EuRBPDB

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  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000145191 (Gene tree)
Gene ID
8893
Gene Symbol
EIF2B5
Alias
EIF2Bepsilon|EIF-2B
Full Name
eukaryotic translation initiation factor 2B subunit epsilon
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
11,678 bases
Position
chr3:184,134,435-184,146,112
Accession
3261
RBP type
canonical RBP
Summary
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000273783W2PF02020.188.3e-1811
ENSP00000497160W2PF02020.188.3e-1811
ENSP00000498164W2PF02020.188.4e-1811

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28961236Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation.PLoS Biol2017 Sep 29Brady LKdoi: 10.1371/journal.pbio.2002623
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000648630EIF2B5-2232674-ENSP00000497887382 (aa)--
ENST00000649688EIF2B5-2292932-ENSP00000497097269 (aa)-UPI000020A895
ENST00000498831EIF2B5-215597--- (aa)--
ENST00000648890EIF2B5-2262552-ENSP00000497503530 (aa)--
ENST00000650244EIF2B5-231696-ENSP0000049722741 (aa)--
ENST00000481054EIF2B5-2083460--- (aa)--
ENST00000648599EIF2B5-2222613-ENSP00000497159269 (aa)-UPI000020A895
ENST00000492773EIF2B5-2132254-ENSP00000497833141 (aa)--
ENST00000471832EIF2B5-206930-ENSP00000497786113 (aa)-UPI00001A831E
ENST00000648915EIF2B5-2272538XM_011513265ENSP00000497160721 (aa)XP_011511567UPI000013D9CF
ENST00000432982EIF2B5-203597-ENSP0000040819892 (aa)-H7C2X0
ENST00000273783EIF2B5-2012656-ENSP00000273783721 (aa)-Q13144
ENST00000648682EIF2B5-2242665-ENSP00000498185389 (aa)--
ENST00000479250EIF2B5-207466--- (aa)--
ENST00000491144EIF2B5-2113038--- (aa)--
ENST00000493740EIF2B5-214564--- (aa)--
ENST00000491008EIF2B5-2103298--- (aa)--
ENST00000468748EIF2B5-2054410--- (aa)--
ENST00000648189EIF2B5-2192345-ENSP00000497241231 (aa)--
ENST00000648256EIF2B5-2202483-ENSP00000497356267 (aa)--
ENST00000649814EIF2B5-2303084--- (aa)--
ENST00000492226EIF2B5-2123790--- (aa)--
ENST00000648314EIF2B5-2212760-ENSP00000496920314 (aa)--
ENST00000648882EIF2B5-2252505-ENSP00000497603113 (aa)-UPI00001A831E
ENST00000650270EIF2B5-2322389-ENSP00000497711546 (aa)--
ENST00000484154EIF2B5-2093961--- (aa)--
ENST00000649545EIF2B5-2282164-ENSP00000497598230 (aa)--
ENST00000432569EIF2B5-202585-ENSP00000414775107 (aa)-C9JRD9
ENST00000465218EIF2B5-2042850--- (aa)--
ENST00000647909EIF2B5-2172222-ENSP00000498164729 (aa)--
ENST00000647636EIF2B5-2162596-ENSP00000497505402 (aa)--
ENST00000648145EIF2B5-2182307-ENSP00000497476310 (aa)--
Gene Model
Click here to download ENSG00000145191's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145191's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000145191EIF2B59972.727ENSAPOG00000001134eif2b59067.254Acanthochromis_polyacanthus
ENSG00000145191EIF2B59997.143ENSAMEG00000017299EIF2B59492.604Ailuropoda_melanoleuca
ENSG00000145191EIF2B59972.727ENSACIG00000006830eif2b59567.651Amphilophus_citrinellus
ENSG00000145191EIF2B59972.727ENSAOCG00000017129eif2b59567.059Amphiprion_ocellaris
ENSG00000145191EIF2B59972.727ENSAPEG00000020580eif2b59566.912Amphiprion_percula
ENSG00000145191EIF2B59972.727ENSATEG00000006871eif2b59566.667Anabas_testudineus
