EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145982 (Gene tree)
Gene ID: 10667
Gene Symbol: FARS2
Alias: dJ236A3.1|FARS1
Full Name: phenylalanyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 568,175 bases
Position: chr6:5,261,018-5,829,192
Accession: 21062
RBP type: canonical RBP
Summary: This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000274680	tRNA-synt_2d	PF01409.20	3.4e-48	1	2
ENSP00000274680	tRNA-synt_2d	PF01409.20	3.4e-48	2	2
ENSP00000316335	tRNA-synt_2d	PF01409.20	3.4e-48	1	2
ENSP00000316335	tRNA-synt_2d	PF01409.20	3.4e-48	2	2
ENSP00000392525	tRNA-synt_2d	PF01409.20	1.5e-14	1	1
ENSP00000274680	FDX-ACB	PF03147.14	3.3e-21	1	1
ENSP00000316335	FDX-ACB	PF03147.14	3.3e-21	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19737557	Large-scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase.	FEBS Lett	2009 Oct 6	Yadavalli SS	doi: 10.1016/j.febslet.2009.09.008

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000648580	FARS2-205	3884	-	ENSP00000497889	433 (aa)	-	-
ENST00000274680	FARS2-201	1663	XM_005248812	ENSP00000274680	451 (aa)	XP_005248869	O95363
ENST00000445533	FARS2-203	434	XM_006714966	ENSP00000392525	101 (aa)	XP_006715029	Q5JRF7
ENST00000602691	FARS2-204	562	-	ENSP00000473394	47 (aa)	-	R4GMX6
ENST00000324331	FARS2-202	1692	-	ENSP00000316335	451 (aa)	-	O95363

Gene Model

Click here to download ENSG00000145982's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000145982	Heart Failure	1.1199371E-004	-
ENSG00000145982	Alcoholism	6.57E-05	-
ENSG00000145982	Fibrinogen	5.8160000E-005	-
ENSG00000145982	Fibrinogen	3.1330000E-005	-
ENSG00000145982	Glomerular Filtration Rate	9.5877141E-005	-
ENSG00000145982	Platelet Function Tests	3.0400000E-006	-
ENSG00000145982	Platelet Function Tests	3.6935700E-005	-
ENSG00000145982	Cholesterol	4.6740000E-005	-
ENSG00000145982	Creatine Kinase	4.2320000E-005	-
ENSG00000145982	Lactate Dehydrogenases	4.8190000E-005	-
ENSG00000145982	Selenium	3.6470000E-006	-
ENSG00000145982	Obesity	5E-7	23563609
ENSG00000145982	Body Height	3E-6	21998595
ENSG00000145982	Electrocardiography	4E-7	27958378
ENSG00000145982	Sulfonylurea Compounds	4E-7	27958378
ENSG00000145982	Glaucoma, Open-Angle	9E-7	27001270

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000145982	rs200214	6	5478560	?	JT interval (sulfonylurea treatment interaction)	27958378	[2.23-4.97] ms decrease	3.6	EFO_0007885\|EFO_0007922
ENSG00000145982	rs9328321	6	5600205	A	Obesity (early onset extreme)	23563609	[1.13-1.32]	1.22	EFO_0001073
ENSG00000145982	rs433295	6	5475252	?	Glaucoma (primary open-angle)	27001270			EFO_0004190
ENSG00000145982	rs6906241	6	5262479	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145982's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145982	FARS2	99	66.337	ENSAPOG00000014855	fars2	88	70.398	Acanthochromis_polyacanthus
ENSG00000145982	FARS2	99	91.000	ENSAMEG00000017443	FARS2	100	89.703	Ailuropoda_melanoleuca
ENSG00000145982	FARS2	95	70.103	ENSACIG00000020060	fars2	94	61.792	Amphilophus_citrinellus
ENSG00000145982	FARS2	99	65.347	ENSAOCG00000016927	fars2	68	70.980	Amphiprion_ocellaris
