EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145833 (Gene tree)
Gene ID: 9879
Gene Symbol: DDX46
Alias: KIAA0801|FLJ25329|PRPF5|Prp5
Full Name: DEAD-box helicase 46
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 96,400 bases
Position: chr5:134,758,734-134,855,133
Accession: 18681
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000346236	DEAD	PF00270.29	2.6e-50	1	1
ENSP00000416534	DEAD	PF00270.29	2.6e-50	1	1
ENSP00000487025	DEAD	PF00270.29	1.7e-33	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14610285	ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.	Proc Natl Acad Sci U S A	2003 Nov 25	Perriman R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505592	DDX46-204	555	-	-	- (aa)	-	-
ENST00000628477	DDX46-212	1584	XM_011543758	ENSP00000487025	471 (aa)	XP_011542060	D6RJA6
ENST00000506332	DDX46-205	1589	-	-	- (aa)	-	-
ENST00000452510	DDX46-202	5689	-	ENSP00000416534	1032 (aa)	-	A0A0C4DG89
ENST00000507392	DDX46-207	3565	-	ENSP00000427290	471 (aa)	-	D6RJA6
ENST00000507053	DDX46-206	530	-	ENSP00000425073	70 (aa)	-	H0Y9U3
ENST00000509255	DDX46-209	398	-	-	- (aa)	-	-
ENST00000513987	DDX46-211	543	-	-	- (aa)	-	-
ENST00000513592	DDX46-210	571	-	ENSP00000426767	29 (aa)	-	H0YAD5
ENST00000503946	DDX46-203	4078	-	-	- (aa)	-	-
ENST00000509178	DDX46-208	766	-	-	- (aa)	-	-
ENST00000354283	DDX46-201	3821	-	ENSP00000346236	1031 (aa)	-	Q7L014

Gene Model

Click here to download ENSG00000145833's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145833's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145833	DDX46	99	97.101	ENSAPOG00000000193	ddx46	90	85.506	Acanthochromis_polyacanthus
ENSG00000145833	DDX46	100	99.709	ENSAMEG00000017873	DDX46	100	99.709	Ailuropoda_melanoleuca
ENSG00000145833	DDX46	99	97.101	ENSACIG00000013235	ddx46	90	84.333	Amphilophus_citrinellus
ENSG00000145833	DDX46	99	97.101	ENSAOCG00000007758	ddx46	94	78.206	Amphiprion_ocellaris
ENSG00000145833	DDX46	99	97.101	ENSAPEG00000022648	ddx46	94	78.311	Amphiprion_percula
ENSG00000145833	DDX46	99	97.101	ENSATEG00000012998	ddx46	91	81.779	Anabas_testudineus
ENSG00000145833	DDX46	99	100.000	ENSAPLG00000013208	DDX46	89	92.441	Anas_platyrhynchos
ENSG00000145833	DDX46	99	100.000	ENSACAG00000001437	DDX46	100	92.281	Anolis_carolinensis
ENSG00000145833	DDX46	100	100.000	ENSANAG00000032116	DDX46	100	100.000	Aotus_nancymaae
ENSG00000145833	DDX46	99	97.101	ENSACLG00000014804	ddx46	92	85.520	Astatotilapia_calliptera
ENSG00000145833	DDX46	99	98.551	ENSAMXG00000008413	ddx46	89	81.878	Astyanax_mexicanus
ENSG00000145833	DDX46	100	99.709	ENSBTAG00000021520	DDX46	100	99.709	Bos_taurus
ENSG00000145833	DDX46	100	99.903	ENSCJAG00000005697	DDX46	100	99.903	Callithrix_jacchus
ENSG00000145833	DDX46	100	99.806	ENSCAFG00000001048	DDX46	100	99.806	Canis_familiaris
ENSG00000145833	DDX46	100	99.806	ENSCAFG00020006070	DDX46	100	99.806	Canis_lupus_dingo
