EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000144895 (Gene tree)
Gene ID
83939
Gene Symbol
EIF2A
Alias
EIF-2A
Full Name
eukaryotic translation initiation factor 2A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
39,339 bases
Position
chr3:150,546,678-150,586,016
Accession
3254
RBP type
canonical RBP
Summary
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000385292eIF2APF08662.118.6e-7711
ENSP00000417229eIF2APF08662.111.5e-7611
ENSP00000420537eIF2APF08662.112.3e-7611
ENSP00000273435eIF2APF08662.116.5e-7611
ENSP00000420611eIF2APF08662.114.9e-7011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27470367The protective effect of the earthworm active ingredients on hepatocellular injury induced by endoplasmic reticulum stress.Biomed Pharmacother2016 AugWang Qdoi: 10.1016/j.biopha.2016.05.001
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000469331EIF2A-207553--- (aa)--
ENST00000462221EIF2A-204817-ENSP0000042049540 (aa)-H7C5Q4
ENST00000487799EIF2A-2141913-ENSP00000420537560 (aa)-Q9BY44
ENST00000473499EIF2A-209634--- (aa)--
ENST00000477551EIF2A-2111906-ENSP00000420493158 (aa)-H7C5Q3
ENST00000472926EIF2A-208557--- (aa)--
ENST00000482471EIF2A-213287--- (aa)--
ENST00000490505EIF2A-215568-ENSP0000041757575 (aa)-F8WAT3
ENST00000494558EIF2A-216710-ENSP0000041945659 (aa)-F8WF18
ENST00000460851EIF2A-2032198XM_011513224ENSP00000417229585 (aa)XP_011511526Q9BY44
ENST00000482093EIF2A-212725-ENSP00000418698236 (aa)-C9IZE1
ENST00000463863EIF2A-205565--- (aa)--
ENST00000273435EIF2A-2012083-ENSP00000273435580 (aa)-F8WAE5
ENST00000474505EIF2A-2101010--- (aa)--
ENST00000465535EIF2A-2061273XM_024453787ENSP00000420611316 (aa)XP_024309555H7C5R5
ENST00000406576EIF2A-2021795-ENSP00000385292524 (aa)-Q9BY44
Gene Model
Click here to download ENSG00000144895's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144895's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000144895EIF2A9961.486ENSAPOG00000008520eif2a9861.831Acanthochromis_polyacanthus
ENSG00000144895EIF2A7459.227ENSAMEG00000008671-9658.755Ailuropoda_melanoleuca
ENSG00000144895EIF2A9994.854ENSAMEG00000010505-9994.854Ailuropoda_melanoleuca
ENSG00000144895EIF2A9765.202ENSACIG00000024095eif2a9265.202Amphilophus_citrinellus
ENSG00000144895EIF2A9965.722ENSAOCG00000006919eif2a9866.028Amphiprion_ocellaris
ENSG00000144895EIF2A9966.006ENSAPEG00000019145eif2a9866.202Amphiprion_percula
ENSG00000144895EIF2A9966.041ENSATEG00000019832eif2a9866.376Anabas_testudineus
ENSG00000144895EIF2A9884.266ENSAPLG00000010076EIF2A9884.266Anas_platyrhynchos
ENSG00000144895EIF2A9780.702ENSACAG00000007685EIF2A9879.094Anolis_carolinensis
ENSG00000144895EIF2A10098.393ENSANAG00000038084EIF2A10098.393Aotus_nancymaae
ENSG00000144895EIF2A9964.456ENSACLG00000009872eif2a9864.870Astatotilapia_calliptera
ENSG00000144895EIF2A9868.522ENSAMXG00000013924eif2a9868.522Astyanax_mexicanus
ENSG00000144895EIF2A10093.846ENSBTAG00000009106EIF2A10093.846Bos_taurus