ENSG00000145982	FARS2	99	66.337	ENSAPEG00000002964	fars2	94	70.647	Amphiprion_percula
ENSG00000145982	FARS2	99	72.277	ENSATEG00000016534	fars2	80	66.408	Anabas_testudineus
ENSG00000145982	FARS2	52	75.472	ENSAPLG00000005643	FARS2	90	71.861	Anas_platyrhynchos
ENSG00000145982	FARS2	99	77.000	ENSACAG00000029677	FARS2	92	72.902	Anolis_carolinensis
ENSG00000145982	FARS2	96	94.845	ENSANAG00000019047	FARS2	100	79.823	Aotus_nancymaae
ENSG00000145982	FARS2	99	70.297	ENSACLG00000018607	fars2	91	69.524	Astatotilapia_calliptera
ENSG00000145982	FARS2	99	69.307	ENSAMXG00000019001	fars2	88	72.549	Astyanax_mexicanus
ENSG00000145982	FARS2	99	91.000	ENSBTAG00000018072	FARS2	100	85.144	Bos_taurus
ENSG00000145982	FARS2	100	50.467	WBGene00013361	fars-2	99	49.180	Caenorhabditis_elegans
ENSG00000145982	FARS2	100	93.348	ENSCJAG00000021369	FARS2	100	93.348	Callithrix_jacchus
ENSG00000145982	FARS2	100	89.823	ENSCAFG00000009483	FARS2	100	89.823	Canis_familiaris
ENSG00000145982	FARS2	100	89.602	ENSCAFG00020013360	FARS2	100	89.602	Canis_lupus_dingo
ENSG00000145982	FARS2	99	92.000	ENSCHIG00000017678	FARS2	100	84.035	Capra_hircus
ENSG00000145982	FARS2	100	80.488	ENSCAPG00000008055	FARS2	100	80.488	Cavia_aperea
ENSG00000145982	FARS2	100	86.696	ENSCPOG00000003994	FARS2	100	86.696	Cavia_porcellus
ENSG00000145982	FARS2	100	80.851	ENSCCAG00000021067	FARS2	97	91.829	Cebus_capucinus
ENSG00000145982	FARS2	100	96.452	ENSCATG00000038588	FARS2	100	96.452	Cercocebus_atys
ENSG00000145982	FARS2	99	90.000	ENSCLAG00000017316	FARS2	100	86.475	Chinchilla_lanigera
ENSG00000145982	FARS2	99	93.000	ENSCSAG00000007344	FARS2	96	96.069	Chlorocebus_sabaeus
ENSG00000145982	FARS2	99	85.000	ENSCPBG00000008751	FARS2	92	70.574	Chrysemys_picta_bellii
ENSG00000145982	FARS2	89	51.111	ENSCING00000012827	-	97	51.957	Ciona_intestinalis
ENSG00000145982	FARS2	89	55.556	ENSCSAVG00000011625	-	94	50.714	Ciona_savignyi
ENSG00000145982	FARS2	100	96.452	ENSCANG00000042851	FARS2	100	96.452	Colobus_angolensis_palliatus
ENSG00000145982	FARS2	99	87.000	ENSCGRG00001022626	Fars2	99	85.588	Cricetulus_griseus_chok1gshd
ENSG00000145982	FARS2	99	87.000	ENSCGRG00000007344	Fars2	99	85.588	Cricetulus_griseus_crigri
ENSG00000145982	FARS2	99	71.287	ENSCSEG00000018234	fars2	89	69.512	Cynoglossus_semilaevis
ENSG00000145982	FARS2	99	69.307	ENSCVAG00000008305	fars2	87	72.829	Cyprinodon_variegatus
ENSG00000145982	FARS2	99	72.277	ENSDARG00000091247	fars2	90	71.891	Danio_rerio
ENSG00000145982	FARS2	99	90.000	ENSDNOG00000018118	FARS2	100	84.035	Dasypus_novemcinctus
ENSG00000145982	FARS2	99	92.000	ENSDORG00000014796	Fars2	100	88.914	Dipodomys_ordii
ENSG00000145982	FARS2	94	50.111	FBgn0275436	PheRS-m	98	50.111	Drosophila_melanogaster
ENSG00000145982	FARS2	99	62.054	ENSETEG00000016493	FARS2	100	62.054	Echinops_telfairi
ENSG00000145982	FARS2	99	51.961	ENSEBUG00000007120	fars2	76	56.790	Eptatretus_burgeri
ENSG00000145982	FARS2	99	94.000	ENSEASG00005012111	FARS2	100	91.626	Equus_asinus_asinus
ENSG00000145982	FARS2	99	93.000	ENSECAG00000000279	FARS2	100	91.796	Equus_caballus
ENSG00000145982	FARS2	100	64.523	ENSEEUG00000007412	FARS2	100	64.523	Erinaceus_europaeus
