EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144736 (Gene tree)
Gene ID: 55164
Gene Symbol: SHQ1
Alias: FLJ10539|Shq1p
Full Name: SHQ1, H/ACA ribonucleoprotein assembly factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 112,638 bases
Position: chr3:72,749,277-72,861,914
Accession: 25543
RBP type: canonical RBP
Summary: SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000417452	SHQ1	PF04925.15	1.6e-68	1	1
ENSP00000315182	SHQ1	PF04925.15	1.8e-68	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22085966	The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.	Genes Dev	2011 Nov 15	Walbott H	doi: 10.1101/gad.176834.111.
22117216	Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.	EMBO J	2011 Nov 25	Li S	doi: 10.1038/emboj.2011.427.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471526	SHQ1-206	553	-	ENSP00000417739	63 (aa)	-	F8WBC6
ENST00000482785	SHQ1-208	502	-	ENSP00000418398	110 (aa)	-	C9J6N3
ENST00000325599	SHQ1-201	2879	XM_011533895	ENSP00000315182	577 (aa)	XP_011532197	Q6PI26
ENST00000468347	SHQ1-204	134	-	-	- (aa)	-	-
ENST00000463369	SHQ1-203	2065	-	ENSP00000417452	549 (aa)	-	Q6PI26
ENST00000475558	SHQ1-207	666	-	-	- (aa)	-	-
ENST00000444040	SHQ1-202	2844	-	ENSP00000402447	50 (aa)	-	F8WDZ9
ENST00000468371	SHQ1-205	4024	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000144736's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000144736	Autistic Disorder	9.7947000E-006	-
ENSG00000144736	Autistic Disorder	3.3172000E-006	-
ENSG00000144736	Autistic Disorder	3.7960000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144736	rs115077075	3	72825871	C	Monocyte chemoattractant protein-1 levels	27989323	[0.38-1.08] SD units decrease	0.7289	EFO_0004749

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144736's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144736	SHQ1	96	70.833	ENSAPOG00000000397	shq1	92	53.287	Acanthochromis_polyacanthus
ENSG00000144736	SHQ1	96	95.833	ENSAMEG00000015140	SHQ1	100	81.865	Ailuropoda_melanoleuca
ENSG00000144736	SHQ1	96	72.917	ENSACIG00000021249	shq1	67	62.621	Amphilophus_citrinellus
ENSG00000144736	SHQ1	96	72.917	ENSAOCG00000023311	shq1	70	63.387	Amphiprion_ocellaris
ENSG00000144736	SHQ1	96	72.917	ENSAPEG00000021686	shq1	92	53.741	Amphiprion_percula
ENSG00000144736	SHQ1	96	75.000	ENSATEG00000008475	shq1	67	62.740	Anabas_testudineus
ENSG00000144736	SHQ1	96	83.333	ENSAPLG00000013926	SHQ1	100	64.902	Anas_platyrhynchos
ENSG00000144736	SHQ1	96	89.583	ENSACAG00000014809	SHQ1	83	64.716	Anolis_carolinensis
ENSG00000144736	SHQ1	100	93.241	ENSANAG00000029241	SHQ1	100	93.241	Aotus_nancymaae
ENSG00000144736	SHQ1	100	86.364	ENSANAG00000030500	-	99	73.158	Aotus_nancymaae
ENSG00000144736	SHQ1	96	68.750	ENSACLG00000023077	shq1	69	57.399	Astatotilapia_calliptera
ENSG00000144736	SHQ1	96	79.167	ENSAMXG00000043822	shq1	90	49.907	Astyanax_mexicanus
