EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145388 (Gene tree)
Gene ID: 57721
Gene Symbol: METTL14
Alias: KIAA1627
Full Name: methyltransferase like 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,070 bases
Position: chr4:118,685,364-118,715,433
Accession: 29330
RBP type: canonical RBP
Summary: (Methyltransferase Like 14) is a Protein Coding gene. Diseases associated with METTL14 include Dental Pulp Necrosis. Among its related pathways are Chromatin Regulation / Acetylation and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000373474	MT-A70	PF05063.14	8.9e-63	1	1
ENSP00000424111	MT-A70	PF05063.14	9.8e-31	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30306128	Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.	Sci Adv	2018 Oct 3	Panneerdoss S	doi: 10.1126/sciadv.aar8263
27627798	Structural insights into the molecular mechanism of the m(6)A writer complex.	Elife	2016 Sep 14	Sledz P	doi: 10.7554/eLife.18434.
27281194	Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.	Nature	2016 Jun 23	Wang X	doi: 10.1038/nature18298
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965
27072590	Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia.	Sci Rep	2016 Apr 13	Yang Y	doi: 10.1038/srep24345.
27179969	N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.	Mol Biotechnol	2016 Jul	Wu R	doi: 10.1007/s12033-016-9947-9.
29348140	Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.	RNA	2018 Apr	Scholler E	doi: 10.1261/rna.064063.117
30867593	Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.	Nature	2019 Mar	Huang H	doi: 10.1038/s41586-019-1016-7
31149892	The dynamics of FTO binding and demethylation from the m6A motifs.	RNA Biol	2019 May 31:1-11	Li Y	doi: 10.1080/15476286.2019.1621120

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508801	METTL14-204	485	-	ENSP00000425460	121 (aa)	-	D6RD73
ENST00000626212	METTL14-205	522	-	ENSP00000486381	64 (aa)	-	A0A0D9SF88
ENST00000502564	METTL14-202	432	-	-	- (aa)	-	-
ENST00000628452	METTL14-206	6625	-	ENSP00000486933	89 (aa)	-	A0A0D9SFW0
ENST00000506780	METTL14-203	927	-	ENSP00000424111	137 (aa)	-	D6RBL4
ENST00000388822	METTL14-201	6669	XM_005263166	ENSP00000373474	456 (aa)	XP_005263223	Q9HCE5

Gene Model

Click here to download ENSG00000145388's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145388's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145388	METTL14	100	87.500	ENSAPOG00000006601	mettl14	87	84.596	Acanthochromis_polyacanthus
ENSG00000145388	METTL14	100	100.000	ENSAMEG00000011578	METTL14	100	99.561	Ailuropoda_melanoleuca
ENSG00000145388	METTL14	100	84.375	ENSACIG00000010309	mettl14	86	79.293	Amphilophus_citrinellus
ENSG00000145388	METTL14	100	85.938	ENSAOCG00000006449	mettl14	87	84.343	Amphiprion_ocellaris
ENSG00000145388	METTL14	100	85.938	ENSAPEG00000017730	mettl14	87	84.343	Amphiprion_percula
ENSG00000145388	METTL14	100	79.688	ENSATEG00000017832	mettl14	87	84.091	Anabas_testudineus
ENSG00000145388	METTL14	78	96.262	ENSAPLG00000002025	METTL14	85	94.493	Anas_platyrhynchos
ENSG00000145388	METTL14	100	93.750	ENSACAG00000013631	METTL14	87	93.434	Anolis_carolinensis
ENSG00000145388	METTL14	100	99.342	ENSANAG00000024273	METTL14	100	99.342	Aotus_nancymaae