ENSG00000145833	DDX46	100	99.806	ENSCHIG00000026009	DDX46	100	99.806	Capra_hircus
ENSG00000145833	DDX46	100	100.000	ENSTSYG00000003177	DDX46	100	100.000	Carlito_syrichta
ENSG00000145833	DDX46	99	93.590	ENSCAPG00000010776	-	96	93.590	Cavia_aperea
ENSG00000145833	DDX46	100	99.709	ENSCPOG00000011362	DDX46	100	99.709	Cavia_porcellus
ENSG00000145833	DDX46	100	99.903	ENSCCAG00000026721	DDX46	100	99.903	Cebus_capucinus
ENSG00000145833	DDX46	100	100.000	ENSCATG00000040891	DDX46	100	100.000	Cercocebus_atys
ENSG00000145833	DDX46	100	99.903	ENSCLAG00000014581	DDX46	100	99.903	Chinchilla_lanigera
ENSG00000145833	DDX46	99	63.768	ENSCHOG00000005683	DDX46	80	78.091	Choloepus_hoffmanni
ENSG00000145833	DDX46	99	100.000	ENSCPBG00000008261	DDX46	96	93.303	Chrysemys_picta_bellii
ENSG00000145833	DDX46	99	75.000	ENSCING00000006813	-	100	73.307	Ciona_intestinalis
ENSG00000145833	DDX46	99	73.913	ENSCSAVG00000002353	-	97	77.083	Ciona_savignyi
ENSG00000145833	DDX46	60	99.692	ENSCANG00000014766	DDX46	100	99.692	Colobus_angolensis_palliatus
ENSG00000145833	DDX46	99	100.000	ENSCGRG00001024140	Ddx46	99	98.529	Cricetulus_griseus_chok1gshd
ENSG00000145833	DDX46	99	100.000	ENSCGRG00000005152	Ddx46	100	99.025	Cricetulus_griseus_crigri
ENSG00000145833	DDX46	99	97.101	ENSCSEG00000016886	ddx46	94	81.393	Cynoglossus_semilaevis
ENSG00000145833	DDX46	99	95.652	ENSCVAG00000022900	ddx46	93	83.778	Cyprinodon_variegatus
ENSG00000145833	DDX46	99	98.551	ENSDARG00000099458	ddx46	92	82.590	Danio_rerio
ENSG00000145833	DDX46	100	99.225	ENSDNOG00000011448	DDX46	100	99.225	Dasypus_novemcinctus
ENSG00000145833	DDX46	99	100.000	ENSDORG00000005447	Ddx46	89	91.135	Dipodomys_ordii
ENSG00000145833	DDX46	99	100.000	ENSETEG00000018455	DDX46	79	88.761	Echinops_telfairi
ENSG00000145833	DDX46	57	73.063	ENSEBUG00000013320	ddx46	65	73.063	Eptatretus_burgeri
ENSG00000145833	DDX46	100	99.788	ENSEASG00005020329	DDX46	100	99.788	Equus_asinus_asinus
ENSG00000145833	DDX46	100	99.806	ENSECAG00000018217	DDX46	100	99.806	Equus_caballus
ENSG00000145833	DDX46	60	100.000	ENSEEUG00000003602	-	67	75.217	Erinaceus_europaeus
ENSG00000145833	DDX46	99	97.101	ENSELUG00000000817	ddx46	93	83.721	Esox_lucius
ENSG00000145833	DDX46	100	99.612	ENSFCAG00000026229	DDX46	100	99.612	Felis_catus
ENSG00000145833	DDX46	99	100.000	ENSFALG00000007947	DDX46	100	94.205	Ficedula_albicollis
ENSG00000145833	DDX46	100	99.709	ENSFDAG00000021262	DDX46	100	99.709	Fukomys_damarensis
ENSG00000145833	DDX46	99	95.652	ENSFHEG00000020055	ddx46	93	82.743	Fundulus_heteroclitus
ENSG00000145833	DDX46	99	97.101	ENSGMOG00000007990	ddx46	91	82.811	Gadus_morhua
ENSG00000145833	DDX46	99	100.000	ENSGALG00000006404	DDX46	90	92.324	Gallus_gallus
ENSG00000145833	DDX46	99	95.652	ENSGAFG00000007153	ddx46	91	78.049	Gambusia_affinis
ENSG00000145833	DDX46	99	95.652	ENSGACG00000000166	ddx46	91	82.397	Gasterosteus_aculeatus
