EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000145012 (Gene tree)
Gene ID: 4026
Gene Symbol: LPP
Alias: N
Full Name: LIM domain containing preferred translocation partner in lipoma
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 738,529 bases
Position: chr3:188,152,143-188,890,671
Accession: 6679
RBP type: non-canonical RBP
Summary: This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494044	LPP-218	300	-	-	- (aa)	-	-
ENST00000459897	LPP-211	548	-	-	- (aa)	-	-
ENST00000484468	LPP-216	578	-	-	- (aa)	-	-
ENST00000454789	LPP-209	343	-	ENSP00000394257	65 (aa)	-	C9JT42
ENST00000430340	LPP-206	521	-	ENSP00000397166	52 (aa)	-	C9J2R5
ENST00000471917	LPP-213	998	-	-	- (aa)	-	-
ENST00000494233	LPP-219	412	-	-	- (aa)	-	-
ENST00000415906	LPP-202	888	-	ENSP00000393008	252 (aa)	-	C9JXK9
ENST00000414139	LPP-201	502	-	ENSP00000392667	93 (aa)	-	C9J1K7
ENST00000618621	LPP-221	18277	XM_011512836	ENSP00000482617	590 (aa)	XP_011511138	A0A087WZF1
ENST00000483938	LPP-215	368	-	-	- (aa)	-	-
ENST00000462758	LPP-212	564	-	-	- (aa)	-	-
ENST00000474472	LPP-214	499	-	-	- (aa)	-	-
ENST00000443217	LPP-207	400	-	ENSP00000404679	46 (aa)	-	C9JE51
ENST00000416784	LPP-203	612	-	ENSP00000410340	151 (aa)	-	C9J4E3
ENST00000487347	LPP-217	582	-	-	- (aa)	-	-
ENST00000426274	LPP-205	386	-	ENSP00000397017	66 (aa)	-	C9J3U9
ENST00000640853	LPP-222	18277	-	ENSP00000491657	612 (aa)	-	Q93052
ENST00000457242	LPP-210	479	-	ENSP00000403825	57 (aa)	-	C9JIY7
ENST00000448637	LPP-208	5835	XM_017006381	ENSP00000393602	428 (aa)	XP_016861870	C9JUT4
ENST00000617246	LPP-220	18220	XM_005247446	ENSP00000478901	612 (aa)	XP_005247503	Q93052
ENST00000420410	LPP-204	535	-	ENSP00000405138	111 (aa)	-	C9J5C8

Gene Model

Click here to download ENSG00000145012's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000145012	Cholesterol, LDL	8.78169922178262E-5	17903299
ENSG00000145012	Alcohol Drinking	1.27000672611015E-11	-
ENSG00000145012	Alcoholism	8.06444e-005	22978509
ENSG00000145012	Obesity	8.8440000E-005	-
ENSG00000145012	Antihypertensive Agents	6.9980000E-005	-
ENSG00000145012	Fibrinogen	7.9320000E-005	-
ENSG00000145012	Fibrinogen	1.6010000E-005	-
ENSG00000145012	Fibrinogen	1.1340000E-005	-
ENSG00000145012	Triglycerides	2.5250000E-005	-
ENSG00000145012	Erythrocyte Count	9.3580000E-005	-
ENSG00000145012	Urine	8.4328980E-005	-
ENSG00000145012	Platelet Function Tests	4.5400000E-006	-
ENSG00000145012	Platelet Function Tests	4.5400000E-006	-
ENSG00000145012	Platelet Function Tests	4.5811569E-006	-
ENSG00000145012	Platelet Function Tests	1.4682889E-006	-
ENSG00000145012	Child Development Disorders, Pervasive	3.6837600E-006	-
ENSG00000145012	Child Development Disorders, Pervasive	4.3484400E-005	-
ENSG00000145012	Child Development Disorders, Pervasive	6.0354600E-006	-
ENSG00000145012	Child Development Disorders, Pervasive	1.9562000E-005	-
ENSG00000145012	Child Development Disorders, Pervasive	3.3958000E-005	-
ENSG00000145012	Vitamin A	4.1000000E-005	-
ENSG00000145012	Cytokines	8E-8	22610502
ENSG00000145012	Vaccine Potency	8E-8	22610502