ENSG00000145388	METTL14	100	85.938	ENSACLG00000018000	mettl14	87	84.091	Astatotilapia_calliptera
ENSG00000145388	METTL14	86	89.091	ENSAMXG00000039626	mettl14	86	80.808	Astyanax_mexicanus
ENSG00000145388	METTL14	100	100.000	ENSBTAG00000014080	METTL14	100	99.561	Bos_taurus
ENSG00000145388	METTL14	100	100.000	ENSCJAG00000003361	METTL14	100	99.342	Callithrix_jacchus
ENSG00000145388	METTL14	99	98.462	ENSCAFG00000025409	METTL14	100	98.462	Canis_familiaris
ENSG00000145388	METTL14	100	100.000	ENSCAFG00020017450	METTL14	100	99.561	Canis_lupus_dingo
ENSG00000145388	METTL14	100	100.000	ENSCHIG00000024680	METTL14	100	99.561	Capra_hircus
ENSG00000145388	METTL14	100	100.000	ENSTSYG00000000357	METTL14	100	99.123	Carlito_syrichta
ENSG00000145388	METTL14	100	82.863	ENSCAPG00000016608	METTL14	100	83.080	Cavia_aperea
ENSG00000145388	METTL14	100	98.904	ENSCPOG00000037880	METTL14	100	98.904	Cavia_porcellus
ENSG00000145388	METTL14	100	100.000	ENSCCAG00000037076	METTL14	100	99.561	Cebus_capucinus
ENSG00000145388	METTL14	100	99.561	ENSCATG00000040790	METTL14	100	99.561	Cercocebus_atys
ENSG00000145388	METTL14	100	98.465	ENSCLAG00000013189	METTL14	100	98.465	Chinchilla_lanigera
ENSG00000145388	METTL14	100	99.342	ENSCSAG00000003762	METTL14	100	99.342	Chlorocebus_sabaeus
ENSG00000145388	METTL14	100	93.750	ENSCPBG00000024769	METTL14	86	93.939	Chrysemys_picta_bellii
ENSG00000145388	METTL14	99	54.947	ENSCING00000001564	-	80	60.000	Ciona_intestinalis
ENSG00000145388	METTL14	78	61.682	ENSCSAVG00000005613	-	71	66.116	Ciona_savignyi
ENSG00000145388	METTL14	100	99.342	ENSCANG00000040370	METTL14	100	99.342	Colobus_angolensis_palliatus
ENSG00000145388	METTL14	100	95.312	ENSCGRG00001019193	Mettl14	100	86.623	Cricetulus_griseus_chok1gshd
ENSG00000145388	METTL14	78	100.000	ENSCGRG00000002596	Mettl14	100	99.686	Cricetulus_griseus_crigri
ENSG00000145388	METTL14	81	92.308	ENSCSEG00000009185	mettl14	87	83.586	Cynoglossus_semilaevis
ENSG00000145388	METTL14	100	87.500	ENSCVAG00000018016	mettl14	87	83.586	Cyprinodon_variegatus
ENSG00000145388	METTL14	100	87.500	ENSDARG00000070278	mettl14	87	84.596	Danio_rerio
ENSG00000145388	METTL14	100	96.875	ENSDNOG00000002149	METTL14	92	92.841	Dasypus_novemcinctus
ENSG00000145388	METTL14	100	100.000	ENSDORG00000016008	Mettl14	100	99.342	Dipodomys_ordii
ENSG00000145388	METTL14	89	61.800	FBgn0032016	Mettl14	93	61.194	Drosophila_melanogaster
ENSG00000145388	METTL14	80	98.039	ENSETEG00000014609	-	65	100.000	Echinops_telfairi
ENSG00000145388	METTL14	90	65.281	ENSEBUG00000006504	mettl14	73	71.795	Eptatretus_burgeri
ENSG00000145388	METTL14	100	100.000	ENSEASG00005009697	METTL14	100	99.561	Equus_asinus_asinus
ENSG00000145388	METTL14	100	100.000	ENSECAG00000021458	METTL14	100	99.561	Equus_caballus
ENSG00000145388	METTL14	100	98.438	ENSEEUG00000006655	-	100	75.562	Erinaceus_europaeus
ENSG00000145388	METTL14	100	100.000	ENSFCAG00000007068	METTL14	100	99.561	Felis_catus
ENSG00000145388	METTL14	100	95.312	ENSFALG00000002126	METTL14	85	94.697	Ficedula_albicollis
ENSG00000145388	METTL14	100	98.684	ENSFDAG00000005916	METTL14	100	98.684	Fukomys_damarensis
ENSG00000145388	METTL14	100	85.938	ENSFHEG00000009836	mettl14	87	82.828	Fundulus_heteroclitus
ENSG00000145388	METTL14	89	79.607	ENSGMOG00000003923	mettl14	85	79.798	Gadus_morhua