ENSG00000145191EIF2B59978.247ENSAPLG00000005467EIF2B59874.458Anas_platyrhynchos
ENSG00000145191EIF2B59974.286ENSACAG00000010709EIF2B59673.077Anolis_carolinensis
ENSG00000145191EIF2B510095.327ENSANAG00000030694EIF2B59794.126Aotus_nancymaae
ENSG00000145191EIF2B59972.403ENSACLG00000019387eif2b59567.456Astatotilapia_calliptera
ENSG00000145191EIF2B59974.026ENSAMXG00000019751eif2b59365.538Astyanax_mexicanus
ENSG00000145191EIF2B59997.857ENSBTAG00000011414EIF2B59394.231Bos_taurus
ENSG00000145191EIF2B59995.455ENSCJAG00000013108EIF2B59793.696Callithrix_jacchus
ENSG00000145191EIF2B59999.286ENSCAFG00000012158EIF2B59494.379Canis_familiaris
ENSG00000145191EIF2B59999.286ENSCAFG00020002276EIF2B59494.379Canis_lupus_dingo
ENSG00000145191EIF2B59997.857ENSCHIG00000026144EIF2B59593.731Capra_hircus
ENSG00000145191EIF2B59997.143ENSTSYG00000012456EIF2B59594.675Carlito_syrichta
ENSG00000145191EIF2B59997.143ENSCAPG00000007276EIF2B59490.447Cavia_aperea
ENSG00000145191EIF2B59997.143ENSCPOG00000012458EIF2B59391.272Cavia_porcellus
ENSG00000145191EIF2B510095.327ENSCCAG00000028693EIF2B59793.553Cebus_capucinus
ENSG00000145191EIF2B5100100.000ENSCATG00000043245EIF2B510098.336Cercocebus_atys
ENSG00000145191EIF2B59996.429ENSCLAG00000012914EIF2B59392.456Chinchilla_lanigera
ENSG00000145191EIF2B510097.226ENSCSAG00000013546EIF2B510097.226Chlorocebus_sabaeus
ENSG00000145191EIF2B59996.429ENSCHOG00000002782EIF2B55596.364Choloepus_hoffmanni
ENSG00000145191EIF2B59979.870ENSCPBG00000015584EIF2B59576.923Chrysemys_picta_bellii
ENSG00000145191EIF2B57940.868ENSCING00000000067-9638.798Ciona_intestinalis
ENSG00000145191EIF2B59947.619ENSCSAVG00000010000-9939.736Ciona_savignyi
ENSG00000145191EIF2B5100100.000ENSCANG00000041978EIF2B59998.197Colobus_angolensis_palliatus
ENSG00000145191EIF2B59994.286ENSCGRG00001008638Eif2b59491.272Cricetulus_griseus_chok1gshd
ENSG00000145191EIF2B59994.286ENSCGRG00000013467Eif2b59491.272Cricetulus_griseus_crigri
ENSG00000145191EIF2B59970.779ENSCSEG00000009494eif2b59558.260Cynoglossus_semilaevis
ENSG00000145191EIF2B59995.714ENSDNOG00000007493EIF2B59792.117Dasypus_novemcinctus
ENSG00000145191EIF2B59997.143ENSDORG00000005107Eif2b59491.568Dipodomys_ordii
ENSG00000145191EIF2B59934.906FBgn0023512eIF2Bepsilon8534.302Drosophila_melanogaster
ENSG00000145191EIF2B59993.571ENSETEG00000004754EIF2B59485.059Echinops_telfairi
ENSG00000145191EIF2B58648.507ENSEBUG00000002292eif2b59843.697Eptatretus_burgeri
ENSG00000145191EIF2B59996.429ENSEASG00005014406EIF2B59692.204Equus_asinus_asinus
ENSG00000145191EIF2B59996.429ENSECAG00000018745EIF2B59392.751Equus_caballus
ENSG00000145191EIF2B59972.403ENSELUG00000016252eif2b59667.651Esox_lucius
ENSG00000145191EIF2B59997.857ENSFCAG00000007787EIF2B59793.266Felis_catus
ENSG00000145191EIF2B59978.571ENSFALG00000007923EIF2B59874.299Ficedula_albicollis
ENSG00000145191EIF2B59997.143ENSFDAG00000016085EIF2B59392.012Fukomys_damarensis
ENSG00000145191EIF2B59972.857ENSFHEG00000017754eif2b59566.422Fundulus_heteroclitus
ENSG00000145191EIF2B59973.052ENSGMOG00000015264eif2b59464.948Gadus_morhua
ENSG00000145191EIF2B59978.247ENSGALG00000008376EIF2B59474.551Gallus_gallus
ENSG00000145191EIF2B59972.727ENSGAFG00000006159eif2b59566.520Gambusia_affinis