ENSG00000145012	Body Weight	6E-6	19851299
ENSG00000145012	Vitiligo	1E-11	20410501
ENSG00000145012	Cisplatin	4E-6	21844884
ENSG00000145012	White Matter	6E-6	23218918
ENSG00000145012	Carcinoma, Basal Cell	1E-14	27539887
ENSG00000145012	Asthma	7E-9	27182965
ENSG00000145012	Chemokine CCL11	9E-6	23251661
ENSG00000145012	Hypersensitivity	3E-10	23817571
ENSG00000145012	Lupus Erythematosus, Systemic	4E-15	27399966
ENSG00000145012	Schizophrenia	9E-6	26198764
ENSG00000145012	Immunoglobulin E	2E-6	22075330
ENSG00000145012	Skin Neoplasms	1E-7	27424798
ENSG00000145012	Celiac Disease	5E-9	18311140
ENSG00000145012	Body Mass Index	3E-6	19851299
ENSG00000145012	Vitiligo	9E-8	22951725
ENSG00000145012	Inflammatory Bowel Diseases	9E-10	28067908
ENSG00000145012	Lupus Erythematosus, Systemic	6E-7	27399966
ENSG00000145012	Lupus Erythematosus, Systemic	8E-10	27399966
ENSG00000145012	Hodgkin Disease	2E-7	28112199
ENSG00000145012	Multiple Myeloma	2E-7	28112199
ENSG00000145012	Leukemia, Lymphocytic, Chronic, B-Cell	2E-7	28112199
ENSG00000145012	Lymphoma, Follicular	1E-10	25279986
ENSG00000145012	Crohn Disease	6E-10	28067908
ENSG00000145012	Hypersensitivity	3E-8	27182965
ENSG00000145012	Leukemia, Lymphocytic, Chronic, B-Cell	5E-6	28165464
ENSG00000145012	Hypersensitivity	1E-9	23817569
ENSG00000145012	Glucose	3E-6	25524916
ENSG00000145012	Insulin Resistance	3E-6	25524916
ENSG00000145012	Schizophrenia	5E-6	26198764
ENSG00000145012	Mortality	2E-7	27639821
ENSG00000145012	Sepsis	2E-7	27639821
ENSG00000145012	Celiac Disease	3E-40	20190752
ENSG00000145012	Crohn Disease	6E-10	28067908
ENSG00000145012	Leukemia, Lymphocytic, Chronic, B-Cell	4E-8	26956414

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000145012	rs4420855	3	188339419	A	Intraocular pressure	29617998	[0.079-0.139] unit increase	0.1094	EFO_0004695
ENSG00000145012	rs4459895	3	188236626	A	Hodgkin's lymphoma	29196614	[1.23-1.38]	1.3	EFO_0000183
ENSG00000145012	rs4459895	3	188236626	A	Nodular sclerosis Hodgkin lymphoma	29196614	[1.28-1.50]	1.39	EFO_0004708
ENSG00000145012	rs9815073	3	188397894	A	Blood protein levels	29875488	[0.15-0.27] unit increase	0.21	EFO_0007937
ENSG00000145012	rs6444305	3	188582114	G	Follicular lymphoma	25279986	[1.14-1.28]	1.21	EFO_0000096
ENSG00000145012	rs150062338	3	188287160	T	Mortality in sepsis	27639821		38.6	HP_0100806\|EFO_0004352
ENSG00000145012	rs6762714	3	188752450	T	Systemic lupus erythematosus	27399966	[1.09-1.19]	1.14	EFO_0002690
ENSG00000145012	rs6762714	3	188752450	T	Systemic lupus erythematosus	27399966	[1.12-1.29]	1.2	EFO_0002690
ENSG00000145012	rs6762714	3	188752450	T	Systemic lupus erythematosus	27399966	[1.12-1.20]	1.16	EFO_0002690
ENSG00000145012	rs9815073	3	188397894	C	Chronic lymphocytic leukemia	26956414	[1.11-1.25]	1.18	EFO_0000095
ENSG00000145012	rs191177147	3	188374758	T	Basal cell carcinoma	27539887	[NR]	1.11	EFO_0004193
ENSG00000145012	rs11920292	3	188528469	?	Glucose homeostasis traits	25524916	[16.52-40.36] unit increase	28.44	EFO_0004471\|EFO_0006896
