EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145414 (Gene tree)
Gene ID: 92345
Gene Symbol: NAF1
Alias: N
Full Name: nuclear assembly factor 1 ribonucleoprotein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 57,789 bases
Position: chr4:163,109,133-163,166,921
Accession: 25126
RBP type: canonical RBP
Summary: (Nuclear Assembly Factor 1 Ribonucleoprotein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000408963	Gar1	PF04410.14	9.3e-44	1	1
ENSP00000274054	Gar1	PF04410.14	1.5e-43	1	1
ENSP00000427518	Gar1	PF04410.14	3e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12515383	Naf1 p is a box H/ACA snoRNP assembly factor.	RNA	2002 Dec	Fatica A	-
22117216	Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.	EMBO J	2011 Nov 25	Li S	doi: 10.1038/emboj.2011.427.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000502973	NAF1-203	1159	-	-	- (aa)	-	-
ENST00000509884	NAF1-206	718	-	-	- (aa)	-	-
ENST00000509232	NAF1-204	2329	-	-	- (aa)	-	-
ENST00000509434	NAF1-205	385	-	ENSP00000427518	42 (aa)	-	D6RIB3
ENST00000274054	NAF1-201	1907	XM_011532410	ENSP00000274054	494 (aa)	XP_011530712	Q96HR8
ENST00000422287	NAF1-202	1604	-	ENSP00000408963	389 (aa)	-	Q96HR8

Gene Model

Click here to download ENSG00000145414's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000145414	Platelet Function Tests	5.3500000E-006	-
ENSG00000145414	Platelet Function Tests	7.9700000E-006	-
ENSG00000145414	Platelet Function Tests	6.4200000E-006	-
ENSG00000145414	Platelet Function Tests	1.1389600E-005	-
ENSG00000145414	Platelet Function Tests	1.3258600E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000145414	rs2320614	4	163148970	C	Lung adenocarcinoma	28604730	[1.053889519-1.123891441]	1.0883278	EFO_0000571

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145414's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145414	NAF1	95	92.500	ENSAMEG00000014688	NAF1	100	78.000	Ailuropoda_melanoleuca
ENSG00000145414	NAF1	95	62.500	ENSAOCG00000003518	-	65	43.345	Amphiprion_ocellaris
ENSG00000145414	NAF1	95	62.500	ENSAPEG00000004453	-	64	43.345	Amphiprion_percula
ENSG00000145414	NAF1	95	82.500	ENSAPLG00000003210	NAF1	88	55.696	Anas_platyrhynchos
ENSG00000145414	NAF1	95	77.500	ENSACAG00000005081	-	100	68.182	Anolis_carolinensis
ENSG00000145414	NAF1	100	97.619	ENSANAG00000025253	NAF1	98	97.619	Aotus_nancymaae
ENSG00000145414	NAF1	95	57.500	ENSACLG00000017092	-	56	50.633	Astatotilapia_calliptera
ENSG00000145414	NAF1	95	92.500	ENSBTAG00000034700	NAF1	95	66.667	Bos_taurus
ENSG00000145414	NAF1	98	95.122	ENSCJAG00000012406	NAF1	98	95.122	Callithrix_jacchus
ENSG00000145414	NAF1	95	92.500	ENSCAFG00000029679	NAF1	100	81.879	Canis_familiaris
ENSG00000145414	NAF1	95	92.500	ENSCAFG00020005334	NAF1	93	73.922	Canis_lupus_dingo
ENSG00000145414	NAF1	95	92.500	ENSCHIG00000018430	NAF1	93	65.722	Capra_hircus
ENSG00000145414	NAF1	100	88.095	ENSTSYG00000005946	NAF1	98	88.095	Carlito_syrichta
ENSG00000145414	NAF1	95	85.000	ENSCAPG00000017838	NAF1	94	83.898	Cavia_aperea
ENSG00000145414	NAF1	95	87.500	ENSCPOG00000010331	NAF1	100	77.336	Cavia_porcellus