ENSG00000145191EIF2B59972.078ENSGACG00000014136eif2b59366.913Gasterosteus_aculeatus
ENSG00000145191EIF2B59979.870ENSGAGG00000005222EIF2B59677.071Gopherus_agassizii
ENSG00000145191EIF2B5100100.000ENSGGOG00000007425EIF2B510099.584Gorilla_gorilla
ENSG00000145191EIF2B59972.403ENSHBUG00000023533eif2b59866.977Haplochromis_burtoni
ENSG00000145191EIF2B59997.143ENSHGLG00000017325EIF2B59392.012Heterocephalus_glaber_female
ENSG00000145191EIF2B59997.143ENSHGLG00100018496EIF2B59491.864Heterocephalus_glaber_male
ENSG00000145191EIF2B59972.638ENSHCOG00000015732eif2b59664.853Hippocampus_comes
ENSG00000145191EIF2B59971.429ENSIPUG00000005756eif2b59664.749Ictalurus_punctatus
ENSG00000145191EIF2B59997.857ENSSTOG00000021575EIF2B59492.604Ictidomys_tridecemlineatus
ENSG00000145191EIF2B59993.182ENSJJAG00000004949Eif2b59491.272Jaculus_jaculus
ENSG00000145191EIF2B59971.753ENSKMAG00000019967eif2b59566.373Kryptolebias_marmoratus
ENSG00000145191EIF2B59874.638ENSLBEG00000003488-9563.877Labrus_bergylta
ENSG00000145191EIF2B59974.026ENSLBEG00000002990eif2b59567.061Labrus_bergylta
ENSG00000145191EIF2B59974.026ENSLACG00000012068EIF2B59469.675Latimeria_chalumnae
ENSG00000145191EIF2B59975.325ENSLOCG00000004645eif2b59366.913Lepisosteus_oculatus
ENSG00000145191EIF2B59993.571ENSLAFG00000014782EIF2B59490.680Loxodonta_africana
ENSG00000145191EIF2B5100100.000ENSMFAG00000045589EIF2B510098.336Macaca_fascicularis
ENSG00000145191EIF2B5100100.000ENSMMUG00000006562EIF2B510098.336Macaca_mulatta
ENSG00000145191EIF2B510099.065ENSMNEG00000035864EIF2B59795.845Macaca_nemestrina
ENSG00000145191EIF2B5100100.000ENSMLEG00000028338EIF2B510098.197Mandrillus_leucophaeus
ENSG00000145191EIF2B59972.143ENSMAMG00000016617eif2b59367.160Mastacembelus_armatus
ENSG00000145191EIF2B59972.403ENSMZEG00005011930eif2b59567.456Maylandia_zebra
ENSG00000145191EIF2B59978.571ENSMGAG00000008878EIF2B59674.408Meleagris_gallopavo
ENSG00000145191EIF2B59997.143ENSMAUG00000018803Eif2b59490.963Mesocricetus_auratus
ENSG00000145191EIF2B59997.143ENSMICG00000049428EIF2B59494.970Microcebus_murinus
ENSG00000145191EIF2B59992.143ENSMOCG00000016708Eif2b59490.680Microtus_ochrogaster
ENSG00000145191EIF2B59987.013ENSMODG00000003196EIF2B59880.945Monodelphis_domestica
ENSG00000145191EIF2B59973.052ENSMALG00000011865eif2b59565.533Monopterus_albus
ENSG00000145191EIF2B59993.571MGP_CAROLIEiJ_G0020576Eif2b59489.793Mus_caroli
ENSG00000145191EIF2B59993.571ENSMUSG00000003235Eif2b59489.645Mus_musculus
ENSG00000145191EIF2B59992.857MGP_PahariEiJ_G0016280Eif2b59490.828Mus_pahari
ENSG00000145191EIF2B59993.571MGP_SPRETEiJ_G0021473Eif2b59489.645Mus_spretus
ENSG00000145191EIF2B59997.857ENSMPUG00000002433EIF2B59493.047Mustela_putorius_furo
ENSG00000145191EIF2B59997.143ENSMLUG00000013520EIF2B59494.231Myotis_lucifugus
ENSG00000145191EIF2B59992.857ENSNGAG00000023841Eif2b59490.976Nannospalax_galili
ENSG00000145191EIF2B59972.078ENSNBRG00000017303eif2b59567.308Neolamprologus_brichardi
ENSG00000145191EIF2B510098.890ENSNLEG00000006103EIF2B510098.890Nomascus_leucogenys
ENSG00000145191EIF2B59988.312ENSMEUG00000002530EIF2B59882.462Notamacropus_eugenii
ENSG00000145191EIF2B59995.000ENSOPRG00000005555EIF2B59790.237Ochotona_princeps
ENSG00000145191EIF2B59997.857ENSODEG00000012756EIF2B59691.272Octodon_degus