ENSG00000144895EIF2A9938.889WBGene00008480eif-2A9735.811Caenorhabditis_elegans
ENSG00000144895EIF2A10098.750ENSCJAG00000001199EIF2A10098.750Callithrix_jacchus
ENSG00000144895EIF2A10096.068ENSCAFG00000008407EIF2A10096.068Canis_familiaris
ENSG00000144895EIF2A8896.755ENSCAFG00020004502EIF2A9096.755Canis_lupus_dingo
ENSG00000144895EIF2A10094.872ENSCHIG00000023786EIF2A10094.872Capra_hircus
ENSG00000144895EIF2A9895.803ENSTSYG00000014247EIF2A9895.803Carlito_syrichta
ENSG00000144895EIF2A9889.474ENSCPOG00000006568EIF2A10089.474Cavia_porcellus
ENSG00000144895EIF2A10098.393ENSCCAG00000032810-10098.393Cebus_capucinus
ENSG00000144895EIF2A9888.133ENSCCAG00000026029-9591.734Cebus_capucinus
ENSG00000144895EIF2A10098.282ENSCATG00000030017EIF2A10098.282Cercocebus_atys
ENSG00000144895EIF2A10093.504ENSCLAG00000002863EIF2A10093.504Chinchilla_lanigera
ENSG00000144895EIF2A10098.120ENSCSAG00000011568EIF2A10098.120Chlorocebus_sabaeus
ENSG00000144895EIF2A10085.915ENSCHOG00000005256EIF2A9479.159Choloepus_hoffmanni
ENSG00000144895EIF2A9884.146ENSCPBG00000014430EIF2A9884.146Chrysemys_picta_bellii
ENSG00000144895EIF2A10040.635ENSCING00000002504-9841.468Ciona_intestinalis
ENSG00000144895EIF2A9946.789ENSCSAVG00000003057-9844.340Ciona_savignyi
ENSG00000144895EIF2A10098.473ENSCANG00000037097EIF2A10098.473Colobus_angolensis_palliatus
ENSG00000144895EIF2A10092.491ENSCGRG00001016171Eif2a10092.491Cricetulus_griseus_chok1gshd
ENSG00000144895EIF2A10092.491ENSCGRG00000009072Eif2a10092.491Cricetulus_griseus_crigri
ENSG00000144895EIF2A9764.499ENSCSEG00000006247eif2a9564.231Cynoglossus_semilaevis
ENSG00000144895EIF2A9963.063ENSCVAG00000001346eif2a9966.377Cyprinodon_variegatus
ENSG00000144895EIF2A9868.467ENSDARG00000101061eif2a9869.406Danio_rerio
ENSG00000144895EIF2A10095.043ENSDNOG00000014002EIF2A10095.043Dasypus_novemcinctus
ENSG00000144895EIF2A9987.619ENSDORG00000012408Eif2a9889.780Dipodomys_ordii
ENSG00000144895EIF2A9936.364FBgn0037135CG74149736.758Drosophila_melanogaster
ENSG00000144895EIF2A9792.982ENSETEG00000020032EIF2A9886.496Echinops_telfairi
ENSG00000144895EIF2A9852.269ENSEBUG00000009787eif2a9752.340Eptatretus_burgeri
ENSG00000144895EIF2A10095.043ENSEASG00005021392EIF2A10095.043Equus_asinus_asinus
ENSG00000144895EIF2A10095.214ENSECAG00000024832EIF2A10095.214Equus_caballus
ENSG00000144895EIF2A9893.695ENSEEUG00000011239EIF2A9493.695Erinaceus_europaeus
ENSG00000144895EIF2A10069.270ENSELUG00000006270eif2a9869.391Esox_lucius
ENSG00000144895EIF2A10096.071ENSFCAG00000011331EIF2A10095.802Felis_catus
ENSG00000144895EIF2A9976.298ENSFALG00000005241EIF2A9776.148Ficedula_albicollis
ENSG00000144895EIF2A9994.340ENSFDAG00000019484EIF2A9594.590Fukomys_damarensis
ENSG00000144895EIF2A9964.726ENSFHEG00000008768eif2a9963.130Fundulus_heteroclitus
ENSG00000144895EIF2A9566.245ENSGMOG00000001939eif2a10066.245Gadus_morhua
ENSG00000144895EIF2A9884.495ENSGALG00000010401EIF2A9884.495Gallus_gallus
ENSG00000144895EIF2A10064.334ENSGAFG00000016886eif2a9865.035Gambusia_affinis