ENSG00000145012	rs11715549	3	188370330	G	Cutaneous squamous cell carcinoma	27424798		1.1	EFO_1001927
ENSG00000145012	rs16863064	3	188169789	G	Schizophrenia	26198764	[NR]	1.0638298	EFO_0000692
ENSG00000145012	rs7610761	3	188467141	A	Schizophrenia	26198764	[NR]	1.05	EFO_0000692
ENSG00000145012	rs1975991	3	188227136	?	White matter integrity (bipolar disorder risk interaction)	23218918			EFO_0004641
ENSG00000145012	rs9865818	3	188354725	G	Allergic sensitization	23817571	[1.09-1.16]	1.12	EFO_0005298
ENSG00000145012	rs9860547	3	188411191	A	Self-reported allergy	23817569	[0.050-0.098] unit increase	0.0741	EFO_0003785
ENSG00000145012	rs9851967	3	188369840	?	Vitiligo	22951725	[1.09-1.19]	1.14	EFO_0004208
ENSG00000145012	rs1152846	3	188703109	G	Weight	19851299	[NR] kg decrease	1.7	EFO_0004338
ENSG00000145012	rs1152846	3	188703109	G	Body mass index	19851299	[NR] kg decrease	0.09	EFO_0004340
ENSG00000145012	rs1464510	3	188394766	A	Celiac disease	20190752	[1.25-1.34]	1.29	EFO_0001060
ENSG00000145012	rs1464510	3	188394766	T	Vitiligo	20410501	[1.21-1.41]	1.31	EFO_0004208
ENSG00000145012	rs1254774	3	188701738	?	Response to platinum-based chemotherapy (cisplatin)	21844884			GO_0072718
ENSG00000145012	rs10937355	3	188571909	A	Obesity-related traits	23251661	[NR] pg/mL increase	0.03	EFO_0005188
ENSG00000145012	rs13076750	3	188341655	?	Intraocular pressure	29235454	[NR] unit increase	0.1	EFO_0004695
ENSG00000145012	rs66756607	3	188365131	G	Multiple sclerosis	24076602	[1.04-1.09]	1.06	EFO_0003885
ENSG00000145012	rs13076312	3	188371466	T	Vitiligo	27723757	[1.26-1.38]	1.319	EFO_0004208
ENSG00000145012	rs2030519	3	188402113	A	Celiac disease	22057235		1.3157895	EFO_0001060
ENSG00000145012	rs13079741	3	188384073	G	Itch intensity from mosquito bite	28199695	[0.014-0.028] unit decrease	0.0210922	EFO_0008377
ENSG00000145012	rs9815073	3	188397894	C	Mosquito bite size	28199695	[0.021-0.045] unit decrease	0.033384	EFO_0008378
ENSG00000145012	rs1464510	3	188394766	A	Diastolic blood pressure	27618447	mmHg increase	0.141	EFO_0006336
ENSG00000145012	rs6771736	3	188348649	G	Glaucoma (primary open-angle)	29891935	[1.05-1.12]	1.0869565	EFO_0004190
ENSG00000145012	rs12485444	3	188417995	A	Granulocyte percentage of myeloid white cells	27863252	[0.015-0.03] unit increase	0.02221896	EFO_0007997
ENSG00000145012	rs4122385	3	188422865	A	Verbal memory performance (immediate recall level)	28800603	NR unit decrease		EFO_0004874
ENSG00000145012	rs9864529	3	188387268	A	Alopecia areata	25608926		1.18093	EFO_0004192
ENSG00000145012	rs56116661	3	188683372	?	Crohn's disease	28067908			EFO_0000384
ENSG00000145012	rs56116661	3	188683372	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000145012	rs73192661	3	188411006	C	Chronic lymphocytic leukemia	28165464	[1.08-1.2]	1.14	EFO_0000095
ENSG00000145012	rs12485444	3	188417995	A	Monocyte percentage of white cells	27863252	[0.021-0.035] unit decrease	0.028056	EFO_0007989
ENSG00000145012	rs542618547	3	188728876	G	Neutrophil percentage of granulocytes	27863252	[0.019-0.034] unit decrease	0.02678185	EFO_0007994