ENSG00000145191EIF2B59972.638ENSONIG00000015592eif2b59867.085Oreochromis_niloticus
ENSG00000145191EIF2B59984.740ENSOANG00000001406EIF2B59884.675Ornithorhynchus_anatinus
ENSG00000145191EIF2B59995.714ENSOCUG00000004536EIF2B59790.961Oryctolagus_cuniculus
ENSG00000145191EIF2B59974.286ENSORLG00000011987eif2b59566.373Oryzias_latipes
ENSG00000145191EIF2B59973.571ENSORLG00020008225eif2b59566.373Oryzias_latipes_hni
ENSG00000145191EIF2B59973.571ENSORLG00015000054eif2b59566.226Oryzias_latipes_hsok
ENSG00000145191EIF2B59972.857ENSOMEG00000012506eif2b59565.639Oryzias_melastigma
ENSG00000145191EIF2B59995.000ENSOGAG00000016131EIF2B59489.053Otolemur_garnettii
ENSG00000145191EIF2B59997.857ENSOARG00000020620EIF2B59894.234Ovis_aries
ENSG00000145191EIF2B5100100.000ENSPPAG00000030604EIF2B510099.445Pan_paniscus
ENSG00000145191EIF2B59997.143ENSPPRG00000002680EIF2B59792.837Panthera_pardus
ENSG00000145191EIF2B59997.857ENSPTIG00000016942EIF2B59792.418Panthera_tigris_altaica
ENSG00000145191EIF2B5100100.000ENSPTRG00000015679EIF2B510099.723Pan_troglodytes
ENSG00000145191EIF2B5100100.000ENSPANG00000017089EIF2B510098.197Papio_anubis
ENSG00000145191EIF2B59973.701ENSPKIG00000005606eif2b59566.864Paramormyrops_kingsleyae
ENSG00000145191EIF2B59979.870ENSPSIG00000013933EIF2B59576.627Pelodiscus_sinensis
ENSG00000145191EIF2B59995.000ENSPEMG00000009037Eif2b59490.976Peromyscus_maniculatus_bairdii
ENSG00000145191EIF2B59987.857ENSPCIG00000025618EIF2B59481.591Phascolarctos_cinereus
ENSG00000145191EIF2B59971.429ENSPFOG00000016049eif2b59565.786Poecilia_formosa
ENSG00000145191EIF2B59971.429ENSPLAG00000004531eif2b59565.492Poecilia_latipinna
ENSG00000145191EIF2B59971.429ENSPLAG00000017440-9565.492Poecilia_latipinna
ENSG00000145191EIF2B59970.779ENSPMEG00000006729eif2b59565.639Poecilia_mexicana
ENSG00000145191EIF2B59970.130ENSPREG00000021790eif2b59565.492Poecilia_reticulata
ENSG00000145191EIF2B510098.752ENSPPYG00000014344EIF2B510098.752Pongo_abelii
ENSG00000145191EIF2B59995.000ENSPCOG00000010623EIF2B59494.083Propithecus_coquereli
ENSG00000145191EIF2B59995.000ENSPVAG00000004836EIF2B59493.639Pteropus_vampyrus
ENSG00000145191EIF2B59972.403ENSPNYG00000017764eif2b59567.308Pundamilia_nyererei
ENSG00000145191EIF2B59974.026ENSPNAG00000004608eif2b59366.027Pygocentrus_nattereri
ENSG00000145191EIF2B59991.234ENSRNOG00000038160Eif2b59489.793Rattus_norvegicus
ENSG00000145191EIF2B5100100.000ENSRBIG00000043590EIF2B510098.197Rhinopithecus_bieti
ENSG00000145191EIF2B5100100.000ENSRROG00000037560EIF2B510098.336Rhinopithecus_roxellana
ENSG00000145191EIF2B59936.250YDR211W-5836.211Saccharomyces_cerevisiae
ENSG00000145191EIF2B510095.327ENSSBOG00000028500EIF2B59793.553Saimiri_boliviensis_boliviensis
ENSG00000145191EIF2B59987.857ENSSHAG00000000803EIF2B59880.828Sarcophilus_harrisii
ENSG00000145191EIF2B59975.000ENSSFOG00015013408eif2b59568.584Scleropages_formosus
ENSG00000145191EIF2B59973.052ENSSMAG00000013864eif2b59666.617Scophthalmus_maximus
ENSG00000145191EIF2B59973.701ENSSDUG00000000890eif2b59566.765Seriola_dumerili
ENSG00000145191EIF2B59974.026ENSSLDG00000001909eif2b59566.912Seriola_lalandi_dorsalis
ENSG00000145191EIF2B59093.525ENSSARG00000008159EIF2B57093.023Sorex_araneus