ENSG00000144895EIF2A9961.054ENSGACG00000004748eif2a9861.285Gasterosteus_aculeatus
ENSG00000144895EIF2A9883.972ENSGAGG00000020541EIF2A9883.972Gopherus_agassizii
ENSG00000144895EIF2A10099.643ENSGGOG00000015391EIF2A10099.643Gorilla_gorilla
ENSG00000144895EIF2A9964.456ENSHBUG00000017252eif2a9864.870Haplochromis_burtoni
ENSG00000144895EIF2A10094.188ENSHGLG00000019241-10094.188Heterocephalus_glaber_female
ENSG00000144895EIF2A9789.474ENSHGLG00000002495-10081.522Heterocephalus_glaber_female
ENSG00000144895EIF2A10094.188ENSHGLG00100008925-10094.188Heterocephalus_glaber_male
ENSG00000144895EIF2A9789.474ENSHGLG00100005448-10081.522Heterocephalus_glaber_male
ENSG00000144895EIF2A9959.354ENSHCOG00000006342eif2a9859.896Hippocampus_comes
ENSG00000144895EIF2A9869.580ENSIPUG00000013822eif2a9869.755Ictalurus_punctatus
ENSG00000144895EIF2A10093.846ENSSTOG00000003374EIF2A10093.846Ictidomys_tridecemlineatus
ENSG00000144895EIF2A9890.799ENSJJAG00000011257Eif2a9790.957Jaculus_jaculus
ENSG00000144895EIF2A9965.128ENSKMAG00000007156eif2a9865.734Kryptolebias_marmoratus
ENSG00000144895EIF2A9876.182ENSLACG00000009147EIF2A9876.182Latimeria_chalumnae
ENSG00000144895EIF2A9867.944ENSLOCG00000001831eif2a9867.944Lepisosteus_oculatus
ENSG00000144895EIF2A9894.241ENSLAFG00000003767EIF2A9894.241Loxodonta_africana
ENSG00000144895EIF2A10098.571ENSMFAG00000045972EIF2A10098.571Macaca_fascicularis
ENSG00000144895EIF2A10098.571ENSMMUG00000017696EIF2A10098.571Macaca_mulatta
ENSG00000144895EIF2A9998.730ENSMNEG00000034637EIF2A10090.940Macaca_nemestrina
ENSG00000144895EIF2A10098.571ENSMLEG00000032824EIF2A10098.571Mandrillus_leucophaeus
ENSG00000144895EIF2A9765.969ENSMAMG00000018484eif2a9866.028Mastacembelus_armatus
ENSG00000144895EIF2A9964.456ENSMZEG00005001832eif2a9864.870Maylandia_zebra
ENSG00000144895EIF2A9384.037ENSMGAG00000010935EIF2A9784.037Meleagris_gallopavo
ENSG00000144895EIF2A10092.650ENSMAUG00000017191Eif2a10092.650Mesocricetus_auratus
ENSG00000144895EIF2A10096.786ENSMICG00000049004EIF2A10096.786Microcebus_murinus
ENSG00000144895EIF2A9988.567ENSMOCG00000017111Eif2a9587.805Microtus_ochrogaster
ENSG00000144895EIF2A9967.508ENSMMOG00000009546eif2a9762.821Mola_mola
ENSG00000144895EIF2A9889.024ENSMODG00000028858EIF2A10089.078Monodelphis_domestica
ENSG00000144895EIF2A9965.057ENSMALG00000018747eif2a10064.130Monopterus_albus
ENSG00000144895EIF2A10092.650MGP_CAROLIEiJ_G0025009Eif2a10092.032Mus_caroli
ENSG00000144895EIF2A10092.821ENSMUSG00000027810Eif2a10092.032Mus_musculus
ENSG00000144895EIF2A10091.966MGP_PahariEiJ_G0026453Eif2a10091.633Mus_pahari
ENSG00000144895EIF2A10092.821MGP_SPRETEiJ_G0025949Eif2a10092.032Mus_spretus
ENSG00000144895EIF2A10095.385ENSMPUG00000002592EIF2A9895.637Mustela_putorius_furo
ENSG00000144895EIF2A9894.618ENSMLUG00000010497EIF2A9994.618Myotis_lucifugus
ENSG00000144895EIF2A9986.549ENSNGAG00000007717Eif2a9888.142Nannospalax_galili
ENSG00000144895EIF2A9962.323ENSNBRG00000007149eif2a9563.784Neolamprologus_brichardi
