EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144867 (Gene tree)
Gene ID: 58477
Gene Symbol: SRPRB
Alias: APMCF1|SR-beta
Full Name: SRP receptor subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 41,740 bases
Position: chr3:133,784,033-133,825,772
Accession: 24085
RBP type: canonical RBP
Summary: The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000418401	MMR_HSR1	PF01926.23	3.3e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494297	SRPRB-205	555	-	-	- (aa)	-	-
ENST00000484684	SRPRB-204	512	-	ENSP00000417096	92 (aa)	-	C9J5Z8
ENST00000466490	SRPRB-201	2827	-	ENSP00000418401	271 (aa)	-	Q9Y5M8
ENST00000466636	SRPRB-202	917	-	ENSP00000417316	160 (aa)	-	H7C4H2
ENST00000481356	SRPRB-203	1487	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000144867's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000144867	C-Reactive Protein	1.904e-005	19060910
ENSG00000144867	Transferrin	7.766e-005	-
ENSG00000144867	Iron	1E-9	19084217
ENSG00000144867	Alcohol Drinking	2E-17	21665994

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144867	rs1534166	3	133818223	G	Blood protein levels	29875488	[0.22-0.34] unit decrease	0.28	EFO_0007937
ENSG00000144867	rs1830084	3	133789620	A	Iron status biomarkers	19084217	[NR] s.d. increase	0.43	EFO_0004461
ENSG00000144867	rs12490148	3	133805129	?	Mean corpuscular volume	29403010	[0.024-0.041] unit decrease novel	0.03225	EFO_0004526
ENSG00000144867	rs1534166	3	133818223	A	Alcohol consumption (transferrin glycosylation)	21665994	[0.22-0.36] unit decrease	0.289	EFO_0004329

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144867's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144867	SRPRB	99	97.484	ENSANAG00000028236	SRPRB	100	95.941	Aotus_nancymaae
ENSG00000144867	SRPRB	99	96.226	ENSBTAG00000044075	SRPRB	92	92.620	Bos_taurus
ENSG00000144867	SRPRB	99	97.484	ENSCJAG00000002845	SRPRB	100	95.941	Callithrix_jacchus
ENSG00000144867	SRPRB	99	97.484	ENSCAFG00020027568	SRPRB	100	92.989	Canis_lupus_dingo
ENSG00000144867	SRPRB	99	94.969	ENSCHIG00000019717	SRPRB	100	91.513	Capra_hircus
ENSG00000144867	SRPRB	99	93.082	ENSTSYG00000031948	SRPRB	100	91.513	Carlito_syrichta
ENSG00000144867	SRPRB	100	85.870	ENSCPOG00000030107	SRPRB	100	84.502	Cavia_porcellus
ENSG00000144867	SRPRB	99	96.226	ENSCCAG00000033027	SRPRB	100	93.727	Cebus_capucinus
ENSG00000144867	SRPRB	100	98.155	ENSCATG00000033438	SRPRB	100	98.155	Cercocebus_atys
ENSG00000144867	SRPRB	99	94.969	ENSCLAG00000002810	SRPRB	100	91.882	Chinchilla_lanigera
ENSG00000144867	SRPRB	100	98.155	ENSCSAG00000010699	SRPRB	100	98.155	Chlorocebus_sabaeus
ENSG00000144867	SRPRB	99	91.824	ENSCHOG00000011792	SRPRB	100	86.716	Choloepus_hoffmanni
ENSG00000144867	SRPRB	100	96.739	ENSCANG00000043327	SRPRB	100	80.443	Colobus_angolensis_palliatus
ENSG00000144867	SRPRB	99	96.226	ENSCGRG00001018121	Srprb	100	91.144	Cricetulus_griseus_chok1gshd
ENSG00000144867	SRPRB	99	96.226	ENSCGRG00000014367	Srprb	99	91.860	Cricetulus_griseus_crigri
ENSG00000144867	SRPRB	99	93.711	ENSDNOG00000032146	SRPRB	100	91.144	Dasypus_novemcinctus
ENSG00000144867	SRPRB	99	91.824	ENSDORG00000000764	Srprb	85	89.498	Dipodomys_ordii
ENSG00000144867	SRPRB	99	97.484	ENSEASG00005003967	SRPRB	100	93.358	Equus_asinus_asinus
ENSG00000144867	SRPRB	99	97.484	ENSECAG00000036666	SRPRB	100	93.358	Equus_caballus
ENSG00000144867	SRPRB	99	95.597	ENSFCAG00000037571	SRPRB	92	91.513	Felis_catus
ENSG00000144867	SRPRB	99	95.597	ENSFDAG00000017529	SRPRB	100	91.882	Fukomys_damarensis
ENSG00000144867	SRPRB	100	99.262	ENSGGOG00000027849	SRPRB	100	99.262	Gorilla_gorilla
ENSG00000144867	SRPRB	99	95.597	ENSHGLG00000016818	SRPRB	100	91.882	Heterocephalus_glaber_female