ENSG00000145012	rs2030519	3	188402113	G	Allergic rhinitis	30013184	[1.04-1.07]	1.06	EFO_0005854
ENSG00000145012	rs9865818	3	188354725	G	Allergic sensitization	30013184	[1.09-1.19]	1.14	EFO_0005298
ENSG00000145012	rs9290877	3	188724692	C	IgE levels	22075330	[NR] unit decrease	0.04	EFO_0004579
ENSG00000145012	rs13067593	3	188866891	G	Immune reponse to smallpox (secreted IFN-alpha)	22610502			EFO_0004645\|EFO_0004873
ENSG00000145012	rs1464510	3	188394766	A	Celiac disease	18311140	[1.15-1.32]	1.23	EFO_0001060
ENSG00000145012	rs73196739	3	188684683	?	Asthma	27182965	[1.05-1.11]	1.0845987	EFO_0000270
ENSG00000145012	rs2030519	3	188402113	?	Allergy	27182965	[1.028-1.059]	1.043	EFO_0003785
ENSG00000145012	rs542618547	3	188728876	G	Eosinophil percentage of granulocytes	27863252	[0.021-0.037] unit increase	0.02906495	EFO_0007996
ENSG00000145012	rs542618547	3	188728876	G	Sum eosinophil basophil counts	27863252	[0.021-0.036] unit increase	0.02816335	EFO_0005090\|EFO_0004842
ENSG00000145012	rs542618547	3	188728876	G	Eosinophil percentage of white cells	27863252	[0.023-0.038] unit increase	0.03009134	EFO_0007991
ENSG00000145012	rs542618547	3	188728876	G	Eosinophil counts	27863252	[0.022-0.038] unit increase	0.02996942	EFO_0004842
ENSG00000145012	rs4132172	3	188343926	C	Intraocular pressure	29785010	[0.064-0.122] unit increase	0.093	EFO_0004695
ENSG00000145012	rs80236973	3	188283226	?	Body mass index	30595370			EFO_0004340
ENSG00000145012	rs2030519	3	188402113	?	Autoimmune traits	30595370			EFO_0005140
ENSG00000145012	rs12634152	3	188403231	?	Hypothyroidism	30595370			EFO_0004705
ENSG00000145012	rs13099273	3	188415730	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000145012	rs17670280	3	188682451	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000145012	rs2030520	3	188401794	?	Red blood cell count	30595370			EFO_0004305
ENSG00000145012	rs60946162	3	188415548	?	Eczema	30595370			HP_0000964
ENSG00000145012	rs73196739	3	188684683	?	Eczema	30595370			HP_0000964
ENSG00000145012	rs9815874	3	188723373	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145012's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	15649318.22665060.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0007155	cell adhesion	-	IEA	Process
GO:0008150	biological_process	-	ND	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26028032	LPP inhibits collective cell migration during lung cancer dissemination.	Oncogene	2016 Feb 25	Kuriyama S	doi: 10.1038/onc.2015.155
23447672	A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.	J Cell Sci	2013 May 1	Ngan E	doi: 10.1242/jcs.118315
28436416	LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis.	Nat Commun	2017 Apr 24	Ngan E	doi: 10.1038/ncomms15059.
30621612	Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control study.	BMC Cancer	2019 Jan 8	Yan S	doi: 10.1186/s12885-018-5241-5.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	188609587	Missense_Mutation	NA	G286R	0.1
BLCA	chr3	188760246	Silent	novel	A458A	0.38
BLCA	chr3	188866206	Missense_Mutation	novel	L473V	0.65