ENSG00000145414	NAF1	100	97.619	ENSCCAG00000030023	NAF1	100	97.619	Cebus_capucinus
ENSG00000145414	NAF1	100	100.000	ENSCATG00000022663	NAF1	100	100.000	Cercocebus_atys
ENSG00000145414	NAF1	95	82.500	ENSCLAG00000017209	NAF1	100	73.092	Chinchilla_lanigera
ENSG00000145414	NAF1	100	93.173	ENSCSAG00000003199	NAF1	100	93.775	Chlorocebus_sabaeus
ENSG00000145414	NAF1	88	97.297	ENSCHOG00000011393	NAF1	85	83.699	Choloepus_hoffmanni
ENSG00000145414	NAF1	95	80.000	ENSCPBG00000003379	NAF1	92	46.526	Chrysemys_picta_bellii
ENSG00000145414	NAF1	95	52.500	ENSCING00000023345	-	54	40.000	Ciona_intestinalis
ENSG00000145414	NAF1	100	52.381	ENSCSAVG00000002886	-	57	40.323	Ciona_savignyi
ENSG00000145414	NAF1	100	100.000	ENSCANG00000039151	NAF1	100	100.000	Colobus_angolensis_palliatus
ENSG00000145414	NAF1	95	92.500	ENSCGRG00001018484	Naf1	100	72.874	Cricetulus_griseus_chok1gshd
ENSG00000145414	NAF1	95	92.500	ENSCGRG00000001742	Naf1	95	76.504	Cricetulus_griseus_crigri
ENSG00000145414	NAF1	95	57.500	ENSCSEG00000010914	-	52	42.000	Cynoglossus_semilaevis
ENSG00000145414	NAF1	90	68.421	ENSCVAG00000003483	-	53	53.939	Cyprinodon_variegatus
ENSG00000145414	NAF1	95	77.500	ENSDARG00000057929	naf1	54	46.875	Danio_rerio
ENSG00000145414	NAF1	95	90.000	ENSDNOG00000031106	NAF1	100	79.317	Dasypus_novemcinctus
ENSG00000145414	NAF1	95	92.500	ENSDORG00000011327	Naf1	100	75.911	Dipodomys_ordii
ENSG00000145414	NAF1	70	56.215	ENSETEG00000002872	-	64	55.591	Echinops_telfairi
ENSG00000145414	NAF1	95	92.500	ENSEASG00005022201	NAF1	100	81.690	Equus_asinus_asinus
ENSG00000145414	NAF1	95	92.500	ENSECAG00000016738	NAF1	100	82.093	Equus_caballus
ENSG00000145414	NAF1	95	82.500	ENSEEUG00000008335	-	100	65.407	Erinaceus_europaeus
ENSG00000145414	NAF1	95	92.500	ENSFCAG00000031652	NAF1	100	78.400	Felis_catus
ENSG00000145414	NAF1	95	85.000	ENSFALG00000011110	NAF1	66	55.873	Ficedula_albicollis
ENSG00000145414	NAF1	86	94.444	ENSFDAG00000007497	NAF1	100	73.992	Fukomys_damarensis
ENSG00000145414	NAF1	95	82.500	ENSGALG00000009496	NAF1	71	56.508	Gallus_gallus
ENSG00000145414	NAF1	95	62.500	ENSGAFG00000017883	-	52	47.101	Gambusia_affinis
ENSG00000145414	NAF1	100	100.000	ENSGGOG00000000894	NAF1	100	100.000	Gorilla_gorilla
ENSG00000145414	NAF1	95	57.500	ENSHBUG00000002404	-	53	63.125	Haplochromis_burtoni
ENSG00000145414	NAF1	95	87.500	ENSHGLG00000014899	NAF1	100	77.822	Heterocephalus_glaber_female
ENSG00000145414	NAF1	95	87.500	ENSHGLG00100007507	NAF1	100	77.822	Heterocephalus_glaber_male
ENSG00000145414	NAF1	95	90.000	ENSSTOG00000023858	NAF1	100	81.964	Ictidomys_tridecemlineatus
ENSG00000145414	NAF1	95	85.000	ENSJJAG00000012147	-	94	80.000	Jaculus_jaculus
ENSG00000145414	NAF1	95	60.000	ENSKMAG00000005434	-	53	43.007	Kryptolebias_marmoratus
ENSG00000145414	NAF1	95	60.000	ENSLBEG00000020414	-	60	46.763	Labrus_bergylta
ENSG00000145414	NAF1	95	72.500	ENSLACG00000004353	-	57	52.128	Latimeria_chalumnae
ENSG00000145414	NAF1	95	75.000	ENSLOCG00000007989	NAF1	67	51.673	Lepisosteus_oculatus
ENSG00000145414	NAF1	95	87.500	ENSLAFG00000009193	-	100	70.231	Loxodonta_africana