ENSG00000144895EIF2A9996.000ENSNLEG00000003219EIF2A10096.000Nomascus_leucogenys
ENSG00000144895EIF2A9494.495ENSMEUG00000000747EIF2A9574.915Notamacropus_eugenii
ENSG00000144895EIF2A10089.744ENSOPRG00000014400EIF2A9689.744Ochotona_princeps
ENSG00000144895EIF2A9894.828ENSODEG00000000457-10094.828Octodon_degus
ENSG00000144895EIF2A10084.810ENSODEG00000001987-9491.144Octodon_degus
ENSG00000144895EIF2A9964.957ENSONIG00000017284eif2a9865.385Oreochromis_niloticus
ENSG00000144895EIF2A9679.769ENSOANG00000005785EIF2A9687.421Ornithorhynchus_anatinus
ENSG00000144895EIF2A8684.982ENSOCUG00000013487-9184.806Oryctolagus_cuniculus
ENSG00000144895EIF2A8383.206ENSOCUG00000007577-9779.935Oryctolagus_cuniculus
ENSG00000144895EIF2A10094.872ENSOCUG00000016095-10094.872Oryctolagus_cuniculus
ENSG00000144895EIF2A9963.953ENSORLG00015012728eif2a9863.112Oryzias_latipes_hsok
ENSG00000144895EIF2A9964.451ENSOMEG00000016817eif2a9863.937Oryzias_melastigma
ENSG00000144895EIF2A10095.385ENSOGAG00000010148EIF2A10095.385Otolemur_garnettii
ENSG00000144895EIF2A10095.043ENSOARG00000004511EIF2A10095.043Ovis_aries
ENSG00000144895EIF2A10099.464ENSPPAG00000043784EIF2A10099.464Pan_paniscus
ENSG00000144895EIF2A10095.893ENSPPRG00000020244EIF2A10095.893Panthera_pardus
ENSG00000144895EIF2A10096.071ENSPTIG00000017401EIF2A10096.071Panthera_tigris_altaica
ENSG00000144895EIF2A10099.643ENSPTRG00000015528EIF2A10099.643Pan_troglodytes
ENSG00000144895EIF2A10098.750ENSPANG00000017829EIF2A10098.750Papio_anubis
ENSG00000144895EIF2A10067.747ENSPKIG00000014595eif2a9567.832Paramormyrops_kingsleyae
ENSG00000144895EIF2A9883.972ENSPSIG00000005644EIF2A9883.972Pelodiscus_sinensis
ENSG00000144895EIF2A9265.769ENSPMGG00000020947eif2a9466.603Periophthalmus_magnuspinnatus
ENSG00000144895EIF2A10093.333ENSPEMG00000015613Eif2a10093.333Peromyscus_maniculatus_bairdii
ENSG00000144895EIF2A9889.199ENSPCIG00000022274EIF2A10089.249Phascolarctos_cinereus
ENSG00000144895EIF2A9964.041ENSPFOG00000008701eif2a9864.510Poecilia_formosa
ENSG00000144895EIF2A9964.555ENSPLAG00000017279eif2a9865.035Poecilia_latipinna
ENSG00000144895EIF2A9964.041ENSPMEG00000005215eif2a9864.510Poecilia_mexicana
ENSG00000144895EIF2A9962.342ENSPREG00000021793eif2a8559.083Poecilia_reticulata
ENSG00000144895EIF2A9987.989ENSPPYG00000029636-10099.722Pongo_abelii
ENSG00000144895EIF2A10083.051ENSPCAG00000010767EIF2A9485.166Procavia_capensis
ENSG00000144895EIF2A10096.429ENSPCOG00000024978EIF2A10096.429Propithecus_coquereli
ENSG00000144895EIF2A10093.220ENSPVAG00000011535EIF2A9593.645Pteropus_vampyrus
ENSG00000144895EIF2A9964.456ENSPNYG00000023276eif2a9864.870Pundamilia_nyererei
ENSG00000144895EIF2A9870.209ENSPNAG00000022086eif2a9870.209Pygocentrus_nattereri
ENSG00000144895EIF2A10092.308ENSRNOG00000013393Eif2a9792.321Rattus_norvegicus
ENSG00000144895EIF2A10098.571ENSRBIG00000038363EIF2A10098.571Rhinopithecus_bieti
ENSG00000144895EIF2A10098.929ENSRROG00000039293EIF2A10098.929Rhinopithecus_roxellana