BLCA	chr3	188609320	Missense_Mutation	rs372539871	G197R	0.38
BLCA	chr3	188874514	3'UTR	novel		0.13
BLCA	chr3	188609318	Missense_Mutation	NA	I196T	0.16
BLCA	chr3	188524695	Missense_Mutation	novel	R113G	0.34
BLCA	chr3	188760255	Missense_Mutation	rs760883702	K461N	0.24
BLCA	chr3	188874471	Missense_Mutation	novel	D611N	0.06
BLCA	chr3	188609381	Missense_Mutation	rs751571549	S217L	0.11
BLCA	chr3	188524694	Silent	novel	E112E	0.32
BRCA	chr3	188874474	Missense_Mutation	NA	L612V	0.32
BRCA	chr3	188760263	Missense_Mutation	NA	Y464C	0.29
BRCA	chr3	188609217	Silent	novel	K162K	0.14
BRCA	chr3	188866365	Missense_Mutation	novel	E526K	0.1
BRCA	chr3	188866246	Missense_Mutation	rs756003756	R486Q	0.22
BRCA	chr3	188760268	Missense_Mutation	rs749505857	E466K	0.07
BRCA	chr3	188484652	Missense_Mutation	NA	S85C	0.13
BRCA	chr3	188866235	Silent	NA	P482P	0.13
BRCA	chr3	188874605	3'UTR	novel		0.27
BRCA	chr3	188609653	Missense_Mutation	NA	G308R	0.12
CESC	chr3	188877079	3'UTR	novel		0.2
CESC	chr3	188874730	3'UTR	novel		0.26
CESC	chr3	188484687	Missense_Mutation	novel	E97K	0.53
CESC	chr3	188876065	3'UTR	novel		0.13
CESC	chr3	188406314	Splice_Site	novel	X65_splice	0.25
CESC	chr3	188878815	3'UTR	novel		0.33
CESC	chr3	188609787	Silent	NA	K352K	0.2
CESC	chr3	188878598	3'UTR	novel		0.28
CESC	chr3	188874391	Missense_Mutation	NA	C584Y	0.2
CHOL	chr3	188872654	Missense_Mutation	NA	P534L	0.44
COAD	chr3	188872654	Missense_Mutation	NA	P534L	0.21
COAD	chr3	188609385	Silent	rs754782287	R218R	0.37
COAD	chr3	188609815	Frame_Shift_Ins	NA	*C364Lfs29**	0.29
COAD	chr3	188708523	Intron	novel		0.13
COAD	chr3	188524712	Silent	rs146490639	D118D	0.29
COAD	chr3	188609825	Missense_Mutation	rs770028872	A365V	0.32
COAD	chr3	188874356	Silent	rs754547383	C572C	0.12
COAD	chr3	188760178	Missense_Mutation	NA	V436F	0.16
COAD	chr3	188866239	Missense_Mutation	novel	M484V	0.35
COAD	chr3	188760114	Splice_Region	novel	G414G	0.1
COAD	chr3	188874489	3'UTR	novel		0.4
ESCA	chr3	188875849	3'UTR	novel		0.37
ESCA	chr3	188524666	Missense_Mutation	novel	G103V	0.07
ESCA	chr3	188876234	3'UTR	novel		0.32
GBM	chr3	188688812	Intron	novel		0.16
GBM	chr3	188609341	Nonsense_Mutation	NA	Q204*	0.35
GBM	chr3	188872760	Silent	rs776169572	C569C	0.49
GBM	chr3	188874350	Splice_Site	novel	X571_splice	0.19
GBM	chr3	188866279	Missense_Mutation	novel	P497L	0.06
GBM	chr3	188609777	Missense_Mutation	novel	T349S	0.05
HNSC	chr3	188872674	Nonsense_Mutation	novel	E541*	0.06
HNSC	chr3	188866324	Missense_Mutation	novel	I512S	0.12
HNSC	chr3	188609410	Missense_Mutation	novel	S227A	0.11
HNSC	chr3	188524728	Silent	novel	L124L	0.3
HNSC	chr3	188872763	Splice_Region	novel	E570E	0.28
HNSC	chr3	188406204	Silent	novel	S28S	0.1
HNSC	chr3	188760207	In_Frame_Del	novel	I446_N448del	0.3
HNSC	chr3	188708506	Intron	novel		0.12
KIRC	chr3	188872699	Missense_Mutation	rs777898649	Q549R	0.23
KIRP	chr3	188609193	Silent	novel	V154V	0.54
LGG	chr3	188609414	Missense_Mutation	novel	A228D	0.47
LGG	chr3	188874463	Missense_Mutation	NA	A608V	0.4
LIHC	chr3	188524699	Missense_Mutation	novel	R114P	0.23