ENSG00000145388	METTL14	100	95.312	ENSGALG00000012000	METTL14	86	94.697	Gallus_gallus
ENSG00000145388	METTL14	100	81.250	ENSGAFG00000020519	mettl14	90	83.081	Gambusia_affinis
ENSG00000145388	METTL14	100	84.375	ENSGACG00000018009	mettl14	87	82.828	Gasterosteus_aculeatus
ENSG00000145388	METTL14	100	93.750	ENSGAGG00000020861	METTL14	86	93.939	Gopherus_agassizii
ENSG00000145388	METTL14	100	100.000	ENSGGOG00000016449	METTL14	100	100.000	Gorilla_gorilla
ENSG00000145388	METTL14	100	85.938	ENSHBUG00000003958	mettl14	85	76.010	Haplochromis_burtoni
ENSG00000145388	METTL14	100	98.465	ENSHGLG00000014068	METTL14	100	98.465	Heterocephalus_glaber_female
ENSG00000145388	METTL14	100	98.465	ENSHGLG00100007671	METTL14	100	98.465	Heterocephalus_glaber_male
ENSG00000145388	METTL14	100	82.812	ENSHCOG00000017822	mettl14	87	83.586	Hippocampus_comes
ENSG00000145388	METTL14	100	84.375	ENSIPUG00000002539	mettl14	87	83.838	Ictalurus_punctatus
ENSG00000145388	METTL14	100	98.035	ENSSTOG00000014707	METTL14	100	98.035	Ictidomys_tridecemlineatus
ENSG00000145388	METTL14	100	93.202	ENSJJAG00000010557	Mettl14	100	93.202	Jaculus_jaculus
ENSG00000145388	METTL14	100	84.375	ENSKMAG00000000103	mettl14	87	82.828	Kryptolebias_marmoratus
ENSG00000145388	METTL14	100	82.812	ENSLBEG00000008085	mettl14	87	83.838	Labrus_bergylta
ENSG00000145388	METTL14	100	85.938	ENSLACG00000002440	METTL14	86	87.879	Latimeria_chalumnae
ENSG00000145388	METTL14	100	89.062	ENSLOCG00000003385	mettl14	86	87.879	Lepisosteus_oculatus
ENSG00000145388	METTL14	100	99.123	ENSLAFG00000001857	METTL14	100	99.123	Loxodonta_africana
ENSG00000145388	METTL14	100	98.438	ENSMFAG00000045633	METTL14	100	99.544	Macaca_fascicularis
ENSG00000145388	METTL14	100	99.561	ENSMMUG00000007292	METTL14	100	99.561	Macaca_mulatta
ENSG00000145388	METTL14	100	99.561	ENSMNEG00000032737	METTL14	100	99.561	Macaca_nemestrina
ENSG00000145388	METTL14	100	99.561	ENSMLEG00000022386	METTL14	100	99.561	Mandrillus_leucophaeus
ENSG00000145388	METTL14	100	81.250	ENSMAMG00000018629	mettl14	87	84.091	Mastacembelus_armatus
ENSG00000145388	METTL14	100	85.938	ENSMZEG00005023630	mettl14	87	84.091	Maylandia_zebra
ENSG00000145388	METTL14	78	96.262	ENSMGAG00000010804	METTL14	86	89.333	Meleagris_gallopavo
ENSG00000145388	METTL14	100	98.026	ENSMAUG00000014022	Mettl14	100	98.026	Mesocricetus_auratus
ENSG00000145388	METTL14	100	100.000	ENSMICG00000013017	METTL14	100	99.781	Microcebus_murinus
ENSG00000145388	METTL14	100	98.026	ENSMOCG00000014583	Mettl14	100	98.026	Microtus_ochrogaster
ENSG00000145388	METTL14	100	84.375	ENSMMOG00000007123	mettl14	86	81.313	Mola_mola
ENSG00000145388	METTL14	76	78.035	ENSMODG00000018962	METTL14	84	78.035	Monodelphis_domestica
ENSG00000145388	METTL14	100	78.125	ENSMALG00000004416	mettl14	87	84.091	Monopterus_albus
ENSG00000145388	METTL14	100	98.684	MGP_CAROLIEiJ_G0025602	Mettl14	100	98.684	Mus_caroli
ENSG00000145388	METTL14	100	98.684	ENSMUSG00000028114	Mettl14	100	98.684	Mus_musculus
ENSG00000145388	METTL14	100	98.465	MGP_PahariEiJ_G0027049	Mettl14	100	98.465	Mus_pahari
ENSG00000145388	METTL14	100	98.684	MGP_SPRETEiJ_G0026555	Mettl14	100	98.684	Mus_spretus
ENSG00000145388	METTL14	100	100.000	ENSMPUG00000017434	METTL14	97	98.434	Mustela_putorius_furo
ENSG00000145388	METTL14	100	98.465	ENSMLUG00000003235	METTL14	100	98.465	Myotis_lucifugus