ENSG00000145982	FARS2	100	70.588	ENSELUG00000004874	fars2	87	72.277	Esox_lucius
ENSG00000145982	FARS2	99	92.000	ENSFCAG00000014441	FARS2	100	88.470	Felis_catus
ENSG00000145982	FARS2	99	81.000	ENSFALG00000013171	FARS2	92	76.372	Ficedula_albicollis
ENSG00000145982	FARS2	99	89.000	ENSFDAG00000018935	FARS2	100	86.696	Fukomys_damarensis
ENSG00000145982	FARS2	99	70.297	ENSFHEG00000011155	fars2	88	64.320	Fundulus_heteroclitus
ENSG00000145982	FARS2	99	69.307	ENSGMOG00000015750	fars2	88	68.317	Gadus_morhua
ENSG00000145982	FARS2	99	82.000	ENSGALG00000042481	FARS2	92	76.029	Gallus_gallus
ENSG00000145982	FARS2	95	67.010	ENSGAFG00000002233	fars2	88	64.356	Gambusia_affinis
ENSG00000145982	FARS2	96	69.388	ENSGACG00000002036	fars2	87	67.822	Gasterosteus_aculeatus
ENSG00000145982	FARS2	99	83.000	ENSGAGG00000012914	FARS2	91	78.469	Gopherus_agassizii
ENSG00000145982	FARS2	100	99.113	ENSGGOG00000011842	FARS2	100	99.113	Gorilla_gorilla
ENSG00000145982	FARS2	99	70.297	ENSHBUG00000003439	fars2	91	69.762	Haplochromis_burtoni
ENSG00000145982	FARS2	100	87.140	ENSHGLG00000004389	FARS2	100	87.140	Heterocephalus_glaber_female
ENSG00000145982	FARS2	100	87.140	ENSHGLG00100010315	FARS2	100	87.140	Heterocephalus_glaber_male
ENSG00000145982	FARS2	100	63.107	ENSHCOG00000005861	fars2	93	65.025	Hippocampus_comes
ENSG00000145982	FARS2	99	72.277	ENSIPUG00000000375	fars2	88	73.383	Ictalurus_punctatus
ENSG00000145982	FARS2	100	88.470	ENSSTOG00000012156	FARS2	99	88.470	Ictidomys_tridecemlineatus
ENSG00000145982	FARS2	99	92.000	ENSJJAG00000002799	Fars2	100	84.257	Jaculus_jaculus
ENSG00000145982	FARS2	97	69.697	ENSKMAG00000002336	fars2	60	73.123	Kryptolebias_marmoratus
ENSG00000145982	FARS2	71	79.167	ENSLBEG00000019049	fars2	100	69.163	Labrus_bergylta
ENSG00000145982	FARS2	99	75.000	ENSLACG00000006541	FARS2	95	74.615	Latimeria_chalumnae
ENSG00000145982	FARS2	99	74.000	ENSLOCG00000011667	fars2	84	76.423	Lepisosteus_oculatus
ENSG00000145982	FARS2	99	94.000	ENSLAFG00000007104	FARS2	100	85.144	Loxodonta_africana
ENSG00000145982	FARS2	100	95.787	ENSMFAG00000043484	FARS2	100	95.787	Macaca_fascicularis
ENSG00000145982	FARS2	100	95.787	ENSMMUG00000016352	FARS2	100	95.787	Macaca_mulatta
ENSG00000145982	FARS2	100	95.565	ENSMNEG00000044897	FARS2	100	95.565	Macaca_nemestrina
ENSG00000145982	FARS2	100	96.009	ENSMLEG00000038594	FARS2	100	96.009	Mandrillus_leucophaeus
ENSG00000145982	FARS2	99	71.287	ENSMAMG00000008166	fars2	88	69.779	Mastacembelus_armatus
ENSG00000145982	FARS2	99	69.307	ENSMZEG00005020256	fars2	91	69.048	Maylandia_zebra
ENSG00000145982	FARS2	52	73.585	ENSMGAG00000003984	FARS2	72	76.077	Meleagris_gallopavo
ENSG00000145982	FARS2	99	88.000	ENSMAUG00000008493	Fars2	100	85.588	Mesocricetus_auratus
ENSG00000145982	FARS2	99	95.000	ENSMICG00000003828	FARS2	100	94.064	Microcebus_murinus
ENSG00000145982	FARS2	99	92.000	ENSMOCG00000021203	Fars2	100	86.031	Microtus_ochrogaster
ENSG00000145982	FARS2	99	67.327	ENSMMOG00000019236	fars2	90	69.324	Mola_mola
ENSG00000145982	FARS2	99	85.000	ENSMODG00000009839	FARS2	94	77.647	Monodelphis_domestica