ENSG00000145191EIF2B59976.948ENSSPUG00000013415EIF2B59573.638Sphenodon_punctatus
ENSG00000145191EIF2B59972.727ENSSPAG00000022919eif2b59566.324Stegastes_partitus
ENSG00000145191EIF2B59997.143ENSSSCG00000011783EIF2B59393.491Sus_scrofa
ENSG00000145191EIF2B59977.922ENSTGUG00000010097EIF2B59774.704Taeniopygia_guttata
ENSG00000145191EIF2B59973.377ENSTRUG00000007854eif2b59565.198Takifugu_rubripes
ENSG00000145191EIF2B59974.351ENSTNIG00000007928eif2b59464.265Tetraodon_nigroviridis
ENSG00000145191EIF2B59995.714ENSTBEG00000008196EIF2B59879.624Tupaia_belangeri
ENSG00000145191EIF2B59997.857ENSTTRG00000003093EIF2B58395.134Tursiops_truncatus
ENSG00000145191EIF2B59997.857ENSUAMG00000005923EIF2B59492.604Ursus_americanus
ENSG00000145191EIF2B59997.857ENSUMAG00000006171EIF2B59792.604Ursus_maritimus
ENSG00000145191EIF2B58299.123ENSVPAG00000000393EIF2B59099.123Vicugna_pacos
ENSG00000145191EIF2B59999.286ENSVVUG00000007208EIF2B59494.527Vulpes_vulpes
ENSG00000145191EIF2B59976.429ENSXETG00000014293eif2b59466.913Xenopus_tropicalis
ENSG00000145191EIF2B59971.753ENSXCOG00000007851eif2b59566.226Xiphophorus_couchianus
ENSG00000145191EIF2B59971.753ENSXMAG00000000316eif2b59566.373Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001541ovarian follicle development15507143.IMPProcess
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0003743translation initiation factor activity16289705.IDAFunction
GO:0003743translation initiation factor activity8688466.NASFunction
GO:0005085guanyl-nucleotide exchange factor activity21873635.IBAFunction
GO:0005085guanyl-nucleotide exchange factor activity11323413.IDAFunction
GO:0005085guanyl-nucleotide exchange factor activity15054402.IMPFunction
GO:0005085guanyl-nucleotide exchange factor activity-ISSFunction
GO:0005515protein binding10481074.15060152.IPIFunction
GO:0005634nucleus12426392.IDAComponent
GO:0005634nucleus-ISSComponent
GO:0005737cytoplasm11323413.12426392.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005851eukaryotic translation initiation factor 2B complex21873635.IBAComponent
GO:0005851eukaryotic translation initiation factor 2B complex11323413.15060152.IDAComponent
GO:0006413translational initiation16289705.IDAProcess
GO:0007568aging-IEAProcess
GO:0009408response to heat15723074.IMPProcess
GO:0009408response to heat-ISSProcess
GO:0009408response to heat12499492.TASProcess
GO:0009749response to glucose-ISSProcess
GO:0010226response to lithium ion-IEAProcess
GO:0014002astrocyte development15723074.IMPProcess
GO:0014003oligodendrocyte development15217090.IMPProcess
GO:0021766hippocampus development-IEAProcess
GO:0031369translation initiation factor binding21873635.IBAFunction
GO:0031369translation initiation factor binding-ISSFunction
GO:0034976response to endoplasmic reticulum stress16041584.IMPProcess
GO:0042552myelination14566705.15723074.IMPProcess
GO:0043065positive regulation of apoptotic process-IEAProcess
GO:0043434response to peptide hormone-ISSProcess
GO:0045948positive regulation of translational initiation-ISSProcess
GO:0048708astrocyte differentiation15723074.IMPProcess
GO:0050852T cell receptor signaling pathway8626696.IDAProcess

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