ENSG00000144867	SRPRB	99	95.597	ENSHGLG00100018893	SRPRB	100	91.882	Heterocephalus_glaber_male
ENSG00000144867	SRPRB	100	85.240	ENSSTOG00000022718	SRPRB	100	85.240	Ictidomys_tridecemlineatus
ENSG00000144867	SRPRB	100	98.155	ENSMFAG00000039758	SRPRB	100	98.155	Macaca_fascicularis
ENSG00000144867	SRPRB	100	98.155	ENSMMUG00000008918	SRPRB	100	98.155	Macaca_mulatta
ENSG00000144867	SRPRB	100	98.155	ENSMNEG00000032832	SRPRB	100	98.155	Macaca_nemestrina
ENSG00000144867	SRPRB	100	98.155	ENSMLEG00000035589	SRPRB	100	98.155	Mandrillus_leucophaeus
ENSG00000144867	SRPRB	99	96.226	ENSMAUG00000021695	Srprb	100	91.513	Mesocricetus_auratus
ENSG00000144867	SRPRB	100	94.834	ENSMICG00000048959	SRPRB	100	94.834	Microcebus_murinus
ENSG00000144867	SRPRB	99	88.050	ENSMODG00000018493	SRPRB	100	83.026	Monodelphis_domestica
ENSG00000144867	SRPRB	99	94.969	MGP_CAROLIEiJ_G0032586	Srprb	100	90.406	Mus_caroli
ENSG00000144867	SRPRB	99	94.969	ENSMUSG00000032553	Srprb	100	90.406	Mus_musculus
ENSG00000144867	SRPRB	99	95.597	MGP_PahariEiJ_G0015454	Srprb	100	90.775	Mus_pahari
ENSG00000144867	SRPRB	99	94.969	MGP_SPRETEiJ_G0033731	Srprb	100	91.144	Mus_spretus
ENSG00000144867	SRPRB	99	96.855	ENSMPUG00000009687	SRPRB	100	92.251	Mustela_putorius_furo
ENSG00000144867	SRPRB	99	96.226	ENSNGAG00000024311	-	100	90.037	Nannospalax_galili
ENSG00000144867	SRPRB	100	98.155	ENSNLEG00000003655	SRPRB	100	98.155	Nomascus_leucogenys
ENSG00000144867	SRPRB	99	94.340	ENSODEG00000018092	SRPRB	100	91.513	Octodon_degus
ENSG00000144867	SRPRB	99	97.484	ENSOCUG00000007623	SRPRB	100	93.727	Oryctolagus_cuniculus
ENSG00000144867	SRPRB	99	95.597	ENSOGAG00000005243	SRPRB	100	94.465	Otolemur_garnettii
ENSG00000144867	SRPRB	99	94.969	ENSOARG00000008412	SRPRB	92	93.607	Ovis_aries
ENSG00000144867	SRPRB	100	99.262	ENSPPAG00000023940	SRPRB	100	99.262	Pan_paniscus
ENSG00000144867	SRPRB	99	95.597	ENSPPRG00000023305	SRPRB	100	91.513	Panthera_pardus
ENSG00000144867	SRPRB	99	95.597	ENSPTIG00000007351	SRPRB	100	91.513	Panthera_tigris_altaica
ENSG00000144867	SRPRB	100	99.262	ENSPTRG00000015413	SRPRB	100	99.262	Pan_troglodytes
ENSG00000144867	SRPRB	100	97.826	ENSPANG00000023015	SRPRB	100	97.786	Papio_anubis
ENSG00000144867	SRPRB	99	96.226	ENSPEMG00000017954	Srprb	100	91.144	Peromyscus_maniculatus_bairdii
ENSG00000144867	SRPRB	100	98.893	ENSPPYG00000014115	SRPRB	100	98.893	Pongo_abelii
ENSG00000144867	SRPRB	100	81.919	ENSPCAG00000013823	SRPRB	100	81.919	Procavia_capensis
ENSG00000144867	SRPRB	99	96.855	ENSPVAG00000011319	SRPRB	100	91.882	Pteropus_vampyrus
ENSG00000144867	SRPRB	100	97.786	ENSRBIG00000027819	SRPRB	100	97.786	Rhinopithecus_bieti
ENSG00000144867	SRPRB	100	97.786	ENSRROG00000030536	SRPRB	100	97.786	Rhinopithecus_roxellana
ENSG00000144867	SRPRB	100	89.130	ENSSBOG00000015129	SRPRB	100	94.030	Saimiri_boliviensis_boliviensis
ENSG00000144867	SRPRB	99	93.711	ENSSARG00000012943	SRPRB	100	90.037	Sorex_araneus
ENSG00000144867	SRPRB	99	93.711	ENSSSCG00000011639	SRPRB	100	91.144	Sus_scrofa
ENSG00000144867	SRPRB	99	93.082	ENSTBEG00000006116	SRPRB	99	89.591	Tupaia_belangeri
ENSG00000144867	SRPRB	100	85.870	ENSTTRG00000007802	SRPRB	100	84.502	Tursiops_truncatus
ENSG00000144867	SRPRB	99	96.226	ENSUAMG00000018135	SRPRB	100	91.513	Ursus_americanus
ENSG00000144867	SRPRB	99	95.597	ENSUMAG00000015817	SRPRB	100	91.144	Ursus_maritimus
ENSG00000144867	SRPRB	99	96.855	ENSVVUG00000005707	SRPRB	100	92.989	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005525	GTP binding	-	IEA	Function
GO:0005737	cytoplasm	19664239.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005881	cytoplasmic microtubule	23264731.	IDA	Component
GO:0016020	membrane	22375059.	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process