ENSG00000145833	DDX46	99	100.000	ENSGAGG00000014910	DDX46	90	92.605	Gopherus_agassizii
ENSG00000145833	DDX46	100	100.000	ENSGGOG00000013843	DDX46	100	100.000	Gorilla_gorilla
ENSG00000145833	DDX46	99	97.101	ENSHBUG00000021074	ddx46	92	85.714	Haplochromis_burtoni
ENSG00000145833	DDX46	100	99.612	ENSHGLG00000010455	DDX46	100	99.612	Heterocephalus_glaber_female
ENSG00000145833	DDX46	100	99.612	ENSHGLG00100016515	DDX46	100	99.612	Heterocephalus_glaber_male
ENSG00000145833	DDX46	79	77.089	ENSHCOG00000010877	ddx46	74	75.733	Hippocampus_comes
ENSG00000145833	DDX46	99	98.551	ENSIPUG00000002564	ddx46	90	82.791	Ictalurus_punctatus
ENSG00000145833	DDX46	67	99.363	ENSSTOG00000025564	DDX46	75	100.000	Ictidomys_tridecemlineatus
ENSG00000145833	DDX46	100	99.224	ENSJJAG00000013906	Ddx46	100	99.224	Jaculus_jaculus
ENSG00000145833	DDX46	99	95.652	ENSKMAG00000019510	ddx46	91	79.569	Kryptolebias_marmoratus
ENSG00000145833	DDX46	99	97.101	ENSLBEG00000027425	ddx46	94	81.120	Labrus_bergylta
ENSG00000145833	DDX46	99	100.000	ENSLACG00000007965	DDX46	90	90.456	Latimeria_chalumnae
ENSG00000145833	DDX46	99	98.551	ENSLOCG00000010169	ddx46	90	86.120	Lepisosteus_oculatus
ENSG00000145833	DDX46	100	99.419	ENSLAFG00000010465	DDX46	100	99.419	Loxodonta_africana
ENSG00000145833	DDX46	100	100.000	ENSMFAG00000044528	DDX46	100	100.000	Macaca_fascicularis
ENSG00000145833	DDX46	100	100.000	ENSMMUG00000012463	DDX46	100	100.000	Macaca_mulatta
ENSG00000145833	DDX46	100	100.000	ENSMNEG00000029903	DDX46	100	100.000	Macaca_nemestrina
ENSG00000145833	DDX46	100	100.000	ENSMLEG00000033516	DDX46	100	100.000	Mandrillus_leucophaeus
ENSG00000145833	DDX46	99	97.101	ENSMAMG00000021755	ddx46	91	83.965	Mastacembelus_armatus
ENSG00000145833	DDX46	99	97.101	ENSMZEG00005008989	ddx46	92	85.520	Maylandia_zebra
ENSG00000145833	DDX46	99	100.000	ENSMGAG00000008226	DDX46	90	93.615	Meleagris_gallopavo
ENSG00000145833	DDX46	99	100.000	ENSMAUG00000003267	Ddx46	100	98.826	Mesocricetus_auratus
ENSG00000145833	DDX46	99	100.000	ENSMICG00000028626	DDX46	100	94.956	Microcebus_murinus
ENSG00000145833	DDX46	99	100.000	ENSMOCG00000012141	Ddx46	99	91.240	Microtus_ochrogaster
ENSG00000145833	DDX46	99	95.652	ENSMMOG00000013470	ddx46	91	85.504	Mola_mola
ENSG00000145833	DDX46	99	100.000	ENSMODG00000014331	DDX46	90	96.544	Monodelphis_domestica
ENSG00000145833	DDX46	99	97.101	ENSMALG00000016796	ddx46	92	83.554	Monopterus_albus
ENSG00000145833	DDX46	99	100.000	MGP_CAROLIEiJ_G0018573	Ddx46	100	98.837	Mus_caroli
ENSG00000145833	DDX46	99	100.000	ENSMUSG00000021500	Ddx46	100	98.934	Mus_musculus
ENSG00000145833	DDX46	99	100.000	MGP_PahariEiJ_G0019638	Ddx46	100	98.739	Mus_pahari
ENSG00000145833	DDX46	99	100.000	MGP_SPRETEiJ_G0019453	Ddx46	100	98.934	Mus_spretus
ENSG00000145833	DDX46	100	99.709	ENSMPUG00000010045	DDX46	100	99.709	Mustela_putorius_furo