ENSG00000144895EIF2A7932.770YGR054W-7132.135Saccharomyces_cerevisiae
ENSG00000144895EIF2A9598.201ENSSBOG00000022479EIF2A10098.201Saimiri_boliviensis_boliviensis
ENSG00000144895EIF2A9980.508ENSSHAG00000018554EIF2A9783.669Sarcophilus_harrisii
ENSG00000144895EIF2A9868.935ENSSFOG00015017634eif2a9868.935Scleropages_formosus
ENSG00000144895EIF2A9967.329ENSSMAG00000005233eif2a9667.837Scophthalmus_maximus
ENSG00000144895EIF2A9967.009ENSSDUG00000005404eif2a9867.308Seriola_dumerili
ENSG00000144895EIF2A9966.838ENSSLDG00000006171eif2a9867.133Seriola_lalandi_dorsalis
ENSG00000144895EIF2A10088.136ENSSARG00000013191EIF2A9591.106Sorex_araneus
ENSG00000144895EIF2A9782.953ENSSPUG00000010458EIF2A10082.953Sphenodon_punctatus
ENSG00000144895EIF2A10055.085ENSSPAG00000005081eif2a9967.102Stegastes_partitus
ENSG00000144895EIF2A10094.530ENSSSCG00000011710EIF2A10094.530Sus_scrofa
ENSG00000144895EIF2A9981.002ENSTGUG00000011386EIF2A9780.952Taeniopygia_guttata
ENSG00000144895EIF2A8769.203ENSTRUG00000002918eif2a9263.976Takifugu_rubripes
ENSG00000144895EIF2A9962.393ENSTNIG00000011202eif2a9462.957Tetraodon_nigroviridis
ENSG00000144895EIF2A9794.737ENSTBEG00000017179EIF2A9689.915Tupaia_belangeri
ENSG00000144895EIF2A10093.220ENSTTRG00000007521EIF2A9690.427Tursiops_truncatus
ENSG00000144895EIF2A9994.701ENSUAMG00000027103EIF2A9896.115Ursus_americanus
ENSG00000144895EIF2A9895.462ENSUMAG00000012261EIF2A10095.423Ursus_maritimus
ENSG00000144895EIF2A9894.957ENSVPAG00000006109EIF2A10094.957Vicugna_pacos
ENSG00000144895EIF2A10096.068ENSVVUG00000011028EIF2A10096.068Vulpes_vulpes
ENSG00000144895EIF2A10075.468ENSXETG00000020093eif2a9875.742Xenopus_tropicalis
ENSG00000144895EIF2A9664.758ENSXCOG00000012657eif2a9965.022Xiphophorus_couchianus
ENSG00000144895EIF2A9965.068ENSXMAG00000014008eif2a9865.559Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000049tRNA binding21873635.IBAFunction
GO:0000049tRNA binding12133843.IMPFunction
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0003743translation initiation factor activity12133843.IMPFunction
GO:0005515protein binding18816594.IPIFunction
GO:0005615extracellular space22664934.HDAComponent
GO:0005737cytoplasm12133843.IDAComponent
GO:0005850eukaryotic translation initiation factor 2 complex12133843.IDAComponent
GO:0006413translational initiation-IEAProcess
GO:0006417regulation of translation12133843.IMPProcess
GO:0006468protein phosphorylation-IEAProcess
GO:0009967positive regulation of signal transduction-IEAProcess
GO:0022627cytosolic small ribosomal subunit21873635.IBAComponent
GO:0032933SREBP signaling pathway-IEAProcess
GO:0042255ribosome assembly12133843.IMPProcess
GO:0043022ribosome binding21873635.IBAFunction
GO:0043022ribosome binding12133843.IMPFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0072562blood microparticle22516433.HDAComponent
GO:1990928response to amino acid starvation-IEAProcess

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