ENSG00000145388	METTL14	100	98.684	ENSNGAG00000013681	Mettl14	100	98.684	Nannospalax_galili
ENSG00000145388	METTL14	100	85.938	ENSNBRG00000014523	mettl14	87	84.343	Neolamprologus_brichardi
ENSG00000145388	METTL14	100	100.000	ENSNLEG00000008883	METTL14	100	100.000	Nomascus_leucogenys
ENSG00000145388	METTL14	66	97.619	ENSMEUG00000012290	METTL14	86	71.658	Notamacropus_eugenii
ENSG00000145388	METTL14	100	87.500	ENSODEG00000000993	-	87	89.239	Octodon_degus
ENSG00000145388	METTL14	100	98.684	ENSODEG00000008761	-	100	98.684	Octodon_degus
ENSG00000145388	METTL14	100	85.938	ENSONIG00000014586	mettl14	87	84.848	Oreochromis_niloticus
ENSG00000145388	METTL14	83	96.084	ENSOANG00000003309	METTL14	100	96.084	Ornithorhynchus_anatinus
ENSG00000145388	METTL14	95	94.954	ENSOCUG00000003062	METTL14	95	94.954	Oryctolagus_cuniculus
ENSG00000145388	METTL14	100	84.375	ENSORLG00000006053	mettl14	87	84.343	Oryzias_latipes
ENSG00000145388	METTL14	100	84.375	ENSORLG00020021803	mettl14	87	84.343	Oryzias_latipes_hni
ENSG00000145388	METTL14	100	84.375	ENSORLG00015001835	mettl14	87	84.343	Oryzias_latipes_hsok
ENSG00000145388	METTL14	100	84.375	ENSOMEG00000008909	mettl14	87	84.596	Oryzias_melastigma
ENSG00000145388	METTL14	100	99.123	ENSOGAG00000000646	METTL14	100	99.123	Otolemur_garnettii
ENSG00000145388	METTL14	100	100.000	ENSOARG00000017247	METTL14	100	99.561	Ovis_aries
ENSG00000145388	METTL14	100	100.000	ENSPPAG00000029930	METTL14	100	100.000	Pan_paniscus
ENSG00000145388	METTL14	100	100.000	ENSPPRG00000013792	METTL14	100	99.561	Panthera_pardus
ENSG00000145388	METTL14	100	100.000	ENSPTIG00000012504	METTL14	100	99.561	Panthera_tigris_altaica
ENSG00000145388	METTL14	100	100.000	ENSPTRG00000016391	METTL14	100	100.000	Pan_troglodytes
ENSG00000145388	METTL14	100	99.561	ENSPANG00000015932	METTL14	100	99.561	Papio_anubis
ENSG00000145388	METTL14	100	82.812	ENSPKIG00000021821	mettl14	87	86.111	Paramormyrops_kingsleyae
ENSG00000145388	METTL14	100	95.312	ENSPSIG00000007603	METTL14	86	94.192	Pelodiscus_sinensis
ENSG00000145388	METTL14	100	78.125	ENSPMGG00000001602	mettl14	86	79.040	Periophthalmus_magnuspinnatus
ENSG00000145388	METTL14	100	98.026	ENSPEMG00000023538	Mettl14	100	98.026	Peromyscus_maniculatus_bairdii
ENSG00000145388	METTL14	100	100.000	ENSPCIG00000020546	METTL14	86	94.192	Phascolarctos_cinereus
ENSG00000145388	METTL14	100	81.250	ENSPFOG00000005875	mettl14	87	82.828	Poecilia_formosa
ENSG00000145388	METTL14	100	81.250	ENSPLAG00000006272	mettl14	87	82.828	Poecilia_latipinna
ENSG00000145388	METTL14	100	81.250	ENSPMEG00000016646	mettl14	87	82.828	Poecilia_mexicana
ENSG00000145388	METTL14	100	81.250	ENSPREG00000009092	mettl14	87	82.576	Poecilia_reticulata
ENSG00000145388	METTL14	83	100.000	ENSPPYG00000015020	METTL14	100	100.000	Pongo_abelii
ENSG00000145388	METTL14	95	92.148	ENSPVAG00000008521	METTL14	93	92.148	Pteropus_vampyrus
ENSG00000145388	METTL14	100	85.938	ENSPNYG00000022649	mettl14	87	84.091	Pundamilia_nyererei
ENSG00000145388	METTL14	100	84.375	ENSPNAG00000009807	mettl14	87	84.091	Pygocentrus_nattereri
ENSG00000145388	METTL14	100	98.465	ENSRNOG00000015250	Mettl14	100	98.465	Rattus_norvegicus
ENSG00000145388	METTL14	95	88.222	ENSRBIG00000035236	METTL14	95	88.222	Rhinopithecus_bieti