ENSG00000145833	DDX46	100	99.516	ENSMLUG00000012607	DDX46	100	99.516	Myotis_lucifugus
ENSG00000145833	DDX46	99	100.000	ENSNGAG00000020157	Ddx46	97	99.378	Nannospalax_galili
ENSG00000145833	DDX46	99	97.101	ENSNBRG00000008155	ddx46	92	85.601	Neolamprologus_brichardi
ENSG00000145833	DDX46	100	99.903	ENSNLEG00000008167	DDX46	100	99.903	Nomascus_leucogenys
ENSG00000145833	DDX46	99	100.000	ENSMEUG00000014890	-	60	98.630	Notamacropus_eugenii
ENSG00000145833	DDX46	99	100.000	ENSOPRG00000006646	DDX46	100	98.157	Ochotona_princeps
ENSG00000145833	DDX46	99	100.000	ENSODEG00000010023	DDX46	100	99.708	Octodon_degus
ENSG00000145833	DDX46	99	97.101	ENSONIG00000017282	ddx46	91	82.885	Oreochromis_niloticus
ENSG00000145833	DDX46	99	100.000	ENSOANG00000001842	DDX46	96	93.838	Ornithorhynchus_anatinus
ENSG00000145833	DDX46	99	100.000	ENSOCUG00000012206	DDX46	100	98.935	Oryctolagus_cuniculus
ENSG00000145833	DDX46	99	97.101	ENSORLG00000000903	ddx46	98	80.957	Oryzias_latipes
ENSG00000145833	DDX46	99	97.101	ENSORLG00020022093	ddx46	98	80.957	Oryzias_latipes_hni
ENSG00000145833	DDX46	99	97.101	ENSORLG00015007282	ddx46	98	80.957	Oryzias_latipes_hsok
ENSG00000145833	DDX46	99	97.101	ENSOMEG00000003338	ddx46	94	83.241	Oryzias_melastigma
ENSG00000145833	DDX46	99	100.000	ENSOGAG00000034921	-	100	97.481	Otolemur_garnettii
ENSG00000145833	DDX46	99	100.000	ENSOGAG00000011690	-	99	90.185	Otolemur_garnettii
ENSG00000145833	DDX46	100	99.710	ENSOARG00000014348	DDX46	100	99.710	Ovis_aries
ENSG00000145833	DDX46	100	100.000	ENSPPAG00000037804	DDX46	100	100.000	Pan_paniscus
ENSG00000145833	DDX46	100	99.612	ENSPPRG00000010743	DDX46	100	99.612	Panthera_pardus
ENSG00000145833	DDX46	100	99.321	ENSPTIG00000012382	DDX46	99	99.321	Panthera_tigris_altaica
ENSG00000145833	DDX46	100	100.000	ENSPTRG00000017248	DDX46	100	100.000	Pan_troglodytes
ENSG00000145833	DDX46	100	99.363	ENSPANG00000025084	DDX46	99	99.363	Papio_anubis
ENSG00000145833	DDX46	99	98.551	ENSPKIG00000010351	ddx46	90	85.111	Paramormyrops_kingsleyae
ENSG00000145833	DDX46	99	100.000	ENSPSIG00000004522	DDX46	90	93.118	Pelodiscus_sinensis
ENSG00000145833	DDX46	78	81.301	ENSPMGG00000019800	ddx46	83	81.694	Periophthalmus_magnuspinnatus
ENSG00000145833	DDX46	99	100.000	ENSPEMG00000013593	Ddx46	100	98.934	Peromyscus_maniculatus_bairdii
ENSG00000145833	DDX46	99	84.058	ENSPMAG00000007922	ddx46	86	75.444	Petromyzon_marinus
ENSG00000145833	DDX46	99	100.000	ENSPCIG00000009215	DDX46	100	97.709	Phascolarctos_cinereus
ENSG00000145833	DDX46	99	95.652	ENSPFOG00000004966	ddx46	91	78.732	Poecilia_formosa
ENSG00000145833	DDX46	99	95.652	ENSPLAG00000023562	ddx46	90	83.278	Poecilia_latipinna
ENSG00000145833	DDX46	99	95.652	ENSPMEG00000013401	ddx46	95	80.717	Poecilia_mexicana
ENSG00000145833	DDX46	99	95.652	ENSPREG00000005444	ddx46	87	81.517	Poecilia_reticulata
ENSG00000145833	DDX46	99	100.000	ENSPPYG00000015792	DDX46	69	96.047	Pongo_abelii