LIHC	chr3	188609443	Missense_Mutation	novel	P238S	0.07
LUAD	chr3	188609258	Missense_Mutation	NA	K176R	0.47
LUAD	chr3	188609450	Nonsense_Mutation	NA	S240*	0.05
LUAD	chr3	188866199	Splice_Site	NA	X471_splice	0.09
LUAD	chr3	188708280	Missense_Mutation	novel	G376V	0.14
LUAD	chr3	188406232	Frame_Shift_Del	novel	*Q39Afs14**	0.2
LUAD	chr3	188708420	Intron	novel		0.32
LUAD	chr3	188406178	Missense_Mutation	rs771264620	P20S	0.18
LUAD	chr3	188484657	Missense_Mutation	NA	N87Y	0.15
LUAD	chr3	188760175	Missense_Mutation	novel	Q435E	0.07
LUAD	chr3	188688832	Intron	rs756836674		0.44
LUAD	chr3	188609553	In_Frame_Del	novel	Y275del	0.04
LUAD	chr3	188609178	Silent	novel	T149T	0.38
LUAD	chr3	188872722	Missense_Mutation	novel	A557S	0.4
LUAD	chr3	188866341	Missense_Mutation	novel	A518S	0.28
LUAD	chr3	188609612	Missense_Mutation	rs756633064	G294E	0.14
LUSC	chr3	188406164	Missense_Mutation	rs757883563	P15L	0.14
LUSC	chr3	188406165	Silent	novel	P15P	0.14
LUSC	chr3	188609417	Missense_Mutation	novel	Q229L	0.1
LUSC	chr3	188874519	3'UTR	novel		0.24
LUSC	chr3	188609462	Missense_Mutation	novel	Y244F	0.59
LUSC	chr3	188484633	Missense_Mutation	novel	S79C	0.24
LUSC	chr3	188874552	3'UTR	novel		0.08
LUSC	chr3	188406134	Missense_Mutation	novel	S5C	0.05
LUSC	chr3	188484700	Frame_Shift_Del	novel	*V101Dfs24**	0.14
LUSC	chr3	188866298	Silent	rs373435708	V503V	0.14
LUSC	chr3	188484631	Missense_Mutation	NA	S78F	0.3
LUSC	chr3	188524713	Missense_Mutation	novel	A119P	0.25
LUSC	chr3	188866330	Missense_Mutation	rs756943851	F514C	0.21
LUSC	chr3	188524754	Missense_Mutation	NA	E132D	0.04
LUSC	chr3	188866261	Missense_Mutation	novel	T491N	0.19
LUSC	chr3	188524778	Silent	novel	R140R	0.21
LUSC	chr3	188609411	Missense_Mutation	rs775933619	S227L	0.09
LUSC	chr3	188609287	Missense_Mutation	novel	P186T	0.35
OV	chr3	188876796	3'UTR	novel		0.13
OV	chr3	188874441	Missense_Mutation	NA	I601L	0.15
OV	chr3	188874518	3'UTR	novel		0.17
OV	chr3	188609599	Missense_Mutation	novel	A290S	0.05
OV	chr3	188872728	Missense_Mutation	NA	D559H	0.18
PAAD	chr3	188874447	Missense_Mutation	NA	V603L	0.04
PAAD	chr3	188609460	Missense_Mutation	novel	I243M	0.21
PAAD	chr3	188866262	Silent	rs138205223	T491T	0.13
PAAD	chr3	188872760	Silent	rs776169572	C569C	0.23
PRAD	chr3	188609367	Silent	NA	T212T	0.34
PRAD	chr3	188524768	Missense_Mutation	rs756147443	Y137C	0.22
READ	chr3	188866258	Missense_Mutation	novel	A490V	0.35
SARC	chr3	188874661	3'UTR	novel		1
SARC	chr3	188878073	3'UTR	novel		0.18
SARC	chr3	188878341	3'UTR	novel		0.12
SKCM	chr3	188609782	Missense_Mutation	novel	P351S	0.17
SKCM	chr3	188524775	Silent	NA	P139P	0.24
SKCM	chr3	188866234	Missense_Mutation	novel	P482L	0.48
SKCM	chr3	188708475	Intron	novel		0.21
SKCM	chr3	188872712	Silent	novel	V553V	0.25
SKCM	chr3	188484609	Missense_Mutation	rs747032677	P71S	0.25
SKCM	chr3	188874437	Silent	NA	A599A	0.31
SKCM	chr3	188609570	Missense_Mutation	NA	G280E	0.08
SKCM	chr3	188872713	Missense_Mutation	rs779323597	R554C	0.36
SKCM	chr3	188688850	Intron	rs375704067		0.41
SKCM	chr3	188609414	Missense_Mutation	NA	A228V	0.48