ENSG00000145414	NAF1	100	100.000	ENSMFAG00000040952	NAF1	100	100.000	Macaca_fascicularis
ENSG00000145414	NAF1	100	100.000	ENSMMUG00000001717	NAF1	100	100.000	Macaca_mulatta
ENSG00000145414	NAF1	100	100.000	ENSMNEG00000032677	NAF1	100	100.000	Macaca_nemestrina
ENSG00000145414	NAF1	100	100.000	ENSMLEG00000035330	NAF1	100	100.000	Mandrillus_leucophaeus
ENSG00000145414	NAF1	95	62.500	ENSMAMG00000003269	-	77	46.388	Mastacembelus_armatus
ENSG00000145414	NAF1	95	57.500	ENSMZEG00005005830	-	58	50.633	Maylandia_zebra
ENSG00000145414	NAF1	95	82.500	ENSMGAG00000002133	NAF1	91	58.163	Meleagris_gallopavo
ENSG00000145414	NAF1	95	92.500	ENSMAUG00000013072	Naf1	100	64.170	Mesocricetus_auratus
ENSG00000145414	NAF1	100	90.476	ENSMICG00000038661	NAF1	98	90.476	Microcebus_murinus
ENSG00000145414	NAF1	95	90.000	ENSMOCG00000010360	Naf1	100	71.862	Microtus_ochrogaster
ENSG00000145414	NAF1	95	92.500	MGP_CAROLIEiJ_G0031097	Naf1	62	83.714	Mus_caroli
ENSG00000145414	NAF1	95	92.500	ENSMUSG00000014907	Naf1	59	81.250	Mus_musculus
ENSG00000145414	NAF1	95	90.000	MGP_PahariEiJ_G0021563	-	100	69.080	Mus_pahari
ENSG00000145414	NAF1	95	92.500	MGP_SPRETEiJ_G0032213	-	94	68.834	Mus_spretus
ENSG00000145414	NAF1	95	92.500	ENSMPUG00000001861	NAF1	100	78.486	Mustela_putorius_furo
ENSG00000145414	NAF1	95	75.610	ENSMLUG00000004627	NAF1	100	76.096	Myotis_lucifugus
ENSG00000145414	NAF1	95	90.000	ENSNGAG00000023833	Naf1	100	75.654	Nannospalax_galili
ENSG00000145414	NAF1	100	100.000	ENSNLEG00000006459	-	100	100.000	Nomascus_leucogenys
ENSG00000145414	NAF1	95	87.500	ENSODEG00000006528	NAF1	100	76.152	Octodon_degus
ENSG00000145414	NAF1	95	60.000	ENSONIG00000001826	-	74	46.693	Oreochromis_niloticus
ENSG00000145414	NAF1	95	90.000	ENSOANG00000014157	-	77	66.667	Ornithorhynchus_anatinus
ENSG00000145414	NAF1	95	90.000	ENSOCUG00000000485	NAF1	100	79.158	Oryctolagus_cuniculus
ENSG00000145414	NAF1	95	57.500	ENSORLG00000002191	-	60	45.548	Oryzias_latipes
ENSG00000145414	NAF1	95	57.500	ENSORLG00020013478	-	60	45.548	Oryzias_latipes_hni
ENSG00000145414	NAF1	95	57.500	ENSORLG00015012985	-	60	45.364	Oryzias_latipes_hsok
ENSG00000145414	NAF1	95	52.500	ENSOMEG00000021322	-	64	42.905	Oryzias_melastigma
ENSG00000145414	NAF1	95	92.500	ENSOARG00000013716	NAF1	100	68.938	Ovis_aries
ENSG00000145414	NAF1	100	100.000	ENSPPAG00000034674	NAF1	100	100.000	Pan_paniscus
ENSG00000145414	NAF1	95	92.500	ENSPPRG00000003688	NAF1	100	78.600	Panthera_pardus
ENSG00000145414	NAF1	95	92.500	ENSPTIG00000017246	NAF1	100	78.600	Panthera_tigris_altaica
ENSG00000145414	NAF1	100	100.000	ENSPTRG00000016560	NAF1	100	100.000	Pan_troglodytes
ENSG00000145414	NAF1	100	100.000	ENSPANG00000015574	NAF1	100	100.000	Papio_anubis
ENSG00000145414	NAF1	95	85.000	ENSPSIG00000006545	NAF1	80	58.900	Pelodiscus_sinensis
ENSG00000145414	NAF1	95	92.500	ENSPEMG00000014321	Naf1	91	81.948	Peromyscus_maniculatus_bairdii
ENSG00000145414	NAF1	95	60.000	ENSPFOG00000010705	-	63	50.216	Poecilia_formosa
ENSG00000145414	NAF1	95	95.000	ENSPPYG00000029771	-	100	98.973	Pongo_abelii