ENSG00000145833	DDX46	99	100.000	ENSPCAG00000012364	DDX46	86	98.658	Procavia_capensis
ENSG00000145833	DDX46	77	100.000	ENSPCOG00000018969	DDX46	89	98.039	Propithecus_coquereli
ENSG00000145833	DDX46	100	98.351	ENSPVAG00000015655	DDX46	100	98.351	Pteropus_vampyrus
ENSG00000145833	DDX46	99	81.429	ENSPNYG00000012327	ddx46	92	84.424	Pundamilia_nyererei
ENSG00000145833	DDX46	74	96.154	ENSPNAG00000010806	ddx46	86	84.910	Pygocentrus_nattereri
ENSG00000145833	DDX46	99	100.000	ENSRNOG00000021637	Ddx46	100	98.740	Rattus_norvegicus
ENSG00000145833	DDX46	99	100.000	ENSRBIG00000041150	DDX46	69	95.988	Rhinopithecus_bieti
ENSG00000145833	DDX46	100	100.000	ENSRROG00000029467	DDX46	100	100.000	Rhinopithecus_roxellana
ENSG00000145833	DDX46	99	100.000	ENSSBOG00000027666	DDX46	99	74.491	Saimiri_boliviensis_boliviensis
ENSG00000145833	DDX46	99	100.000	ENSSHAG00000014408	DDX46	80	96.544	Sarcophilus_harrisii
ENSG00000145833	DDX46	99	97.101	ENSSFOG00015020093	ddx46	93	84.372	Scleropages_formosus
ENSG00000145833	DDX46	99	97.101	ENSSMAG00000007229	ddx46	89	83.574	Scophthalmus_maximus
ENSG00000145833	DDX46	99	97.101	ENSSDUG00000020991	ddx46	92	85.601	Seriola_dumerili
ENSG00000145833	DDX46	99	97.101	ENSSLDG00000016854	ddx46	92	85.601	Seriola_lalandi_dorsalis
ENSG00000145833	DDX46	99	100.000	ENSSARG00000011073	DDX46	100	92.195	Sorex_araneus
ENSG00000145833	DDX46	99	85.507	ENSSPUG00000008985	DDX46	100	93.203	Sphenodon_punctatus
ENSG00000145833	DDX46	99	97.101	ENSSPAG00000017946	ddx46	95	80.083	Stegastes_partitus
ENSG00000145833	DDX46	100	99.612	ENSSSCG00000026644	DDX46	100	99.612	Sus_scrofa
ENSG00000145833	DDX46	99	100.000	ENSTGUG00000001260	-	90	93.871	Taeniopygia_guttata
ENSG00000145833	DDX46	99	95.652	ENSTRUG00000008878	ddx46	91	78.848	Takifugu_rubripes
ENSG00000145833	DDX46	99	95.652	ENSTNIG00000016100	ddx46	87	85.281	Tetraodon_nigroviridis
ENSG00000145833	DDX46	99	100.000	ENSTBEG00000002799	DDX46	81	100.000	Tupaia_belangeri
ENSG00000145833	DDX46	99	100.000	ENSTTRG00000016869	DDX46	100	92.823	Tursiops_truncatus
ENSG00000145833	DDX46	100	99.788	ENSUAMG00000017616	-	100	99.788	Ursus_americanus
ENSG00000145833	DDX46	100	99.788	ENSUMAG00000017446	DDX46	100	99.788	Ursus_maritimus
ENSG00000145833	DDX46	99	100.000	ENSVPAG00000001591	DDX46	100	96.896	Vicugna_pacos
ENSG00000145833	DDX46	100	99.806	ENSVVUG00000017549	DDX46	100	99.806	Vulpes_vulpes
ENSG00000145833	DDX46	99	97.101	ENSXETG00000010405	ddx46	90	87.513	Xenopus_tropicalis
ENSG00000145833	DDX46	99	95.652	ENSXCOG00000004162	ddx46	95	79.698	Xiphophorus_couchianus
ENSG00000145833	DDX46	99	95.652	ENSXMAG00000008312	ddx46	95	84.035	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001650	fibrillar center	-	IDA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0015030	Cajal body	-	IEA	Component
GO:0016020	membrane	-	IEA	Component
GO:0016607	nuclear speck	-	IDA	Component