ENSG00000145388	METTL14	100	99.342	ENSRROG00000041175	METTL14	100	99.342	Rhinopithecus_roxellana
ENSG00000145388	METTL14	100	100.000	ENSSBOG00000002153	METTL14	100	99.561	Saimiri_boliviensis_boliviensis
ENSG00000145388	METTL14	100	100.000	ENSSHAG00000014237	METTL14	86	94.697	Sarcophilus_harrisii
ENSG00000145388	METTL14	100	85.938	ENSSFOG00015013743	mettl14	87	87.374	Scleropages_formosus
ENSG00000145388	METTL14	100	81.250	ENSSMAG00000009127	mettl14	87	83.333	Scophthalmus_maximus
ENSG00000145388	METTL14	100	85.938	ENSSDUG00000000688	mettl14	87	85.354	Seriola_dumerili
ENSG00000145388	METTL14	100	85.938	ENSSLDG00000004181	mettl14	87	85.354	Seriola_lalandi_dorsalis
ENSG00000145388	METTL14	78	100.000	ENSSARG00000013839	METTL14	100	98.802	Sorex_araneus
ENSG00000145388	METTL14	100	93.750	ENSSPUG00000008722	METTL14	86	93.434	Sphenodon_punctatus
ENSG00000145388	METTL14	100	87.500	ENSSPAG00000013237	mettl14	87	84.596	Stegastes_partitus
ENSG00000145388	METTL14	100	99.123	ENSSSCG00000009113	METTL14	100	99.730	Sus_scrofa
ENSG00000145388	METTL14	100	95.312	ENSTGUG00000001867	-	86	94.697	Taeniopygia_guttata
ENSG00000145388	METTL14	100	81.250	ENSTRUG00000000401	mettl14	87	84.596	Takifugu_rubripes
ENSG00000145388	METTL14	51	88.571	ENSTNIG00000005201	mettl14	75	89.503	Tetraodon_nigroviridis
ENSG00000145388	METTL14	90	91.768	ENSTBEG00000003518	METTL14	95	91.768	Tupaia_belangeri
ENSG00000145388	METTL14	100	100.000	ENSTTRG00000015160	METTL14	97	99.123	Tursiops_truncatus
ENSG00000145388	METTL14	100	100.000	ENSUAMG00000027301	METTL14	100	99.561	Ursus_americanus
ENSG00000145388	METTL14	100	100.000	ENSUMAG00000003593	METTL14	100	99.561	Ursus_maritimus
ENSG00000145388	METTL14	100	98.438	ENSVPAG00000011056	METTL14	93	92.148	Vicugna_pacos
ENSG00000145388	METTL14	100	100.000	ENSVVUG00000008131	METTL14	100	99.561	Vulpes_vulpes
ENSG00000145388	METTL14	100	87.500	ENSXETG00000004037	mettl14	87	86.869	Xenopus_tropicalis
ENSG00000145388	METTL14	100	81.250	ENSXCOG00000000993	mettl14	87	83.081	Xiphophorus_couchianus
ENSG00000145388	METTL14	100	81.250	ENSXMAG00000017846	mettl14	87	82.828	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	25719671.	IMP	Process
GO:0003729	mRNA binding	27281194.27373337.27627798.	IDA	Function
GO:0005515	protein binding	24316715.24394384.26496610.27281194.27373337.29507755.	IPI	Function
GO:0005634	nucleus	24316715.26458103.29348140.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006402	mRNA catabolic process	-	IEA	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	24316715.	IDA	Function
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	27627798.	IDA	Function
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	27281194.27373337.27627798.	IDA	Function
GO:0019827	stem cell population maintenance	-	ISS	Process
GO:0021861	forebrain radial glial cell differentiation	-	ISS	Process
GO:0036396	RNA N6-methyladenosine methyltransferase complex	24316715.24981863.27627798.29348140.29507755.	IDA	Component
GO:0042063	gliogenesis	-	ISS	Process
GO:0061157	mRNA destabilization	-	ISS	Process
GO:0080009	mRNA methylation	27281194.27373337.27627798.	IDA	Process
GO:0080009	mRNA methylation	24316715.25719671.	IMP	Process
GO:1904047	S-adenosyl-L-methionine binding	27281194.	IDA	Function