ENSG00000145414	NAF1	95	87.500	ENSPVAG00000016222	NAF1	100	79.518	Pteropus_vampyrus
ENSG00000145414	NAF1	98	56.098	ENSPNYG00000021456	-	53	41.667	Pundamilia_nyererei
ENSG00000145414	NAF1	95	92.500	ENSRNOG00000026403	Naf1	98	71.659	Rattus_norvegicus
ENSG00000145414	NAF1	100	100.000	ENSRBIG00000030027	NAF1	100	100.000	Rhinopithecus_bieti
ENSG00000145414	NAF1	100	100.000	ENSRROG00000040912	NAF1	100	100.000	Rhinopithecus_roxellana
ENSG00000145414	NAF1	100	95.238	ENSSBOG00000002085	NAF1	100	95.238	Saimiri_boliviensis_boliviensis
ENSG00000145414	NAF1	95	72.500	ENSSFOG00015014207	naf1	59	42.320	Scleropages_formosus
ENSG00000145414	NAF1	95	62.500	ENSSMAG00000015529	-	66	42.321	Scophthalmus_maximus
ENSG00000145414	NAF1	95	62.500	ENSSDUG00000005987	-	63	46.316	Seriola_dumerili
ENSG00000145414	NAF1	88	66.667	ENSSARG00000006627	-	99	65.507	Sorex_araneus
ENSG00000145414	NAF1	95	77.500	ENSSPUG00000004087	NAF1	98	58.209	Sphenodon_punctatus
ENSG00000145414	NAF1	95	92.500	ENSSSCG00000008887	NAF1	100	69.478	Sus_scrofa
ENSG00000145414	NAF1	95	85.000	ENSTGUG00000005798	NAF1	100	69.730	Taeniopygia_guttata
ENSG00000145414	NAF1	95	60.000	ENSTRUG00000011908	-	61	48.684	Takifugu_rubripes
ENSG00000145414	NAF1	95	60.000	ENSTNIG00000001660	-	100	60.440	Tetraodon_nigroviridis
ENSG00000145414	NAF1	95	92.500	ENSTTRG00000010106	NAF1	100	69.076	Tursiops_truncatus
ENSG00000145414	NAF1	95	92.500	ENSUAMG00000017043	NAF1	100	79.400	Ursus_americanus
ENSG00000145414	NAF1	95	92.500	ENSUMAG00000019748	NAF1	100	79.200	Ursus_maritimus
ENSG00000145414	NAF1	95	90.000	ENSVPAG00000007182	-	91	90.870	Vicugna_pacos
ENSG00000145414	NAF1	95	92.500	ENSVVUG00000022303	NAF1	86	85.580	Vulpes_vulpes
ENSG00000145414	NAF1	95	62.500	ENSXCOG00000013058	-	92	39.815	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000454	snoRNA guided rRNA pseudouridine synthesis	-	ISS	Process
GO:0000493	box H/ACA snoRNP assembly	21873635.	IBA	Process
GO:0000493	box H/ACA snoRNP assembly	-	ISS	Process
GO:0000493	box H/ACA snoRNP assembly	27510903.	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	16618814.	IDA	Function
GO:0003723	RNA binding	18082603.22527283.	IPI	Function
GO:0005515	protein binding	16601202.16618814.19179534.20010695.25416956.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005732	small nucleolar ribonucleoprotein complex	21873635.	IBA	Component
GO:0005732	small nucleolar ribonucleoprotein complex	16601202.17135485.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0032212	positive regulation of telomere maintenance via telomerase	22527283.	TAS	Process
GO:0042254	ribosome biogenesis	21873635.	IBA	Process
GO:0042254	ribosome biogenesis	16618814.	IDA	Process
GO:0043489	RNA stabilization	-	ISS	Process
GO:0051973	positive regulation of telomerase activity	27510903.	IMP	Process
GO:0070034	telomerase RNA binding	18082603.22527283.	IPI	Function
GO:0090669	telomerase RNA stabilization	27510903.	IMP	Process
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	27510903.	IMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1905323	telomerase holoenzyme complex assembly	27510903.	IMP	Process