ENSG00000144736	SHQ1	96	95.833	ENSBTAG00000005436	SHQ1	100	80.379	Bos_taurus
ENSG00000144736	SHQ1	96	45.833	WBGene00021655	Y48A5A.1	92	35.225	Caenorhabditis_elegans
ENSG00000144736	SHQ1	100	94.545	ENSCJAG00000015131	SHQ1	100	93.588	Callithrix_jacchus
ENSG00000144736	SHQ1	96	91.667	ENSCAFG00000006434	SHQ1	99	83.074	Canis_familiaris
ENSG00000144736	SHQ1	96	91.667	ENSCAFG00020016743	SHQ1	99	82.902	Canis_lupus_dingo
ENSG00000144736	SHQ1	96	95.833	ENSCHIG00000012271	SHQ1	91	81.239	Capra_hircus
ENSG00000144736	SHQ1	96	93.750	ENSTSYG00000014439	SHQ1	99	83.363	Carlito_syrichta
ENSG00000144736	SHQ1	100	88.393	ENSCAPG00000009343	SHQ1	97	92.857	Cavia_aperea
ENSG00000144736	SHQ1	100	90.000	ENSCPOG00000011443	SHQ1	99	77.797	Cavia_porcellus
ENSG00000144736	SHQ1	96	97.917	ENSCCAG00000027080	SHQ1	100	81.976	Cebus_capucinus
ENSG00000144736	SHQ1	100	80.909	ENSCCAG00000036087	-	99	73.693	Cebus_capucinus
ENSG00000144736	SHQ1	96	100.000	ENSCATG00000041238	SHQ1	100	95.321	Cercocebus_atys
ENSG00000144736	SHQ1	96	93.750	ENSCLAG00000004206	SHQ1	99	77.625	Chinchilla_lanigera
ENSG00000144736	SHQ1	100	92.727	ENSCSAG00000011514	SHQ1	100	94.877	Chlorocebus_sabaeus
ENSG00000144736	SHQ1	100	48.182	ENSCHOG00000003273	-	99	75.731	Choloepus_hoffmanni
ENSG00000144736	SHQ1	96	87.500	ENSCPBG00000006441	SHQ1	93	65.734	Chrysemys_picta_bellii
ENSG00000144736	SHQ1	96	50.000	ENSCING00000008013	-	85	43.641	Ciona_intestinalis
ENSG00000144736	SHQ1	96	50.000	ENSCSAVG00000002332	-	88	43.577	Ciona_savignyi
ENSG00000144736	SHQ1	99	95.439	ENSCANG00000039295	SHQ1	99	95.439	Colobus_angolensis_palliatus
ENSG00000144736	SHQ1	100	85.714	ENSCGRG00001012583	Shq1	100	84.016	Cricetulus_griseus_chok1gshd
ENSG00000144736	SHQ1	100	85.714	ENSCGRG00000009849	Shq1	100	84.016	Cricetulus_griseus_crigri
ENSG00000144736	SHQ1	96	79.167	ENSCSEG00000007829	shq1	66	62.651	Cynoglossus_semilaevis
ENSG00000144736	SHQ1	100	74.000	ENSCVAG00000020049	shq1	95	52.686	Cyprinodon_variegatus
ENSG00000144736	SHQ1	100	66.000	ENSDARG00000058522	shq1	69	59.662	Danio_rerio
ENSG00000144736	SHQ1	96	93.750	ENSDNOG00000033937	SHQ1	100	81.897	Dasypus_novemcinctus
ENSG00000144736	SHQ1	98	97.959	ENSETEG00000005766	SHQ1	100	67.526	Echinops_telfairi
ENSG00000144736	SHQ1	100	58.182	ENSEBUG00000005445	shq1	72	49.536	Eptatretus_burgeri
ENSG00000144736	SHQ1	96	95.833	ENSEASG00005002237	SHQ1	100	86.356	Equus_asinus_asinus
ENSG00000144736	SHQ1	96	95.833	ENSECAG00000015673	SHQ1	97	86.783	Equus_caballus
ENSG00000144736	SHQ1	96	95.833	ENSEEUG00000010568	SHQ1	99	80.763	Erinaceus_europaeus
ENSG00000144736	SHQ1	100	72.000	ENSELUG00000003476	shq1	93	51.531	Esox_lucius
ENSG00000144736	SHQ1	96	95.833	ENSFCAG00000012781	SHQ1	100	81.002	Felis_catus
ENSG00000144736	SHQ1	96	85.417	ENSFALG00000013428	SHQ1	95	62.931	Ficedula_albicollis
ENSG00000144736	SHQ1	96	93.750	ENSFDAG00000005595	SHQ1	91	73.950	Fukomys_damarensis