SKCM	chr3	188609713	Missense_Mutation	rs201370939	R328W	0.21
SKCM	chr3	188708444	Intron	novel		0.19
SKCM	chr3	188866261	Missense_Mutation	novel	T491I	0.39
SKCM	chr3	188866262	Silent	rs138205223	T491T	0.39
SKCM	chr3	188609698	Missense_Mutation	NA	P323S	0.48
SKCM	chr3	188524762	Missense_Mutation	rs767696813	S135Y	0.13
SKCM	chr3	188609675	Missense_Mutation	novel	P315L	0.23
STAD	chr3	188872694	Silent	novel	P547P	0.35
STAD	chr3	188406169	Missense_Mutation	rs139718801	G17S	0.31
STAD	chr3	188406185	Missense_Mutation	rs767518342	R22Q	0.33
STAD	chr3	188609713	Missense_Mutation	rs201370939	R328W	0.28
STAD	chr3	188609738	Missense_Mutation	rs754338664	G336A	0.29
STAD	chr3	188874520	3'UTR	novel		0.05
STAD	chr3	188874521	3'UTR	novel		0.05
STAD	chr3	188609652	Frame_Shift_Ins	novel	*R310Qfs3**	0.21
STAD	chr3	188760196	Missense_Mutation	NA	F442L	0.3
STAD	chr3	188609273	Missense_Mutation	NA	K181R	0.13
STAD	chr3	188524711	Missense_Mutation	novel	D118V	0.36
STAD	chr3	188609540	Missense_Mutation	rs368980722	G270A	0.06
STAD	chr3	188874566	3'UTR	novel		0.12
STAD	chr3	188524735	Missense_Mutation	NA	S126N	0.29
STAD	chr3	188406161	Missense_Mutation	novel	E14V	0.06
THCA	chr3	188708327	Missense_Mutation	NA	E392Q	0.1
THCA	chr3	188866219	Missense_Mutation	NA	N477S	0.42
UCEC	chr3	188708384	Missense_Mutation	rs147109696	E411K	0.18
UCEC	chr3	188484594	Missense_Mutation	NA	D66N	0.3
UCEC	chr3	188406240	Missense_Mutation	novel	Q40H	0.34
UCEC	chr3	188524735	Missense_Mutation	novel	S126I	0.13
UCEC	chr3	188609195	Missense_Mutation	rs150267429	S155L	0.25
UCEC	chr3	188708525	Intron	novel		0.23
UCEC	chr3	188872654	Missense_Mutation	NA	P534L	0.29
UCEC	chr3	188874667	3'UTR	novel		0.51
UCEC	chr3	188872648	Missense_Mutation	novel	F532C	0.04
UCEC	chr3	188872714	Missense_Mutation	NA	R554H	0.42
UCEC	chr3	188609314	Missense_Mutation	novel	P195T	0.36
UCEC	chr3	188872760	Silent	rs776169572	C569C	0.45
UCEC	chr3	188878480	3'UTR	novel		0.18
UCEC	chr3	188888492	3'UTR	novel		0.33
UCEC	chr3	188866295	Silent	rs780360674	C502C	0.26
UCEC	chr3	188874597	3'UTR	novel		0.12
UCEC	chr3	188878613	3'UTR	rs143832107		0.35
UCEC	chr3	188708272	Silent	novel	G373G	0.29
UCEC	chr3	188708431	Intron	novel		0.2
UCEC	chr3	188609349	Silent	novel	V206V	0.19
UCEC	chr3	188708379	Missense_Mutation	novel	A409V	0.24
UCEC	chr3	188524673	Silent	rs532070553	P105P	0.6
UCEC	chr3	188609367	Silent	rs749902032	T212T	0.5
UCEC	chr3	188708384	Missense_Mutation	rs147109696	E411K	0.29
UCEC	chr3	188872713	Missense_Mutation	rs779323597	R554C	0.12
UCEC	chr3	188708295	Missense_Mutation	rs139075681	S381L	0.6
UCEC	chr3	188484625	Missense_Mutation	novel	D76G	0.27
UCEC	chr3	188874865	3'UTR	novel		0.48
UCEC	chr3	188406152	Missense_Mutation	novel	S11I	0.45
UCEC	chr3	188484682	Missense_Mutation	novel	D95G	0.25
UCEC	chr3	188878021	3'UTR	novel		0.6
UCEC	chr3	188874597	3'UTR	novel		0.05
UCEC	chr3	188708429	Intron	rs201478647		0.41
UCEC	chr3	188874686	3'UTR	novel		0.38
UCEC	chr3	188876820	3'UTR	novel		0.68
UCEC	chr3	188874933	3'UTR	novel		0.44
UCEC	chr3	188876270	3'UTR	novel		0.44
UCEC	chr3	188609430	Missense_Mutation	novel	H233Q	0.23
