST00000475193	DYNC1LI1-207	814	-	-	- (aa)	-	-
ENST00000481915	DYNC1LI1-208	4791	-	-	- (aa)	-	-
ENST00000424991	DYNC1LI1-203	666	-	ENSP00000409019	192 (aa)	-	C9JLW1
ENST00000413350	DYNC1LI1-202	616	-	ENSP00000390507	190 (aa)	-	C9JGM7
ENST00000472985	DYNC1LI1-205	646	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000144635's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05132	Salmonella infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144635's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144635	DYNC1LI1	98	62.622	ENSG00000135720	DYNC1LI2	93	73.611	Homo_sapiens
ENSG00000144635	DYNC1LI1	98	64.384	ENSMUSG00000035770	Dync1li2	99	62.471	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000776	kinetochore	19229290.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000922	spindle pole	19229290.	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003777	microtubule motor activity	-	IEA	Function
GO:0005515	protein binding	25272277.25416956.27482052.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005525	GTP binding	25272277.	IDA	Function
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005868	cytoplasmic dynein complex	21873635.	IBA	Component
GO:0005868	cytoplasmic dynein complex	19229290.25272277.	IDA	Component
GO:0005874	microtubule	-	IEA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0019003	GDP binding	25272277.	IDA	Function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045504	dynein heavy chain binding	21873635.	IBA	Function
GO:0045504	dynein heavy chain binding	25272277.	IPI	Function
GO:0051301	cell division	-	IEA	Process
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	19229290.	IMP	Process
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component