ENSG00000144736	SHQ1	100	78.000	ENSFHEG00000017552	shq1	94	53.125	Fundulus_heteroclitus
ENSG00000144736	SHQ1	100	66.000	ENSGMOG00000007350	shq1	100	59.000	Gadus_morhua
ENSG00000144736	SHQ1	96	81.250	ENSGALG00000007798	SHQ1	93	63.222	Gallus_gallus
ENSG00000144736	SHQ1	100	74.000	ENSGACG00000011797	shq1	100	61.461	Gasterosteus_aculeatus
ENSG00000144736	SHQ1	100	97.920	ENSGGOG00000034818	SHQ1	100	97.920	Gorilla_gorilla
ENSG00000144736	SHQ1	96	68.750	ENSHBUG00000010857	shq1	68	61.151	Haplochromis_burtoni
ENSG00000144736	SHQ1	100	89.286	ENSHGLG00000003637	SHQ1	90	75.680	Heterocephalus_glaber_female
ENSG00000144736	SHQ1	100	89.286	ENSHGLG00100011957	SHQ1	90	75.939	Heterocephalus_glaber_male
ENSG00000144736	SHQ1	100	68.000	ENSHCOG00000010799	shq1	90	52.747	Hippocampus_comes
ENSG00000144736	SHQ1	100	72.000	ENSIPUG00000001247	shq1	70	58.373	Ictalurus_punctatus
ENSG00000144736	SHQ1	96	91.667	ENSSTOG00000010043	SHQ1	100	74.081	Ictidomys_tridecemlineatus
ENSG00000144736	SHQ1	100	84.000	ENSJJAG00000017611	Shq1	100	84.016	Jaculus_jaculus
ENSG00000144736	SHQ1	100	70.000	ENSKMAG00000004457	shq1	91	53.996	Kryptolebias_marmoratus
ENSG00000144736	SHQ1	100	73.874	ENSLACG00000014243	SHQ1	86	60.279	Latimeria_chalumnae
ENSG00000144736	SHQ1	96	68.750	ENSLOCG00000009970	shq1	99	55.690	Lepisosteus_oculatus
ENSG00000144736	SHQ1	100	96.000	ENSMFAG00000039148	SHQ1	100	95.147	Macaca_fascicularis
ENSG00000144736	SHQ1	99	71.924	ENSMFAG00000037396	-	99	71.924	Macaca_fascicularis
ENSG00000144736	SHQ1	100	95.455	ENSMMUG00000009571	SHQ1	99	93.978	Macaca_mulatta
ENSG00000144736	SHQ1	99	71.404	ENSMMUG00000021761	-	99	71.404	Macaca_mulatta
ENSG00000144736	SHQ1	100	96.000	ENSMNEG00000032667	SHQ1	100	95.147	Macaca_nemestrina
ENSG00000144736	SHQ1	96	100.000	ENSMLEG00000038493	SHQ1	100	95.147	Mandrillus_leucophaeus
ENSG00000144736	SHQ1	100	72.000	ENSMAMG00000023432	shq1	87	53.093	Mastacembelus_armatus
ENSG00000144736	SHQ1	96	68.750	ENSMZEG00005008649	shq1	68	61.391	Maylandia_zebra
ENSG00000144736	SHQ1	96	83.333	ENSMGAG00000009640	SHQ1	93	62.478	Meleagris_gallopavo
ENSG00000144736	SHQ1	100	84.821	ENSMAUG00000022030	Shq1	100	84.836	Mesocricetus_auratus
ENSG00000144736	SHQ1	100	93.805	ENSMICG00000009224	SHQ1	100	84.444	Microcebus_murinus
ENSG00000144736	SHQ1	100	84.000	ENSMOCG00000017836	Shq1	98	85.656	Microtus_ochrogaster
ENSG00000144736	SHQ1	96	75.000	ENSMMOG00000010569	shq1	69	61.408	Mola_mola
ENSG00000144736	SHQ1	96	79.167	ENSMODG00000003926	SHQ1	98	62.996	Monodelphis_domestica
ENSG00000144736	SHQ1	96	75.000	ENSMALG00000008870	shq1	92	53.322	Monopterus_albus
ENSG00000144736	SHQ1	100	82.000	MGP_CAROLIEiJ_G0028689	Shq1	98	83.197	Mus_caroli
ENSG00000144736	SHQ1	100	82.000	ENSMUSG00000035378	Shq1	98	83.607	Mus_musculus
ENSG00000144736	SHQ1	100	82.000	MGP_PahariEiJ_G0022440	Shq1	98	84.836	Mus_pahari
