EuRBPDB

Description

Ensembl ID: ENSG00000146109 (Gene tree)
Gene ID: 29777
Gene Symbol: ABT1
Alias: Esf2
Full Name: activator of basal transcription 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,802 bases
Position: chr6:26,596,943-26,600,744
Accession: 17369
RBP type: non-canonical RBP
Summary: Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000274849	ABT1-201	2949	-	ENSP00000274849	272 (aa)	-	Q9ULW3

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146109	Lupus Erythematosus, Systemic	1.44913E-9	18204098
ENSG00000146109	Platelet Function Tests	1.9965200E-005	-
ENSG00000146109	Platelet Function Tests	1.5147800E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000146109	rs45527431	6	26599281	G	Depression (broad)	29662059	[0.0078-0.0152] unit decrease	0.0115	EFO_0003761

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000146109	ABT1	82	87.111	ENSMUSG00000036376	Abt1	98	78.571	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003713	transcription coactivator activity	10648625.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	19299493.25416956.	IPI	Function
GO:0005634	nucleus	10648625.	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	-	IEA	Process
GO:0021522	spinal cord motor neuron differentiation	-	IEA	Process
GO:0034462	small-subunit processome assembly	21873635.	IBA	Process
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process