ENSG00000145982	FARS2	99	71.287	ENSMALG00000021209	fars2	77	69.268	Monopterus_albus
ENSG00000145982	FARS2	99	90.000	MGP_CAROLIEiJ_G0018432	Fars2	100	85.588	Mus_caroli
ENSG00000145982	FARS2	99	90.000	ENSMUSG00000021420	Fars2	100	89.954	Mus_musculus
ENSG00000145982	FARS2	99	91.000	MGP_PahariEiJ_G0019500	Fars2	100	86.031	Mus_pahari
ENSG00000145982	FARS2	99	90.000	MGP_SPRETEiJ_G0019312	Fars2	100	84.922	Mus_spretus
ENSG00000145982	FARS2	99	91.000	ENSMPUG00000000534	FARS2	91	88.470	Mustela_putorius_furo
ENSG00000145982	FARS2	89	66.667	ENSMLUG00000009677	FARS2	99	88.327	Myotis_lucifugus
ENSG00000145982	FARS2	99	90.000	ENSNGAG00000021589	Fars2	100	86.475	Nannospalax_galili
ENSG00000145982	FARS2	99	70.297	ENSNBRG00000016915	fars2	91	69.286	Neolamprologus_brichardi
ENSG00000145982	FARS2	100	98.448	ENSNLEG00000011479	FARS2	100	98.448	Nomascus_leucogenys
ENSG00000145982	FARS2	99	88.000	ENSMEUG00000003495	-	100	78.947	Notamacropus_eugenii
ENSG00000145982	FARS2	78	84.375	ENSOPRG00000000428	FARS2	78	84.375	Ochotona_princeps
ENSG00000145982	FARS2	99	90.000	ENSODEG00000006881	FARS2	100	86.253	Octodon_degus
ENSG00000145982	FARS2	99	68.317	ENSONIG00000013394	fars2	86	69.492	Oreochromis_niloticus
ENSG00000145982	FARS2	97	83.673	ENSOANG00000001199	-	95	77.866	Ornithorhynchus_anatinus
ENSG00000145982	FARS2	99	90.000	ENSOCUG00000014165	FARS2	100	86.062	Oryctolagus_cuniculus
ENSG00000145982	FARS2	99	68.317	ENSORLG00000003287	fars2	88	69.042	Oryzias_latipes
ENSG00000145982	FARS2	99	68.317	ENSORLG00020010934	fars2	88	68.796	Oryzias_latipes_hni
ENSG00000145982	FARS2	99	68.317	ENSORLG00015007676	fars2	88	68.796	Oryzias_latipes_hsok
ENSG00000145982	FARS2	99	69.307	ENSOMEG00000001412	fars2	70	70.915	Oryzias_melastigma
ENSG00000145982	FARS2	99	94.000	ENSOGAG00000001040	FARS2	100	91.131	Otolemur_garnettii
ENSG00000145982	FARS2	96	92.784	ENSOARG00000018718	-	100	67.442	Ovis_aries
ENSG00000145982	FARS2	100	100.000	ENSPPAG00000040551	FARS2	96	99.535	Pan_paniscus
ENSG00000145982	FARS2	99	91.000	ENSPPRG00000006027	FARS2	100	88.027	Panthera_pardus
ENSG00000145982	FARS2	99	92.000	ENSPTIG00000016684	FARS2	100	88.027	Panthera_tigris_altaica
ENSG00000145982	FARS2	100	97.872	ENSPTRG00000017692	FARS2	91	99.070	Pan_troglodytes
ENSG00000145982	FARS2	100	95.787	ENSPANG00000018208	FARS2	100	95.787	Papio_anubis
ENSG00000145982	FARS2	99	73.267	ENSPKIG00000010545	fars2	89	71.046	Paramormyrops_kingsleyae
ENSG00000145982	FARS2	99	81.000	ENSPSIG00000007752	FARS2	91	78.147	Pelodiscus_sinensis
ENSG00000145982	FARS2	99	66.337	ENSPMGG00000011665	fars2	91	67.980	Periophthalmus_magnuspinnatus
ENSG00000145982	FARS2	71	91.667	ENSPEMG00000017477	-	100	90.411	Peromyscus_maniculatus_bairdii
ENSG00000145982	FARS2	100	62.136	ENSPMAG00000001580	fars2	100	61.575	Petromyzon_marinus
ENSG00000145982	FARS2	99	67.327	ENSPFOG00000017241	fars2	93	64.977	Poecilia_formosa
ENSG00000145982	FARS2	97	67.677	ENSPLAG00000010636	fars2	58	61.776	Poecilia_latipinna
ENSG00000145982	FARS2	97	67.677	ENSPMEG00000016166	fars2	78	69.565	Poecilia_mexicana
ENSG00000145982	FARS2	99	65.347	ENSPREG00000010118	fars2	88	67.574	Poecilia_reticulata