ENSG00000144736	SHQ1	100	82.000	MGP_SPRETEiJ_G0029717	Shq1	98	84.016	Mus_spretus
ENSG00000144736	SHQ1	96	97.917	ENSMPUG00000017006	SHQ1	98	81.865	Mustela_putorius_furo
ENSG00000144736	SHQ1	100	79.825	ENSMLUG00000013539	SHQ1	96	74.667	Myotis_lucifugus
ENSG00000144736	SHQ1	100	81.250	ENSNGAG00000023317	Shq1	99	69.474	Nannospalax_galili
ENSG00000144736	SHQ1	100	57.391	ENSNBRG00000024004	shq1	62	59.756	Neolamprologus_brichardi
ENSG00000144736	SHQ1	100	98.182	ENSNLEG00000002731	SHQ1	100	97.400	Nomascus_leucogenys
ENSG00000144736	SHQ1	94	85.106	ENSMEUG00000009350	-	99	44.424	Notamacropus_eugenii
ENSG00000144736	SHQ1	100	92.000	ENSOPRG00000013963	-	74	91.176	Ochotona_princeps
ENSG00000144736	SHQ1	96	91.667	ENSODEG00000009192	SHQ1	98	85.950	Octodon_degus
ENSG00000144736	SHQ1	96	68.750	ENSONIG00000020264	shq1	68	61.391	Oreochromis_niloticus
ENSG00000144736	SHQ1	100	88.393	ENSOCUG00000016695	SHQ1	100	80.137	Oryctolagus_cuniculus
ENSG00000144736	SHQ1	96	68.750	ENSORLG00000023538	shq1	80	58.744	Oryzias_latipes
ENSG00000144736	SHQ1	96	70.833	ENSORLG00020003697	shq1	79	59.417	Oryzias_latipes_hni
ENSG00000144736	SHQ1	96	70.833	ENSORLG00015021040	shq1	74	60.241	Oryzias_latipes_hsok
ENSG00000144736	SHQ1	96	68.750	ENSOMEG00000001225	shq1	74	61.205	Oryzias_melastigma
ENSG00000144736	SHQ1	96	93.750	ENSOGAG00000003898	SHQ1	100	86.736	Otolemur_garnettii
ENSG00000144736	SHQ1	96	95.833	ENSOARG00000009547	SHQ1	100	80.034	Ovis_aries
ENSG00000144736	SHQ1	99	73.150	ENSPPAG00000043263	-	99	76.604	Pan_paniscus
ENSG00000144736	SHQ1	100	99.480	ENSPPAG00000027714	SHQ1	100	99.480	Pan_paniscus
ENSG00000144736	SHQ1	96	95.833	ENSPPRG00000004769	SHQ1	100	81.693	Panthera_pardus
ENSG00000144736	SHQ1	96	95.833	ENSPTIG00000011478	SHQ1	100	77.720	Panthera_tigris_altaica
ENSG00000144736	SHQ1	100	99.653	ENSPTRG00000015106	SHQ1	100	99.653	Pan_troglodytes
ENSG00000144736	SHQ1	99	72.117	ENSPTRG00000048303	-	99	75.472	Pan_troglodytes
ENSG00000144736	SHQ1	96	100.000	ENSPANG00000002881	SHQ1	100	95.667	Papio_anubis
ENSG00000144736	SHQ1	96	72.917	ENSPKIG00000021517	shq1	93	48.348	Paramormyrops_kingsleyae
ENSG00000144736	SHQ1	96	87.500	ENSPSIG00000005536	SHQ1	93	65.210	Pelodiscus_sinensis
ENSG00000144736	SHQ1	100	72.000	ENSPMGG00000008838	shq1	75	59.193	Periophthalmus_magnuspinnatus
ENSG00000144736	SHQ1	100	86.000	ENSPEMG00000000251	Shq1	98	85.246	Peromyscus_maniculatus_bairdii
ENSG00000144736	SHQ1	100	76.000	ENSPMAG00000005372	shq1	99	55.310	Petromyzon_marinus
ENSG00000144736	SHQ1	100	78.000	ENSPFOG00000003118	shq1	97	53.737	Poecilia_formosa
ENSG00000144736	SHQ1	100	50.877	ENSPMEG00000011076	shq1	96	50.955	Poecilia_mexicana
ENSG00000144736	SHQ1	100	53.097	ENSPREG00000000591	shq1	92	51.076	Poecilia_reticulata
ENSG00000144736	SHQ1	100	97.227	ENSPPYG00000013717	SHQ1	100	97.227	Pongo_abelii
