EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145216 (Gene tree)
Gene ID: 81608
Gene Symbol: FIP1L1
Alias: DKFZp586K0717|FIP1
Full Name: factor interacting with PAPOLA and CPSF1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 84,969 bases
Position: chr4:53,377,643-53,462,611
Accession: 19124
RBP type: canonical RBP
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425456	Fip1	PF05182.13	9e-25	1	1
ENSP00000302993	Fip1	PF05182.13	2.9e-24	1	1
ENSP00000351383	Fip1	PF05182.13	3.4e-24	1	1
ENSP00000336752	Fip1	PF05182.13	3.4e-24	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

Show entries

Search:

PID	Title	Article	Time	Author	Doi
16282318	An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits.	J Biol Chem	2006 Jan 6	Forbes KP	-
14749727	Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.	EMBO J	2004 Feb 11	Kaufmann I	-
12626716	Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.	Nucleic Acids Res	2003 Mar 15	Tacahashi Y	-
9742111	Processivity of the Saccharomyces cerevisiae poly(A) polymerase requires interactions at the carboxyl-terminal RNA binding domain.	Mol Cell Biol	1998 Oct	Zhelkovsky A	-

Showing 1 to 4 of 4 entries

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Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000513975	FIP1L1-212	1464	-	-	- (aa)	-	-
ENST00000337488	FIP1L1-202	2198	XM_005265769	ENSP00000336752	594 (aa)	XP_005265826	Q6UN15
ENST00000504094	FIP1L1-204	2177	-	ENSP00000421691	254 (aa)	-	H0Y8P7
ENST00000513008	FIP1L1-211	1070	-	-	- (aa)	-	-
ENST00000507206	FIP1L1-206	341	-	-	- (aa)	-	-
ENST00000306932	FIP1L1-201	1878	XM_005265781	ENSP00000302993	520 (aa)	XP_005265838	Q6UN15
ENST00000511055	FIP1L1-209	723	-	-	- (aa)	-	-
ENST00000511376	FIP1L1-210	582	-	-	- (aa)	-	-
ENST00000510668	FIP1L1-208	599	-	-	- (aa)	-	-
ENST00000358575	FIP1L1-203	2180	XM_017008664	ENSP00000351383	588 (aa)	XP_016864153	Q6UN15
ENST00000514543	FIP1L1-213	1465	-	ENSP00000421241	26 (aa)	-	H0Y8J4
ENST00000507922	FIP1L1-207	1335	-	ENSP00000425456	378 (aa)	-	Q6UN15
ENST00000505125	FIP1L1-205	3180	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000145216's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000145216	Potassium	5.5200000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000145216	rs13142904	4	53452247	C	Macrophage Migration Inhibitory Factor levels	27989323	[0.14-0.31] SD units increase	0.223	EFO_0008221

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145216's network

CanvasJS.com

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145216	FIP1L1	100	100.000	ENSANAG00000032461	FIP1L1	100	100.000	Aotus_nancymaae
ENSG00000145216	FIP1L1	100	100.000	ENSCJAG00000018490	FIP1L1	100	100.000	Callithrix_jacchus
ENSG00000145216	FIP1L1	100	99.320	ENSCAFG00020001745	FIP1L1	100	99.320	Canis_lupus_dingo
ENSG00000145216	FIP1L1	100	97.500	ENSTSYG00000002808	FIP1L1	100	97.500	Carlito_syrichta
ENSG00000145216	FIP1L1	100	98.425	ENSCSAG00000004975	FIP1L1	100	98.342	Chlorocebus_sabaeus
ENSG00000145216	FIP1L1	100	100.000	ENSCANG00000004785	FIP1L1	100	100.000	Colobus_angolensis_palliatus
ENSG00000145216	FIP1L1	100	92.523	ENSDORG00000005629	-	100	92.523	Dipodomys_ordii
ENSG00000145216	FIP1L1	100	99.663	ENSECAG00000019415	FIP1L1	100	99.663	Equus_caballus
ENSG00000145216	FIP1L1	100	100.000	ENSGGOG00000006427	FIP1L1	100	100.000	Gorilla_gorilla
ENSG00000145216	FIP1L1	100	98.822	ENSLAFG00000002605	FIP1L1	100	98.822	Loxodonta_africana
ENSG00000145216	FIP1L1	100	100.000	ENSMFAG00000034699	FIP1L1	100	100.000	Macaca_fascicularis
ENSG00000145216	FIP1L1	100	100.000	ENSMNEG00000026332	FIP1L1	100	100.000	Macaca_nemestrina
ENSG00000145216	FIP1L1	100	100.000	ENSMLEG00000041763	FIP1L1	100	100.000	Mandrillus_leucophaeus
ENSG00000145216	FIP1L1	99	99.204	ENSMICG00000008149	FIP1L1	100	93.077	Microcebus_murinus
ENSG00000145216	FIP1L1	100	100.000	ENSNLEG00000008187	FIP1L1	100	100.000	Nomascus_leucogenys
ENSG00000145216	FIP1L1	100	97.244	ENSOCUG00000000100	FIP1L1	100	96.186	Oryctolagus_cuniculus
ENSG00000145216	FIP1L1	100	98.824	ENSOGAG00000009545	FIP1L1	100	98.824	Otolemur_garnettii
ENSG00000145216	FIP1L1	100	99.327	ENSPPRG00000002221	FIP1L1	100	99.327	Panthera_pardus
ENSG00000145216	FIP1L1	100	97.244	ENSPTIG00000010757	FIP1L1	95	99.292	Panthera_tigris_altaica
ENSG00000145216	FIP1L1	100	100.000	ENSPTRG00000016060	FIP1L1	100	100.000	Pan_troglodytes
ENSG00000145216	FIP1L1	100	98.507	ENSPTRG00000050184	-	100	98.507	Pan_troglodytes
ENSG00000145216	FIP1L1	100	100.000	ENSPANG00000011213	FIP1L1	100	100.000	Papio_anubis
ENSG00000145216	FIP1L1	100	98.425	ENSPPYG00000014773	FIP1L1	100	98.342	Pongo_abelii
ENSG00000145216	FIP1L1	99	99.469	ENSPCOG00000021280	FIP1L1	82	99.289	Propithecus_coquereli
ENSG00000145216	FIP1L1	100	100.000	ENSRBIG00000042397	FIP1L1	100	100.000	Rhinopithecus_bieti
ENSG00000145216	FIP1L1	100	99.660	ENSSSCG00000031636	FIP1L1	100	99.660	Sus_scrofa
ENSG00000145216	FIP1L1	99	93.112	ENSTTRG00000015793	FIP1L1	100	96.909	Tursiops_truncatus
ENSG00000145216	FIP1L1	99	99.735	ENSUAMG00000010607	FIP1L1	98	99.391	Ursus_americanus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	15937220.19224921.25416956.29276085.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0098789	pre-mRNA cleavage required for polyadenylation	21873635.	IBA	Process