ENSG00000145982	FARS2	100	98.891	ENSPPYG00000016197	FARS2	100	98.891	Pongo_abelii
ENSG00000145982	FARS2	96	92.784	ENSPCAG00000002324	FARS2	100	73.171	Procavia_capensis
ENSG00000145982	FARS2	100	80.931	ENSPCOG00000015666	FARS2	100	80.931	Propithecus_coquereli
ENSG00000145982	FARS2	100	61.702	ENSPVAG00000015327	FARS2	80	77.409	Pteropus_vampyrus
ENSG00000145982	FARS2	99	69.307	ENSPNYG00000009469	fars2	76	70.109	Pundamilia_nyererei
ENSG00000145982	FARS2	99	73.267	ENSPNAG00000000440	fars2	87	73.383	Pygocentrus_nattereri
ENSG00000145982	FARS2	99	91.000	ENSRNOG00000016135	Fars2	100	82.415	Rattus_norvegicus
ENSG00000145982	FARS2	100	96.009	ENSRROG00000030357	FARS2	91	96.009	Rhinopithecus_roxellana
ENSG00000145982	FARS2	89	36.123	YPR047W	MSF1	95	36.123	Saccharomyces_cerevisiae
ENSG00000145982	FARS2	100	92.461	ENSSBOG00000025432	FARS2	100	92.461	Saimiri_boliviensis_boliviensis
ENSG00000145982	FARS2	97	85.714	ENSSHAG00000016860	-	97	85.714	Sarcophilus_harrisii
ENSG00000145982	FARS2	99	75.248	ENSSFOG00015020636	fars2	88	73.632	Scleropages_formosus
ENSG00000145982	FARS2	100	67.647	ENSSMAG00000010353	fars2	92	67.464	Scophthalmus_maximus
ENSG00000145982	FARS2	99	69.307	ENSSDUG00000016357	fars2	88	70.000	Seriola_dumerili
ENSG00000145982	FARS2	82	64.420	ENSSLDG00000008683	fars2	88	64.420	Seriola_lalandi_dorsalis
ENSG00000145982	FARS2	99	84.000	ENSSARG00000001129	FARS2	98	73.824	Sorex_araneus
ENSG00000145982	FARS2	100	81.188	ENSSPUG00000006717	-	74	74.468	Sphenodon_punctatus
ENSG00000145982	FARS2	99	67.327	ENSSPAG00000001346	fars2	88	68.796	Stegastes_partitus
ENSG00000145982	FARS2	99	89.000	ENSSSCG00000038717	FARS2	100	88.372	Sus_scrofa
ENSG00000145982	FARS2	99	81.000	ENSTGUG00000002269	FARS2	100	79.302	Taeniopygia_guttata
ENSG00000145982	FARS2	99	65.049	ENSTRUG00000005887	fars2	96	68.661	Takifugu_rubripes
ENSG00000145982	FARS2	99	64.356	ENSTNIG00000005800	fars2	94	66.588	Tetraodon_nigroviridis
ENSG00000145982	FARS2	67	60.133	ENSTBEG00000001804	-	100	60.133	Tupaia_belangeri
ENSG00000145982	FARS2	99	90.000	ENSTTRG00000000063	FARS2	100	84.141	Tursiops_truncatus
ENSG00000145982	FARS2	99	90.000	ENSUMAG00000018618	FARS2	100	88.496	Ursus_maritimus
ENSG00000145982	FARS2	100	80.266	ENSVPAG00000010451	FARS2	100	80.266	Vicugna_pacos
ENSG00000145982	FARS2	100	89.845	ENSVVUG00000005409	FARS2	100	89.845	Vulpes_vulpes
ENSG00000145982	FARS2	52	68.610	ENSXETG00000031776	FARS2	94	68.610	Xenopus_tropicalis
ENSG00000145982	FARS2	97	65.657	ENSXCOG00000000559	-	60	68.132	Xiphophorus_couchianus
ENSG00000145982	FARS2	51	62.264	ENSXMAG00000027185	fars2	83	69.626	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	10329163.	IDA	Function
GO:0004826	phenylalanine-tRNA ligase activity	21873635.	IBA	Function
GO:0004826	phenylalanine-tRNA ligase activity	10329163.	IDA	Function
GO:0004826	phenylalanine-tRNA ligase activity	-	TAS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006432	phenylalanyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006432	phenylalanyl-tRNA aminoacylation	10329163.	IDA	Process
GO:0008033	tRNA processing	10329163.	IDA	Process