ENSG00000144736	SHQ1	96	95.833	ENSPCAG00000009035	SHQ1	99	81.722	Procavia_capensis
ENSG00000144736	SHQ1	96	93.750	ENSPCOG00000008415	SHQ1	100	87.500	Propithecus_coquereli
ENSG00000144736	SHQ1	96	95.833	ENSPVAG00000017392	SHQ1	100	85.838	Pteropus_vampyrus
ENSG00000144736	SHQ1	96	68.750	ENSPNYG00000003878	shq1	68	61.391	Pundamilia_nyererei
ENSG00000144736	SHQ1	96	79.167	ENSPNAG00000026840	shq1	90	50.697	Pygocentrus_nattereri
ENSG00000144736	SHQ1	100	82.000	ENSRNOG00000005433	Shq1	99	72.637	Rattus_norvegicus
ENSG00000144736	SHQ1	96	100.000	ENSRBIG00000026280	SHQ1	99	90.018	Rhinopithecus_bieti
ENSG00000144736	SHQ1	96	100.000	ENSRROG00000034126	SHQ1	99	95.088	Rhinopithecus_roxellana
ENSG00000144736	SHQ1	96	95.833	ENSSBOG00000021038	SHQ1	100	85.615	Saimiri_boliviensis_boliviensis
ENSG00000144736	SHQ1	96	83.333	ENSSHAG00000015077	SHQ1	99	64.550	Sarcophilus_harrisii
ENSG00000144736	SHQ1	100	70.000	ENSSFOG00015016241	shq1	91	53.996	Scleropages_formosus
ENSG00000144736	SHQ1	96	72.917	ENSSMAG00000016151	shq1	72	63.431	Scophthalmus_maximus
ENSG00000144736	SHQ1	96	72.917	ENSSDUG00000011986	shq1	67	63.221	Seriola_dumerili
ENSG00000144736	SHQ1	96	68.750	ENSSLDG00000013908	shq1	67	62.864	Seriola_lalandi_dorsalis
ENSG00000144736	SHQ1	96	91.667	ENSSARG00000007119	SHQ1	100	63.574	Sorex_araneus
ENSG00000144736	SHQ1	100	69.912	ENSSPUG00000011526	-	90	61.983	Sphenodon_punctatus
ENSG00000144736	SHQ1	96	97.917	ENSSSCG00000011518	SHQ1	99	80.796	Sus_scrofa
ENSG00000144736	SHQ1	96	83.333	ENSTGUG00000009933	SHQ1	97	63.298	Taeniopygia_guttata
ENSG00000144736	SHQ1	96	79.167	ENSTRUG00000009446	shq1	92	51.332	Takifugu_rubripes
ENSG00000144736	SHQ1	96	70.833	ENSTNIG00000007354	shq1	90	58.173	Tetraodon_nigroviridis
ENSG00000144736	SHQ1	94	95.745	ENSTBEG00000011295	SHQ1	80	95.745	Tupaia_belangeri
ENSG00000144736	SHQ1	96	93.750	ENSTTRG00000005320	SHQ1	100	80.895	Tursiops_truncatus
ENSG00000144736	SHQ1	96	95.833	ENSUMAG00000024031	SHQ1	98	80.634	Ursus_maritimus
ENSG00000144736	SHQ1	96	72.097	ENSVPAG00000004880	SHQ1	100	73.596	Vicugna_pacos
ENSG00000144736	SHQ1	96	91.667	ENSVVUG00000013906	SHQ1	99	83.074	Vulpes_vulpes
ENSG00000144736	SHQ1	96	79.167	ENSXETG00000032215	shq1	93	54.545	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000493	box H/ACA snoRNP assembly	21873635.	IBA	Process
GO:0005515	protein binding	19383767.25416956.	IPI	Function
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	19383767.	IDA	Component
GO:0005730	nucleolus	19383767.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	19383767.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0015030	Cajal body	19383767.	IDA	Component
GO:0022618	ribonucleoprotein complex assembly	19383767.	IDA	Process
GO:0043065	positive regulation of apoptotic process	20663920.	IDA	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:2000233	negative regulation of rRNA processing	20663920.	IDA	Process