UCEC	chr3	188708525	Intron	novel		0.31
UCEC	chr3	188875630	3'UTR	novel		0.27
UCEC	chr3	188874626	3'UTR	novel		0.3
UCEC	chr3	188609826	Silent	rs139912286	A365A	0.37
UCEC	chr3	188878196	3'UTR	novel		0.23
UCEC	chr3	188878586	3'UTR	novel		0.12
UCEC	chr3	188875828	3'UTR	rs192191219		0.37
UCEC	chr3	188609762	Missense_Mutation	NA	G344E	0.06
UCEC	chr3	188876333	3'UTR	novel		0.39
UCEC	chr3	188609580	Silent	rs201879607	P283P	0.32
UCEC	chr3	188874565	3'UTR	rs555709117		0.61
UCEC	chr3	188876383	3'UTR	novel		0.17
UCEC	chr3	188876897	3'UTR	novel		0.33
UCEC	chr3	188878581	3'UTR	novel		0.32
UCEC	chr3	188760115	Missense_Mutation	rs756437011	R415C	0.21
UCEC	chr3	188876270	3'UTR	novel		0.12
UCEC	chr3	188484690	Missense_Mutation	novel	A98T	0.47
UCEC	chr3	188878527	3'UTR	novel		0.58
UCEC	chr3	188878137	3'UTR	novel		0.35
UCEC	chr3	188876435	3'UTR	novel		0.31
UCEC	chr3	188874597	3'UTR	novel		0.17
UCEC	chr3	188866342	Missense_Mutation	NA	A518V	0.42
UCEC	chr3	188484671	Silent	novel	P91P	0.08
UCEC	chr3	188875668	3'UTR	novel		0.22
UCEC	chr3	188866245	Missense_Mutation	novel	R486W	0.33
UCEC	chr3	188874565	3'UTR	rs555709117		0.3
UCEC	chr3	188866347	Missense_Mutation	rs755218802	G520R	0.4
UCEC	chr3	188874614	3'UTR	novel		0.19
UCEC	chr3	188406204	Silent	novel	S28S	0.08
UCEC	chr3	188874625	3'UTR	rs566599068		0.26
UCEC	chr3	188872714	Missense_Mutation	NA	R554H	0.39
UCEC	chr3	188872655	Silent	NA	P534P	0.36
UCEC	chr3	188874562	3'UTR	novel		0.15
UCEC	chr3	188609319	Silent	rs55674610	I196I	0.17
UCEC	chr3	188609844	Missense_Mutation	novel	K371N	0.37
UCEC	chr3	188874728	3'UTR	novel		0.47
UCEC	chr3	188874496	3'UTR	novel		0.22
UCEC	chr3	188609545	Missense_Mutation	NA	D272N	0.3
UCEC	chr3	188609825	Missense_Mutation	rs770028872	A365V	0.22
UCEC	chr3	188760226	Nonsense_Mutation	rs202115941	R452*	0.27
UCEC	chr3	188874463	Missense_Mutation	NA	A608V	0.3
UCEC	chr3	188874588	3'UTR	novel		0.53
UCEC	chr3	188878137	3'UTR	novel		0.32
UCEC	chr3	188874565	3'UTR	rs555709117		0.32
UCEC	chr3	188875665	3'UTR	novel		0.38
UCEC	chr3	188878134	3'UTR	novel		0.32
UCEC	chr3	188878220	3'UTR	novel		0.49
UCEC	chr3	188609480	Missense_Mutation	novel	G250V	0.23
UCS	chr3	188609771	Missense_Mutation	novel	P347R	0.37
UCS	chr3	188872656	Nonsense_Mutation	novel	R535*	0.96

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4387	0.0018563
KIRC	AMP	0.1174	2.0306e-05
KIRP	AMP	0.3229	0.15981
LUAD	DEL	0.1977	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1595	0.0086757
TGCT	AMP	0.26	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00055	Kaplan-Meier Survival Analysis
SARC	0.035	Kaplan-Meier Survival Analysis
MESO	0.019	Kaplan-Meier Survival Analysis
SKCM	0.0044	Kaplan-Meier Survival Analysis
PAAD	0.002	Kaplan-Meier Survival Analysis
CESC	0.042	Kaplan-Meier Survival Analysis
LAML	0.042	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0052	Kaplan-Meier Survival Analysis
CHOL	0.037	Kaplan-Meier Survival Analysis
THCA	0.0031	Kaplan-Meier Survival Analysis
UVM	0.046	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742